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1. 发明授权

US09365495B2 Process for manufacturing aryloxyacetamides 有权
标题翻译：制备芳氧基乙酰胺的方法
公开(公告)号：US09365495B2
公开(公告)日：2016-06-14
申请号：US14365822
申请日：2012-12-20
申请人： Maximilian Dochnahl , Michael Rack , Michael Keil , Bernd Wolf , Uwe Josef Vogelbacher , Joachim Gebhardt , Timo Frassetto , Volker Maywald
发明人： Maximilian Dochnahl , Michael Rack , Michael Keil , Bernd Wolf , Uwe Josef Vogelbacher , Joachim Gebhardt , Timo Frassetto , Volker Maywald
IPC分类号： C07C231/24 , C07D413/04 , C07C231/12 , C07C235/20 , C07D207/06 , C07D211/06 , C07D295/185 , C07C235/34 , C07D207/16 , C07D211/16
CPC分类号： C07C231/24 , C07C231/12 , C07C235/20 , C07C235/34 , C07D207/06 , C07D207/16 , C07D211/16 , C07D295/185 , C07D413/04
摘要： The present invention relates to a process for manufacturing aryloxyacetamides of formula (I), by reacting haloacetamides of formula (II) with a phenol of formula (III); wherein the variables are defined according to the description, and aryloxyacetamides of formula (I).
摘要翻译：本发明涉及通过使式（II）的卤代乙酰胺与式（III）的苯酚反应制备式（I）的芳氧基乙酰胺的方法; 其中所述变量根据描述定义，和式（I）的芳氧基乙酰胺。

2. 发明授权

US08598222B2 Method for preparing 1,3,4-substituted pyrazol compounds 有权
标题翻译：制备1,3,4-取代吡唑化合物的方法
公开(公告)号：US08598222B2
公开(公告)日：2013-12-03
申请号：US12990340
申请日：2009-05-04
申请人： Bernd Wolf , Volker Maywald , Michael Keil , Christopher Koradin , Michael Rack , Thomas Zierke , Martin Sukopp
发明人： Bernd Wolf , Volker Maywald , Michael Keil , Christopher Koradin , Michael Rack , Thomas Zierke , Martin Sukopp
IPC分类号： A61K31/415 , C07D231/14
CPC分类号： C07D409/12 , C07C251/76 , C07C251/84 , C07C251/86 , C07D231/14
摘要： The present invention relates to a process for preparing 1,3-substituted pyrazole compounds of the formula I in which X is especially a CX1X2X3 group in which X1, X2 and X3 are each independently especially hydrogen, fluorine or chlorine, R1 is C1-C4-alkyl or cyclopropyl, and R2 is hydrogen, CN or a CO2R2a group in which R2a is especially C1-C6-alkyl, comprising the following steps: i) reacting a compound of the formula II with a hydrazone of the formula III where the variables X and R2 in formula II are each as defined for formula I, Y is oxygen, an NRy1 group or an [NRy2Ry3]+Z− group, R3 is OR3a or an NR3bR3c group, and where the variable R1 in formula III is as defined for formula I, R4 and R5 are each independently hydrogen, C1-C6-alkyl, optionally substituted phenyl, where at least one of the R4 and R5 radicals is different from hydrogen, and where R4 and R5 together with the carbon atom to which they are bonded may also be a 5- to 10-membered saturated carbocycle; ii) treating the reaction product obtained with an acid in the presence of water.
摘要翻译：本发明涉及一种制备式I的1,3-取代吡唑化合物的方法，其中X特别是X 1，X 2和X 3各自独立地是氢，氟或氯，R 1是C 1 -C 4 - 烷基或环丙基，并且R 2是氢，CN或其中R 2a特别是C 1 -C 6 - 烷基的CO 2 R 2 a基团，包括以下步骤：i）使式II化合物与式III的腙反应，其中变量式II中的X和R 2各自如式I所定义，Y是氧，NRy1基或[NRy2Ry3] + Z-基，R3是OR3a或NR3bR3c基团，其中式III中的变量R1如所定义对于式I，R 4和R 5各自独立地为氢，C 1 -C 6 - 烷基，任选取代的苯基，其中R 4和R 5基团中的至少一个不同于氢，并且其中R 4和R 5与它们的碳原子一起键也可以是5至10元饱和碳环; ii）在水存在下用酸处理反应产物。

3. 发明授权

US08350046B2 Method for manufacturing aryl carboxamides 有权
标题翻译：芳基甲酰胺的制备方法
公开(公告)号：US08350046B2
公开(公告)日：2013-01-08
申请号：US12990892
申请日：2009-05-06
申请人： Wolfgang Reichert , Christopher Koradin , Sebastian Peer Smidt , Volker Maywald , Bernd Wolf , Michael Rack , Thomas Zierke , Michael Keil
发明人： Wolfgang Reichert , Christopher Koradin , Sebastian Peer Smidt , Volker Maywald , Bernd Wolf , Michael Rack , Thomas Zierke , Michael Keil
IPC分类号： C07D213/82 , C07D231/14
CPC分类号： C07C231/02 , C07C2601/14 , C07D213/82 , C07D231/14 , C07D231/16 , C07C233/65 , C07C233/75
摘要： A process for preparing arylcarboxamides of the formula (I) where Ar=a mono- to trisubstituted phenyl, pyridyl or pyrazolyl ring, where the substituents are selected from halogen, C1-C4-alkyl and C1-C4-haloalkyl; M=thienyl or phenyl, which may bear a halogen substituent; Q=direct bond, cyclopropylene, fused bicyclo[2.2.1]heptane or bicyclo[2.2.1]heptene ring; R1=hydrogen, halogen, C1-C6-alkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, mono- to trisubstituted phenyl, where the substituents are selected from halogen and trifluoromethylthio, or cyclopropyl; by reacting an acid chloride of the formula (II) with an arylamine (III) in a suitable nonaqueous solvent, wherein, in the absence of an auxiliary base, a) the acid chloride (II) is initially charged, b) a pressure of from 0 to 700 mbar is established, c) the arylamine (III) is metered in an approximately stoichiometric amount and d) the product of value is isolated.
摘要翻译：制备式（I）的芳基羧酰胺的方法，其中Ar =单 - 三取代的苯基，吡啶基或吡唑基环，其中取代基选自卤素，C 1 -C 4 - 烷基和C 1 -C 4卤代烷基; M =噻吩基或苯基，其可以带有卤素取代基; Q =直接键合，亚环丙基，稠合双环[2.2.1]庚烷或双环[2.2.1]庚烯环; R1 =氢，卤素，C1-C6-烷基，C1-C4-烷氧基，C1-C4-卤代烷氧基，一至三取代的苯基，其中取代基选自卤素和三氟甲硫基，或环丙基; 通过使式（II）的酰氯与芳基胺（III）在合适的非水溶剂中反应，其中在没有辅助碱的情况下，a）最初加入酰氯（II），b）建立0至700毫巴，c）芳基胺（III）以约化学计量的量计量，并且d）分离产物的值。

4. 发明申请

US20080214878A1 Method For The Production Of 1,3,5-Trifluoro-2,4,6-Trichlorobenzene From Fluorobenzene Derivatives 失效
标题翻译：从氟苯衍生物生产1,3,5-三氟-2,4,6-三氯苯的方法
公开(公告)号：US20080214878A1
公开(公告)日：2008-09-04
申请号：US11911971
申请日：2006-04-21
申请人： Michael Rack , Sebastian Peer Smidt , Manuel Budich , Volker Maywald , Michael Keil , Bernd Wolf
发明人： Michael Rack , Sebastian Peer Smidt , Manuel Budich , Volker Maywald , Michael Keil , Bernd Wolf
IPC分类号： C07C17/12
CPC分类号： C07C25/13 , C07C17/12 , C07C17/208 , C07C17/23
摘要： Method for the production of 1,3,5-trifluoro-2,4,6-trichlorobenzene from fluorobenzene comprising steps A) and B): A) chlorination of fluorobenzene derivatives of formula (II), in which X=fluorine of H, Z=nitro, bromo or chloro and n=0 or 1-4 and B) fluorination of the distillation residue and separation by distillation of the 1,3,5-trifluoro-2,4,6-trichlorobenzene thus produced.
摘要翻译：由氟代苯制备1,3,5-三氟-2,4,6-三氯苯的方法，包括步骤A）和B）：A）氯化式（II）的氟代苯衍生物，其中X = H的氟， Z =硝基，溴或氯，n = 0或1-4，B）氟化蒸馏残余物并通过蒸馏分离由此制得的1,3,5-三氟-2,4,6-三氯苯。

5. 发明授权

US07253323B2 Method for the production of benzophenones 有权
标题翻译：二苯甲酮生产方法
公开(公告)号：US07253323B2
公开(公告)日：2007-08-07
申请号：US10535710
申请日：2003-12-01
申请人： Volker Maywald , Nico Hoffmann , Michael Keil , Uwe Josef Vogelbacher , Jan Hendrik Wevers
发明人： Volker Maywald , Nico Hoffmann , Michael Keil , Uwe Josef Vogelbacher , Jan Hendrik Wevers
IPC分类号： C07C45/00
CPC分类号： C07C51/363 , C07C45/46 , C07C45/81 , C07C51/60 , C07C49/84 , C07C65/21
摘要： A process for preparing benzophenones of the formula I, where X may be chlorine, hydroxyl, methoxy or C1-C6-alkylcarbonyloxy, and Y may be chlorine or bromine, by reacting an acid chloride of the formula II where X and Y are as defined above with 3,4,5-trimethoxytoluene, which comprises carrying out the reaction in the presence of a) an aromatic hydrocarbon as a diluent and b) from 0.01 to 0.2 mol % of an iron catalyst, based on the acid chloride, c) at a temperature between 60° C. and the boiling point of the particular diluent.
摘要翻译：制备式I的二苯甲酮的方法，其中X可以是氯，羟基，甲氧基或C 1 -C 6 - 烷基羰氧基，Y可以是氯或溴，通过使式II的酰氯与其中X和Y如上所定义的酰氯与3,4,5-三甲氧基甲苯反应，其包括在a）芳族烃作为稀释剂存在下进行反应，和b）从0.01至 0.2mol％的铁催化剂，基于酰氯，c）在60℃和特定稀释剂的沸点之间的温度下。

6. 发明授权

US06201135B1 Method for separating contaminants from 3-(2′-Acetoxy-Ethyl-Dihydro-2(3H)-Furanone 失效
标题翻译：从3-（2'-乙酰氧基 - 乙基 - 二氢-2（3H） - 呋喃酮分离污染物的方法
公开(公告)号：US06201135B1
公开(公告)日：2001-03-13
申请号：US09530132
申请日：2000-04-27
申请人： Volker Maywald , Norbert Götz , Thomas Kükenhöhner , Dirk Borchers , Hartmann König , Horst Hartmann , Rupert Wagner
发明人： Volker Maywald , Norbert Götz , Thomas Kükenhöhner , Dirk Borchers , Hartmann König , Horst Hartmann , Rupert Wagner
IPC分类号： C07D30758
CPC分类号： C07D307/33
摘要： A process for removing impurities from 3-(2′-acetoxyethyl)-dihydro-2(3H)-furanone (I), which comprises initially preparing the 3-(2′-acetoxyethyl)-dihydro-2(3H)-furanone containing the undesirable impurities in a manner known per se by acetylating 3-(2′-hydroxylethyl)-dihydro-2(3H)-furanone, subsequently treating it with strong mineral acids and finally removing the decomposition products of the undesirable impurities from I.
摘要翻译：一种从3-（2'-乙酰氧基乙基） - 二氢-2（3H） - 呋喃酮（I）中除去杂质的方法，其中包括最初制备含有3-（2'-乙酰氧基乙基） - 二氢-2（3H） - 呋喃酮通过乙酰化3-（2'-羟基乙基） - 二氢-2（3H） - 呋喃酮，本身已知的方法是不需要的杂质，随后用强无机酸处理，最后从I中除去不需要的杂质的分解产物。

7. 发明授权

US5576270A Isoxazolecarboxamides, their preparation and their use 失效
标题翻译：异硫脲酰胺，其制备及其应用
公开(公告)号：US5576270A
公开(公告)日：1996-11-19
申请号：US313176
申请日：1994-09-29
申请人： Volker Maywald , Thomas Kuekenhoehner , Peter Muenster , Wolfgang von Deyn , Helmut Walter , Matthias Gerber , Karl-Otto Westphalen , Uwe Kardorff
发明人： Volker Maywald , Thomas Kuekenhoehner , Peter Muenster , Wolfgang von Deyn , Helmut Walter , Matthias Gerber , Karl-Otto Westphalen , Uwe Kardorff
IPC分类号： A01N43/80 , C07D261/18 , C07D413/12 , A61K31/42 , C07D261/06
CPC分类号： C07D413/10 , A01N43/80 , C07D261/18
摘要： The invention pertains to isoxazolecarboxamides of the formula I ##STR1## where R.sup.1 is alkyl, cycloalkyl, alkoxyalkyl, alkenyl, alkynyl, phenyl or unsubstituted or substituted benzyl,R.sup.2 is hydrogen or alkyl andR.sup.3 is alkyl, cycloalkyl, alkenyl, alkynyl, phenyl or unsubstituted or substituted benzyl,and the plant-tolerated salts of those compounds in which R.sup.2 is hydrogen, their preparation and their use.
摘要翻译： PCT No.PCT / EP93 / 00918 Sec。 371日期1994年9月29日 102（e）1994年9月29日PCT 1994年4月16日PCT PCT。公开号WO93 / 22295 日本公开号为1993年11月11日本发明涉及式I的异恶唑甲酰胺，其中R1是烷基，环烷基，烷氧基烷基，烯基，炔基，苯基或未取代或取代的苄基，R2是氢或烷基，R3是烷基，环烷基，烯基，炔基，苯基或未取代或取代的苄基，以及其中R2为氢的那些化合物的植物耐受盐，其制备及其用途。

8. 发明授权

US09359312B2 Process for manufacturing benzoxazinones 有权
标题翻译：制备苯并恶嗪酮的方法
公开(公告)号：US09359312B2
公开(公告)日：2016-06-07
申请号：US14365829
申请日：2012-12-20
申请人： Maximilian Dochnahl , Michael Rack , Michael Keil , Bernd Wolf , Uwe Josef Vogelbacher , Joachim Gebhardt , Timo Frassetto , Volker Maywald
发明人： Maximilian Dochnahl , Michael Rack , Michael Keil , Bernd Wolf , Uwe Josef Vogelbacher , Joachim Gebhardt , Timo Frassetto , Volker Maywald
IPC分类号： C07D265/36 , C07D413/04 , C07C231/12
CPC分类号： C07D265/36 , C07C231/12 , C07D413/04
摘要： The present invention relates to a process for manufacturing a benzoxazinone of formula (I), by reacting a nitro compound of formula (II) with a reducing agent to obtain an amino compound of formula (III), and then reacting the amino compound of formula (III) with an acid; wherein the variables are defined according to the description, and benzoxazinone of formula (I).
摘要翻译：本发明涉及式（I）的苯并恶嗪酮的制备方法，通式（II）的硝基化合物与还原剂反应得到式（III）的氨基化合物，然后使式（III）与酸反应; 其中根据描述定义变量，和式（I）的苯并嗪酮。

9. 发明授权

US09000152B2 Process for manufacturing triazinon-benzoxazinones 有权
标题翻译：制备三嗪酮 - 苯并恶嗪酮的方法
公开(公告)号：US09000152B2
公开(公告)日：2015-04-07
申请号：US14364160
申请日：2012-12-20
申请人： Bernd Wolf , Volker Maywald , Uwe Josef Vogelbacher , Michael Rack , Maximilian Dochnahl , Michael Keil , Timo Frassetto , Joachim Gebhardt
发明人： Bernd Wolf , Volker Maywald , Uwe Josef Vogelbacher , Michael Rack , Maximilian Dochnahl , Michael Keil , Timo Frassetto , Joachim Gebhardt
IPC分类号： C07D413/14 , A01N43/84 , C07D413/04
CPC分类号： C07D413/04 , A01N43/84
摘要： The present invention relates to a process for manufacturing triazinon-benzoxazinones of formula (I), by reacting amino-benzoxazinones of formula (II) with 1,1′-carbonyldiimidazole (CDI) and a (thio)urea compound of formula (III); wherein the variables are defined according to the description.
摘要翻译：本发明涉及通过使式（II）的氨基 - 苯并嗪酮与1,1'-羰基二咪唑（CDI）和式（III）的（硫代）脲化合物反应制备式（I）的三嗪酮 - 苯并恶嗪酮的方法， ; 其中根据描述定义变量。

10. 发明申请

US20150018545A1 Process for manufacturing 4-substituted amino-benzoxazinones 有权
公开(公告)号：US20150018545A1
公开(公告)日：2015-01-15
申请号：US14365774
申请日：2012-12-20
申请人： Bernd WOLF , Joachim GEBHARDT , Uwe Josef VOGELBACHER , Maximilian DOCHNAHL , Michael RACK , Michael KEIL , Timo FRASSETTO , Volker MAYWALD
发明人： Bernd WOLF , Joachim GEBHARDT , Uwe Josef VOGELBACHER , Maximilian DOCHNAHL , Michael RACK , Michael KEIL , Timo FRASSETTO , Volker MAYWALD
IPC分类号： C07D265/36
CPC分类号： C07D265/36 , C07D413/04
摘要： The present invention relates to a process for manufacturing 4-substituted amino-benzoxazinones of formula (I), by reacting a NH-benzoxazinone of formula (II) with a compound of formula (III); wherein the variables are defined according to the description.

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