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1. 发明申请

US20100324072A1 PYRROLOPYRIDINE DERIVATIVES AND THEIR USE AS BACE INHIBITORS 审中-公开
标题翻译：吡咯并吡啶衍生物及其作为BACE抑制剂的用途
公开(公告)号：US20100324072A1
公开(公告)日：2010-12-23
申请号：US12600177
申请日：2008-05-14
申请人： Gianni Chessari , Miles Stuart Congreve , Jorg Holenz , Christopher Murray , Sahil Patel , Laszlo Rakos , Didier Rotticci
发明人： Gianni Chessari , Miles Stuart Congreve , Jorg Holenz , Christopher Murray , Sahil Patel , Laszlo Rakos , Didier Rotticci
IPC分类号： A61K31/506 , C07D471/04 , A61K31/437 , A61P25/00 , A61P25/28 , A61P25/16
CPC分类号： C07D471/04
摘要： This invention relates to novel compounds having the structural formula I below: (I) and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译：本发明涉及具有以下结构式I的新化合物：（I）及其药学上可接受的盐，组合物和使用方法。这些新化合物提供了认知障碍，阿尔茨海默病，神经变性和痴呆症的治疗或预防。

2. 发明申请

US20090233945A9 NEW COMPOUNDS 834 失效
标题翻译：新化合物834
公开(公告)号：US20090233945A9
公开(公告)日：2009-09-17
申请号：US12120736
申请日：2008-05-15
申请人： Gianni Chessari , Miles Stuart Congreve , Jorg Holenz , Christopher Murray , Sahil Patel , Laszlo Rakos , Didier Rotticci
发明人： Gianni Chessari , Miles Stuart Congreve , Jorg Holenz , Christopher Murray , Sahil Patel , Laszlo Rakos , Didier Rotticci
IPC分类号： A61K31/506 , C07D471/04 , C12N9/99 , A61P25/16 , A61P25/28 , A61K31/437
CPC分类号： C07D471/04
摘要： This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译：本发明涉及具有以下结构式I的新化合物及其药学上可接受的盐，组合物和使用方法。这些新化合物提供了认知障碍，阿尔茨海默病，神经变性和痴呆症的治疗或预防。

3. 发明申请

US20080287462A1 NEW COMPOUNDS 834 失效
标题翻译：新化合物834
公开(公告)号：US20080287462A1
公开(公告)日：2008-11-20
申请号：US12120736
申请日：2008-05-15
申请人： Gianni Chessari , Miles Stuart Congreve , Jorg Holenz , Christopher Murray , Sahil Patel , Laszlo Rakos , Didier Rotticci
发明人： Gianni Chessari , Miles Stuart Congreve , Jorg Holenz , Christopher Murray , Sahil Patel , Laszlo Rakos , Didier Rotticci
IPC分类号： A61K31/506 , C07D471/04 , C12N9/99 , A61P25/16 , A61P25/28 , A61K31/437
CPC分类号： C07D471/04
摘要： This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译：本发明涉及具有以下结构式I的新化合物及其药学上可接受的盐，组合物和使用方法。这些新化合物提供了认知障碍，阿尔茨海默病，神经变性和痴呆症的治疗或预防。

4. 发明申请

US20080171771A1 New Compounds 391 失效
标题翻译：新化合物391
公开(公告)号：US20080171771A1
公开(公告)日：2008-07-17
申请号：US11762487
申请日：2007-06-13
申请人： James Arnold , Phil Edwards , Mark Sylvester , Stefan Berg , Jorg Holenz , Annika Kers , Karin Kolmodin , Laszlo Rakos , Liselotte Ohberg , Rotticci Didier , Gianni Chessari , Miles Congreve , Christopher Murray , Sahil Patel
发明人： James Arnold , Phil Edwards , Mark Sylvester , Stefan Berg , Jorg Holenz , Annika Kers , Karin Kolmodin , Laszlo Rakos , Liselotte Ohberg , Rotticci Didier , Gianni Chessari , Miles Congreve , Christopher Murray , Sahil Patel
IPC分类号： A61K31/4439 , C07D209/44 , A61K31/4035 , A61P25/00 , A61P25/16 , A61P25/28 , C07D401/10
CPC分类号： A61K31/4035 , A61K31/4433 , A61K31/4439 , A61K31/506 , C07D209/44 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/14 , C07D513/04
摘要： This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译：本发明涉及具有以下结构式I的新化合物及其药学上可接受的盐，组合物和使用方法。这些新化合物提供了认知障碍，阿尔茨海默病，神经变性和痴呆症的治疗或预防。

5. 发明申请

US20080293709A1 Novel 2-Amino-Heterocycles Useful in the Treatment of Abeta-Related Pathologies 审中-公开
标题翻译：新型2-氨基杂环可用于治疗与Abeta相关的病理学
公开(公告)号：US20080293709A1
公开(公告)日：2008-11-27
申请号：US12093631
申请日：2006-11-13
申请人： Jeffrey Albert , Gianni Chessari , Miles Stuart Congreve , Phil Edwards , Christopher Murray , Sahil Patel , Mark Sylvester
发明人： Jeffrey Albert , Gianni Chessari , Miles Stuart Congreve , Phil Edwards , Christopher Murray , Sahil Patel , Mark Sylvester
IPC分类号： A61K31/472 , A61P25/00 , C07D217/22 , C07D401/02 , A61K31/517 , C07D495/04 , A61K31/536 , A61K31/4725 , C07D239/72 , C07D265/14
CPC分类号： C07D217/22 , C07D239/94 , C07D265/20 , C07D401/04 , C07D495/04
摘要： This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salts, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译：本发明涉及具有以下结构式I的新化合物及其药学上可接受的盐，组合物和使用方法。这些新化合物提供了认知障碍，阿尔茨海默病，神经变性和痴呆症的治疗或预防。

6. 发明申请

US20220134985A1 Self-Restrained Radiator Protection and Filter 有权
公开(公告)号：US20220134985A1
公开(公告)日：2022-05-05
申请号：US17085711
申请日：2020-10-30
申请人： Sahil Patel
发明人： Sahil Patel
IPC分类号： B60R19/52 , B32B7/05
摘要： A radiator protection device that protects a vehicle radiator from debris and damage is disclosed. The device is a multi-layer system that is flexible enough to be installed and removed through the radiator grill or other openings into the vehicle's radiator compartment. Installed configuration requires no mounting features nor support provisions due to the nature of fitment and resiliency of device to return to original shape.

7. 发明申请

US20160148121A1 EMERGENCY-ROOM RESERVATION SYSTEM AND METHOD 审中-公开
标题翻译：紧急预约系统和方法
公开(公告)号：US20160148121A1
公开(公告)日：2016-05-26
申请号：US14554771
申请日：2014-11-26
申请人： Chris DURHAM , Sahil PATEL
发明人： Chris DURHAM , Sahil PATEL
IPC分类号： G06Q10/02 , G06Q50/22
CPC分类号： G06Q10/02 , G06Q50/22
摘要： Reservations for emergency/urgent care are made by users using a queue feature that identifies earliest available reservations at nearby care facilities that are identified based on user-selected facility search parameters. The queue feature identifies the earliest available reservations based on user-selected treatment categories and facility-selected capacity characteristics for the treatment categories, and recommends a best reservation. The treatment categories can be for example adult, child/pediatric, urgent care, direct admit, walk-in, or worker's comp. And the capacity characteristics can be for example wait time, black-out period, and/or maximum number of reservations per time period. In addition, a reservation-update feature enables the care facilities to update the capacity characteristics for the treatment categories at their facilities to reflect changed conditions. And a reservation-confirmation feature enables the users to rerun the queue process to identify a new best reservation in light of the updated capacity characteristics for the treatment categories.
摘要翻译：用户使用队列功能进行紧急/紧急护理的预约，该队列功能可识别基于用户选择的设施搜索参数识别的附近护理设施的最早可用预留。队列功能根据用户选择的治疗类别和治疗类别的设施选择容量特征识别最早的可用预留，并建议最佳预约。治疗类别可以是成人，儿童/儿科，紧急护理，直接入院，步入式或工作人员。并且容量特性可以是例如每个时间段的等待时间，停电期和/或最大保留数。另外，预约更新功能使护理设施更新其设施处理类别的容量特征，以反映改变的状况。并且预订确认功能使得用户可以根据治疗类别的更新容量特征来重新运行队列过程以识别新的最佳预约。

8. 发明授权

US07629356B2 Substituted pyrrolo[3,4-b]pyridinamines and pharmaceutical compositions 失效
标题翻译：取代的吡咯并[3,4-b]吡啶胺和药物组合物
公开(公告)号：US07629356B2
公开(公告)日：2009-12-08
申请号：US12120736
申请日：2008-05-15
申请人： Gianni Chessari , Miles Stuart Congreve , Jörg Holenz , Christopher Murray , Sahil Patel , Laszlo Rakos , Didier Rotticci
发明人： Gianni Chessari , Miles Stuart Congreve , Jörg Holenz , Christopher Murray , Sahil Patel , Laszlo Rakos , Didier Rotticci
IPC分类号： A01N43/42
CPC分类号： C07D471/04
摘要： This invention relates to substituted pyrrolo[3,4-b]pyridinamines having the structural formula IA below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译：本发明涉及以下结构式IA的取代的吡咯并[3,4-b]吡啶胺及其药学上可接受的盐，组合物和使用方法。这些新化合物提供了认知障碍，阿尔茨海默病，神经变性和痴呆症的治疗或预防。

9. 发明申请

US20090062282A1 Substituted Amino-Pyrimidones and Uses Thereof 审中-公开
标题翻译：取代的氨基嘧啶酮及其用途
公开(公告)号：US20090062282A1
公开(公告)日：2009-03-05
申请号：US11577154
申请日：2005-10-14
申请人： Jeffrey Scott Albert , Don Andisik , James Arnold , Dean Brown , Owen Callaghan , James Campbell , Robin Arthur Ellis Carr , Gianni Chessari , Miles Stuart Congreve , Phil Edwards , James R. Empfield , Martyn Frederickson , Gerard M. Koether , Jennifer Krumrine , Russ Mauger , Christopher William Murray , Sahil Patel , Mark Sylvester , Scott Throner
发明人： Jeffrey Scott Albert , Don Andisik , James Arnold , Dean Brown , Owen Callaghan , James Campbell , Robin Arthur Ellis Carr , Gianni Chessari , Miles Stuart Congreve , Phil Edwards , James R. Empfield , Martyn Frederickson , Gerard M. Koether , Jennifer Krumrine , Russ Mauger , Christopher William Murray , Sahil Patel , Mark Sylvester , Scott Throner
IPC分类号： A61K31/5377 , C07D239/22 , A61K31/513 , C12N9/99 , A61P25/28 , C07D413/10
CPC分类号： C07D239/47 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/10 , C07D405/14 , C07D409/10
摘要： This invention relates to novel compounds having the structural formula Ia or formula Ib below: (Ia, Ib), and their pharmaceutically acceptable salts, tautomers or in vivo hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of Aβ related pathologies such as cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译：本发明涉及具有结构式Ia或式Ib的新化合物：（Ia，Ib）及其药学上可接受的盐，互变异构体或体内可水解的前体，组合物及其使用方法。这些新型化合物提供治疗或预防Abeta相关病理学，如认知障碍，阿尔茨海默病，神经变性和痴呆。

10. 发明申请

US20080293718A1 Novel 2-Amino-Imidazole-4-One Compounds and Their Use in the Manufacture of a Medicament to Be Used in the Treatment of Cognitive Impairment, Alzheimer's Disease, Neurodegeneration and Dementia 审中-公开
标题翻译：新型2-氨基 - 咪唑-4-酮化合物及其在制造用于治疗认知功能障碍，阿尔茨海默病，神经退行性和痴呆症药物中的应用
公开(公告)号：US20080293718A1
公开(公告)日：2008-11-27
申请号：US12094276
申请日：2006-11-20
申请人： Stefan Berg , Jeremy Burrows , Gianni Chessari , Miles Stuart Congreve , Johan Hedstrom , Sven Hellberg , Katharina Hogdin , Jacob Kihlstrom , Karin Kolmodin , Johan Lindstrom , Christopher Murray , Sahil Patel
发明人： Stefan Berg , Jeremy Burrows , Gianni Chessari , Miles Stuart Congreve , Johan Hedstrom , Sven Hellberg , Katharina Hogdin , Jacob Kihlstrom , Karin Kolmodin , Johan Lindstrom , Christopher Murray , Sahil Patel
IPC分类号： A61K31/5377 , C07D401/10 , A61K31/4725 , C07D339/08 , A61P25/28 , C07F7/08 , C12N9/99 , C07D413/12
CPC分类号： C07D233/88 , C07C25/22 , C07C25/24 , C07C39/373 , C07C43/1747 , C07C43/23 , C07C47/575 , C07C49/792 , C07C49/813 , C07C49/83 , C07C49/84 , C07D209/08 , C07D217/06 , C07D233/86 , C07D265/36 , C07D307/79 , C07D339/08 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D417/04 , C07F7/1804
摘要： This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译：本发明涉及具有以下结构式I的新化合物及其药学上可接受的盐，组合物和使用方法。这些新化合物提供了认知障碍，阿尔茨海默病，神经变性和痴呆症的治疗或预防。

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