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51. 发明申请

US20150125930A1 COLLAPSIBLE BAG WITH FLEXIBLE VORTEX BREAKER 有权
标题翻译：具有柔性VORTEX断路器的可拆卸袋
公开(公告)号：US20150125930A1
公开(公告)日：2015-05-07
申请号：US14410574
申请日：2013-06-20
申请人： GE Healthcare Bio-Sciences AB
发明人： Klaus Heinrich Gebauer , Rolf Axel Hjorth , David Ronnholm
IPC分类号： C12M1/06 , B01F13/08 , C12M1/00 , B01F15/00
CPC分类号： C12M27/02 , B01F13/08 , B01F13/0827 , B01F15/0085 , B01F15/00896 , B01F2215/0073 , C12M23/14 , C12M23/26 , C12M27/20
摘要： A generally cylindrical collapsible mixing vessel, comprising: a) a flexible plastic film side wall, a top wall and a bottom wall, wherein both the top wall and the bottom wall are attached to the side wall and the side, top and bottom walls define an inner volume of the vessel; b) an agitator located in the inner volume and; c) at least one vortex breaker made from flexible plastic film, located in the inner volume and attached to the bottom wall and/or the side wall via string elements, wherein said vortex breaker extends along the side wall and inwards in a generally radial direction.
摘要翻译：一种大致圆柱形的可折叠混合容器，包括：a）柔性塑料膜侧壁，顶壁和底壁，其中顶壁和底壁都附接到侧壁，并且侧壁，顶壁和底壁限定容器的内容积; b）位于内部容积中的搅拌器; c）至少一个由柔性塑料薄膜制成的涡流破碎机，其位于内部体积中，并通过弦线元件附接到底壁和/或侧壁，其中所述涡流破碎机沿着侧壁延伸并沿大致径向方向向内延伸。

52. 发明授权

US08870443B2 Flexible pouch with a mixing apparatus 有权
标题翻译：柔性袋与混合装置
公开(公告)号：US08870443B2
公开(公告)日：2014-10-28
申请号：US12933453
申请日：2009-03-27
申请人： Gerhard Greller , Guenter Pradel
发明人： Gerhard Greller , Guenter Pradel
IPC分类号： B01F7/16 , B01F13/06 , B01F15/00 , C12M1/06 , F16C3/03 , B01F7/00 , C12M1/00 , B01F7/22
CPC分类号： B01F7/00633 , B01F7/00691 , B01F7/007 , B01F7/00716 , B01F7/22 , B01F15/00831 , B01F15/0085 , C12M23/14 , C12M27/02 , F16C3/03
摘要： A flexible pouch has a mixing apparatus, the mixer shaft of which is adjustable in length for use as a bioreactor for culturing microorganisms and cells.
摘要翻译：柔性袋具有混合装置，其混合器轴的长度可调节用作用于培养微生物和细胞的生物反应器。

53. 发明申请

US20140308738A1 MICROFLUIDIC DEVICE WITH INTEGRATED STIRRING STRUCTURE AND MANUFACTURING METHOD THEREOF 有权
标题翻译：具有集成式搅拌结构的微流体装置及其制造方法
公开(公告)号：US20140308738A1
公开(公告)日：2014-10-16
申请号：US14250098
申请日：2014-04-10
申请人： STMicroelectronics S.r.l.
发明人： Sabrina Conoci , Paolo Ferrari
IPC分类号： B01L3/00 , C12M1/06
CPC分类号： B81C1/00198 , B01F11/0082 , B01F13/0059 , B01F13/0091 , B01L3/502707 , B01L3/50273 , B01L2200/12 , B01L2300/06 , B81C1/00166 , B81C1/00182 , C12M27/02 , Y10T29/49009
摘要： A microfluidic device, comprising: a semiconductor body, having a first side and a second side, opposite to one another in a first direction; and at least one well, configured for containing a fluid, extending in the semiconductor body starting from the first side and being delimited at the bottom by a bottom surface. The microfluidic device further comprises a stirring structure integrated in the well at the bottom surface, the stirring structure including a first stirring portion coupled to the semiconductor body and provided with at least one first suspended beam configured for being moved in a second direction so as to generate, in use, agitation of the fluid present in said well.
摘要翻译：一种微流体装置，包括：半导体本体，具有在第一方向上彼此相对的第一侧和第二侧; 以及至少一个孔，构造成用于容纳流体，所述流体在所述半导体本体中从所述第一侧开始并且在底部由底面限定。微流体装置还包括集成在底表面中的井中的搅拌结构，搅拌结构包括耦合到半导体主体并设置有至少一个第一悬置梁的第一搅拌部分，所述第一悬吊梁被配置为沿第二方向移动，以便在使用中产生在所述井中存在的流体的搅动。

54. 发明授权

US08845182B2 Vessel for processing a biopharmaceutical product including protection means 有权
标题翻译：用于加工包括保护装置在内的生物制药产品的容器
公开(公告)号：US08845182B2
公开(公告)日：2014-09-30
申请号：US12681419
申请日：2008-10-01
申请人： Frederic Bernard , Eric Chevalier
发明人： Frederic Bernard , Eric Chevalier
IPC分类号： B01F7/16 , B65D30/20
CPC分类号： B01F15/0085 , B01F7/162 , B01F15/00831 , B01F2215/0032 , B65D83/0055 , C12M23/00 , C12M23/14 , C12M27/02
摘要： A vessel includes: a pocket capable of assuming a folded state and an expanded state, processing element including an active inner portion; protection element including a side wall, a lower portion and an upper portion defining an inner space, the lower portion being attached to the upper portion of the pocket, the active inner portion being provided in the inner space when the pocket is in the folded state, the peripheral portion of the inner space about the processing element defining a protection chamber; at least one insertion and/or draining opening. The active inner portion is provided inside the pocket adjacent to the lower end portion thereof, the processing element and the protection element are independent in terms of their movements, and the height of the protection chamber is variable and automatically adapts itself based on respectively, the flat-folded, unfolded and expanded states or any intermediate state of the pocket.
摘要翻译：容器包括：能够承受折叠状态和膨胀状态的袋，包括主动内部的处理元件; 保护元件包括侧壁，下部和限定内部空间的上部，所述下部附接到所述凹部的上部，所述主动内部在所述口袋处于折叠状态时设置在所述内部空间中围绕处理元件的内部空间的周边部分限定保护室; 至少一个插入和/或排出开口。主动内部部分设置在与其下端部分相邻的口袋内部，处理元件和保护元件在它们的移动方面是独立的，并且保护室的高度是可变的并且基于分别自动适应自身平折，展开和展开状态或口袋的任何中间状态。

55. 发明授权

US08785180B2 Biochemical reactor 有权
标题翻译：生化反应器
公开(公告)号：US08785180B2
公开(公告)日：2014-07-22
申请号：US12871539
申请日：2010-08-30
申请人： Siliang Zhang , Yuefang Zhang , Jian Liu , Xujun Yuan , Meijin Guo , Liqing He , Gongjian Chen , Ming Zhang , Guoqiang Sun , Wenfeng Ma , Ju Chu , Yingping Zhuang , Yonghong Wang , Mingzhi Huang , Haifeng Hang , Jianye Xia
发明人： Siliang Zhang , Yuefang Zhang , Jian Liu , Xujun Yuan , Meijin Guo , Liqing He , Gongjian Chen , Ming Zhang , Guoqiang Sun , Wenfeng Ma , Ju Chu , Yingping Zhuang , Yonghong Wang , Mingzhi Huang , Haifeng Hang , Jianye Xia
IPC分类号： C12M1/34 , C12M3/00 , G01N21/64 , G01N21/25 , C12M1/00 , C12M1/06
CPC分类号： G01N21/6428 , C12M27/02 , C12M41/06 , C12M41/36 , C12M41/46 , G01N21/253 , G02B21/0016
摘要： A biochemical reactor involves an online cell examination microscope thereon. The online cell examination microscope comprises a main body, an objective lens, an observation entrance window, a sampling device, an external light source system. Said observation entrance window lies in front of said main body and the sampling device lies in front of said observation entrance window. An objective lens and said external light source system lie behind the observation entrance window in the main body. A reflector prism is installed between the external light source system and the objective lens. A reflector lies behind the objective lens and in front of the observation entrance window. An annular diaphragm is placed in front of the reflecting prism. A CCD or an area image sensor is arranged on the upper side of the reflectance prism.
摘要翻译：生化反应器包括其上的在线细胞检查显微镜。在线细胞检查显微镜包括主体，物镜，观察入口窗，取样装置，外部光源系统。所述观察入口窗位于所述主体的前方，并且所述取样装置位于所述观察入口窗前。物镜和外部光源系统位于主体的观察入口窗后面。反射棱镜安装在外部光源系统和物镜之间。反射器位于物镜的后面，在观察入口窗前。环形隔膜放置在反射棱镜的前面。 CCD或区域图像传感器布置在反射棱镜的上侧。

56. 发明申请

US20140193853A1 BIOPROCESSING 有权
标题翻译：生物学
公开(公告)号：US20140193853A1
公开(公告)日：2014-07-10
申请号：US14196589
申请日：2014-03-04
申请人： Xyleco, Inc.
发明人： Marshall Medoff , Thomas Craig Masterman
IPC分类号： C12P19/14 , C12P19/02
CPC分类号： C12M29/12 , B01F3/04106 , B01F3/04539 , B01F3/04609 , B01F5/0212 , B01F5/0231 , B01F5/10 , B01F15/0022 , B01F15/00389 , B01F15/00396 , B01F2215/0073 , B01F2215/0463 , B01F2215/0481 , C12M27/00 , C12M27/02 , C12M27/18 , C12M29/00 , C12M29/06 , C12M29/22 , C12M33/00 , C12M41/02 , C12M41/12 , C12M41/26 , C12M41/28 , C12M41/32 , C12M41/34 , C12M41/46 , C12M41/48 , C12P19/02 , C12P19/14
摘要： Bioreactors are provided that include a vessel and a jet mixer disposed in the vessel. Methods that utilize the bioreactors are provided, involving placing a microorganism or cells and a fluid medium in the bioreactor.
摘要翻译：提供了包括设置在容器中的容器和喷射混合器的生物反应器。提供了利用生物反应器的方法，包括将微生物或细胞和流体介质置于生物反应器中。

57. 发明申请

US20140186908A1 ENZYMATIC TRANSESTERIFICATION/ESTERIFICATION PROCESSES EMPLOYING LIPASES IMMOBILIZED ON HYDROPHOBIC RESINS IN THE PRESENCE OF WATER SOLUTIONS 审中-公开
标题翻译：在水溶液存在下，使用在疏水性树脂上固化的液体的酶化转移/纯化方法
公开(公告)号：US20140186908A1
公开(公告)日：2014-07-03
申请号：US14143258
申请日：2013-12-30
申请人： Trans Biodiesel Ltd.
发明人： Sobhi BASHEER , Usama MOHSEN
IPC分类号： C12P7/64
CPC分类号： C12M21/18 , C12M23/58 , C12M25/02 , C12M25/20 , C12M27/02 , C12M29/00 , C12M29/18 , C12M41/12 , C12M41/22 , C12M41/44 , C12M47/10 , C12N11/08 , C12P7/6436 , C12P7/649 , C12Y301/01003 , Y02E50/13
摘要： Disclosed are processing systems and processes for carrying out enzymatic batchwise or continuous process for the production of fatty acid alkyl esters for use in the biofuels, food and detergent industries.
摘要翻译：公开了用于进行用于生物燃料，食品和洗涤剂行业的用于生产脂肪酸烷基酯的酶分批或连续方法的处理系统和方法。

58. 发明申请

US20140162363A1 METHOD OF CELL CULTURES AND DEVICE FOR IMPLEMENTING IT 审中-公开
标题翻译：细胞培养方法及其实现装置
公开(公告)号：US20140162363A1
公开(公告)日：2014-06-12
申请号：US14093578
申请日：2013-12-02
申请人： ARTELIS S.A.
发明人： Jose Antonio CASTILLO FERNANDEZ
IPC分类号： C12M1/06
CPC分类号： C12M27/02 , B01F7/1635 , B01F13/0836 , C12M23/34 , C12M27/22 , C12M27/24 , Y10S435/818
摘要： The invention generally provides a cell culture vessel having at least one first zone and at least one second zone, wherein the first zone is a transfer zone for a culture medium which essentially contains no cells and the second zone is a cell culture zone. The invention further includes methods utilizing the cell culture vessel.
摘要翻译：本发明通常提供具有至少一个第一区和至少一个第二区的细胞培养容器，其中第一区域是用于培养基的转移区，其基本上不含细胞，第二区是细胞培养区。本发明还包括利用细胞培养容器的方法。

59. 发明授权

US08708319B2 Mixing bag with integral sparger and sensor receiver 有权
标题翻译：混合袋与整体式分布器和传感器接收器
公开(公告)号：US08708319B2
公开(公告)日：2014-04-29
申请号：US13599652
申请日：2012-08-30
申请人： Alexandre N. Terentiev , Sergey Terentiev
发明人： Alexandre N. Terentiev , Sergey Terentiev
IPC分类号： B01F3/04
CPC分类号： B01F15/00123 , B01F3/04248 , B01F3/04262 , B01F3/04531 , B01F7/162 , B01F13/00 , B01F13/08 , B01F13/0827 , B01F15/00207 , B01F15/00824 , B01F15/0085 , B01F2215/0037 , C12M23/14 , C12M23/22 , C12M27/02 , C12M29/06
摘要： A mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element driven by an external motive device is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are also disclosed.
摘要翻译：公开了一种用于生物处理的混合袋，其中使用由外部动力装置驱动的内部流体搅拌元件容纳和搅拌流体。该袋可以包括一体式的分布器和传感器接收器。还公开了相关方法。

60. 发明授权

US08690129B2 Disposable mixing vessel 有权
标题翻译：一次性混合容器
公开(公告)号：US08690129B2
公开(公告)日：2014-04-08
申请号：US12921407
申请日：2009-03-18
申请人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Guenther Pradel , Michael Bates , Magail Barbaroux , Stephane Baud , Isabelle Gay , Sebastian Chaussin
发明人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Guenther Pradel , Michael Bates , Magail Barbaroux , Stephane Baud , Isabelle Gay , Sebastian Chaussin
IPC分类号： B01F3/04
CPC分类号： B01F3/04269 , B01F7/00633 , B01F7/00691 , B01F7/1695 , B01F7/22 , B01F13/0827 , B01F13/0872 , B01F15/00071 , B01F15/00123 , B01F15/00396 , B01F15/00707 , B01F15/00831 , B01F15/0085 , B01F15/065 , B01F2003/04326 , B01F2003/04361 , B01F2003/04879 , B01F2003/04893 , B01F2015/062 , B01F2215/0073 , C12M23/26 , C12M27/02 , C12M29/06
摘要： A disposable mixing vessel comprising a flexible container, a centrally disposed shaft having first and second ends with one or more impellers thereon and a magnetic element associated with a first shaft end, a first flange adapted to rotatably engage the first shaft end and a second flange adapted to rotatably engage the second shaft end.
摘要翻译：一种一次性混合容器，包括柔性容器，居中设置的轴，其具有在其上的一个或多个叶轮的第一和第二端和与第一轴端相关联的磁性元件，适于可旋转地接合第一轴端的第一凸缘和第二凸缘适于可旋转地接合第二轴端。

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