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1. 发明授权

US08231547B2 Puncturing system for withdrawing a body fluid 有权
标题翻译：用于抽出体液的穿刺系统
公开(公告)号：US08231547B2
公开(公告)日：2012-07-31
申请号：US11849280
申请日：2007-09-01
申请人： Frank Deck , Ortrud Quarder , Thomas Weiss , Christian Hörauf , Michael Keil , Ahmet Konya , Herbert Harttig , Felix Baader , Hans List , Karl-Peter Ebert
发明人： Frank Deck , Ortrud Quarder , Thomas Weiss , Christian Hörauf , Michael Keil , Ahmet Konya , Herbert Harttig , Felix Baader , Hans List , Karl-Peter Ebert
IPC分类号： A61B5/00
CPC分类号： A61B5/15148 , A61B5/150022 , A61B5/15019 , A61B5/150198 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150572 , A61B5/150832 , A61B5/150916 , A61B5/15113 , A61B5/15117 , A61B5/15128 , A61B5/1519 , A61B5/15194 , A61B5/15196
摘要： The present invention provides a puncturing system for withdrawing body fluid. The puncturing system comprises a disposable puncturing unit, which includes a needle element for piercing into skin and a puncturing depth reference element with a skin contact area. The system includes a puncturing instrument which has a puncturing drive, wherein the puncturing drive is coupled by a coupling mechanism to the puncturing unit for driving the needle element to a puncturing depth, the puncturing depth being determined by the distance in the piercing direction between the skin contact area and the position of the tip of the needle at a reversal point of the puncturing movement. The puncturing depth reference element is connected to the needle element such that the puncturing depth reference element moves with the needle element during at least part of the puncturing movement. The puncturing depth reference element has a defined longitudinal position in the piercing direction relative to the needle element at least at the reversal point of the puncturing movement.
摘要翻译：本发明提供一种用于抽出体液的穿刺系统。穿刺系统包括一次性穿刺单元，其包括用于刺入皮肤的针元件和具有皮肤接触区域的穿刺深度参考元件。该系统包括具有穿刺驱动器的穿刺器具，其中穿刺驱动器通过联接机构联接到穿刺单元，用于将针元件驱动到穿刺深度，穿刺深度由穿刺方向上的距离确定皮肤接触区域和针的尖端在穿刺运动的反转点处的位置。穿刺深度参考元件连接到针元件，使得穿刺深度参考元件在穿刺运动的至少一部分期间与针元件一起移动。穿刺深度参考元件至少在穿刺运动的反转点处具有相对于针元件在穿刺方向上的限定的纵向位置。

2. 发明申请

US20080082023A1 PUNCTURING SYSTEM FOR WITHDRAWING A BODY FLUID 有权
标题翻译：用于取出身体液体的冲洗系统
公开(公告)号：US20080082023A1
公开(公告)日：2008-04-03
申请号：US11849280
申请日：2007-09-01
申请人： Frank Deck , Ortrud Quarder , Thomas Weiss , Christian Horauf , Michael Keil , Ahmet Konya , Herbert Harttig , Felix Baader , Hans List , Karl-Peter Ebert
发明人： Frank Deck , Ortrud Quarder , Thomas Weiss , Christian Horauf , Michael Keil , Ahmet Konya , Herbert Harttig , Felix Baader , Hans List , Karl-Peter Ebert
IPC分类号： A61B5/157 , A61B5/151
CPC分类号： A61B5/15148 , A61B5/150022 , A61B5/15019 , A61B5/150198 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150572 , A61B5/150832 , A61B5/150916 , A61B5/15113 , A61B5/15117 , A61B5/15128 , A61B5/1519 , A61B5/15194 , A61B5/15196
摘要： The present invention provides a puncturing system for withdrawing body fluid. The puncturing system comprises a disposable puncturing unit, which includes a needle element for piercing into skin and a puncturing depth reference element with a skin contact area. The system includes a puncturing instrument which has a puncturing drive, wherein the puncturing drive is coupled by a coupling mechanism to the puncturing unit for driving the needle element to a puncturing depth, the puncturing depth being determined by the distance in the piercing direction between the skin contact area and the position of the tip of the needle at a reversal point of the puncturing movement. The puncturing depth reference element is connected to the needle element such that the puncturing depth reference element moves with the needle element during at least part of the puncturing movement. The puncturing depth reference element has a defined longitudinal position in the piercing direction relative to the needle element at least at the reversal point of the puncturing movement.
摘要翻译：本发明提供一种用于抽出体液的穿刺系统。穿刺系统包括一次性穿刺单元，其包括用于刺入皮肤的针元件和具有皮肤接触区域的穿刺深度参考元件。该系统包括具有穿刺驱动器的穿刺器具，其中穿刺驱动器通过联接机构联接到穿刺单元，用于将针元件驱动到穿刺深度，穿刺深度由穿刺方向上的距离确定皮肤接触区域和针的尖端在穿刺运动的反转点处的位置。穿刺深度参考元件连接到针元件，使得穿刺深度参考元件在穿刺运动的至少一部分期间与针元件一起移动。穿刺深度参考元件至少在穿刺运动的反转点处具有相对于针元件在穿刺方向上的限定的纵向位置。

3. 发明申请

US20050137471A1 Continuous glucose monitoring device 审中-公开
标题翻译：连续葡萄糖监测装置
公开(公告)号：US20050137471A1
公开(公告)日：2005-06-23
申请号：US10740056
申请日：2003-12-18
申请人： Hans-Peter Haar , Hans List , Felix Baader , Herbert Harttig , George Meacham
发明人： Hans-Peter Haar , Hans List , Felix Baader , Herbert Harttig , George Meacham
IPC分类号： A61B5/00 , G01N35/00 , A61K9/22
CPC分类号： A61B5/14528 , A61B5/14532 , A61B5/686 , A61B2562/0295 , Y10T436/110833
摘要： The present invention is generally directed towards devices for sensing a concentration of chemical constituents in body fluid such as interstitial fluid, including but not limited to glucose. The devices also relates to systems for measuring and reporting the concentration of body fluid constituents at time intervals shorter than the physiological response time, thereby providing effectively continuous concentration measurements. The device according to the present invention comprises a probe, a reservoir with perfusion fluid connected to an inlet of the probe, at least one test zones which comprise a reagent, to react with the analyte to produce a detectable change, a reader unit which reads test zones wetted with fluid containing the analyte, where the reader unit produces signals according to the concentration of the analyte in the fluid; and a processing unit for processing the signals and the concentration of the analyte.
摘要翻译：本发明通常涉及用于感测体液中诸如间质液体（包括但不限于葡萄糖）的化学成分浓度的装置。这些装置还涉及用于在比生理反应时间短的时间间隔测量和报告体液组分的浓度的系统，从而提供有效的连续浓度测量。根据本发明的装置包括探针，具有连接到探针的入口的灌注流体的储存器，包含试剂的至少一个测试区域，以与分析物反应以产生可检测的变化;读取器单元，其读取用含有分析物的流体润湿的测试区域，其中读取器单元根据流体中分析物的浓度产生信号; 以及用于处理信号和分析物浓度的处理单元。

4. 发明授权

US06407437B1 Micromechanical pipetting device 失效
标题翻译：微机械移液装置
公开(公告)号：US06407437B1
公开(公告)日：2002-06-18
申请号：US09044735
申请日：1998-03-19
申请人： Jürgen Burger , Felix Baader , Rudolf Buser , Olivier Elsenhans , Nicolas Szita
发明人： Jürgen Burger , Felix Baader , Rudolf Buser , Olivier Elsenhans , Nicolas Szita
IPC分类号： H01L2984
CPC分类号： B01L3/0268 , B01L3/021 , B01L2200/146 , B01L2400/0481 , G01N2035/1039
摘要： A micromechanical pipetting device comprising an integrally built pipetting module which has an inlet/outlet which may be connected to a removable pipetting tip or integrally built with a pipetting tip. The pipetting module comprises a micromechanical structure which is integrally built on a silicon wafer. In order to improve the accuracy of the pipetted volume the device is characterized in that it comprises a) a first chamber located within said pipetting module, the volume comprised within said first chamber being alterable by displacement of a membrane which is a portion of a wall of said chamber, said first chamber having an opening, said opening being permanently open and allowing fluid flow into and from the interior of said first chamber, b) a channel located within said pipetting module, said channel establishing a direct, valveless and permanent fluidical connection between said opening of the first chamber and the inlet/outlet of the pipetting module, c) actuator means for displacing said membrane, and thereby aspiring or expelling a volume of air or of a liquid into or from said first chamber, which in turn causes aspiring or expelling a volume of a liquid sample into respectively from said pipetting tip, and d) first sensor means for generating a first output signal related to the displacement of the membrane.
摘要翻译：一种微机械移液装置，其包括一体式构造的移液模块，其具有可连接到可移动移液末端或与移液头一体构建的入口/出口。移液模块包括一体地构建在硅晶片上的微机械结构。为了提高吸移体积的精度，该装置的特征在于它包括：a）位于所述移液模块内的第一腔室，包含在所述第一腔室内的体积可以通过膜的位移而变化，所述膜是壁的一部分所述腔室，所述第一腔室具有开口，所述开口永久地打开并允许流体流入和流出所述第一腔室的内部，b）位于所述移液模块内的通道，所述通道建立直接，无阀和永久的流体连接在所述第一室的所述开口和所述移液模块的入口/出口之间，c）用于移动所述膜的致动器装置，从而将一定体积的空气或液体向所述第一室吸入或排出，分别从所述移液头吸取或排出体积的液体样品，以及d）用于产生与t相关的第一输出信号的第一传感器装置他的膜的位移。

5. 发明授权

US5667548A Process for producing ceramic green compacts by double layer compression 失效
标题翻译：通过双层压缩生产陶瓷压坯的方法
公开(公告)号：US5667548A
公开(公告)日：1997-09-16
申请号：US351370
申请日：1995-02-03
申请人： Thomas Graule , Ludwig J. Gauckler , Felix Baader
发明人： Thomas Graule , Ludwig J. Gauckler , Felix Baader
IPC分类号： C04B35/622 , C04B35/632 , C03B40/02
CPC分类号： C04B35/622 , C04B35/632
摘要： The invention concerns the field of slip casting for producing green compacts. The disadvantage of state-of-the art slip casting is among others the need for removing the water through porous molds, the resulting shrinkage and the tendency of the green compact to form shrinkage cracks. These disadvantages are eliminated by internally coagulating by compression the double layer of solid slip particles, so that the green compact may be solidified without the need for removing the water.
摘要翻译： PCT No.PCT / CH94 / 00070 Sec。 371日期：1995年2月3日 102（e）1995年2月3日PCT PCT 1994年4月7日PCT公布。出版物WO94 / 24064 日期：1994年10月27日本发明涉及用于制造生坯的滑动铸造领域。现有技术的滑移浇注的缺点在于，需要通过多孔模具去除水分，导致收缩率和生坯的形成收缩裂缝的趋势。通过压缩双层固体滑爽颗粒进行内部凝结来消除这些缺点，使得生坯可以固化而不需要去除水分。

6. 发明申请

US20120041541A1 IMPLANT AND METHOD FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：植物及其生产方法
公开(公告)号：US20120041541A1
公开(公告)日：2012-02-16
申请号：US13206204
申请日：2011-08-09
申请人： Ullrich Bayer , Felix Baader , Eric Wittchow
发明人： Ullrich Bayer , Felix Baader , Eric Wittchow
IPC分类号： A61F2/82 , C25D11/02 , C25D5/54 , C25D5/44 , C25D11/04
CPC分类号： C25D11/36 , A61L31/022 , A61L31/088 , C25D11/04
摘要： An implant, in particular an intraluminal endoprosthesis, having an implant body (2, 4) containing an aluminum compound, preferably an aluminum alloy and/or aluminum oxide. Improved biocompatibility of the implant is achieved in that at least the part of the surface of the implant body (2, 4) which is formed by the aluminum compound has a first layer (6) which contains an aluminum phosphate. Furthermore, a cost-effective method for producing such an implant is described.
摘要翻译：植入物，特别是管腔内假体，具有含有铝化合物，优选铝合金和/或氧化铝的植入体（2,4）。实现了植入物的生物相容性的改善在于，由铝化合物形成的至少一部分植入体（2,4）的表面具有含有磷酸铝的第一层（6）。此外，描述了用于制造这种植入物的成本有效的方法。

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