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51. 发明申请

US20070003449A1 Valve for facilitating and maintaining fluid separation 审中-公开
标题翻译：用于促进和维持流体分离的阀
公开(公告)号：US20070003449A1
公开(公告)日：2007-01-04
申请号：US11451240
申请日：2006-06-12
申请人： Mehdi Hatamian , Mehrtosh Ghalebi , Matin Ebneshahrashoob
发明人： Mehdi Hatamian , Mehrtosh Ghalebi , Matin Ebneshahrashoob
IPC分类号： B01L11/00
CPC分类号： B01L3/5021 , B01L2300/042 , B01L2400/0616 , B01L2400/0633
摘要： Some embodiments include a valve positioned within a test tube to maintain a separation between components of liquid with different densities after centrifugation. The valve preferably includes a cylindrically shaped housing with a spherical plug configured to nest within the housing. The valve permits varying amounts of fluid flow depending upon the angular velocity of centrifugation applied to the test tube.
摘要翻译：一些实施方案包括位于试管内的阀，以在离心后保持不同密度的液体组分之间的分离。阀优选地包括圆柱形壳体，其具有构造成嵌入壳体内的球形塞子。阀根据施加到试管的离心角速度，允许不同量的流体流动。

52. 发明申请

US20070003438A1 Column, sample preparation apparatus using the column, and auto analyzer 审中-公开
标题翻译：柱，样品制备装置使用色谱柱和自动分析仪
公开(公告)号：US20070003438A1
公开(公告)日：2007-01-04
申请号：US11451066
申请日：2006-06-12
申请人： Hironori Kobayashi , Hideki Ishihara , Koichi Yamagata , Satoshi Nakayama
发明人： Hironori Kobayashi , Hideki Ishihara , Koichi Yamagata , Satoshi Nakayama
IPC分类号： G01N33/48 , B01L11/00
CPC分类号： G01N1/405 , G01N2030/085 , G01N2035/1053
摘要： A column is described, as representative one of which includes: a disposable column used in a measuring sample preparator, comprising: a support immobilized a substance capable of conjugating a protein, a support holding part for holding the support, a fluid connecting part for connecting to the sample preparator, and a liquid storing part for receiving a liquid through the support held by the support holding part and storing the liquid to be collectively from the top.
摘要翻译：描述了一列，其代表性的一个包括：用于测量样品制备器中的一次性柱，包括：固定有能够结合蛋白质的物质的载体，用于保持载体的支撑保持部分，用于连接的流体连接部分以及用于通过由支撑保持部保持的支撑体接收液体并将液体从顶部集中储存的液体收容部。

53. 发明申请

US20060263266A1 Device and method for separating components of a fluid sample 有权
公开(公告)号：US20060263266A1
公开(公告)日：2006-11-23
申请号：US11411458
申请日：2006-04-26
申请人： Paul DiCesare , Richmond Cohen
发明人： Paul DiCesare , Richmond Cohen
IPC分类号： B01L11/00
CPC分类号： G01N33/491 , B01L3/50215 , B01L2400/0633 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A device and method is provided for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents comprising a container and a composite element in the container. The composite element is a separator comprising at least two components and more particularly an elastic portion and a plug member. A fluid sample is delivered to the container and the device is subjected to centrifugation whereby the centrifugal load causes the elastic portion of the separator to deform so that the separator migrates into the fluid sample and stabilizes between the heavier and lighter fractions of the fluid sample. The elastic portion of the separator will resiliently return to its initial configuration upon termination of the centrifugal load such that the elastic portion sealingly engages the container and separates the heavier and lighter fractions of the fluid sample.

54. 发明授权

US07135150B2 Blood examination instrument 失效
标题翻译：血液检查仪
公开(公告)号：US07135150B2
公开(公告)日：2006-11-14
申请号：US10476404
申请日：2002-09-02
申请人： Yuichiro Noda
发明人： Yuichiro Noda
IPC分类号： B01L11/00
CPC分类号： G01N33/525 , Y10T436/2575
摘要： A blood testing tool is provided, which can recover blood plasma or blood serum with a high yield without causing hemolysis of blood cells. A recovery porous membrane 1 to be impregnated with blood serum or blood plasma contained in blood and retain it and a separation porous membrane 2 for separating blood cells from the blood are provided. The separation porous membrane 2 is laminated on the recovery porous membrane 1 while satisfying the condition that pores on an upper surface side of the recovery porous membrane have an average pore size that is in a range from 10 to 1000 μm and is larger than that of pores on a lower surface side of the separation porous membrane, thus providing a blood testing tool according to the present invention.
摘要翻译：提供血液检测工具，可以高产率回收血浆或血清，而不会引起血细胞溶血。提供了含有血液中含有的血清或血浆并保留的回收多孔膜1和用于从血液中分离血细胞的分离多孔膜2。分离多孔膜2层压在回收多孔膜1上，同时满足恢复多孔膜的上表面侧的孔的平均孔径为10〜1000μm的范围，大于在分离多孔膜的下表面侧的孔，从而提供根据本发明的血液检测工具。

55. 发明授权

US07128876B2 Microdevice and method for component separation in a fluid 有权
公开(公告)号：US07128876B2
公开(公告)日：2006-10-31
申请号：US09908231
申请日：2001-07-17
申请人： Hongfeng Yin , Kevin Killeen
发明人： Hongfeng Yin , Kevin Killeen
IPC分类号： B01L3/02 , B01L11/00 , G01N21/00 , G01N30/02 , B01D15/08
CPC分类号： B29C66/02 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L2200/0689 , B01L2200/12 , B01L2300/123 , B01L2400/0622 , B01L2400/0644 , B29C43/56 , B29C59/02 , B29C59/14 , B29C59/142 , B29C65/48 , B29C65/4835 , B29C66/54 , B29C66/71 , B29C66/72321 , B29C66/73752 , B29C66/73756 , B29C66/73921 , B29C66/73941 , B29C66/7465 , B29C2071/022 , B29K2071/00 , B29K2079/08 , B29K2309/08 , B29K2995/0039 , B29K2995/0041 , B29L2031/756 , B81B1/00 , B81C1/00357 , B81C2201/019 , G01N27/44791 , G01N30/6052 , G01N30/6095 , Y10T137/86863 , Y10T436/25375 , Y10T436/2575 , B29K2077/00 , B29K2075/00 , B29K2069/00 , B29K2067/00 , B29K2055/02 , B29K2033/12 , B29K2033/08 , B29K2027/12 , B29K2025/06 , B29K2023/00
摘要： The present invention relates to a microdevice for separating the components of a fluid sample. A cover plate is arranged over the first surface of a substrate, and, in combination with a microchannel formed in the first surface, defines a separation conduit for separating the components of the fluid sample. A sample inlet port in fluid communication with the conduit allows a fluid sample introduced from a sample source to be conveyed in a defined sample flow path such that the sample fluid travels, in order, through the sample inlet port, the separation conduit and a sample outlet port. The microdevice also includes an integrated introducing means for controllably introducing a volume of the fluid sample from a sample source into the sample inlet port and through the separation conduit. A method for separating the components of a fluid sample using the microdevice is also provided.

56. 发明授权

US07118711B1 Microcolumn reactor 有权
标题翻译：微柱反应器
公开(公告)号：US07118711B1
公开(公告)日：2006-10-10
申请号：US09914874
申请日：2000-02-25
申请人： Johann Michael Koehler
发明人： Johann Michael Koehler
IPC分类号： B01L11/00
CPC分类号： G01N30/56 , B01J19/0046 , B01J19/0093 , B01J2219/00313 , B01J2219/00351 , B01J2219/00423 , B01J2219/00459 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00783 , B01J2219/00828 , B01J2219/00833 , B01J2219/00891 , B01J2219/00907 , B01J2219/00952 , B01L3/5027 , C40B60/14 , G01N30/58 , G01N30/6095 , G01N2030/565 , Y10T436/2575
摘要： The invention relates to a microcolumn reactor for carrying out reactions on solid phases and/or with biological cells. The aim of the invention is to provide a microcolumn reactor for processes of synthesis and separation on small sample volumina that replaces an alternating sequence of binding and elution processes on a phase that is stationary bound during a test series and makes it possible to exchange the stationary phase, for example once it has been loaded. To this end, the microcolumn reactor consists of at least one first and one second substrate wafer (1; 2) that are linked with one another across their surfaces. At least one of the substrate wafers (1; 2) is provided with an elongate channel (3) which comprises in a defined section (a) of its length two passage openings (41, 42) that are implemented in the opposite substrate wafer. Said openings (41, 42) are separated from the channel (3) by a partially permeable sieve-type membrane (5). The areas of acceptance (51) of said membrane have a diameter that is chosen in such a manner as to specifically prevent microbeads and/or cells introduced into the channel from entering the passage openings (41, 42). The channel (3) is provided with at least two further openings (61, 62) outside the section (a) that is comprised by the passage openings (41, 42). Said further openings permit the microbeads and/or cells that are provided above the section (a) to be introduced and/or displaced by applying a fluid pressure (p). Means are provided that temporarily close at least one of the passage openings (41, 42) and one of openings (61, 62).
摘要翻译：本发明涉及用于在固相和/或生物细胞上进行反应的微柱反应器。本发明的目的是提供一种微柱反应器，用于在小样品体积上的合成和分离过程，其在测试序列期间在静止界限的相上替代交替的结合和洗脱过程，并且使得可以交换固定相位，例如一旦它被加载。为此，微柱反应器由至少一个在其表面上彼此连接的第一和第二基底晶片（1; 2）组成。衬底晶片（1; 2）中的至少一个设置有细长通道（3），其在其长度的限定部分（a）中包括实现在相对的衬底晶片中的两个通道开口（41,42）。所述开口（41,42）通过部分渗透的筛型膜（5）与通道（3）分离。所述膜的接受区域（51）具有以特定方式选择的直径，以便特定地防止引入通道的微珠和/或细胞进入通道开口（41,42）。通道（3）在由通道开口（41,42）组成的部分（a）外部设置有至少两个另外的开口（61,62）。所述另外的开口允许通过施加流体压力（p）将设置在部分（a）上方的微珠和/或细胞引入和/或移位。提供了临时关闭通道开口（41,42）和开口（61,62）中的至少一个的装置。

57. 发明授权

US07105133B2 Fluid sampling apparatus and fluid analyzer having the same 有权
公开(公告)号：US07105133B2
公开(公告)日：2006-09-12
申请号：US10253023
申请日：2002-09-24
申请人： Dong-Hyun Kim , Do-Hyun Cho , Woo-Dong Sung , Jin-Suk Kim , Won-Suk Choi
发明人： Dong-Hyun Kim , Do-Hyun Cho , Woo-Dong Sung , Jin-Suk Kim , Won-Suk Choi
IPC分类号： B01L3/02 , B01L11/00 , G01N21/00 , G01N15/00
CPC分类号： G01N35/10 , G01N1/16 , G01N1/18 , Y10T436/11 , Y10T436/111666 , Y10T436/119163 , Y10T436/2575
摘要： A fluid sampling apparatus and associated fluid analyzer sample process fluids used in semiconductor manufacturing at a plurality of measurement points. The fluid sampling apparatus includes a first nozzle assembly having a plurality of outlet nozzles. The plurality of outlet nozzles are connected to lines supplying the process fluids. A second nozzle assembly is installed above the first nozzle assembly and includes an inlet nozzle connected to an apparatus for measuring a contamination level of the process fluids. A motor is connected to the second nozzle assembly to align a selected outlet nozzle with the inlet nozzle. A pneumatic cylinder is coupled to the first nozzle assembly to connect the selected outlet nozzle with the inlet nozzle. In this manner, it is possible to measure the contamination level of process fluids supplied at a plurality of measurement points by using a single measuring apparatus.

58. 发明授权

US07099778B2 Method for determining diffusivity and molecular weight in a microfluidic device 有权
标题翻译：用于确定微流体装置中的扩散系数和分子量的方法
公开(公告)号：US07099778B2
公开(公告)日：2006-08-29
申请号：US10747066
申请日：2003-12-30
申请人： Ring-Ling Chien
发明人： Ring-Ling Chien
IPC分类号： G01N31/00 , G06F19/00 , B01L3/02 , B01L11/00 , B32B27/04
CPC分类号： G01N30/00 , B01L3/5027 , G01N13/00 , G01N2013/003 , Y10T436/11 , Y10T436/117497 , Y10T436/2575
摘要： The present invention is directed to a method for determining the molecular weight and diffusivity of a sample solute by providing a plus shaped microchannel network on a microfluidic chip, having at least four microchannels intersecting at a cross point; flowing a sample stream comprising a sample solute of unknown diffusivity and a blank stream from separate microchannels through the cross point and out to separate microchannels; creating a sample curve measuring the concentration of the sample solute that diffuses from the sample stream to the blank stream at the cross point while altering the flowrate of one of the blank stream or the sample stream; and determining a diffusion coefficient of the sample solute by extrapolating data from similar curves of at least two solutes having known molecular weights and/or diffusion coefficients created under similar conditions as those generated by the sample solute.
摘要翻译：本发明涉及通过在微流体芯片上提供加成形微通道网络来确定样品溶质的分子量和扩散性的方法，所述微流体芯片具有在交叉点处相交的至少四个微通道; 将包含未知扩散系数的样品溶质和来自分离的微通道的空白流的样品流流过交叉点并流出到分离的微通道; 产生样品曲线，其测量在交叉点处从样品流扩散到空白流中的样品溶质的浓度，同时改变空白流或样品流之一的流速; 以及通过从具有与由样品溶质产生的类似条件下产生的已知分子量和/或扩散系数的至少两种溶质的相似曲线外推数据来确定样品溶质的扩散系数。

59. 发明授权

US07063302B2 Sample valve with integral sample shut off function for chromatograph 有权
公开(公告)号：US07063302B2
公开(公告)日：2006-06-20
申请号：US10093599
申请日：2002-03-08
申请人： Leroy D. Cordill
发明人： Leroy D. Cordill
IPC分类号： F16K31/12 , F16K1/36 , F16K3/32 , F16K5/10 , B01L11/00
CPC分类号： G01N30/20 , G01N2030/201 , G01N2030/202 , G01N2030/205 , G01N2030/8804 , Y10T137/4456 , Y10T436/11 , Y10T436/118339 , Y10T436/2575
摘要： A multiple port valve integrated with the function of the sample shut off valve is disclosed. The integration of the sample shut off function eliminates extra plumbing and labor costs associated with a separate sample shut off valve. Additionally, the multiple port valve integrated with the function of the sample shut off valve provides a shorter equilibration time and less tubing volume.

60. 发明授权

US07014817B1 Disposable remote zero headspace extractor 失效
标题翻译：一次性远程零顶空提取器
公开(公告)号：US07014817B1
公开(公告)日：2006-03-21
申请号：US09966568
申请日：2001-09-27
申请人： Julie J. Hand , Mark P. Roberts
发明人： Julie J. Hand , Mark P. Roberts
IPC分类号： B01L11/00 , G01N1/18
CPC分类号： G01N1/2226 , B01L3/505 , G01N2001/2229 , Y10T436/25375
摘要： The remote zero headspace extractor uses a sampling container inside a stainless steel vessel to perform toxicity characteristics leaching procedure to analyze volatile organic compounds. The system uses an in line filter for ease of replacement. This eliminates cleaning and disassembly of the extractor. All connections are made with quick connect fittings which can be easily replaced. After use, the bag can be removed and disposed of, and a new sampling container is inserted for the next extraction.
摘要翻译：远程零顶空提取器使用不锈钢容器内的取样容器进行毒性特征浸出程序分析挥发性有机化合物。系统使用在线过滤器以方便更换。这样可以消除提取器的清洁和拆卸。所有连接均采用快速连接配件，可轻松更换。使用后，袋子可以被去除和处理，并且插入一个新的取样容器用于下一次提取。

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