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61. 发明授权

US06579526B1 Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes 有权
标题翻译：与多发性硬化相关的病毒材料和核苷酸片段，用于诊断，预防和治疗目的
公开(公告)号：US06579526B1
公开(公告)日：2003-06-17
申请号：US09374766
申请日：1999-08-16
申请人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand
发明人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/51 , C12N2740/10022 , C12Q1/6883 , C12Q1/702
摘要： Viral material, in the isolated or purified state, in which the genome comprises a nucleotide sequence chosen from the group including sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, their complementary sequences and their equivalent sequences, in particular nucleotide sequences displaying, for any succession of 100 contiguous monomers, at least 50% and preferably at least 70% homology with the said sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, respectively, and their complementary sequences.
摘要翻译：分离或纯化状态的病毒物质，其中基因组包含选自SEQ ID NO：46，SEQ ID NO：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：53的核苷酸序列 SEQ ID NO：46，SEQ ID NO：56，其互补序列及其等同序列，特别是核苷酸序列，显示100个连续单体的任何连续序列，与所述序列SEQ ID NO：46，SEQ ID NO为至少50％，优选至少70％：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：56及其互补序列。

62. 发明授权

US6133047A Superparamagnetic monodisperse particles 失效
标题翻译：超顺磁单分散颗粒
公开(公告)号：US6133047A
公开(公告)日：2000-10-17
申请号：US983040
申请日：1998-01-15
申请人： Abdelhamid Elaissari , Christian Pichot , Bernard Mandrand , Florence Sauzedde
发明人： Abdelhamid Elaissari , Christian Pichot , Bernard Mandrand , Florence Sauzedde
IPC分类号： B03C1/01 , G01N33/537 , G01N33/543 , H01F1/37 , H01F1/44 , G01N33/553 , B05D5/12 , B32B5/16 , G01N33/566
CPC分类号： H01F1/37 , B03C1/01 , G01N33/5375 , G01N33/5434 , H01F1/44 , G01N2446/10 , G01N2446/40 , G01N2446/84 , G01N2446/86 , Y10S436/806 , Y10S436/824 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2998 , Y10T436/24
摘要： The superparamagnetic monodispersed particles comprise a core of a first polymer, an internal layer of a second polymer coating the core and in which a magnetic material is distributed, and an external layer of a third polymer coating the magnetic layer and capable of interacting with at least one biological molecule. At least the second polymer is heat sensitive and has a predetermined lower critical solubility temperature (LCST) of 15-65.degree. C. These particles may be used to isolate at least one biological molecule from a liquid specimen.
摘要翻译： PCT No.PCT / FR97 / 00912 Sec。 371日期1998年1月15日 102（e）日期1998年1月15日PCT提交1997年5月23日PCT公布。出版物WO97 / 45202 日本1997年12月4日超顺磁单分散颗粒包括第一聚合物的芯，涂覆芯的第二聚合物的内层，其中分布有磁性材料，以及涂覆磁性层的第三聚合物的外层，与至少一种生物分子相互作用。至少第二聚合物是热敏感的并且具有15-65℃的预定的较低临界溶解温度（LCST）。这些颗粒可用于从液体样品中分离至少一种生物分子。

63. 发明授权

US5962217A MSRV1 virus and MSRV2 pathogen and/or infective agent associated with multiple sclerosis, and biopolymer constituents thereof 失效
标题翻译： MSRV1病毒和MSRV2病原体和/或与多发性硬化症相关的感染性试剂及其生物聚合物组分
公开(公告)号：US5962217A
公开(公告)日：1999-10-05
申请号：US470006
申请日：1995-06-06
申请人： Herve Perron , Francois Mallet , Bernard Mandrand , Frederic Bedin , Frederic Beseme
发明人： Herve Perron , Francois Mallet , Bernard Mandrand , Frederic Bedin , Frederic Beseme
IPC分类号： G01N33/569 , A61K31/70 , A61K35/76 , A61K38/00 , A61K39/21 , A61P25/00 , A61P31/12 , C07H21/04 , C07K7/06 , C07K14/005 , C07K14/15 , C12N5/08 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/48 , C12Q1/68 , G01N33/68 , C12Q1/70
CPC分类号： C07K14/005 , C12N7/00 , A61K38/00 , C12N2740/10021 , C12N2740/10022 , Y10S435/912
摘要： Composition including two pathogenic and/or infective agents associated with multiple sclerosis, namely a first agent which consists of a human virus possessing reverse transcriptase activity and related to a family of endogenous retroviral elements, or a variant of the virus, and a second agent, or a variant of the second agent, these two pathogenic and/or infective agents originating from the same viral strain chosen from the strains designated, respectively, POL-2 deposited with the ECACC on Jul. 22, 1992 under Accession Number V92072202 and MS7PG deposited with the ECACC on Jan. 8, 1993 under Accession Number V93010816, and from their variant strains.
摘要翻译：包括与多发性硬化症相关的两种致病和/或感染因子的组合物，即由具有逆转录酶活性并与内源性逆转录病毒元件家族或病毒变体相关的人类病毒组成的第一药剂和第二药剂，或来自相同病毒株的两种致病和/或感染因子，分别选自于1992年7月22日以保藏号V92072202和保藏号为V92072202的ECACC分别保藏的POL-2的菌株 1993年1月8日，ECACC以保藏号V93010816和其变体菌株。

64. 发明授权

US5871996A Retrovirus agents MSRV1 and MSRV2 associated with multiple sclerosis 失效
标题翻译：与多发性硬化相关的逆转录病毒药物MSRV1和MSRV2
公开(公告)号：US5871996A
公开(公告)日：1999-02-16
申请号：US384137
申请日：1995-02-06
申请人： Herve Perron , Francois Mallet , Bernard Mandrand , Frederic Bedin , Frederic Beseme
发明人： Herve Perron , Francois Mallet , Bernard Mandrand , Frederic Bedin , Frederic Beseme
IPC分类号： G01N33/569 , A61K31/70 , A61K35/76 , A61K38/00 , A61K39/21 , A61P25/00 , A61P31/12 , C07H21/04 , C07K7/06 , C07K14/005 , C07K14/15 , C12N5/08 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/48 , C12Q1/68 , G01N33/68 , A61K39/12 , A61K39/395
CPC分类号： C07K14/005 , C12N7/00 , A61K38/00 , C12N2740/10021 , C12N2740/10022 , Y10S435/912
摘要： Composition including two pathogenic and/or infective agents associated with multiple sclerosis, namely a first agent which consists of a human virus possessing reverse transcriptase activity and related to a family of endogenous retroviral elements, or a variant of the virus, and a second agent, or a variant of the second agent, these two pathogenic and/or infective agents originating from the same viral strain chosen from the strains designated, respectively, POL-2 deposited with the ECACC on Jul. 22, 1992 under Accession Number V92072202 and MS7PG deposited with the ECACC on Jan. 8, 1993 under Accession Number V93010816, and from their variant strains.
摘要翻译：包括与多发性硬化症相关的两种致病和/或感染因子的组合物，即由具有逆转录酶活性并与内源性逆转录病毒元件家族或病毒变体相关的人类病毒组成的第一药剂和第二药剂，或来自相同病毒株的两种致病和/或感染因子，分别选自于1992年7月22日以保藏号V92072202和保藏号为V92072202的ECACC分别保藏的POL-2的菌株 1993年1月8日，ECACC以保藏号V93010816和其变体菌株。

65. 发明授权

US5695936A Reagent and method for the detection of a nucleotide sequence with signal amplification 失效
标题翻译：用于检测具有信号放大的核苷酸序列的试剂和方法
公开(公告)号：US5695936A
公开(公告)日：1997-12-09
申请号：US433505
申请日：1995-06-14
申请人： Bernard Mandrand , Philippe Cros , Thierry Delair , Marie-Helene Charles , Marie-Noelle Erout , Christian Pichot
发明人： Bernard Mandrand , Philippe Cros , Thierry Delair , Marie-Helene Charles , Marie-Noelle Erout , Christian Pichot
IPC分类号： C08G81/02 , C12Q1/68
CPC分类号： C12Q1/6813 , C08G81/02 , C12Q1/682
摘要： Methods for the detection of a nucleotide sequence of interest comprising at least one nucleotide probe marked with a tracer. The methods comprise use of a reagent essentially comprising a linear backbone copolymer having lateral substituents, whose chain consists of a first type of repetitive unit and at least one other type of repetitive unit, in which at least one part of the units of the first type have a lateral substituent comprising a nucleotide unit, such a lateral substituent not being present on the other types of units. Each of said nucleotide units, all of which are identical, comprise at least one nucleotide sequence capable of hybridizing with said sequence of interest and nucleotide sequence capable of hybridizing with a probe, the reagent containing on average more than two of said nucleotide units, in molar equivalents, per mole of polymer. Such a reagent enables signal amplification to be obtained, and therefor lowers the sensitivity threshold. Application, in particular, in the production of tests for the detection of pathogenic organisms, or in the diagnosis of genetic diseases.
摘要翻译： PCT No.PCT / FR94 / 01084第 371 1995年6月14日第 102（e）1995年6月14日PCT PCT 1994年9月15日PCT公布。 WO95 / 08000 PCT出版物 1995年3月23日的方法检测目标核苷酸序列的方法包括用示踪剂标记的至少一个核苷酸探针。所述方法包括使用基本上包含具有侧向取代基的线性主链共聚物的试剂，其链由第一类型的重复单元和至少一种其它类型的重复单元组成，其中第一类型的单元的至少一部分具有包含核苷酸单元的侧向取代基，这样的侧向取代基不存在于其它类型的单元上。所述全部相同的所述核苷酸单元包含至少一个能够与所述感兴趣序列杂交的核苷酸序列和能够与探针杂交的核苷酸序列，所述试剂平均包含两个以上的所述核苷酸单元，摩尔当量，每摩尔聚合物。这样的试剂能够获得信号放大，从而降低灵敏度阈值。特别是应用于生产用于检测病原体的检测或遗传疾病的诊断。

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