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51. 发明授权

US5939251A Apparatus and method for simplifying the processes in creating a sealed space on slides to conduct molecular biological reactions therein 失效
标题翻译：用于简化在载玻片上形成密封空间以在其中进行分子生物反应的过程的装置和方法
公开(公告)号：US5939251A
公开(公告)日：1999-08-17
申请号：US680324
申请日：1996-07-12
申请人： Min Hu
发明人： Min Hu
IPC分类号： B01L3/00 , G02B21/34 , C12Q1/00
CPC分类号： B01L3/508 , G02B21/34 , B01L2300/0822 , Y10T436/25
摘要： The present invention includes an enclosure dam for defining an sealed space between a slide and a covering means for containing a mixture of target samples and reagents for carrying out a molecular biological reaction therein. The enclosure dam a surrounding wall disposed on the slide wherein the surrounding wall composed of resin type of materials sustainable over a range of reaction conditions for the molecular biological reaction, the surrounding wall defining a securely sealed space on the slide in combination with the covering means provided for covering the surrounding wall whereby the molecular biological reaction can be flexibly and conveniently conducted in the sealed space in situ on the slide.
摘要翻译：本发明包括用于限定载玻片和覆盖装置之间的密封空间的封闭坝，用于容纳用于在其中进行分子生物反应的目标样品和试剂的混合物。外壳围绕设置在载玻片上的周围壁，其中由树脂类型的材料组成的周围壁在分子生物反应的一系列反应条件下可持续，围绕壁与覆盖装置组合在滑动件上限定牢固的密封空间提供用于覆盖周围壁，由此分子生物反应可以在滑动件上原位在密封空间中灵活方便地进行。

52. 发明授权

US09556430B2 Gene methylation and expression 有权
标题翻译：基因甲基化和表达
公开(公告)号：US09556430B2
公开(公告)日：2017-01-31
申请号：US11915645
申请日：2006-05-30
申请人： Kornelia Polyak , Min Hu , Noga Qimron , Jun Yao
发明人： Kornelia Polyak , Min Hu , Noga Qimron , Jun Yao
IPC分类号： C12Q1/68 , C12N15/10
CPC分类号： C12N15/1093 , C12Q1/6855 , C12Q1/6881 , C12Q2600/154 , C12Q2600/158 , C12Q2521/331
摘要： The invention provides a method of analyzing the methylation status of all or part of an entire genome. Moreover, the invention features methods of and reagents for characterizing biological cells containing DNA that is susceptible to methylation. Such methods include methods of diagnosing cancer, e.g., breast cancer.
摘要翻译：本发明提供了分析全部或部分整个基因组的甲基化状态的方法。此外，本发明的特征在于含有易于甲基化的DNA的生物细胞的表征方法和试剂。这些方法包括诊断癌症的方法，例如乳腺癌。

53. 发明授权

US08834780B2 Hydrodynamic spinning of polymer fiber in coaxial laminar flows 有权
标题翻译：聚合物纤维在同轴层流中的流体动力学纺丝
公开(公告)号：US08834780B2
公开(公告)日：2014-09-16
申请号：US12920066
申请日：2009-03-02
申请人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
发明人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
IPC分类号： B29C63/06 , D01D5/24 , A61L27/52 , D01D5/38 , D01D5/28
CPC分类号： D01D5/28 , A61L27/52 , D01D5/24 , D01D5/38
摘要： A polymer fiber is formed by hydrodynamic spinning. Fluids are forced to flow through a conduit to form a laminar flow comprising three or more layers of generally coaxial fluid flows, at respective flow rates selected to define a cross-section of a tubular middle layer of the fluid flows. The middle layer comprises a cross-linkable polymer precursor. Another layer of the fluid flows comprise a cross-linking agent. The polymer precursor, cross-linking agent and fluids are selected to prevent substantial diffusion of the polymer precursor away from the middle layer, and to allow a portion of the cross-linking agent to diffuse from the another layer into the middle layer to facilitate cross-linking of the polymer precursor in the middle layer to form a tubular polymer layer in a polymer fiber. The polymer layer thus has a cross-section generally corresponding to the cross-section of the middle layer.
摘要翻译：聚合物纤维通过流体动力纺丝形成。流体被迫流过导管以形成包含三层或更多层大体上同轴的流体流的层流，其各自的流速被选择为限定流体流的管状中间层的横截面。中间层包含可交联的聚合物前体。流体流的另一层包含交联剂。选择聚合物前体，交联剂和流体以防止聚合物前体远离中间层的实质性扩散，并且允许一部分交联剂从另一层扩散到中间层以促进交叉在中间层中连接聚合物前体以在聚合物纤维中形成管状聚合物层。聚合物层因此具有一般对应于中间层的横截面的横截面。

54. 发明授权

US08558788B2 Diffusing light of a laser 有权
标题翻译：扩散激光的光
公开(公告)号：US08558788B2
公开(公告)日：2013-10-15
申请号：US13066994
申请日：2011-04-29
申请人： Sagi Varghese Mathai , Min Hu , Huel Pel Kuo
发明人： Sagi Varghese Mathai , Min Hu , Huel Pel Kuo
IPC分类号： G02B27/20
CPC分类号： G02B27/20 , G02B5/0278 , G02B6/04 , G06F3/0421
摘要： Embodiments disclosed herein relate to diffusing light of a multi-mode laser. In one embodiment, the multi-mode laser projects a plurality of modes of light and a diffuser reflects the plurality of modes of light to output a single lobe of light.
摘要翻译：本文公开的实施例涉及漫射多模激光器的光。在一个实施例中，多模激光器投射多种模式的光，扩散器反射多种模式的光以输出单个光。

55. 发明申请

US20130122539A1 MICROSIEVE FOR CELLS AND PARTICLES FILTRATION 审中-公开
标题翻译：细胞微粒和颗粒过滤
公开(公告)号：US20130122539A1
公开(公告)日：2013-05-16
申请号：US13696064
申请日：2011-05-03
申请人： Mo-Huang Li , Min Hu , Wal Chye Cheong , Tau Liang Gan
发明人： Mo-Huang Li , Min Hu , Wal Chye Cheong , Tau Liang Gan
IPC分类号： C12M1/26
CPC分类号： C12M33/14 , B01D67/0062 , B01D69/12 , B01L3/502753
摘要： It is disclosed a microsieve comprising two layers, wherein the first layer is a membrane layer having a plurality of micropores contained therein and a thickness of about 10 μm to about 100 μm, and the second layer is a membrane support layer having a plurality of openings contained therein and a thickness of about 100 μm to about 500 μm, wherein the openings are larger in diameter than the micropores, and wherein at least one of the membrane layer or membrane support layer is formed of a SU-8 photoresist material.
摘要翻译：公开了一种包括两层的微筛，其中第一层是其中包含多个微孔的膜层，其厚度约为10μm至约100μm，第二层是具有多个开口的膜支撑层其中所述开口直径大于所述微孔，并且其中所述膜层或膜支撑层中的至少一个由SU-8光致抗蚀剂材料形成。

56. 发明申请

US20110160220A1 CRYSTALLINE FORM OF 6-[(4S)-2-METHYL-4-(2-NAPHTHYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-7-YL]PYRIDAZIN-3-AMINE 有权
标题翻译： 6 - [（4S）-2-甲基-4-（2-萘基）-1,2,3,4-四氢喹啉-7-YL]吡啶-3-胺的晶体形式
公开(公告)号：US20110160220A1
公开(公告)日：2011-06-30
申请号：US12995771
申请日：2009-06-04
申请人： Jun Qiu , Qi Gao , Shuang Liu , Min Hu , Yuh-Lin Allen Yang , Matthew Isherwood , Rasidul Amin
发明人： Jun Qiu , Qi Gao , Shuang Liu , Min Hu , Yuh-Lin Allen Yang , Matthew Isherwood , Rasidul Amin
IPC分类号： A61K31/501 , C07D401/02 , A61P25/24 , A61P25/22 , A61P29/00 , A61P3/04
CPC分类号： C07F5/04 , C07C215/20 , C07C217/58 , C07C223/02 , C07D217/04 , C07D237/20 , C07D401/04 , C07D413/10 , C07F5/022 , C07F5/025
摘要： The present disclosure generally relates to a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form, as well of methods of using a crystalline form in the treatment of depression and other conditions and methods for obtaining such crystalline form.
摘要翻译：本公开内容通常涉及6 - [（4S）-2-甲基-4-（萘基）-1,2,3,4-四氢异喹啉-7-基]哒嗪-3-胺的结晶形式。本公开还通常涉及包含结晶形式的药物组合物，以及在治疗抑郁症和其它病症中使用结晶形式的方法以及获得这种结晶形式的方法。

57. 发明申请

US20110006453A1 HYDRODYNAMIC SPINNING OF POLYMER FIBER IN COAXIAL LAMINAR FLOWS 有权
标题翻译：聚合纤维在同轴层流中的水动力纺丝
公开(公告)号：US20110006453A1
公开(公告)日：2011-01-13
申请号：US12920066
申请日：2009-03-02
申请人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
发明人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
IPC分类号： B29C63/06
CPC分类号： D01D5/28 , A61L27/52 , D01D5/24 , D01D5/38
摘要： A polymer fiber is formed by hydrodynamic spinning. Fluids are forced to flow through a conduit to form a laminar flow comprising three or more layers of generally coaxial fluid flows, at respective flow rates selected to define a cross-section of a tubular middle layer of the fluid flows. The middle layer comprises a cross-linkable polymer precursor. Another layer of the fluid flows comprise a cross-linking agent. The polymer precursor, cross-linking agent and fluids are selected to prevent substantial diffusion of the polymer precursor away from the middle layer, and to allow a portion of the cross-linking agent to diffuse from the another layer into the middle layer to facilitate cross-linking of the polymer precursor in the middle layer to form a tubular polymer layer in a polymer fiber. The polymer layer thus has a cross-section generally corresponding to the cross-section of the middle layer.
摘要翻译：聚合物纤维通过流体动力纺丝形成。流体被迫流过导管以形成包含三层或更多层大体上同轴的流体流的层流，其各自的流速被选择为限定流体流的管状中间层的横截面。中间层包含可交联的聚合物前体。流体流的另一层包含交联剂。选择聚合物前体，交联剂和流体以防止聚合物前体远离中间层的实质性扩散，并且允许一部分交联剂从另一层扩散到中间层以促进交叉在中间层中连接聚合物前体以在聚合物纤维中形成管状聚合物层。聚合物层因此具有一般对应于中间层的横截面的横截面。

58. 发明申请

US20100249105A1 INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF 有权
公开(公告)号：US20100249105A1
公开(公告)日：2010-09-30
申请号：US12727723
申请日：2010-03-19
申请人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
发明人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
IPC分类号： A61K31/55 , A61P25/28 , A61P25/16 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/02 , C07D487/04 , A61K31/439 , C07D471/00
CPC分类号： G01N33/6896 , C07D471/18 , C07D487/10 , G01N33/5058 , G01N2800/2814 , G01N2800/30
摘要： The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

59. 发明申请

US20100087471A1 INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF 有权
标题翻译：吲哚和吲哚衍生物及其使用方法
公开(公告)号：US20100087471A1
公开(公告)日：2010-04-08
申请号：US12568085
申请日：2009-09-28
申请人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
发明人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
IPC分类号： A61K31/439 , C12Q1/02 , C07D471/08
CPC分类号： G01N33/5058 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/6896 , G01N2800/28 , G01N2800/30
摘要： The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译：本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

60. 发明申请

US20090094150A1 Method and client system for implementing online secure payment 审中-公开
标题翻译：用于实施在线安全支付的方法和客户端系统
公开(公告)号：US20090094150A1
公开(公告)日：2009-04-09
申请号：US12287191
申请日：2008-10-07
申请人： Rongfeng Feng , Chunmei Liu , Yi Zhang , Min Hu
发明人： Rongfeng Feng , Chunmei Liu , Yi Zhang , Min Hu
IPC分类号： G06Q40/00
CPC分类号： G06F21/51 , G06F21/52 , G06F2221/2105 , G06Q20/12 , G06Q20/382 , G06Q40/00
摘要： The invention discloses a method for implementing an online secure payment, which comprises steps of: transmitting to a dedicated operating system a secure payment request page for goods which is generated in a general operating system; and completing a payment operation in the secure payment request page of the dedicated operating system, after switching from the general operating system to the dedicated operating system. The invention further comprises a client system for implementing an online secure payment. In the invention, the general operating system for general operations is distinguished from the dedicated operating system for secure payment operations, and the security for the network payment is further enhanced by configuring the firewall and monitoring processes in the dedicated operating system. Furthermore, it is not necessary to make any modification on the existed network transaction system when the technical solution of the present invention is applied, the cost may be reduced and the technical solution of the present invention is facilitated to be deployed and spread.
摘要翻译：本发明公开了一种实现在线安全支付的方法，包括以下步骤：向专用操作系统发送在一般操作系统中产生的商品的安全支付请求页; 并且在从一般操作系统切换到专用操作系统之后，在专用操作系统的安全支付请求页面中完成支付操作。本发明还包括用于实现在线安全支付的客户端系统。在本发明中，一般操作的一般操作系统与用于安全支付操作的专用操作系统不同，并且通过在专用操作系统中配置防火墙和监视进程来进一步增强网络支付的安全性。此外，当应用本发明的技术方案时，不需要对存在的网络交易系统进行任何修改，可以降低成本，并且有助于部署和扩展本发明的技术方案。

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