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1. 发明授权

US08357695B2 Hydrates of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]sulfonyl]benzamide 有权
标题翻译： 2-氯-5- [3,6-二氢-3-甲基-2,6-二氧代-4-（三氟甲基）-1-（2H） - 嘧啶基] -4-氟-N - [[甲基（ 1-甲基乙基）氨基]磺酰基]苯甲酰胺
公开(公告)号：US08357695B2
公开(公告)日：2013-01-22
申请号：US12444651
申请日：2007-10-12
申请人： Thomas Schmidt , Joachim Gebhardt , Sandra Löhr , Michael Keil , Jan Hendrik Wevers , Peter Erk , Heidi Emilia Saxell , Gerhard Hamprecht , Guido Mayer , Bernd Wolf , Gerhard Cox , Alfred Michel , Werner Seitz , Cyrill Zagar , Robert Reinhard , Bernd Sievernich
发明人： Thomas Schmidt , Joachim Gebhardt , Sandra Löhr , Michael Keil , Jan Hendrik Wevers , Peter Erk , Heidi Emilia Saxell , Gerhard Hamprecht , Guido Mayer , Bernd Wolf , Gerhard Cox , Alfred Michel , Werner Seitz , Cyrill Zagar , Robert Reinhard , Bernd Sievernich
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D239/54 , A01N43/54
摘要： The present invention relates to hydrates of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]-sulfonyl]benzamide. The invention also relates to a process for the preparation of these hydrates and to plant protection formulations which comprise hydrates of the phenyluracil I.
摘要翻译：本发明涉及2-氯-5- [3,6-二氢-3-甲基-2,6-二氧代-4-（三氟甲基）-1-（2H）嘧啶基] -4-氟-N- [[甲基（1-甲基乙基）氨基] - 磺酰基]苯甲酰胺。本发明还涉及制备这些水合物的方法以及包含苯基尿嘧啶I的水合物的植物保护制剂。

2. 发明申请

US20120271049A1 BIFUNCTIONAL PHENYL ISO (THIO) CYANATES, PROCESSES AND INTERMEDIATES PRODUCTS FOR THEIR PREPARATION 失效
标题翻译：双功能PHENYL ISO（THIO）氰化物，工艺和中间体产品的制备
公开(公告)号：US20120271049A1
公开(公告)日：2012-10-25
申请号：US13535544
申请日：2012-06-28
申请人： Gerhard Hamprecht , Michael Puhl , Bernd Wolf , Norbert Götz , Michael Keil , Robert Reinhard , Ingo Sagasser , Werner Seitz
发明人： Gerhard Hamprecht , Michael Puhl , Bernd Wolf , Norbert Götz , Michael Keil , Robert Reinhard , Ingo Sagasser , Werner Seitz
IPC分类号： C07C303/34 , C07D317/28 , C07D307/52 , C07C331/28 , C07D213/76 , C07D295/26 , C07D207/48 , C07D211/96 , C07C307/06 , C07D333/20
CPC分类号： C07D213/76 , C07C303/34 , C07C307/06 , C07C331/28 , C07C2601/14 , C07D207/20 , C07D211/18 , C07D211/70 , C07D295/26 , C07D307/52 , C07D319/06 , C07D333/20
摘要： A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described.Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.
摘要翻译：描述式I的苯基异（硫代）氰酸酯的方法，其中将式II化合物或其HCl加合物与W是氧或硫的光气反应剂和Ar和A如权利要求1中所定义的相同。此外，本发明涉及苯基异（硫代）氰酸酯用于制备作物保护剂的用途。

3. 发明申请

US20120190832A1 LOW-MOLECULAR SERINE PROTEASES INHIBITORS COMPRISING POLYHYDROXY-ALKYL AND POLYHYDROXY-CYCLOALKYL RADICALS 审中-公开
标题翻译：包含聚羟基 - 烷基和聚羟基 - 环烷基基团的低分子丝氨酸蛋白酶抑制剂
公开(公告)号：US20120190832A1
公开(公告)日：2012-07-26
申请号：US13277829
申请日：2011-10-20
申请人： Dieter Herr , Helmut Mack , Werner Seitz , Wilfried Hornberger
发明人： Dieter Herr , Helmut Mack , Werner Seitz , Wilfried Hornberger
IPC分类号： C07H15/26
CPC分类号： A61K31/155 , C07H7/00 , C07H15/00
摘要： The invention relates to novel amidines and quanidines, the production and use thereof and the use thereof as trypsine-type serine protease competitive inhibitors, especially thrombine and compliment proteases CIs and C1r. The invention also relates to pharmaceutical compositions which contain said compounds as active ingredients, in addition to the use of the compounds as thrombine inhibitors, anticoagulants, compliment inhibitors and anti-inflammatory agents. The novel compositions are characterised by the linkage of a serine protease inhibitor having amidine or guanidine functions with an alkyl radical having two or more hydroxyl functions, whereby said alkyl radical is derived from sugar derivates. Several sugar structural components or components derived from sugar can therefore be linked to each other. Said principle of linking sugar derivates enables oral active compounds to be obtained.
摘要翻译：本发明涉及新型脒和喹啉，其生产及其用途及其作为胰蛋白酶型丝氨酸蛋白酶竞争性抑制剂的用途，特别是血栓素和补体蛋白酶CI和C1r。除了使用化合物作为血栓抑制剂，抗凝剂，补体抑制剂和抗炎剂之外，本发明还涉及含有所述化合物作为活性成分的药物组合物。该新型组合物的特征在于具有脒或胍功能的丝氨酸蛋白酶抑制剂与具有两个或多个羟基官能团的烷基基团的连接，其中所述烷基衍生自糖衍生物。因此，几种糖结构成分或来自糖的组分可以彼此连接。所述连接糖衍生物的原理使得能够获得口服活性化合物。

4. 发明申请

US20110009640A1 BIFUNCTIONAL PHENYL ISO (THIO) CYANATES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION 有权
标题翻译：双功能苯乙烯（THIO）氰化物，其制备方法和中间体
公开(公告)号：US20110009640A1
公开(公告)日：2011-01-13
申请号：US12886986
申请日：2010-09-21
申请人： Gerhard Hamprecht , Michael Puhl , Bernd Wolf , Norbert Götz , Michael Keil , Robert Reinhard , Ingo Sagasser , Werner Seitz
发明人： Gerhard Hamprecht , Michael Puhl , Bernd Wolf , Norbert Götz , Michael Keil , Robert Reinhard , Ingo Sagasser , Werner Seitz
IPC分类号： C07D249/14 , C07C263/10 , C07C331/28 , C07C265/12 , C07D249/12 , C07C307/02
CPC分类号： C07D213/76 , C07C303/34 , C07C307/06 , C07C331/28 , C07C2601/14 , C07D207/20 , C07D211/18 , C07D211/70 , C07D295/26 , C07D307/52 , C07D319/06 , C07D333/20
摘要： A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described.Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.
摘要翻译：描述式I的苯基异（硫代）氰酸酯的方法，其中将式II化合物或其HCl加合物与W是氧或硫的光气反应剂和Ar和A如权利要求1中所定义的相同。此外，本发明涉及苯基异（硫代）氰酸酯用于制备作物保护剂的用途。

5. 发明申请

US20100105562A1 Crystalline Form of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]sulfonyl]benzamide 有权
标题翻译： 2-氯-5- [3,6-二氢-3-甲基-2,6-二氧代-4-（三氟甲基）-1-（2H） - 嘧啶基] -4-氟-N - [[甲基（1-甲基乙基）氨基]磺酰基]苯甲酰胺
公开(公告)号：US20100105562A1
公开(公告)日：2010-04-29
申请号：US12444653
申请日：2007-10-12
申请人： Thomas Schmidt , Joachim Gebhardt , Sandra Löhr , Michael Keil , Jan Hendrik Wevers , Peter Erk , Heidi Emilia , Gerhard Hamprecht , Werner Seitz , Guido Mayer , Bernd Wolf , Gerhard Cox , Alfred Michel , Cyrill Zagar , Robert Reinhard , Bernd Sievernich
发明人： Thomas Schmidt , Joachim Gebhardt , Sandra Löhr , Michael Keil , Jan Hendrik Wevers , Peter Erk , Heidi Emilia , Gerhard Hamprecht , Werner Seitz , Guido Mayer , Bernd Wolf , Gerhard Cox , Alfred Michel , Cyrill Zagar , Robert Reinhard , Bernd Sievernich
IPC分类号： A01N43/54 , C07D239/54 , A01P13/00
CPC分类号： C07D239/54
摘要： The present invention relates to a crystalline form of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)-amino]sulfonyl]benzamide. The invention also relates to a process for the preparation of this crystalline form and to plant protection formulations which comprise this crystalline form of the phenyluracil.
摘要翻译：本发明涉及2-氯-5- [3,6-二氢-3-甲基-2,6-二氧代-4-（三氟甲基）-1-（2H）嘧啶基] -4-氟 - N - [[甲基（1-甲基乙基） - 氨基]磺酰基]苯甲酰胺。本发明还涉及制备该结晶形式的方法以及包含该苯基尿嘧啶的该结晶形式的植物保护制剂。

6. 发明授权

US07369940B2 Method for operating a display system in a vehicle for driving into a parking space 有权
标题翻译：用于操作车辆中的显示系统以用于驾驶到停车位的方法
公开(公告)号：US07369940B2
公开(公告)日：2008-05-06
申请号：US11060621
申请日：2005-02-17
申请人： Peter Frank , Martin Laufer , Karl-Josef Marks , Werner Seitz
发明人： Peter Frank , Martin Laufer , Karl-Josef Marks , Werner Seitz
IPC分类号： B60Q1/48
CPC分类号： B60R1/00 , B60R2300/305 , B60R2300/806 , B60T2201/10 , G08G1/168
摘要： A method for operating a display system in a vehicle (03) when driving into a parking space (06), uses a camera (01) with an image processing unit in which the image data obtained by the camera (01) can be processed and a display screen (02) in the interior of the vehicle. After the vehicle has moved to the vehicle position in which the first parking-space icon (07) has been brought to overlay the parking space (06) shown in the real-time image, a second parking-space icon (09) is faded into the real-time image on the display screen (02) by the image processing unit, with this second parking-space icon (09) in the real-time image in true scale indicating a region which after moving along a first segment (15) of the travel path (14) towards the parking space (06) must be brought to overlay the parking space (06) shown in the real-time image. After the vehicle has moved to the vehicle position in which the second parking-space icon (09) has been brought to overlay the parking space (06) shown in the real-time image, a third parking-space icon (11) is faded into the real-time image on the display screen (02) by the image processing unit, with said third parking-space icon (11) in the real-time image in true scale indicating a region which after moving along a second segment (16) of the travel path towards the parking space (06) must be brought to overlay the parking space (06) shown in the real-time image.
摘要翻译：在驾驶到停车空间（06）中时，用于在车辆（03）中操作显示系统的方法使用摄像机（01）与图像处理单元，其中可以处理由相机（01）获得的图像数据，在车辆内部的显示屏（02）。在车辆移动到其中已经使第一停车位图标（07）被覆盖在实时图像中所示的停车位（06）的车辆位置之后，第二停车位图标（09）被褪色通过图像处理单元在显示屏幕（02）上的实时图像中，以实际图像的实时图像中的该第二停放空间图标（09）指示沿着第一段（15）移动之后的区域）到停车位（06）的行进路径（14）必须被覆盖在实时图像中所示的停车位（06）上。在车辆移动到已经使第二停车位图标（09）被覆盖在实时图像中所示的停车空间（06）的车辆位置之后，第三停车位图标（11）褪色通过图像处理单元在显示屏幕（02）上进入实时图像，其中实时图像中的所述第三停放空间图标（11）以实际尺度指示沿着第二段（16）移动之后的区域）到停车位（06）的行进路径必须被覆盖在实时图像中所示的停车位（06）上。

7. 发明授权

US07355053B2 1-phenylpyrrolidine-2-one-3-carboxamides 失效
标题翻译： 1-苯基吡咯烷-2-酮-3-甲酰胺
公开(公告)号：US07355053B2
公开(公告)日：2008-04-08
申请号：US10531573
申请日：2003-10-17
申请人： Robert Reinhard , Gerhard Hamprecht , Michael Puhl , Werner Seitz , Liliana Parra Rapado , Annegret Scannell-Lansky , Klaus Groβmann , Helmut Schiffer , Matthias Witschel , Cyrill Zagar , Andreas Landes , Michael Rack
发明人： Robert Reinhard , Gerhard Hamprecht , Michael Puhl , Werner Seitz , Liliana Parra Rapado , Annegret Scannell-Lansky , Klaus Groβmann , Helmut Schiffer , Matthias Witschel , Cyrill Zagar , Andreas Landes , Michael Rack
IPC分类号： A61K31/402 , C07D207/08
CPC分类号： C07D207/277 , A01N43/36 , C07D207/24 , C07D403/06 , C07D405/04 , C07D409/04
摘要： The invention relates to 1-phenylpyrrolidin-2-one-3-carboxamides of the formula I where the variables R1, R2, R3, X, Y, A, n, Ra, Rb, Rc, Rd and Re are as defined in claim 1 and to their agriculturally useful salts. Moreover, the invention relates to the use of compounds I and/or their salts as herbicides; crop protection compositions comprising at least one 1-phenylpyrrolidin-2-one-3-carboxamide of the formula I and/or at least one agriculturally useful salt of I as active substances; and also a method for controlling unwanted vegetation, which comprises allowing a herbicidally effective amount of at least one 1-phenylpyrrolidin-2-one-3-carboxamide of the formula I or an agriculturally useful salt of I to act on plants, their habitat or on seed.
摘要翻译：本发明涉及式I的1-苯基吡咯烷-2-酮-3-甲酰胺，其中R 1，R 2，R 3， >，X，Y，A，n，R a，R b，R c，R d，R d和 R e如权利要求1中所定义，和它们的农业上有用的盐。此外，本发明涉及化合物I和/或其盐作除草剂的用途; 包含式I的至少一种1-苯基吡咯烷-2-酮-3-甲酰胺和/或I的至少一种农业上有用的作为活性物质的盐的作物保护组合物; 以及用于防治有害植物的方法，其包括允许除草有效量的式I的至少一种1-苯基吡咯烷-2-酮-3-甲酰胺或I的农业上有用的盐作用于植物，其栖息地或在种子上

8. 发明授权

US07144902B1 Prodrugs of thrombin inhibitors 有权
标题翻译：凝血酶抑制剂的前药
公开(公告)号：US07144902B1
公开(公告)日：2006-12-05
申请号：US09958349
申请日：2000-04-05
申请人： Dorit Baucke , Helmut Mack , Werner Seitz , Wilfried Hornberger , Gisela Backfisch , Juergen Delzer
发明人： Dorit Baucke , Helmut Mack , Werner Seitz , Wilfried Hornberger , Gisela Backfisch , Juergen Delzer
IPC分类号： A61K31/425 , C07D277/20
CPC分类号： C07K5/06078 , A61K38/00 , C07B43/00 , C07K5/0222
摘要： The present invention relates to prodrugs of pharmacologically active five-membered heterocyclic amidines from which are produced in vivo compounds which are competitive inhibitors of trypsin-like serine proteases, in particular thrombin and kininogenases such as kallikrein, to the preparation thereof and to the use thereof as medicines. The invention also relates to pharmaceutical compositions which comprise the prodrugs of the active compounds as ingredients, and to the use of the compounds as thrombin inhibitors, anticoagulants and as antiinflammatory agents.
摘要翻译：本发明涉及药理活性五元杂环脒的前体药物，它们是体内化合物，其是胰蛋白酶样丝氨酸蛋白酶的竞争性抑制剂，特别是凝血酶和激肽释放酶如激肽释放酶对其制备及其用途作为药物本发明还涉及包含活性化合物作为成分的前药以及该化合物作为凝血酶抑制剂，抗凝剂和抗炎剂的用途的药物组合物。

9. 发明申请

US20060211577A1 Benzenesulphonamide derivatives as herbicides or desiccant/defoliant compounds 失效
公开(公告)号：US20060211577A1
公开(公告)日：2006-09-21
申请号：US10551988
申请日：2004-04-06
申请人： Gerhard Hamprecht , Michael Puhl , Robert Reinhard , Werner Seitz , Cyrill Zagar , Matthias Witschel , Andreas Landes
发明人： Gerhard Hamprecht , Michael Puhl , Robert Reinhard , Werner Seitz , Cyrill Zagar , Matthias Witschel , Andreas Landes
IPC分类号： A01N43/54 , A01N43/653 , A01N43/50 , A01N43/56 , A01N41/06 , C07C313/26 , C07C311/29
CPC分类号： C07D239/54 , A01N43/40 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/64 , A01N43/653 , A01N43/707 , A01N43/90 , A01N47/24 , A01N47/34 , A01N47/36 , A01N47/38 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D521/00
摘要： The present invention relates to benzenesulfonamide derivatives of the formula I in which the variables are as defined below: X1 is hydrogen or halogen; X2 is hydrogen, cyano, CS—NH2, halogen, alkyl or haloalkyl; X3 is hydrogen, cyano, alkyl, alkoxyalkyl, cycloalkyl, alkenyl, alkynyl or phenylalkyl, where the phenyl radical for its part may be substituted; Y is a group —C(A)B, SO2 or SO2NR2; A is oxygen or sulfur; B is oxygen, sulfur, NR2 or a bond; R1 is hydrogen, halogen, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, cycloalkenyl, alkynyl, alkoxy, cycloalkyloxy, alkenyloxy, alkynyloxy, aryl, aryloxy, arylalkyl, where the 13 last mentioned radicals for their part may be substituted; unsubstituted or substituted four- to six-membered heterocyclyl; unsubstituted or substituted four- to six-membered heterocyclyl-C1-C4-alkyl; unsubstituted or substituted five- or six-membered heteroaryl having one to four nitrogen atoms or having one to three nitrogen atoms and one oxygen or one sulfur atom or having one oxygen or sulfur atom; or unsubstituted or substituted five- or six-membered heteroaryl-C1-C4-alkyl having one to four nitrogen atoms or having one to three nitrogen atoms and one oxygen or one sulfur atom or having one oxygen or sulfur atom; R2 is hydrogen,-alkyl, alkenyl, alkynyl, cycloalkyl, where the four last mentioned radicals may be partially or fully halogenated; or R1 and R2 together with the nitrogen atom to which they are attached form an unsubstituted or substituted three- to seven-membered heterocycle; Q is a radical from the group consisting of Q1 to Q39; to processes and intermediates for their preparation and to the use of these compounds or of the compositions comprising these compounds for controlling unwanted plants and for the desiccation/defoliation of plants.

10. 发明申请

US20060019831A1 1-phenylpyrrolidine-2-one-3-carboxamides 失效
标题翻译： 1-苯基吡咯烷-2-酮-3-甲酰胺
公开(公告)号：US20060019831A1
公开(公告)日：2006-01-26
申请号：US10531573
申请日：2003-10-17
申请人： Robert Reinhard , Gerhard Hamprecht , Michael Puhl , Werner Seitz , Liliana Rapado , Annegret Scannell-Lansky , Klaus Grossmann , Helmut Schiffer , Matthias Witschel , Cyrill Zagar
发明人： Robert Reinhard , Gerhard Hamprecht , Michael Puhl , Werner Seitz , Liliana Rapado , Annegret Scannell-Lansky , Klaus Grossmann , Helmut Schiffer , Matthias Witschel , Cyrill Zagar
IPC分类号： A01N43/36 , C07D207/333
CPC分类号： C07D207/277 , A01N43/36 , C07D207/24 , C07D403/06 , C07D405/04 , C07D409/04
摘要： The invention relates to 1-phenylpyrrolidin-2-one-3-carboxamides of the formula I where the variables R1, R2, R3, X, Y, A, n, Ra, Rb, Rc, Rd and Re are as defined in claim 1 and to their agriculturally useful salts. Moreover, the invention relates to the use of compounds I and/or their salts as herbicides; crop protection compositions comprising at least one 1-phenylpyrrolidin-2-one-3-carboxamide of the formula I and/or at least one agriculturally useful salt of I as active substances; and also a method for controlling unwanted vegetation, which comprises allowing a herbicidally effective amount of at least one 1-phenylpyrrolidin-2-one-3-carboxamide of the formula I or an agriculturally useful salt of I to act on plants, their habitat or on seed.
摘要翻译：本发明涉及式I的1-苯基吡咯烷-2-酮-3-甲酰胺，其中R 1，R 2，R 3， >，X，Y，A，n，R a，R b，R c，R d，R d和 R e如权利要求1中所定义，和它们的农业上有用的盐。此外，本发明涉及化合物I和/或其盐作除草剂的用途; 包含式I的至少一种1-苯基吡咯烷-2-酮-3-甲酰胺和/或I的至少一种农业上有用的作为活性物质的盐的作物保护组合物; 以及用于防治有害植物的方法，其包括允许除草有效量的式I的至少一种1-苯基吡咯烷-2-酮-3-甲酰胺或I的农业上有用的盐作用于植物，其栖息地或在种子上

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