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61. 发明申请

US20090176850A1 Novel 2-Amino-Imidazole-4-One Compounds And Their Use In The Manufacture Of A Medicament To Be Used In The Treatment Of Cognitive Impairment, Alzheimer's Disease, Neurodegeneration And Dementia 审中-公开
标题翻译：新型2-氨基 - 咪唑-4-酮化合物及其用于制造治疗认知功能障碍，阿尔茨海默病，神经退行性和痴呆症的药物
公开(公告)号：US20090176850A1
公开(公告)日：2009-07-09
申请号：US12094271
申请日：2006-11-20
申请人： Jeffrey Albert , James Arnold , Gianni Chessari , Miles Stuart Congreve , Phil Edwards , Christopher Murray , Sahil Patel
发明人： Jeffrey Albert , James Arnold , Gianni Chessari , Miles Stuart Congreve , Phil Edwards , Christopher Murray , Sahil Patel
IPC分类号： A61K31/4166 , C07D233/14 , A61P25/28
CPC分类号： C07D233/46 , C07D401/10 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/10
摘要： This invention relates to novel compounds having the structural formula I below and to their pharmaceutically acceptable salts, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译：本发明涉及具有下述结构式I的新化合物及其药学上可接受的盐，组合物和使用方法。这些新化合物提供了认知障碍，阿尔茨海默病，神经变性和痴呆症的治疗或预防。

62. 发明申请

US20080306054A1 Pharmaceutical Compounds 审中-公开
标题翻译：药物化合物
公开(公告)号：US20080306054A1
公开(公告)日：2008-12-11
申请号：US11911447
申请日：2006-04-13
申请人： Gianni Chessari , Miles Stuart Congreve , Eva Figueroa Navarro , Martyn Frederickson , Christopher Murray , Alison Jo-Anne Woolford , Maria Grazia Carr , Michael Alistair O'Brien , Andrew James Woodhead
发明人： Gianni Chessari , Miles Stuart Congreve , Eva Figueroa Navarro , Martyn Frederickson , Christopher Murray , Alison Jo-Anne Woolford , Maria Grazia Carr , Michael Alistair O'Brien , Andrew James Woodhead
IPC分类号： A61K31/54 , C07D241/04 , A61K31/495 , A61K31/5375 , A61K31/435 , C07D211/06 , C07D265/30 , C07D279/12
CPC分类号： C07D401/12 , C07C65/21 , C07D209/08 , C07D209/44 , C07D215/08 , C07D217/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D471/04 , C07D471/10 , C07D491/08 , C07D491/10
摘要： The invention provides a compound for use as an inhibitor of Hsp90, the compound having the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; C1-5 hydrocarbyl and C1-5 hydrocarbyloxy; wherein the C1-5 hydrocarbyl and C1-5 hydrocarbyloxy moieties are each optionally substituted by one or more substituents selected from hydroxy, halogen, C1-2 alkoxy, amino, mono- and di-C1-2 alkylamino, and aryl and heteroaryl groups of 5 to 12 ring members; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and mono- or di-C1-5 hydrocarbyl-amino, wherein the acyclic C1-5 hydrocarbyl group and the mono and di-C1-5 hydrocarbylamino moieties in each instance are optionally substituted by one or more substituents selected from hydroxy, halogen, C1-2 alkoxy, amino, mono- and di-C1-2 alkylamino, and aryl and heteroaryl groups of 5 to 12 ring members; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and R5 and R6 are as defined in the claims.
摘要翻译：本发明提供用作Hsp90抑制剂的化合物，具有式（I）的化合物：或其盐，互变异构体，溶剂合物和N-氧化物; 其中R1是羟基或氢; R2是羟基; 甲氧基或氢; 条件是R 1和R 2中的至少一个是羟基; R3选自氢; 卤素; 氰基; C 1-5烃基和C 1-5烃氧基; 其中C 1-5烃基和C 1-5烃氧基部分各自任选被一个或多个选自羟基，卤素，C 1-2烷氧基，氨基，单和二-C 1-2烷基氨基，和芳基和杂芳基的取代基取代 5至12名成员; R4选自氢; 基团 - （O）n -R 7，其中n为0或1，R 7为无环C 1-5烃基或具有3〜7个环成员的单环碳环或杂环基; 卤素; 氰基羟基; 氨基; 和单 - 或二-C1-5烃基 - 氨基，其中无规C 1〜5烃基和单-C 1〜C 5烃基氨基部分任选被一个或多个选自羟基，卤素，C1 -2-烷氧基，氨基，单和二-C 1-2烷基氨基，以及5至12个环成员的芳基和杂芳基; 或R 3和R 4一起形成5至7个环成员的单环碳环或杂环; 并且R 5和R 6如权利要求中所定义。

63. 发明申请

US20070256480A1 SCANNING PROBE MICROSCOPY TIPS COMPOSED OF NANOPARTICLES AND METHODS TO FORM SAME 审中-公开
标题翻译：扫描探针组成的纳米微粒及其形成方法
公开(公告)号：US20070256480A1
公开(公告)日：2007-11-08
申请号：US11775316
申请日：2007-07-10
申请人： Charles Black , Adam Cohen , Christopher Murray , Robert Sandstrom
发明人： Charles Black , Adam Cohen , Christopher Murray , Robert Sandstrom
IPC分类号： G01B5/28
CPC分类号： G01Q70/16 , G01Q70/14 , Y10S977/924 , Y10T428/254
摘要： A structure and method for improving the spatial resolution of a scanning probe microscope (SPM) tip, which has been coated with a layer of chemically-synthesized nanoparticles. The nanoparticles are either single-species or heterogeneous, such that the single-species nanoparticles can be either ferromagnetic, paramagnetic, superparamagnetic, antiferromagnetic, ferrimagnetic, magneto-optic, ferroelectric, piezoelectric, superconducting, semiconducting, magnetically-doped semiconducting, insulating, fluorescent, or chemically catalytic. The layer of nanoparticles is at least two nanoparticles thick, or alternatively, is a single layer of nanoparticles thick, or alternatively, is a single layer of nanoparticles thick and covers only the tip apex portion of the tip, or alternatively, only a single nanoparticle is affixed to the tip apex. Alternatively, the layer of nanoparticles is transformed into an electrically-continuous magnetic film by annealing at a high temperature.
摘要翻译：用于改善扫描探针显微镜（SPM）尖端的空间分辨率的结构和方法，其已经涂覆有化学合成的纳米颗粒层。纳米颗粒是单种或非均质的，使得单种纳米颗粒可以是铁磁性，顺磁性，超顺磁性，反铁磁性，亚铁磁性，磁光学，铁电体，压电，超导，半导体，磁掺杂半导体，绝缘，荧光，或化学催化。纳米颗粒层是至少两个纳米颗粒厚度，或者可选地，是单层纳米颗粒的厚度，或者可选地，单层纳米颗粒是厚的，并且仅覆盖尖端的顶端部分，或者仅仅是单个纳米颗粒贴在尖端顶端。或者，通过在高温下退火将纳米颗粒层转变成电连续的磁性膜。

64. 发明申请

US20070237706A1 Embedded nanoparticle films and method for their formation in selective areas on a surface 审中-公开
标题翻译：嵌入的纳米颗粒膜及其在表面上的选择性区域中形成的方法
公开(公告)号：US20070237706A1
公开(公告)日：2007-10-11
申请号：US11400390
申请日：2006-04-10
申请人： Charles Black , Christopher Murray , Robert Sandstrom
发明人： Charles Black , Christopher Murray , Robert Sandstrom
IPC分类号： D01F9/12 , B05D3/12 , B05D3/02
CPC分类号： C01B31/0226 , B82Y30/00 , B82Y40/00 , C01B32/16 , C01B32/162 , C01B2202/06 , C01B2202/36 , D01F9/127 , Y10S423/40 , Y10S977/742 , Y10S977/75 , Y10T428/24372 , Y10T428/24521 , Y10T428/24537 , Y10T428/24612 , Y10T428/2462 , Y10T428/2918
摘要： The invention is directed to a method of positioning nanoparticles on a patterned substrate. The method comprises providing a patterned substrate with selectively positioned recesses, and applying a solution or suspension of nanoparticles to the patterned substrate to form a wetted substrate. A wiper member is dragged across the surface of the wetted substrate to remove a portion of the applied nanoparticles from the wetted substrate, and leaving a substantial number of the remaining portion of the applied nanoparticles disposed in the selectively positioned recesses of the substrate. The invention is also directed to a method of making carbon nanotubes from the positioned nanoparticles.
摘要翻译：本发明涉及一种将图案化衬底上的纳米颗粒定位的方法。该方法包括提供具有选择性定位的凹部的图案化衬底，以及将纳米颗粒的溶液或悬浮液施加到图案化衬底以形成润湿衬底。将擦拭器构件拖过湿润衬底的表面以从受湿衬底移除一部分所施加的纳米颗粒，并将大量剩余部分的所施加的纳米颗粒置于衬底的选择性定位的凹槽中。本发明还涉及从定位的纳米颗粒制备碳纳米管的方法。

65. 发明申请

US20070059755A1 Methods for selective targeting 审中-公开
标题翻译：选择性靶向的方法
公开(公告)号：US20070059755A1
公开(公告)日：2007-03-15
申请号：US11588929
申请日：2006-10-27
申请人： Giselle Janssen , Christopher Murray , Deborah Winetzky
发明人： Giselle Janssen , Christopher Murray , Deborah Winetzky
IPC分类号： C40B30/06 , C40B40/08 , C40B40/10
CPC分类号： C07K7/06 , C07K7/08 , C12N15/1034 , C12N15/1037 , C12N15/1072 , C40B30/04 , C40B40/02 , G01N33/6845 , G01N2500/02
摘要： A selective targeting method is disclosed which comprises contacting a peptide library with an anti-target to allow the peptides to bind; separating non-binding peptides from the anti-target bound peptides, contacting the non-binding anti-target peptides with a target allowing the unbound peptides to bind with the target to form a target-bound peptide complex; separating the target-bound peptide complex from peptides which do not bind to the target, and identifying the target-bound peptides. In one embodiment the target is skin or hair. In another embodiment the anti-target is hair when the target is skin, and the anti-target is skin when the target is hair.
摘要翻译：公开了选择性靶向方法，其包括使肽文库与抗靶接触以使肽结合; 从抗靶结合肽分离非结合肽，使非结合抗靶肽与允许未结合的肽与靶结合以形成靶结合肽复合物的靶; 将靶结合肽复合物与不结合靶的肽分离，并鉴定靶结合肽。在一个实施方案中，靶是皮肤或头发。在另一个实施方案中，当靶是皮肤时，抗靶是头发，而当靶是头发时，抗靶是皮肤。

66. 发明申请

US20060191890A1 Temperature indicating soldering assembly 审中-公开
标题翻译：温度指示焊接组件
公开(公告)号：US20060191890A1
公开(公告)日：2006-08-31
申请号：US11297814
申请日：2005-12-08
申请人： Michael Agronin , Scott Kolodziejski , Paul Stephenson , Joe Rogers , Christopher Murray
发明人： Michael Agronin , Scott Kolodziejski , Paul Stephenson , Joe Rogers , Christopher Murray
IPC分类号： H05B3/42 , H05B1/00
CPC分类号： B23K3/027 , B23K3/033
摘要： A soldering assembly has a base with a support member and at least one workpiece support member to support a workpiece. A soldering iron is removably supported by the base support member. The soldering iron includes a heating element and a heatable tip heated by the heating element. The soldering iron also has a temperature indicator that is movable, between positions, depending on the temperature of the heatable tip. Thus, the soldering iron indicates the temperature of the heatable tip to a user.
摘要翻译：焊接组件具有带有支撑构件的基座和至少一个支撑工件的工件支撑构件。烙铁由基座支撑件可拆卸地支承。烙铁包括加热元件和由加热元件加热的可加热顶端。烙铁还具有温度指示器，其可根据可加热尖端的温度在位置之间移动。因此，烙铁表示可加热尖端对使用者的温度。

67. 发明授权

US07092772B2 Home automation system 有权
标题翻译：家庭自动化系统
公开(公告)号：US07092772B2
公开(公告)日：2006-08-15
申请号：US10697795
申请日：2003-10-30
申请人： Christopher Murray , Cory Sorice , James R. Raskin , Carolyn M. Martin , William H. Frederick
发明人： Christopher Murray , Cory Sorice , James R. Raskin , Carolyn M. Martin , William H. Frederick
IPC分类号： G05B15/00
CPC分类号： G09B25/00
摘要： An improved home automation system that permits the user of the system to remotely control the operation of various devices including garage doors and powered entry gates. The system is packaged in a manner that “walks” the user through the initialization process to thereby reduce or eliminate errors associated with the initialization and set-up of the system. Furthermore, the configuration permits the user to initialize the system without the use of tools, such as screwdrivers. The system is configured with improved functionality that permits the user to readily control individual devices and/or selected groups of devices with a powerful hand-held universal remote transmitter.
摘要翻译：改进的家庭自动化系统，其允许系统的用户远程控制包括车库门和动力进入门的各种设备的操作。该系统以“行进”用户通过初始化过程的方式打包，从而减少或消除与系统的初始化和建立相关联的错误。此外，该配置允许用户在不使用诸如螺丝刀的工具的情况下初始化系统。该系统配置有改进的功能，其允许用户使用强大的手持通用远程发射机容易地控制各个设备和/或所选择的设备组。

68. 发明授权

US07082339B2 Home automation system 失效
公开(公告)号：US07082339B2
公开(公告)日：2006-07-25
申请号：US10418022
申请日：2003-04-17
申请人： Christopher Murray , Cory Sorice
发明人： Christopher Murray , Cory Sorice
IPC分类号： G05B15/00
CPC分类号： H04L12/2803 , G09B25/00 , H04L12/282 , H04L2012/2843 , H04L2012/285
摘要： An improved home automation system that permits the user of the system to remotely control the operation of various devices. The system is packaged in a manner that “walks” the user through the initialization process to thereby reduce or eliminate errors associated with the initialization and set-up of the system. Furthermore, the configuration permits the user to initialize the system without the use of tools, such as screwdrivers. The system is configured with improved functionality that permits the user to readily control individual devices and/or selected groups of devices with a powerful hand-held remote transmitter.

69. 发明申请

US20060141456A1 Methods and compositions for milieu-dependent binding of a targeted agent to a target 审中-公开
标题翻译：目标药物与靶标的环境依赖性结合的方法和组合物
公开(公告)号：US20060141456A1
公开(公告)日：2006-06-29
申请号：US10514516
申请日：2003-06-09
申请人： Cynthia Edwards , Judith Fox , Christopher Murray , Volker Schellenberger , Robert Tressler
发明人： Cynthia Edwards , Judith Fox , Christopher Murray , Volker Schellenberger , Robert Tressler
IPC分类号： C12Q1/68
CPC分类号： C07K16/3007 , C07K16/30 , C07K2299/00 , C07K2317/565 , C07K2317/622 , G01N33/53 , G01N33/574 , G01N2500/04
摘要： The present invention provides methods and compositions for milieu-dependent binding of a targeted agent to a target, for example, for the milieu-dependent binding of a diagnostic or therapeutic molecule to a diseased, injured or infected organ, tissue or cell.
摘要翻译：本发明提供了用于目标药物与靶标的环境依赖性结合的方法和组合物，例如用于诊断或治疗分子与患病，受伤或感染的器官，组织或细胞的环境依赖性结合。

70. 发明申请

US20060105523A1 Chemical doping of nano-components 失效
公开(公告)号：US20060105523A1
公开(公告)日：2006-05-18
申请号：US10991582
申请日：2004-11-18
申请人： Ali Afzali-Ardakani , Phaedon Avouris , Jia Chen , Christian Klinke , Christopher Murray , Dmitri Talapin
发明人： Ali Afzali-Ardakani , Phaedon Avouris , Jia Chen , Christian Klinke , Christopher Murray , Dmitri Talapin
IPC分类号： H01L21/336
CPC分类号： H01L21/22 , B82Y10/00 , H01L51/002 , H01L51/0048 , Y10S977/742 , Y10S977/938
摘要： A method is provided for doping nano-components, including nanotubes, nanocrystals and nanowires, by exposing the nano-components to an organic amine-containing dopant. A method is also provided for forming a field effect transistor comprising a nano-component that has been doped using such a dopant.

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