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61. 发明授权

US08231547B2 Puncturing system for withdrawing a body fluid 有权
标题翻译：用于抽出体液的穿刺系统
公开(公告)号：US08231547B2
公开(公告)日：2012-07-31
申请号：US11849280
申请日：2007-09-01
申请人： Frank Deck , Ortrud Quarder , Thomas Weiss , Christian Hörauf , Michael Keil , Ahmet Konya , Herbert Harttig , Felix Baader , Hans List , Karl-Peter Ebert
发明人： Frank Deck , Ortrud Quarder , Thomas Weiss , Christian Hörauf , Michael Keil , Ahmet Konya , Herbert Harttig , Felix Baader , Hans List , Karl-Peter Ebert
IPC分类号： A61B5/00
CPC分类号： A61B5/15148 , A61B5/150022 , A61B5/15019 , A61B5/150198 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150572 , A61B5/150832 , A61B5/150916 , A61B5/15113 , A61B5/15117 , A61B5/15128 , A61B5/1519 , A61B5/15194 , A61B5/15196
摘要： The present invention provides a puncturing system for withdrawing body fluid. The puncturing system comprises a disposable puncturing unit, which includes a needle element for piercing into skin and a puncturing depth reference element with a skin contact area. The system includes a puncturing instrument which has a puncturing drive, wherein the puncturing drive is coupled by a coupling mechanism to the puncturing unit for driving the needle element to a puncturing depth, the puncturing depth being determined by the distance in the piercing direction between the skin contact area and the position of the tip of the needle at a reversal point of the puncturing movement. The puncturing depth reference element is connected to the needle element such that the puncturing depth reference element moves with the needle element during at least part of the puncturing movement. The puncturing depth reference element has a defined longitudinal position in the piercing direction relative to the needle element at least at the reversal point of the puncturing movement.
摘要翻译：本发明提供一种用于抽出体液的穿刺系统。穿刺系统包括一次性穿刺单元，其包括用于刺入皮肤的针元件和具有皮肤接触区域的穿刺深度参考元件。该系统包括具有穿刺驱动器的穿刺器具，其中穿刺驱动器通过联接机构联接到穿刺单元，用于将针元件驱动到穿刺深度，穿刺深度由穿刺方向上的距离确定皮肤接触区域和针的尖端在穿刺运动的反转点处的位置。穿刺深度参考元件连接到针元件，使得穿刺深度参考元件在穿刺运动的至少一部分期间与针元件一起移动。穿刺深度参考元件至少在穿刺运动的反转点处具有相对于针元件在穿刺方向上的限定的纵向位置。

62. 发明授权

US08124818B2 Method for the production of 3-phenyl(thio) uracils and dithiouracils 有权
标题翻译：制备3-苯基（硫代）尿嘧啶和二硫尿嘧啶的方法
公开(公告)号：US08124818B2
公开(公告)日：2012-02-28
申请号：US13040292
申请日：2011-03-04
申请人： Sandra Loehr , Joachim Gebhardt , Guido Mayer , Michael Keil , Thomas Schmidt , Bernd Wolf
发明人： Sandra Loehr , Joachim Gebhardt , Guido Mayer , Michael Keil , Thomas Schmidt , Bernd Wolf
IPC分类号： C07C15/00
CPC分类号： C07D239/54
摘要： The present invention relates to a process for preparing 3-phenyl(thio)uracils and -dithiouracils of the formula I where the variables are each as defined in the description, and also intermediates for their preparation.
摘要翻译：本发明涉及一种制备式I的3-苯基（硫代）尿嘧啶和二硫尿嘧啶的方法，其中各变量各自如说明书中所定义，以及它们制备的中间体。

63. 发明授权

US08061004B2 Method of manufacturing a test strip 有权
标题翻译：制造试纸的方法
公开(公告)号：US08061004B2
公开(公告)日：2011-11-22
申请号：US12544296
申请日：2009-08-20
申请人： Michael Keil
发明人： Michael Keil
IPC分类号： B21D53/00 , A61B5/00
CPC分类号： B01L3/5023 , A61B5/1411 , A61B5/150022 , A61B5/150068 , A61B5/150282 , A61B5/150358 , A61B5/150435 , A61B5/150503 , A61B5/1519 , A61B5/157 , B01L3/502715 , B01L2300/0825 , Y10T29/49789 , Y10T29/49798 , Y10T29/49885 , Y10T156/1052
摘要： The test strip stabilizes skin prior to incision by a lancet tip. The innovative test strip includes a pair of skin contacting tabs that apply pressure linearly to the skin to stretch the skin taut. Beneficially an incision by a lancet tip to an accurate depth can be formed on the taut skin. Moreover, pressure from the tabs is applied linearly to the skin which results in a higher ratio of pressure to surface that can be reached as compared to applying pressure laminarily to skin. Some manufacturing techniques of the skin contacting tabs include cutting or stamping through all of the layers and test area of the test strip to form these tabs. These techniques increase the manufacturing efficiency and cost savings associated with test strips and integrated lancet testing devices. Contamination from other sampling events is eliminated since the test strips are disposed of after each use.
摘要翻译：测试条在刺刀切口之前稳定皮肤。创新的测试条包括一对皮肤接触片，其将皮肤线性地施加压力以拉伸皮肤。可以在绷紧的皮肤上形成有利于刺血针尖至精确深度的切口。此外，与将皮肤叠加施加压力相比，来自翼片的压力线性地施加到皮肤，这导致压力与表面的比例更高。皮肤接触片的一些制造技术包括切割或冲压穿过测试条的所有层和测试区域以形成这些突片。这些技术提高了与测试条和集成的柳叶刀测试装置相关联的制造效率和成本节省。因为在每次使用之后处理测试条，因此消除了其他采样事件的污染。

64. 发明授权

US08049017B2 Preparation of isoxazolin-3-ylacylbenzenes 有权
标题翻译：异恶唑啉-3-基酰基苯的制备
公开(公告)号：US08049017B2
公开(公告)日：2011-11-01
申请号：US13039137
申请日：2011-03-02
申请人： Joachim Rheinheimer , Wolfgang von Deyn , Joachim Gebhardt , Michael Rack , Rene Lochtman , Norbert Götz , Michael Keil , Matthias Witschel , Helmut Hagen , Ulf Miβlitz , Ernst Baumann
发明人： Joachim Rheinheimer , Wolfgang von Deyn , Joachim Gebhardt , Michael Rack , Rene Lochtman , Norbert Götz , Michael Keil , Matthias Witschel , Helmut Hagen , Ulf Miβlitz , Ernst Baumann
IPC分类号： C07D261/04
CPC分类号： C07C249/06 , C07C201/10 , C07C201/12 , C07C205/44 , C07C209/62 , C07C251/48 , C07C253/00 , C07C255/50 , C07C315/04 , C07C319/14 , C07D261/04 , C07D413/10 , C07C323/09 , C07C317/24 , C07C317/32 , C07C205/06 , C07C211/52
摘要： A process is described for preparing isoxazoles of the formula I where the substituents are as defined below: R1 is hydrogen, C1-C6-alkyl, R2 is C1-C6-alkyl, R3, R4, R5 are hydrogen, C1-C6-alkyl, or R4 and R5 together form a bond, R6 is a heterocyclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI where R1, R3, R4 and R5 are as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Also novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates are described.
摘要翻译：描述了制备式I的异恶唑的方法，其中取代基如下所定义：R 1是氢，C 1 -C 6烷基，R 2是C 1 -C 6烷基，R 3，R 4，R 5是氢，C 1 -C 6 - 烷基，或R4和R5一起形成键，R6是杂环，n是0,1或2; 其包括制备式VI的中间体，其中R 1，R 3，R 4和R 5如上定义，然后进行卤化，硫甲基化，氧化和酰化，得到式I化合物。还有用于制备式I化合物的中间体并描述了制备中间体的新方法。

65. 发明申请

US20110218340A1 2-[1-Cyanopropyl)Carbamoyl]-5-Chloromethyl Nicotinic Acids and the Use Thereof in Manufacturing Herbicidal Imidazolinones 有权
标题翻译： 2- [1-氰基丙基）氨基甲酰基] -5-氯甲基烟酸及其用途制造除草咪唑啉酮
公开(公告)号：US20110218340A1
公开(公告)日：2011-09-08
申请号：US13128782
申请日：2009-11-03
申请人： Frederik Menges , Joachim Gebhardt , Michael Rack , Michael Keil , Rodney F. Klima , David Cortes , Robert Leicht , Helmut Zech , Jochen Schröder
发明人： Frederik Menges , Joachim Gebhardt , Michael Rack , Michael Keil , Rodney F. Klima , David Cortes , Robert Leicht , Helmut Zech , Jochen Schröder
IPC分类号： C07D401/04 , C07D213/80
CPC分类号： C07D401/04 , C07D213/81
摘要： 2-[(1-cyanopropyl)carbamoyl]-5-chloromethyl nicotinic acids of formula (I) where Z is hydrogen or halogen; Z1 is hydrogen, halogen, cyano or nitro; R1 is C1-C4 alkyl; R2 is C1-C4 alkyl, C3-C6 cycloalkyl or R1 and R2, when taken together with the atom to which they are attached, represent a C3-C6 cycloalkyl group optionally substituted with methyl, and R3 is hydrogen or a cation preferably selected from the group consisting of alkali metals, alkaline earth metals, manganese, copper, iron, zinc, cobalt, lead, silver, nickel, ammonium and organic ammonium; are useful intermediates for the synthesis of herbicidal imidazolinones.
摘要翻译：其中Z是氢或卤素的式（I）的2- [（1-氰基丙基）氨基甲酰基] -5-氯甲基烟酸; Z1是氢，卤素，氰基或硝基; R1是C1-C4烷基; R 2是C 1 -C 4烷基，C 3 -C 6环烷基或R 1和R 2，当与它们所连接的原子一起表示任选被甲基取代的C 3 -C 6环烷基时，R 3是氢或优选选自由碱金属，碱土金属，锰，铜，铁，锌，钴，铅，银，镍，铵和有机铵组成的组; 是合成除草咪唑啉酮的有用中间体。

66. 发明申请

US20110190510A1 Method for Producing and Purifying Trifluoromethanesulfinic Acid 有权
标题翻译：三氟甲磺酸生产和纯化方法
公开(公告)号：US20110190510A1
公开(公告)日：2011-08-04
申请号：US13121973
申请日：2009-09-28
申请人： Martin Sukopp , Alexander Korte , Stefan Fülster , Michael Keil , Michael Rack
发明人： Martin Sukopp , Alexander Korte , Stefan Fülster , Michael Keil , Michael Rack
IPC分类号： C07D231/44 , C07C313/04 , B01D3/36
CPC分类号： C07D231/44 , C07C313/04
摘要： The invention relates to a process for purifying trifluoromethanesulfinic acid by azeotropic distillation with an aromatic solvent, to processes for preparing purified trifluoromethanesulfinic acid and to the use of the purified trifluoronnethanesulfinic acid for preparing trifluoromethylsulfinylated pyrazole derivatives, especially fipronil.
摘要翻译：本发明涉及一种通过与芳族溶剂共沸蒸馏纯化三氟甲磺酸的方法，以及用于制备纯化的三氟甲磺酸的方法，以及使用纯化的三氟甲磺酰亚胺制备三氟甲基亚硫酰化的吡唑衍生物，特别是氟虫腈。

67. 发明申请

US20110172436A1 Method for preparing 1,3,4-substituted pyrazol compounds 有权
标题翻译：制备1,3,4-取代吡唑化合物的方法
公开(公告)号：US20110172436A1
公开(公告)日：2011-07-14
申请号：US12990340
申请日：2009-05-04
申请人： Bernd Wolf , Volker Maywald , Michael Keil , Christopher Koradin , Michael Rack , Thomas Zierke , Martin Sukopp
发明人： Bernd Wolf , Volker Maywald , Michael Keil , Christopher Koradin , Michael Rack , Thomas Zierke , Martin Sukopp
IPC分类号： C07D231/14 , C07C243/10
CPC分类号： C07D409/12 , C07C251/76 , C07C251/84 , C07C251/86 , C07D231/14
摘要： The invention provides an Ethernet bridge or router comprising a network fabric adapted to provide interconnectivity to a plurality of Ethernet ports, each of the Ethernet ports being adapted to receive and/or transmit Ethernet frames, and wherein the Ethernet bridge or router further comprises an encapsulator connected to receive Ethernet Protocol Data Units from the Ethernet ports, wherein the encapsulator is operable to generate a Fabric Protocol Data Unit from a received Ethernet Protocol Data Unit, the Fabric Protocol Data Unit comprising a header portion, and a payload portion which comprises the Ethernet Protocol Data Unit concerned, and wherein the encapsulator is operable to transform Ethernet destination address information from the Ethernet Protocol Data Unit into a routing definition for the network fabric, and to include this routing definition in the header portion of the Fabric Protocol Data Unit. Also provided is a method of data delivery across a network.
摘要翻译：本发明提供了一种以太网桥或路由器，其包括适于提供与多个以太网端口的互连性的网络结构，每个以太网端口适于接收和/或发送以太网帧，并且其中所述以太网桥或路由器还包括封装器连接以从以太网端口接收以太网协议数据单元，其中所述封装器可操作以从接收到的以太网协议数据单元生成结构协议数据单元，所述结构协议数据单元包括报头部分和包括以太网的有效载荷部分协议数据单元，并且其中所述封装器可操作以将以太网目的地地址信息从以太网协议数据单元转换为所述网络结构的路由定义，并将所述路由定义包括在所述结构协议数据单元的报头部分中。还提供了一种通过网络进行数据传送的方法。

68. 发明申请

US20110046453A1 TEST STRIP WITH A SHAPED TIP FOR SKIN STRAIGHTENING 有权
标题翻译：带有形状提示用于皮肤刺激的测试条
公开(公告)号：US20110046453A1
公开(公告)日：2011-02-24
申请号：US12544296
申请日：2009-08-20
申请人： Michael Keil
发明人： Michael Keil
IPC分类号： A61B5/151 , B32B38/04
CPC分类号： B01L3/5023 , A61B5/1411 , A61B5/150022 , A61B5/150068 , A61B5/150282 , A61B5/150358 , A61B5/150435 , A61B5/150503 , A61B5/1519 , A61B5/157 , B01L3/502715 , B01L2300/0825 , Y10T29/49789 , Y10T29/49798 , Y10T29/49885 , Y10T156/1052
摘要： The test strip stabilizes skin prior to incision by a lancet tip. The innovative test strip includes a pair of skin contacting tabs that apply pressure linearly to the skin to stretch the skin taut. Beneficially an incision by a lancet tip to an accurate depth can be formed on the taut skin. Moreover, pressure from the tabs is applied linearly to the skin which results in a higher ratio of pressure to surface that can be reached as compared to applying pressure laminarily to skin. Some manufacturing techniques of the skin contacting tabs include cutting or stamping through all of the layers and test area of the test strip to form these tabs. These techniques increase the manufacturing efficiency and cost savings associated with test strips and integrated lancet testing devices. Contamination from other sampling events is eliminated since the test strips are disposed of after each use.
摘要翻译：测试条在刺刀切口之前稳定皮肤。创新的测试条包括一对皮肤接触片，其将皮肤线性地施加压力以拉伸皮肤。可以在绷紧的皮肤上形成有利于刺血针尖至精确深度的切口。此外，与将皮肤叠加施加压力相比，来自翼片的压力线性地施加到皮肤，这导致压力与表面的比例更高。皮肤接触片的一些制造技术包括切割或冲压穿过测试条的所有层和测试区域以形成这些突片。这些技术提高了与测试条和集成的柳叶刀测试装置相关联的制造效率和成本节省。因为在每次使用之后处理测试条，因此消除了其他采样事件的污染。

69. 发明申请

US20110009640A1 BIFUNCTIONAL PHENYL ISO (THIO) CYANATES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION 有权
标题翻译：双功能苯乙烯（THIO）氰化物，其制备方法和中间体
公开(公告)号：US20110009640A1
公开(公告)日：2011-01-13
申请号：US12886986
申请日：2010-09-21
申请人： Gerhard Hamprecht , Michael Puhl , Bernd Wolf , Norbert Götz , Michael Keil , Robert Reinhard , Ingo Sagasser , Werner Seitz
发明人： Gerhard Hamprecht , Michael Puhl , Bernd Wolf , Norbert Götz , Michael Keil , Robert Reinhard , Ingo Sagasser , Werner Seitz
IPC分类号： C07D249/14 , C07C263/10 , C07C331/28 , C07C265/12 , C07D249/12 , C07C307/02
CPC分类号： C07D213/76 , C07C303/34 , C07C307/06 , C07C331/28 , C07C2601/14 , C07D207/20 , C07D211/18 , C07D211/70 , C07D295/26 , C07D307/52 , C07D319/06 , C07D333/20
摘要： A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described.Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.
摘要翻译：描述式I的苯基异（硫代）氰酸酯的方法，其中将式II化合物或其HCl加合物与W是氧或硫的光气反应剂和Ar和A如权利要求1中所定义的相同。此外，本发明涉及苯基异（硫代）氰酸酯用于制备作物保护剂的用途。

70. 发明申请

US20100228054A1 Method for Producing Sulfonamides 失效
标题翻译：生产磺酰胺的方法
公开(公告)号：US20100228054A1
公开(公告)日：2010-09-09
申请号：US12095582
申请日：2006-11-23
申请人： Michael Keil , Joachim Gebhardt , Michael Rack , Guido Mayer , Thomas Schmidt , Jan Hendrik Wevers , Sandra Lohr , Axel Pleschke
发明人： Michael Keil , Joachim Gebhardt , Michael Rack , Guido Mayer , Thomas Schmidt , Jan Hendrik Wevers , Sandra Lohr , Axel Pleschke
IPC分类号： C07C307/00 , C07C311/00 , C07C205/06
CPC分类号： C07C303/38 , C07C201/12 , C07C303/40 , C07C311/51 , C07C205/58
摘要： The invention relates to methods for producing sulfonamides of formula I, wherein the variables have the designations cited in the description, by reacting m-nitro-benzoic acid chlorides of formula II with aminosulfons of formula III, under the influence of B equivalents of base IV. Said method is characterised in that, during step a) the aminosulfon of formula III is reacted with B1 equivalents of base IV, and during step b), the reaction mixture resulting from step a) is reacted with m-nitro-benzoic acid chlorides of formula II and B2 equivalents of base IV; B, B1 and B2 having the designations cited in the description.
摘要翻译：本发明涉及制备式I磺酰胺的方法，其中变量具有在本说明书中引用的名称，通过式B的间硝基 - 苯甲酰氯与式III的氨基砜在B当量的碱IV的影响下反应。所述方法的特征在于，在步骤a）期间，将式III的氨基磺酸与B1当量的碱IV反应，并且在步骤b）期间，将由步骤a）得到的反应混合物与间硝基苯甲酸氯化物式Ⅱ和B2当量的碱基IV; B，B1和B2具有说明书中引用的标号。

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