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51. 发明授权

US08528426B2 Device for transfer of body fluids 有权
标题翻译：体液转运装置
公开(公告)号：US08528426B2
公开(公告)日：2013-09-10
申请号：US13120162
申请日：2009-09-23
申请人： Craig Andrew Burke
发明人： Craig Andrew Burke
IPC分类号： G01N1/10
CPC分类号： B01L3/0255 , A61M5/162 , B01L3/0272 , B01L3/5635 , B01L2200/085 , B01L2200/087 , B01L2300/0854 , B01L2400/0457
摘要： A cannula (10) for use in removing samples of fluid from a container sealed with a pierceable membrane, the cannula including a hollow needle like portion (12) having a pointed forward end (20) shaped to allow forcible penetration through the membrane, the rear end (14) having a first bore (26) and an insert (40) located within the first bore (40) that reduces the effective size of the first bore (26) without blocking the first bore (26).
摘要翻译：一种用于从用可刺穿的膜密封的容器中去除流体样本的套管（10），所述套管包括中空针状部分（12），所述中空针状部分具有形成为允许强制穿透膜的尖端（20）具有第一孔（26）和位于第一孔（40）内的插入件（40））的后端（14）能够在不堵塞第一孔（26）的情况下减小第一孔（26）的有效尺寸。

52. 发明申请

US20130210081A1 THERMAL CYCLER AND THERMAL CYCLE METHOD 有权
标题翻译：热循环和热循环方法
公开(公告)号：US20130210081A1
公开(公告)日：2013-08-15
申请号：US13880224
申请日：2011-11-29
申请人： Hiroshi Koeda
发明人： Hiroshi Koeda
IPC分类号： B01L7/00
CPC分类号： B01L7/5255 , B01L3/5082 , B01L7/52 , B01L7/525 , B01L2200/0673 , B01L2300/18 , B01L2400/0457
摘要： A thermal cycler (1) includes a holder (11) that holds a biotip (100) filled with a reaction mixture and liquid having a smaller specific gravity than the reaction mixture and being immiscible with the reaction mixture, the biotip (100) including a channel (110) in which the reaction mixture moves, a heating unit (12) that heats a first portion (111) of the channel when the biotip (100) is in the holder (11), and a driving unit (20) that disposes the holder (11) and the heating unit (12) by making a switch between a first disposition and a second disposition, the first disposition being such that the first portion (111) is in a lowest part of the channel (110) with respect to a gravitational force direction when the biotip (100) is in the holder (11), the second disposition being such that a second portion (112) that is a different portion from the first portion (111) relative to a moving direction of the reaction mixture is in the lowest part of the channel (110) with respect to the gravitational force direction when the biotip (100) is in the holder (11).
摘要翻译：热循环器（1）包括保持器（11），其保持填充有反应混合物的生物体（100）和比反应混合物小的比例的液体，并且与反应混合物不混溶，所述生物体（100）包括通道（110），当所述生物体（100）在所述保持器（11）中时，加热所述通道的第一部分（111）的加热单元（12）和驱动单元（20），所述驱动单元通过在第一配置和第二配置之间进行开关来设置保持器（11）和加热单元（12），第一配置使得第一部分（111）在通道（110）的最下部分具有当所述生物体（100）在所述保持器（11）中时，相对于重力方向，所述第二配置使得与所述第一部分（111）相对于所述第一部分（111）的移动方向的不同部分的第二部分反应混合物相对于g在通道（110）的最低部分中当所述生物体（100）在所述保持器（11）中时，所述湍流力方向。

53. 发明申请

US20130203172A1 SELF-CONTAINED MULTI-REAGENT ASSAY DEVICE 审中-公开
标题翻译：自含多元测试装置
公开(公告)号：US20130203172A1
公开(公告)日：2013-08-08
申请号：US13719828
申请日：2012-12-19
申请人： Bio-Rad Laboratories, Inc.
发明人： Hannah Wex , Matthew Pearce , Richard Hall , Jake Hodgson
IPC分类号： B01L3/00
CPC分类号： B01L3/502 , B01L3/523 , B01L2200/16 , B01L2300/045 , B01L2300/049 , B01L2300/0672 , B01L2300/069 , B01L2300/0832 , B01L2300/0867 , B01L2400/0457 , B01L2400/0644 , B01L2400/0683 , Y10T436/11
摘要： A single closed and compartmentalized vessel is designed to contain all assay reagents necessary to conduct an assay of a liquid sample. The vessel is constructed in parts that are rotatable relative to each other, and processing steps of the assay such as combining, mixing, separating, and measuring are all conducted by either rotating the parts relative to each other or rotating the vessel as a whole, all without opening the receptacle or otherwise exposing the user to any of the liquids or substances within the receptacle.
摘要翻译：单个封闭和分隔的容器设计成包含进行液体样品测定所必需的所有测定试剂。容器构造成能够相对于彼此旋转的部分，并且分析的结合，混合，分离和测量的处理步骤都是通过相对于彼此旋转部件或者使整个容器旋转而进行的，所有这些都不打开容器或以其他方式将使用者暴露在容器内的任何液体或物质中。

54. 发明授权

US08480976B2 Instruments and methods for mixing the contents of a detection chamber 有权
标题翻译：用于混合检测室内容物的仪器和方法
公开(公告)号：US08480976B2
公开(公告)日：2013-07-09
申请号：US13181850
申请日：2011-07-13
申请人： Scott S. Breidenthal , Sara H. Fan , Richard S. Lee , Norman C. Nelson , Matthew J. Scott , Jason A. Taylor
发明人： Scott S. Breidenthal , Sara H. Fan , Richard S. Lee , Norman C. Nelson , Matthew J. Scott , Jason A. Taylor
IPC分类号： B01L3/00
CPC分类号： B01F11/00 , B01F3/1271 , B01F11/0045 , B01F11/0071 , B01F13/0059 , B01F15/00214 , B01F2215/0037 , B01L3/502 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/0621 , B01L2200/0647 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/14 , B01L2200/16 , B01L2300/0816 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2300/1805 , B01L2300/1822 , B01L2300/1883 , B01L2400/0457 , B01L2400/0478 , B01L2400/0481 , B01L2400/0655 , B01L2400/0677 , C12N15/1006 , C12Q1/6806 , C12Q1/6844 , G01N1/44 , G01N21/01 , G01N21/6428 , G01N21/645 , G01N35/0098 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6463 , G01N2035/00544 , G01N2201/0627 , Y10T137/0391 , Y10T436/143333 , Y10T436/25 , Y10T436/255
摘要： A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.
摘要翻译：具有多个互连室的容器，其布置成允许独立地或同时地执行多个工艺步骤或工艺。制造容器以将液体与干燥试剂分开并保持干燥试剂的稳定性。包括不混溶的液体，如油，以控制加工材料的加载，促进干燥试剂的混合和重构，限制蒸发，控制反应材料的加热，浓缩固体支持材料以防止流体连接堵塞，为流体转移，并防止工艺材料粘附到室表面。插座可以适用于具有处理器具的系统，该处理器具包括用于选择性地移动腔室和检测器之间的流体物质的致动器系统。致动器系统可以被布置成集中存在于样品中的分析物。检测器可用于检测由容器的内容物发射的光信号。

55. 发明授权

US08425864B2 Apparatus for transporting biological samples 有权
标题翻译：用于运输生物样品的装置
公开(公告)号：US08425864B2
公开(公告)日：2013-04-23
申请号：US13295230
申请日：2011-11-14
申请人： Bruce C. Haywood , Jamieson William Maclean Crawford , Bradley M. Wilkinson
发明人： Bruce C. Haywood , Jamieson William Maclean Crawford , Bradley M. Wilkinson
IPC分类号： B01L3/00
CPC分类号： B01L3/502 , B01L2200/18 , B01L2300/042 , B01L2300/047 , B01L2300/0609 , B01L2300/0681 , B01L2400/0457 , G01N2001/005
摘要： A container assembly for storing, treating, transporting and stabilizing a biological sample includes a container, a cap and a sample holder removably received in the container. The sample holder can be a platform-like device dimensioned to be supported on a ledge formed in the side wall of the container. The sample holder includes a central cavity for receiving the sample and immersing the sample in the stabilizing agent in the container. In another embodiment, the sample holder has a closure member for closing the open top end of the cavity. The container includes a liquid reagent in an amount sufficient to treat the biological sample. The biological sample is retained in a predetermined containment area of the container to maintain the biological sample immersed in the reagent without regard to the orientation of the container.
摘要翻译：用于存储，处理，运输和稳定生物样品的容器组件包括可移除地容纳在容器中的容器，盖和样品架。样品保持器可以是平台状装置，其尺寸设计成被支撑在形成在容器的侧壁中的凸缘上。样品架包括用于接收样品并将样品浸入容器中的稳定剂中的中心腔。在另一个实施例中，样品保持器具有用于封闭空腔的敞开顶端的封闭构件。容器包括足以处理生物样品的量的液体试剂。将生物样品保留在容器的预定容纳区域中，以将生物样品保持在试剂中，而不考虑容器的取向。

56. 发明授权

US08309040B2 Microfluidic control apparatus and method of assembling the same 有权
标题翻译：微流控制装置及其组装方法
公开(公告)号：US08309040B2
公开(公告)日：2012-11-13
申请号：US12542627
申请日：2009-08-17
申请人： Kwang Hyo Chung , Dae-Sik Lee , Hyun Woo Song , Yo Han Choi
发明人： Kwang Hyo Chung , Dae-Sik Lee , Hyun Woo Song , Yo Han Choi
IPC分类号： B01J8/00 , B01L3/00
CPC分类号： B01J19/0093 , B01J2219/00373 , B01J2219/00376 , B01J2219/00891 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2300/044 , B01L2300/0816 , B01L2300/0867 , B01L2400/0457 , B01L2400/0487 , B01L2400/06 , Y10T29/494 , Y10T29/49826
摘要： Provided is a microfluidic control apparatus that includes at least one control means and a microfluidic control chip. When the microfluidic control chip is loaded to the control means, a needle provided to the control means is inserted into a reaction solution storage chamber of the microfluidic control chip, in which the reaction solution storage chamber is sealed with a sealing tape. Thus, fluid connection is easily formed between the microfluidic control chip and the control means without leakage.
摘要翻译：提供了一种微流控制装置，其包括至少一个控制装置和微流控制芯片。当将微流控制芯片装载到控制装置时，将提供给控制装置的针插入到微流控制芯片的反应溶液储存室中，其中反应溶液储存室用密封胶带密封。因此，在微流控制芯片和控制装置之间容易形成流体连接而没有泄漏。

57. 发明申请

US20120231456A1 INSTRUMENTS AND METHODS FOR MIXING THE CONTENTS OF A DETECTION CHAMBER 有权
标题翻译：用于混合检测室内容的仪器和方法
公开(公告)号：US20120231456A1
公开(公告)日：2012-09-13
申请号：US13414195
申请日：2012-03-07
申请人： Scott S. Breidenthal , Sara H. Fan , Richard S. Lee , Norman C. Nelson , Matthew J. Scott , Jason A. Taylor
发明人： Scott S. Breidenthal , Sara H. Fan , Richard S. Lee , Norman C. Nelson , Matthew J. Scott , Jason A. Taylor
IPC分类号： G01N21/64
CPC分类号： B01F11/00 , B01F3/1271 , B01F11/0045 , B01F11/0071 , B01F13/0059 , B01F15/00214 , B01F2215/0037 , B01L3/502 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/0621 , B01L2200/0647 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/14 , B01L2200/16 , B01L2300/0816 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2300/1805 , B01L2300/1822 , B01L2300/1883 , B01L2400/0457 , B01L2400/0478 , B01L2400/0481 , B01L2400/0655 , B01L2400/0677 , C12N15/1006 , C12Q1/6806 , C12Q1/6844 , G01N1/44 , G01N21/01 , G01N21/6428 , G01N21/645 , G01N35/0098 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6463 , G01N2035/00544 , G01N2201/0627 , Y10T137/0391 , Y10T436/143333 , Y10T436/25 , Y10T436/255
摘要： A receptacle having interconnected chambers arranged to permit multiple process steps to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.
摘要翻译：具有互连室的容器，其布置成允许独立地或同时地执行多个工艺步骤。制造容器以将液体与干燥试剂分开并保持干燥试剂的稳定性。包括不混溶的液体，如油，以控制加工材料的加载，促进干燥试剂的混合和重构，限制蒸发，控制反应材料的加热，浓缩固体支持材料以防止流体连接堵塞，为流体转移，并防止工艺材料粘附到室表面。插座可以适用于具有处理器具的系统，该处理器具包括用于选择性地移动腔室和检测器之间的流体物质的致动器系统。致动器系统可以被布置成集中存在于样品中的分析物。检测器可用于检测由容器的内容物发射的光信号。

58. 发明申请

US20120225001A1 THERMAL CYCLER 有权
标题翻译：热循环
公开(公告)号：US20120225001A1
公开(公告)日：2012-09-06
申请号：US13406584
申请日：2012-02-28
申请人： Hiroshi KOEDA
发明人： Hiroshi KOEDA
IPC分类号： B01L9/00
CPC分类号： B01L7/525 , B01L3/5082 , B01L7/54 , B01L9/06 , B01L2200/0673 , B01L2300/1811 , B01L2300/1822 , B01L2300/1827 , B01L2300/1838 , B01L2400/0457
摘要： A thermal cycler includes a holder receiving a reaction chamber including a channel filled with reaction mixture and an immiscible liquid having different specific gravities and allowing the reaction mixture to move along an opposed inner wall, a temperature gradient forming unit forming a temperature gradient in the movement direction of the reaction mixture relative to the channel during loading into the holder, and a driving unit rotating the holder and temperature gradient forming unit about a rotation axis having a component perpendicular to the gravitational direction and a component perpendicular to the movement direction of the reaction mixture, and a maximum distance from the rotation axis to a point in the channel is smaller than a maximum distance connecting two points in the channel when projected on a plane perpendicular to the rotation axis.
摘要翻译：热循环仪包括容纳反应室的保持器，该反应室包括填充有反应混合物的通道和不同比重的不混溶液体，并允许反应混合物沿着相对的内壁移动，温度梯度形成单元形成运动中的温度梯度在装载到保持器内时反应混合物相对于通道的方向;以及驱动单元，其围绕具有垂直于重力方向的分量的旋转轴线和垂直于反应的移动方向的分量旋转保持器和温度梯度形成单元混合物，并且从旋转轴到通道中的点的最大距离小于当投影在垂直于旋转轴的平面上时连接通道中的两个点的最大距离。

59. 发明授权

US08226332B2 Liquid transporting method and classifying method 有权
标题翻译：液体输送方法和分级方法
公开(公告)号：US08226332B2
公开(公告)日：2012-07-24
申请号：US12712722
申请日：2010-02-25
申请人： Hiroshi Kojima , Seiichi Takagi , Kazuya Hongo
发明人： Hiroshi Kojima , Seiichi Takagi , Kazuya Hongo
IPC分类号： B65G51/00
CPC分类号： B03D3/00 , B01L3/502746 , B01L3/502761 , B01L2200/0647 , B01L2400/0409 , B01L2400/0457 , B01L2400/0487 , B01L2400/084 , Y10T137/0318 , Y10T137/8593
摘要： A method for transporting dispersion, includes: introducing dispersion containing particles into a liquid transporting channel from a dispersion introducing port; transporting the dispersion in a laminar flow through the liquid transporting channel; and discharging the dispersion from a downstream of the liquid transporting channel, and the liquid transporting channel has a bent portion in a vertical direction, and a Dean vortex which cancels an exchange flow that is produced by movement of the particles caused by gravitational force is generated in the bent portion.
摘要翻译：一种输送分散体的方法，包括：从分散体引入口将含有粒子的分散液引入液体输送通道; 通过液体输送通道输送层流中的分散体; 并且从液体输送通道的下游排出分散体，并且液体输送通道在垂直方向上具有弯曲部分，并且产生抵消由引力引起的颗粒运动产生的交换流的迪恩涡流在弯曲部分。

60. 发明授权

US08163535B2 Devices and processes for nucleic acid extraction 有权
标题翻译：用于核酸提取的装置和方法
公开(公告)号：US08163535B2
公开(公告)日：2012-04-24
申请号：US12348244
申请日：2009-01-02
申请人： Michael W. Reed , Oliver Z. Nanassy , Paul V. Haydock , Nigel Rudra Sharma , Ronald L. Bardell , Perry Hargrave
发明人： Michael W. Reed , Oliver Z. Nanassy , Paul V. Haydock , Nigel Rudra Sharma , Ronald L. Bardell , Perry Hargrave
IPC分类号： C12M1/00 , C12M1/36 , G01N15/06 , C07H21/04
CPC分类号： C12Q1/6834 , B01L3/5027 , B01L3/502715 , B01L7/525 , B01L2200/027 , B01L2200/10 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/1827 , B01L2400/0406 , B01L2400/0457 , B01L2400/0487 , B01L2400/0622 , B01L2400/0688 , B01L2400/084 , C12Q1/6806 , C12Q1/6851 , C12Q2565/629 , C12Q2563/173 , C12Q2565/137
摘要： Devices, processes, and kits for the extraction of nucleic acids from biological samples are disclosed. The devices comprise a first port, a second port, and a binding chamber intermediate and in fluid communication with the first port and the second port. The binding chamber comprises an unmodified flat glass surface effective for binding a heterogeneous population of nucleic acids. The first port, second port, and binding chamber define a continuous fluid pathway that is essentially free of nucleic acid-specific binding sites.
摘要翻译：公开了用于从生物样品中提取核酸的装置，方法和试剂盒。这些装置包括中间并与第一端口和第二端口流体连通的第一端口，第二端口和装订室。结合室包含有效用于结合异质核酸群体的未改性平板玻璃表面。第一端口，第二端口和结合室限定基本上不含核酸特异性结合位点的连续流体通路。

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