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1. 发明授权

US08702794B2 Back loaded IOL insertion cartridge 有权
标题翻译：背负荷IOL插入筒
公开(公告)号：US08702794B2
公开(公告)日：2014-04-22
申请号：US12111028
申请日：2008-04-28
申请人： Laurent G. Hoffmann , David A. Ruddocks , Mark C. Cole , Daniel G. Brady
发明人： Laurent G. Hoffmann , David A. Ruddocks , Mark C. Cole , Daniel G. Brady
IPC分类号： A61F2/16 , A61F9/00
CPC分类号： A61F2/1691 , A61F2/1664 , A61F2/167 , A61F2/1678 , A61F2002/1683
摘要： A rear-loaded injector cartridge for an intraocular lens (IOL) having a proximal opening that provides a haptic slot. The haptic slot receives a leading haptic of an IOL loaded therein, and temporarily retains the leading haptic while the optic of the IOL is inserted into a holding area of the cartridge. As the optic passes by, the leading haptic folds over the top of the optic, on its anterior side. The length of the haptic retention slot is sufficient to maintain the leading haptic in its anteriorly folded position while the IOL remains in holding area, typically while the cartridge is mated with a handpiece of the injector. The cartridge also has a rear or proximal cut out which advantageously keys with a similarly-sized rail on the handpiece so that the cartridge cannot be inserted in the wrong way.
摘要翻译：一种用于眼内透镜（IOL）的后装注射器盒，其具有提供触觉槽的近侧开口。触觉槽接收装载在其中的IOL的前触觉，并且当IOL的光学元件插入到盒的保持区域中时，临时保持前触觉。当光学器件通过时，前导触觉件折叠在光学器件的顶部上，在其前侧。触觉保持槽的长度足以将引导触觉保持在其前部折叠位置，同时IOL保持在保持区域中，通常在墨盒与注射器的手持件配合时。盒还具有后部或近端切口，其有利地在手持件上键入类似尺寸的导轨，使得盒不能以错误的方式插入。

2. 发明授权

US08241355B2 Haptic for accommodating intraocular lens 有权
标题翻译：触觉适应眼内透镜
公开(公告)号：US08241355B2
公开(公告)日：2012-08-14
申请号：US11262385
申请日：2005-10-28
申请人： Daniel G. Brady , Henk A. Weeber
发明人： Daniel G. Brady , Henk A. Weeber
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2/1613 , A61F2/1624 , A61F2002/1682 , A61F2002/1683 , A61F2002/1686 , A61F2002/169
摘要： A haptic is provided for use in an accommodating intraocular lens. The haptic has multiple filaments, each connected to the edge of the optic at one end. Each filament has a shape that conforms to an equatorial region of the capsular bag. The haptic couples the forces exerted by the capsular bag of the eye during accommodation radially to the edge of the optic, produce a diametric expansion or compression of the optic. This diametric motion distorts the optic, producing a change in any or all of the anterior radius, the posterior radius, and the thickness. These changes affect the power of the lens and/or location of the image. The haptic may optionally have a thin membrane joining the filaments at the optic end, and may optionally have a connecting ring that joins the filaments at the end opposite that of the optic.
摘要翻译：提供用于容纳眼内透镜的触觉件。触觉具有多个细丝，每个细丝在一端连接到光学元件的边缘。每个细丝具有符合囊袋的赤道区域的形状。触觉装置在径向地放置到光学元件边缘的过程中耦合由眼囊的囊袋施加的力，产生光学元件的直径膨胀或压缩。该直径运动扭曲光学元件，产生前半径，后半径和厚度中的任何或全部的变化。这些变化影响镜头的功率和/或图像的位置。触觉件可以可选地具有在光学端连接长丝的薄膜，并且可以可选地具有连接环，所述连接环在与光学元件相对的端部连接长丝。

3. 发明申请

US20120059465A1 CAPSULAR MEMBRANE IMPLANTS TO INCREASE ACCOMMODATIVE AMPLITUDE 有权
标题翻译：囊体膜植入物增加舒张功能
公开(公告)号：US20120059465A1
公开(公告)日：2012-03-08
申请号：US13043178
申请日：2011-03-08
申请人： Daniel G. Brady , Zsolt Bor , Edward Geraghty , Brooke C. Basinger , Carina R. Reisin , Douglas S. Cali
发明人： Daniel G. Brady , Zsolt Bor , Edward Geraghty , Brooke C. Basinger , Carina R. Reisin , Douglas S. Cali
IPC分类号： A61F2/16
CPC分类号： A61F2/14 , A61F2/1624 , A61F9/00736 , A61F9/008 , A61F9/00838 , A61F2002/1681 , A61F2009/0087 , A61F2009/00889 , A61F2009/00895 , F04C2270/0421
摘要： A support is coupled to the lens capsule to increase accommodation. The support may be adjustable, such that patient refraction and accommodation can be adjusted following surgery. The support may comprise rigidity sufficient to decrease radial movement of the intermediate portion of the lens capsule. The support can be placed on the intermediate portion to decrease radial movement of the intermediate portion of the lens capsule and increase radial stretching of an outer portion of the lens capsule extending between the zonules and the intermediate portion coupled to the support, such that the amount of accommodation of the eye is increased. The support may comprise a biocompatible material capable of stable coupling to the lens capsule following implantation, such that the far vision refraction and accommodation of the eye can be stable following surgery.
摘要翻译：支撑件联接到镜片胶囊以增加调节。支撑件可以是可调节的，使得在手术后可以调整患者的折射和容纳。支撑件可以包括足以减小透镜胶囊的中间部分的径向移动的刚度。可以将支撑件放置在中间部分上以减小透镜胶囊的中间部分的径向移动，并且增加透镜胶囊的在部分与连接到支撑件的中间部分之间延伸的外部部分的径向拉伸，使得量眼睛的适应性增加。支撑体可以包括能够在植入之后稳定地耦合到晶状体囊的生物相容性材料，使得眼睛的远视力折射和适应在手术后可以是稳定的。

4. 外观设计

USD615651S1 Back loaded intraocular lens (IOL) cartridge 有权
标题翻译：背负载人工晶状体（IOL）药筒
公开(公告)号：USD615651S1
公开(公告)日：2010-05-11
申请号：US29317360
申请日：2008-04-28
申请人： Laurent G. Hoffmann , David A. Ruddocks , Mark C. Cole , Daniel G. Brady
设计人： Laurent G. Hoffmann , David A. Ruddocks , Mark C. Cole , Daniel G. Brady

5. 发明授权

US07348038B2 IOL insertion apparatus and method for making and using same 有权
标题翻译： IOL插入装置及其制造和使用方法
公开(公告)号：US07348038B2
公开(公告)日：2008-03-25
申请号：US10738561
申请日：2003-12-16
申请人： Harish Makker , Shih-Liang S. Yang , Daniel G. Brady , Robert E. Glick
发明人： Harish Makker , Shih-Liang S. Yang , Daniel G. Brady , Robert E. Glick
IPC分类号： B05D7/22 , A61F2/16 , A61F9/00
CPC分类号： A61F2/1675 , A61F2/1664
摘要： Apparatus for inserting intraocular lenses (IOLs) into eyes include a hollow tube including a material and having an interior wall defining a hollow space through which an IOL is passed and an outlet through which the IOL is passed from the hollow space into an eye, and a lubricity enhancing component physically secured to said hollow tube and concentrated at or near the interior wall in an amount effective to facilitate the passage of the IOL through the hollow space.
摘要翻译：用于将眼内透镜（IOL）插入眼睛的装置包括：中空管，其包括材料，并且具有限定中空空间的内壁，IOL通过该中空空间和IOL从中空空间穿过眼睛的出口;以及润滑性增强部件物理地固定到所述中空管上并且以有效促进IOL通过中空空间的量在内壁或其附近集中。

6. 发明授权

US07025783B2 Accommodating intraocular lens with integral capsular bag ring 有权
公开(公告)号：US07025783B2
公开(公告)日：2006-04-11
申请号：US10341701
申请日：2003-01-14
申请人： Daniel G. Brady , Stephen W. Laguette , Marlene L. Paul , Elbert Y. Tzeng , Robert E. Glick
发明人： Daniel G. Brady , Stephen W. Laguette , Marlene L. Paul , Elbert Y. Tzeng , Robert E. Glick
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/16 , A61F2/1629 , A61F2/1694 , A61F2002/1699
摘要： An intraocular lens (IOL) includes an optic for focusing light, an outer ring for supporting the optic in a capsular bag of an eye and a plurality of radially spaced apart, elongated intermediate members connecting the optic to the outer ring. The intermediate members are configured to convert radial forces exerted by the capsular bag on the support ring into axial movement of the optic, allowing a presbyopic patient to more effectively focus on near objects. The outer ring is preferably contoured to conform to the portion of the capsular bag between the anterior and posterior zonules, and has sufficient axial thickness to contact both sets of zonules. In addition, the edge of the ring includes at least one sharp edge corner to prevent epithelial cell growth toward the optic. In addition, the outer ring may include weakened areas configured to allow consistent and repeatable deformation in response to compressive forces.

7. 发明授权

US06923815B2 Intraocular lens insertion apparatus 有权
标题翻译：人工晶状体插入装置
公开(公告)号：US06923815B2
公开(公告)日：2005-08-02
申请号：US10145233
申请日：2002-05-14
申请人： Daniel G. Brady , Harish C. Makker
发明人： Daniel G. Brady , Harish C. Makker
IPC分类号： A61F2/16 , A61F9/00
CPC分类号： A61F2/1678
摘要： An intraocular lens (IOL) insertion system for implanting IOLs into the eye. The insertion system includes an insertion cartridge that receives the IOL and cooperates with a handpiece. The cartridge includes a longitudinal lumen from a loading chamber to an open distal mouth that gradually narrows in dimension so as to fold the IOL into a tube for insertion through an incision in the eye. A distal tip member of a plunger rod in the handpiece enters the loading chamber of the cartridge and urges the IOL therethrough. The distal tip member has a portion that enters the folded IOL and is trapped therein for maximum control of IOL advancement. A soft tip, such as silicone, may cover a longitudinally extending portion of the distal tip to effect the IOL trapping. The distal tip member further has a portion that engages and pushes the IOL optic. The pusher portion not only ensures positive advancement of the IOL, but also limits the extent to which the distal tip member becomes trapped inside the folded IOL, thus preventing potential damage thereto.
摘要翻译：用于将IOL植入眼睛的人工晶状体（IOL）插入系统。插入系统包括接收IOL并与手持件配合的插入盒。药筒包括从装载室到开放的远端口的纵向内腔，其逐渐变窄的尺寸，以便将IOL折叠成用于通过眼睛中的切口插入的管。手柄中的柱塞杆的远端部件进入筒的装载室并且通过其推动IOL。远侧末端构件具有进入折叠的IOL并被捕获在其中的部分，以最大限度地控制IOL前进。诸如硅树脂之类的软尖端可以覆盖远侧末端的纵向延伸部分以实现IOL捕获。远侧末端构件还具有接合和推动IOL光学元件的部分。推动器部分不仅确保了IOL的积极进展，而且限制了远侧末端构件被夹在折叠IOL内的程度，从而防止对其的潜在损害。

8. 发明授权

US06585993B2 Controlled release neurotoxin system 失效
标题翻译：控制释放神经毒素系统
公开(公告)号：US06585993B2
公开(公告)日：2003-07-01
申请号：US10096501
申请日：2002-03-11
申请人： Stephen Donovan , Daniel G. Brady
发明人： Stephen Donovan , Daniel G. Brady
IPC分类号： A61F200
CPC分类号： A61K9/0024 , A61K38/4893 , Y10S514/964
摘要： A biocompatible implant for continuous in vivo release of a neurotoxin over a treatment period extending from one month to five years. The implant can be made of casting a solution of a polymer, such as an ethyl vinyl acetate copolymer and the neurotoxin. The neurotoxin can be a botulinum toxin.
摘要翻译：在一个月至五年的治疗期内连续体内释放神经毒素的生物相容性植入物。植入物可以通过浇铸聚合物如乙酸乙烯酯共聚物和神经毒素的溶液来制备。神经毒素可以是肉毒杆菌毒素。

9. 发明授权

US06409763B1 Iris-supported intraocular lenses optics and rigid fixation members 有权
标题翻译：虹膜支持的眼内透镜光学和刚性固定构件
公开(公告)号：US06409763B1
公开(公告)日：2002-06-25
申请号：US09943558
申请日：2001-08-30
申请人： Daniel G. Brady
发明人： Daniel G. Brady
IPC分类号： A61F216
CPC分类号： A61F2/1602 , A61F2/16 , A61F2/1608 , A61F2002/1681
摘要： An iris-supported intraocular lens having an optic portion and a plurality of fixation members coupled thereto. Each fixation member has a pair of pincer arms that separate outward of the optic and converge toward one another at aligned end tips. One or both of the end tips are covered with a soft sleeve or cap. The IOL is fixed in the anterior chamber of the eye by pinching the iris tissue between the end tips of each pair of pincer arms. The soft sleeves eliminate damage to the iris tissue.
摘要翻译：具有光学部分和耦合到其上的多个固定构件的虹膜支撑的眼内透镜。每个固定构件具有一对夹持臂，该对夹臂在光学器件的外部分离并且在对准的端部尖端处朝向彼此会聚。末端尖端中的一个或两个被软套或盖覆盖。 IOL通过在每对钳手臂的末端之间夹紧虹膜组织固定在眼前房中。柔软的袖子消除了虹膜组织的损伤。

10. 发明授权

US06398788B1 Method for making and using IOL insertion apparatus 有权
标题翻译：制造和使用IOL插入装置的方法
公开(公告)号：US06398788B1
公开(公告)日：2002-06-04
申请号：US09535267
申请日：2000-03-23
申请人： Harish Makker , Shih-Liang S. Yang , Daniel G. Brady , Robert E. Glick
发明人： Harish Makker , Shih-Liang S. Yang , Daniel G. Brady , Robert E. Glick
IPC分类号： A61F9007
CPC分类号： A61F2/1675 , A61F2/1664
摘要： Apparatus for inserting intraocular lenses (IOLs) into eyes include a hollow tube including a material and having an interior wall defining a hollow space through which an IOL is passed and an outlet through which the IOL is passed from the hollow space into an eye, and a lubricity enhancing component physically secured to said hollow tube and concentrated at or near the interior wall in an amount effective to facilitate the passage of the IOL through the hollow space.
摘要翻译：用于将眼内透镜（IOL）插入眼睛的装置包括：中空管，其包括材料，并且具有限定中空空间的内壁，IOL通过该中空空间和IOL从中空空间穿过眼睛的出口;以及润滑性增强部件物理地固定到所述中空管上并且以有效促进IOL通过中空空间的量在内壁或其附近集中。

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