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61. 发明授权

US06540754B2 Apparatus and method for multiply folding and inserting an intraocular lens in an eye 有权
标题翻译：将眼内透镜多次折叠并插入眼睛的装置和方法
公开(公告)号：US06540754B2
公开(公告)日：2003-04-01
申请号：US09770867
申请日：2001-01-26
申请人： Daniel G. Brady
发明人： Daniel G. Brady
IPC分类号： A61F900
CPC分类号： A61F2/1664
摘要： An intraocular lens (IOL) insertion system, cartridge and/or combination cartridge and folding member that facilitates multiply folding an IOL within a load chamber of the cartridge prior to insertion in an eye. In the system embodiment, a folding member is provided in a handpiece that interacts with the cartridge to multiply fold the IOL therewithin. Alternatively, the cartridge may incorporate the folding member in its structure, or a separate folding member that interacts with the cartridge may be provided in a combination. The folding member may be a planar element that extends through a slot in the wall of the load chamber to displace a midportion of the IOL away from the inner wall of the load chamber. Desirably, the multiply folded configuration that results is an M-shape or a W-shape, depending on orientation. The cartridge may further include structure that retains the multiply folded configuration of the IOL as it passes through an injection tube and into the eye.
摘要翻译：一种眼内透镜（IOL）插入系统，盒和/或组合盒和折叠构件，其在插入眼睛之前有助于在盒的装载室内将IOL倍增折叠。在系统实施例中，折叠构件设置在与盒相互作用的手持件中以将IOL倍增。或者，盒可以将折叠构件结合到其结构中，或者可以组合地提供与盒相互作用的单独的折叠构件。折叠构件可以是平面元件，其延伸穿过装载室的壁中的槽，以使IOL的中间部分离开装载室的内壁。期望地，取决于取向，导致M形或W形的多重折叠构造。该盒还可以包括当IOL通过注射管并进入眼睛时保持IOL的多重折叠构型的结构。

62. 发明授权

US06468306B1 IOL for inhibiting cell growth and reducing glare 有权
标题翻译： IOL用于抑制细胞生长并减少眩光
公开(公告)号：US06468306B1
公开(公告)日：2002-10-22
申请号：US09507602
申请日：2000-02-18
申请人： Marlene L. Paul , Daniel G. Brady , Jim Deacon
发明人： Marlene L. Paul , Daniel G. Brady , Jim Deacon
IPC分类号： A61F216
CPC分类号： A61F2/16 , A61F2/1613 , A61F2/1659 , A61F2002/009 , A61F2002/0091 , A61F2002/16901 , A61F2002/1696 , A61F2002/1699
摘要： An intraocular lens implantable in an eye includes an optic for placement in the capsular bag of the eye and for directing light toward the retina of the eye. The optic has a central optical axis, an anterior face, an opposing posterior face and a peripheral edge between the faces. The peripheral edge has one or more curved or angled surfaces that reduce glare within the IOL. For instance, a rounded transition surface on the anterior side of the peripheral edge diffuses the intensity of reflected light, or a particular arrangement of straight edge surfaces refracts the light so as not to reflect, or does not reflect at all. The intersection of the peripheral edge and at least one of the anterior face and the posterior face, preferably both of such faces, forms a peripheral corner located at a discontinuity between the peripheral edge and the intersecting face or faces. The present IOLs inhibit cell growth from the eye in front of or in back of the optic and reduce glare obtained in the eye in which the IOL is located.
摘要翻译：可植入眼睛的眼内透镜包括用于放置在眼囊的囊袋中并用于将光引向眼睛的视网膜的光学元件。光学元件具有中心光轴，前表面，相对的后表面和面之间的周边边缘。周边边缘具有一个或多个弯曲或成角度的表面，可减少IOL内的眩光。例如，外围边缘的前侧上的圆形过渡表面扩散反射光的强度，或者直线边缘表面的特定布置折射光以便不反射或完全不反射。外围边缘与前表面和后表面中的至少一个，优选两个这样的表面的交点形成位于周边边缘和相交面或面之间不连续处的周边拐角。本发明的IOL抑制视神经纤维前方或背后的细胞生长，并减少在眼睛中所获得的眩光。

63. 发明授权

US06306423B1 Neurotoxin implant 失效
标题翻译：神经毒素植入物
公开(公告)号：US06306423B1
公开(公告)日：2001-10-23
申请号：US09587250
申请日：2000-06-02
申请人： Stephen Donovan , Daniel G. Brady
发明人： Stephen Donovan , Daniel G. Brady
IPC分类号： A61F200
CPC分类号： A61K9/0024 , A61K38/4893 , Y10S514/964
摘要： A biocompatible implant for continuous in vivo release of a neurotoxin over a treatment period extending from one month to five years. The implant can be made of casting a solution of a polymer, such as an ethyl vinyl acetate copolymer and the neurotoxin. The neurotoxin can be a botulinum toxin.
摘要翻译：在一个月至五年的治疗期内连续体内释放神经毒素的生物相容性植入物。植入物可以通过浇铸聚合物如乙酸乙烯酯共聚物和神经毒素的溶液来制备。神经毒素可以是肉毒杆菌毒素。

64. 发明授权

US06176878B1 Accommodating intraocular lens 有权
标题翻译：容纳人工晶状体
公开(公告)号：US06176878B1
公开(公告)日：2001-01-23
申请号：US09213976
申请日：1998-12-17
申请人： Arlene Gwon , Daniel G. Brady
发明人： Arlene Gwon , Daniel G. Brady
IPC分类号： A61F216
CPC分类号： A61F2/1613 , A61F2/1629
摘要： Intraocular lenses include an optic adapted to focus light toward a retina of an eye and a movement assembly coupled to the optic. The optic includes a far vision correction power for infinity reduced by a diopter power increment. The movement assembly is adapted to cooperate with the eye to move the optic bidirectionally, that is anteriorly in the eye and posteriorly in the eye, for example, from a neutral resting position in the eye, to effect positive accommodating movement of the optic and negative accommodating movement of the optic, respectively. Methods of inserting such intraocular lenses into an eye are also provided.
摘要翻译：人工晶状体包括适于将光聚焦到眼睛的视网膜的光学器件和耦合到光学元件的移动组件。光学元件包括用屈光度功率增量减小的无限远视力校正功率。运动组件适于与眼睛配合以使眼睛双向移动，即眼睛内部和眼睛中的后方，例如从眼睛中的中立静止位置移动视力，以实现光学和阴性的正面适应运动分别容纳光学元件的运动。还提供将眼内透镜插入眼睛的方法。

65. 发明授权

US6162249A IOI for inhibiting cell growth and reducing glare 失效
标题翻译： IOI用于抑制细胞生长并减少眩光
公开(公告)号：US6162249A
公开(公告)日：2000-12-19
申请号：US86882
申请日：1998-05-29
申请人： Jim Deacon , Daniel G. Brady
发明人： Jim Deacon , Daniel G. Brady
IPC分类号： A61F2/00 , A61F2/16
CPC分类号： A61F2/1613 , A61F2/16 , A61F2002/009 , A61F2002/1696 , A61F2002/1699 , A61F2250/0098
摘要： An intraocular lens implantable in an eye includes an optic for placement in the capsular bag of the eye and for directing light toward the retina of the eye. The optic has a central optical axis, an anterior face, an opposing posterior face and a peripheral edge surface between the faces. The peripheral edge surface has a substantially continuous curved configuration in the direction between the faces. The intersection of the peripheral edge surface and at least one of the anterior face and the posterior face, preferably both of such faces, forms a peripheral corner located at a discontinuity between the peripheral edge surface and the intersecting face or faces. The present IOLs inhibit cell growth from the eye in front of or in back of the optic and reduce glare obtained in the eye in which the IOL is located.
摘要翻译：可植入眼睛的眼内透镜包括用于放置在眼囊的囊袋中并用于将光引向眼睛的视网膜的光学元件。光学元件具有中心光轴，前表面，相对的后表面和面之间的周边边缘表面。周边边缘表面在面之间的方向上具有基本连续的弯曲构造。外围边缘表面与前表面和后表面中的至少一个，优选两个这样的表面的交点形成位于周边边缘表面和相交面或表面之间的不连续处的外周角。本发明的IOL抑制视神经纤维前方或背后的细胞生长，并减少在眼睛中所获得的眩光。

66. 发明授权

US6142999A Folding device and method for an intraocular lens 失效
标题翻译：眼内透镜的折叠装置和方法
公开(公告)号：US6142999A
公开(公告)日：2000-11-07
申请号：US316606
申请日：1999-05-21
申请人： Daniel G. Brady , Michael Collinson , Claude A. Vidal
发明人： Daniel G. Brady , Michael Collinson , Claude A. Vidal
IPC分类号： A61F2/16 , A61F9/00
CPC分类号： A61F2/1691 , A61F2/1664
摘要： A folding device for holding and folding an IOL and adapted to allow a surgeon to select between loading the IOL into a removably attached IOL injector and between holding the IOL in a folded state for removal with a separate instrument. The folding device includes a pair of opposing sides, each having an upper surface. A plurality of retaining brackets extend upwardly from the upper surfaces of each side. The brackets are adapted for receiving and removably retaining the IOL injector. A hinge couples the sides together along a fold axis and allows the sides to retain the IOL therebetween. The hinge allows the sides to fold together from a planer position about a first fold direction when using the separate instrument and towards each other about a second fold direction when using the IOL injector. This allows the surgeon to select between attaching the IOL injector to the retaining brackets such that when the sides are folded about the second fold direction, the IOL is released from the sides and loaded into the load chamber and between folding the sides about the first fold direction such that the IOL is folded and maintained in a folded state.
摘要翻译：一种折叠装置，用于保持和折叠IOL并且适于允许外科医生在将IOL装载到可拆卸地附接的IOL注射器之间以及在折叠状态下将IOL保持在一个单独的仪器之间进行选择。折叠装置包括一对相对的侧面，每个侧面具有上表面。多个保持支架从每侧的上表面向上延伸。支架适于接收和可移除地保持IOL注射器。铰链沿着折叠轴线将侧面结合在一起，并且允许侧面将IOL保持在其间。当使用IOL注射器时，铰链允许侧面在使用分离的仪器时围绕第一折叠方向的平面位置折叠在一起，并且在使用IOL注射器时朝向彼此朝向彼此朝向彼此朝向彼此。这允许外科医生在将IOL注射器附接到保持支架之间进行选择，使得当侧面围绕第二折叠方向折叠时，IOL从侧面被释放并且被装载到装载室中并且在围绕第一折叠折叠侧面之间方向使得IOL被折叠并保持在折叠状态。

67. 外观设计

USD431721S Intraocular lens package 失效
公开(公告)号：USD431721S
公开(公告)日：2000-10-10
申请号：US103457
申请日：1999-04-15
申请人： Daniel G. Brady , Arlene Gwon , Jonas H. Bourghardt , Hector R. Santos , Michael Collinson , Claude A. Vidal
设计人： Daniel G. Brady , Arlene Gwon , Jonas H. Bourghardt , Hector R. Santos , Michael Collinson , Claude A. Vidal

68. 发明授权

US06129733A Apparatus for holding intraocular lenses and injectors, and methods for using same 有权
公开(公告)号：US06129733A
公开(公告)日：2000-10-10
申请号：US292146
申请日：1999-04-15
申请人： Daniel G. Brady , Arlene Gwon , Michael Collinson , Claude A. Vidal , Alan K. Plyley
发明人： Daniel G. Brady , Arlene Gwon , Michael Collinson , Claude A. Vidal , Alan K. Plyley
IPC分类号： A61F2/16 , A61F9/00
CPC分类号： A61F2/1691
摘要： Apparatus for holding intraocular lenses and apparatus for holding intraocular lens injectors are provided which provide convenient and effective packaging systems for intraocular lenses and allow convenient and effective transfer of an intraocular lens to an injector in preparation for insertion of the intraocular lens into an eye.

69. 发明授权

US6078849A Vision based precision docking of vehicles 失效
标题翻译：基于视觉的车辆精准对接
公开(公告)号：US6078849A
公开(公告)日：2000-06-20
申请号：US209489
申请日：1998-12-11
申请人： Daniel G. Brady , Darrell R. Hougen , William A Kennedy , Jerome F. Sobetski
发明人： Daniel G. Brady , Darrell R. Hougen , William A Kennedy , Jerome F. Sobetski
IPC分类号： B60T7/22 , G05D1/02 , G06F7/00 , B60T7/16 , G01S3/00 , G06F17/00
CPC分类号： G05D1/0225 , B60T7/22 , G05D1/0234 , G05D1/0255 , G05D1/0272
摘要： A three phase control arrangement is employed after visual detection of a target at greater range than otherwise available. The first and last phases employ an optimization criterion for which errors do not vary with distance from a target; limiting the initial error and process error in an intermediate phase which controls approach trajectory to the intended docking location and yielding repeatable high accuracy docking. The three phase approach with different control criteria and control gain parameters makes feasible a docking maneuver that begins at a much greater range and potentially greater lateral separation from the destination than would otherwise be possible, while providing control of both the final location and final orientation of the vehicle. A preferred visual thresholding technique provides consistency of results over a wide range of illumination and contrast conditions while limiting the computation burden for target image acquisition and tracking.
摘要翻译：在目标的视觉检测之后，在比其他方式更大的范围内采用三相控制装置。第一阶段和最后阶段采用一个优化标准，其误差不随距离目标的距离而变化; 限制中间阶段的初始误差和过程误差，该中间阶段将进近轨迹控制到预期的对接位置，并产生可重复的高精度对接。具有不同控制标准和控制增益参数的三相方法使对接机动变得可行，其开始于比目前可能更大的范围和潜在的比目的地更大的横向分离，同时提供对最终位置和最终取向的控制机动车。优选的视觉阈值技术提供了在宽范围的照明和对比度条件下的结果的一致性，同时限制了目标图像获取和跟踪的计算负担。

70. 发明授权

US5810833A Deformable lens insertion apparatus 失效
标题翻译：可变形透镜插入装置
公开(公告)号：US5810833A
公开(公告)日：1998-09-22
申请号：US681563
申请日：1996-07-29
申请人： Daniel G. Brady , Edward R. Zaleski , Anthony V. Lemus
发明人： Daniel G. Brady , Edward R. Zaleski , Anthony V. Lemus
IPC分类号： A61F2/16 , A61F11/00
CPC分类号： A61F2/1664 , Y10S623/907
摘要： Apparatus for insertion of intraocular lenses into the eye are disclosed. In one embodiment, the apparatus comprises a loading chamber and an injection portion. The loading chamber has a proximal end and a distally extending opening. The loading chamber defines a first lumen and is adapted to receive an intraocular lens in an unfolded state at the distally extending opening and to fold the intraocular lens and maintain the intraocular lens folded as the intraocular lens is placed in the first lumen. The injection portion defines a second lumen aligned with the first lumen and is adapted to receive the folded intraocular lens from the first lumen in the second lumen. The injection portion has an open distal end through which the folded intraocular lens from the second lumen passes to be inserted into an eye.
摘要翻译：公开了将眼内透镜插入眼睛的装置。在一个实施例中，该装置包括装载室和注射部分。装载室具有近端和远端延伸的开口。装载室限定第一腔，并且适于在远侧延伸的开口处接收处于展开状态的眼内透镜并折叠眼内透镜，并且当眼内透镜放置在第一腔内时保持眼内透镜的折叠。注射部分限定与第一内腔对准的第二腔，并且适于从第二腔中的第一腔容纳折叠的眼内透镜。注射部分具有开放的远端，来自第二腔的折叠眼内透镜通过该远端被插入眼睛。

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