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51. 发明授权

US07105301B2 Detecting molecular binding by monitoring feedback controlled cantilever deflections 失效
标题翻译：通过监测反馈控制的悬臂偏转来检测分子结合
公开(公告)号：US07105301B2
公开(公告)日：2006-09-12
申请号：US10667776
申请日：2003-09-22
申请人： Xing Su , Selena Chan , Tae-Woong Koo , Mineo Yamakawa , Andrew A. Berlin
发明人： Xing Su , Selena Chan , Tae-Woong Koo , Mineo Yamakawa , Andrew A. Berlin
IPC分类号： C12Q1/68 , C12Q1/70 , G01N33/566 , G01N33/563
CPC分类号： C12Q1/6825 , B82Y5/00 , G01N33/54373 , G01N2800/52 , Y10S977/924 , C12Q2565/501
摘要： The present methods and apparatus concern the detection and/or identification of target analytes using probe molecules. In various embodiments of the invention, the probes or analytes are attached to one or more cantilevers. Binding of a probe to an analyte results in deflection of the cantilever, detected by a detection unit. A counterbalancing force may be applied to restore the cantilever to its original position. The counterbalancing force may be magnetic, electrical or radiative. The detection unit and the mechanism generating the counterbalancing force may be operably coupled to an information processing and control unit, such as a computer. The computer may regulate a feedback loop that maintains the cantilever in a fixed position by balancing the deflecting force and the counterbalancing force. The concentration of analytes in a sample may be determined from the magnitude of the counterbalancing force required to maintain the cantilever in a fixed position.
摘要翻译：本方法和装置涉及使用探针分子检测和/或鉴定目标分析物。在本发明的各种实施方案中，探针或分析物附着到一个或多个悬臂。将探针与分析物结合导致由检测单元检测到的悬臂的偏转。可以应用平衡力将悬臂恢复到其原始位置。平衡力可以是磁性的，电的或辐射的。生成平衡力的检测单元和机构可以可操作地耦合到诸如计算机的信息处理和控制单元。计算机可以通过平衡偏转力和平衡力来调节将悬臂维持在固定位置的反馈回路。样品中分析物的浓度可以从将悬臂维持在固定位置所需的平衡力的大小来确定。

52. 发明授权

US5764383A Platenless book scanner with line buffering to compensate for image skew 失效
标题翻译：无压纸书扫描器，具有线缓冲功能，可补偿图像偏斜
公开(公告)号：US5764383A
公开(公告)日：1998-06-09
申请号：US657704
申请日：1996-05-30
申请人： Eric Saund , Andrew A. Berlin
发明人： Eric Saund , Andrew A. Berlin
IPC分类号： H04N1/113 , H04N1/193 , H04N1/387 , H04N1/04 , G03B27/32
CPC分类号： H04N1/113 , H04N1/3878 , H04N1/193 , H04N2201/0416 , H04N2201/0434 , H04N2201/0436
摘要： A platenless book scanner with line buffering performs electronic perspective correction to account for rotation of the spine of a non-planar bound document relative to a reference line in a support plane of the platenless book scanner. A pre-scan of the non-planar bound document is performed to provide a geometrical contour map of the bound document. The geometrical contour map, which identifies displacement of the bound document from the support plane, is analyzed to calculate an angular offset between a spine of the bound document and the reference line in the support plane. The angular offset is used to identify a minimum number of scan line buffers for recording image data, from a set of scan line buffers. Once the minimum number of scan line buffers is filled with recorded image data, distortions caused by displacements of the non-planar bound document from the support plane and skew of the bound document relative to the reference line in the support plane are corrected. A scan line of image data is corrected by polling locations in the set of scan line buffers in accordance with the geometrical contour map, and by interpolating the polled locations to provide output pixels. To correct additional scan lines of image data some of the image data stored in the minimum number of image buffers is replaced after recording more image data.
摘要翻译：具有线缓冲器的无压纸书扫描器执行电子透视校正，以考虑非平面装订文档的脊柱相对于无稿机扫描器的支撑平面中的参考线的旋转。执行非平面装订文档的预扫描以提供绑定文档的几何轮廓图。分析识别绑定文档从支撑平面的位移的几何等值线图，以计算绑定文档的脊柱与支撑平面中的参考线之间的角度偏移。角偏移用于从一组扫描线缓冲区中识别用于记录图像数据的扫描线缓冲器的最小数量。一旦扫描线缓冲器的最小数量被填充有记录的图像数据，则校正由非平面装订文档从支撑平面的位移引起的失真和绑定文档相对于支撑平面中的参考线的偏斜。通过根据几何等高线图在扫描线缓冲器组中的轮询位置以及内插轮询位置以提供输出像素来校正图像数据的扫描线。为了校正图像数据的附加扫描线，在记录更多图像数据之后，替换存储在最小数量的图像缓冲器中的一些图像数据。

53. 发明申请

US20100151454A1 MICROFLUIDIC APPARATUS, SYSTEMS, AND METHODS FOR PERFORMING MOLECULAR REACTIONS 审中-公开
标题翻译：用于实施分子反应的微流感设备，系统和方法
公开(公告)号：US20100151454A1
公开(公告)日：2010-06-17
申请号：US12256409
申请日：2008-10-22
申请人： Narayanan Sundararajan , Lei Sun , Yuegang Zhang , Xing Su , Selena Chan , Tae-Woong Koo , Andrew A. Berlin
发明人： Narayanan Sundararajan , Lei Sun , Yuegang Zhang , Xing Su , Selena Chan , Tae-Woong Koo , Andrew A. Berlin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6869 , G01N21/658 , Y10T436/11 , Y10T436/117497 , Y10T436/143333 , C12Q2565/629 , C12Q2521/319 , C12Q2565/632 , C12Q2565/619
摘要： Disclosed herein are methods, apparatuses, and systems for performing nucleic acid sequencing reactions and molecular binding reactions in a microfluidic channel. The methods, apparatuses, and systems can include a restriction barrier to restrict movement of a particle to which a nucleic acid is attached. Furthermore, the methods, apparatuses, and systems can include hydrodynamic focusing of a delivery flow. In addition, the methods, apparatuses, and systems can reduce non-specific interaction with a surface of the microfluidic channel by providing a protective flow between the surface and a delivery flow.
摘要翻译：本文公开了用于在微流体通道中进行核酸测序反应和分子结合反应的方法，装置和系统。方法，装置和系统可以包括限制核酸附着的颗粒运动的限制障碍。此外，方法，装置和系统可以包括输送流的流体动力聚焦。此外，方法，装置和系统可以通过在表面和输送流之间提供保护流来减少与微流体通道的表面的非特异性相互作用。

54. 发明申请

US20090262994A1 MODEL-BASED FUSION OF SCANNING PROBE MICROSCOPIC IMAGES FOR DETECTION AND IDENTIFICATION OF MOLECULAR STRUCTURES 有权
标题翻译：用于探测和识别分子结构的扫描探针微观图像的基于模型的融合
公开(公告)号：US20090262994A1
公开(公告)日：2009-10-22
申请号：US12359637
申请日：2009-01-26
申请人： Horst Haussecker , Andrew A. Berlin , Selena Chan , Eric Hannah , Narayanan Sundararajan , Mineo Yamakawa
发明人： Horst Haussecker , Andrew A. Berlin , Selena Chan , Eric Hannah , Narayanan Sundararajan , Mineo Yamakawa
IPC分类号： G06K9/00
CPC分类号： G01Q30/04 , B82Y35/00
摘要： In certain embodiments of the invention, a plurality of images of one or more subjects may be captured using different imaging techniques, such as different modalities of scanning probe microscopy. Parameters may be estimated from the plurality of images, using one or more models of known molecular structures to provide a model-based analysis. The estimated parameters may be fused, with further input from physical models of known molecular structures. The fused parameters may be used to characterize the subjects. Such characterization may include the detection and/or identification of specific molecular structures, such as proteins, peptides and/or nucleic acids of known sequence and/or structure. In some embodiments of the invention the structural characterizations may be used to identify previously unknown properties of a subject molecule.
摘要翻译：在本发明的某些实施例中，可以使用不同的成像技术（例如扫描探针显微镜的不同方式）捕获一个或多个受试者的多个图像。可以使用已知分子结构的一个或多个模型从多个图像估计参数以提供基于模型的分析。估计的参数可以与已知分子结构的物理模型的进一步输入融合。融合参数可用于表征受试者。这种表征可以包括具体分子结构的检测和/或鉴定，例如已知序列和/或结构的蛋白质，肽和/或核酸。在本发明的一些实施方案中，结构表征可用于鉴定受试者分子的先前未知的性质。

55. 发明授权

US07606403B2 Model-based fusion of scanning probe microscopic images for detection and identification of molecular structures 失效
标题翻译：基于模型的扫描探针显微镜图像融合，用于检测和鉴定分子结构
公开(公告)号：US07606403B2
公开(公告)日：2009-10-20
申请号：US10685867
申请日：2003-10-14
申请人： Horst Haussecker , Andrew A. Berlin , Selena Chan , Eric Hannah , Narayanan Sundararajan , Mineo Yamakawa
发明人： Horst Haussecker , Andrew A. Berlin , Selena Chan , Eric Hannah , Narayanan Sundararajan , Mineo Yamakawa
IPC分类号： G06K9/00
CPC分类号： G01Q30/04 , B82Y35/00
摘要： In certain embodiments of the invention, a plurality of images of one or more subjects may be captured using different imaging techniques, such as different modalities of scanning probe microscopy. Parameters may be estimated from the plurality of images, using one or more models of known molecular structures to provide a model-based analysis. The estimated parameters may be fused, with further input from physical models of known molecular structures. The fused parameters may be used to characterize the subjects. Such characterization may include the detection and/or identification of specific molecular structures, such as proteins, peptides and/or nucleic acids of known sequence and/or structure. In some embodiments of the invention the structural characterizations may be used to identify previously unknown properties of a subject molecule.
摘要翻译：在本发明的某些实施例中，可以使用不同的成像技术（例如扫描探针显微镜的不同方式）捕获一个或多个受试者的多个图像。可以使用已知分子结构的一个或多个模型从多个图像估计参数以提供基于模型的分析。估计的参数可以与已知分子结构的物理模型的进一步输入融合。融合参数可用于表征受试者。这种表征可以包括具体分子结构的检测和/或鉴定，例如已知序列和/或结构的蛋白质，肽和/或核酸。在本发明的一些实施方案中，结构表征可用于鉴定受试者分子的先前未知的性质。

56. 发明申请

US20090170725A1 Methods of producing carbon nanotubes using peptide or nucleic acid micropatterning 审中-公开
标题翻译：使用肽或核酸微图案生产碳纳米管的方法
公开(公告)号：US20090170725A1
公开(公告)日：2009-07-02
申请号：US11344713
申请日：2006-01-31
申请人： Mineo Yamakawa , Yuegang Zhang , Xing Su , Lei Sun , Andrew A. Berlin , Narayanan Sundararajan
发明人： Mineo Yamakawa , Yuegang Zhang , Xing Su , Lei Sun , Andrew A. Berlin , Narayanan Sundararajan
IPC分类号： C40B40/08 , B82B1/00
CPC分类号： B82Y40/00 , B82Y10/00 , B82Y30/00 , C01B32/162 , C01B2202/08 , C01B2202/36 , D01F9/127 , H01L51/0048 , H01L51/0052
摘要： The methods, apparatus and systems disclosed herein concern ordered arrays of carbon nanotubes. In particular embodiments of the invention, the nanotube arrays are formed by a method comprising attaching catalyst nanoparticles 140, 230 to polymer 120, 210 molecules, attaching the polymer 120, 210 molecules to a substrate, removing the polymer 120, 210 molecules and producing carbon nanotubes on the catalyst nanoparticles 140, 230. The polymer 120, 210 molecules can be attached to the substrate in ordered patterns, using self-assembly or molecular alignment techniques. The nanotube arrays can be attached to selected areas 110, 310 of the substrate. Within the selected areas 110, 310, the nanotubes are distributed non-randomly. Other embodiments disclosed herein concern apparatus that include ordered arrays of nanotubes attached to a substrate and systems that include ordered arrays of carbon nanotubes attached to a substrate, produced by the claimed methods. In certain embodiments, provided herein are methods for aligning a molecular wire, by ligating the molecular wire to a double stranded DNA molecule.
摘要翻译：本文公开的方法，装置和系统涉及碳纳米管的有序阵列。在本发明的具体实施方案中，纳米管阵列通过包括将催化剂纳米颗粒140,230连接到聚合物120,210分子，将聚合物120,210分子连接到基底上的方法形成，除去聚合物120,210分子并产生碳催化剂纳米颗粒140,230上的纳米管。聚合物120,210分子可以使用自组装或分子对准技术以有序图案附着到基底上。纳米管阵列可以附着到基板的选定区域110,310。在所选择的区域110,310内，纳米管是非随机分布的。本文公开的其它实施方案涉及包括连接到衬底的纳米管的有序阵列和包括通过所要求保护的方法产生的连接到衬底的碳纳米管的有序阵列的系统的装置。在某些实施方案中，本文提供了通过将分子线连接到双链DNA分子来对齐分子线的方法。

57. 发明申请

US20090018826A1 Methods, Systems and Devices for Speech Transduction 审中-公开
标题翻译：用于语音转换的方法，系统和设备
公开(公告)号：US20090018826A1
公开(公告)日：2009-01-15
申请号：US12173021
申请日：2008-07-14
申请人： Andrew A. Berlin
发明人： Andrew A. Berlin
IPC分类号： G10L19/12
CPC分类号： G10L21/02 , G10L15/07 , G10L21/0232
摘要： Methods, systems, and devices for speech transduction are disclosed. One aspect of the invention involves a computer-implemented method in which a computer receives far-field acoustic data acquired by one or more microphones. The far-field acoustic data are analyzed. The far-field acoustic data are modified to reduce characteristics of the far-field acoustic data that are incompatible with human speech characteristics of near-field acoustic data.
摘要翻译：公开了用于语音转换的方法，系统和装置。本发明的一个方面涉及计算机实现的方法，其中计算机接收由一个或多个麦克风获取的远场声学数据。分析远场声学数据。修改远场声学数据以减少与近场声学数据的人类语音特性不兼容的远场声学数据的特性。

58. 发明授权

US07442339B2 Microfluidic apparatus, Raman spectroscopy systems, and methods for performing molecular reactions 有权
标题翻译：微流体装置，拉曼光谱系统和进行分子反应的方法
公开(公告)号：US07442339B2
公开(公告)日：2008-10-28
申请号：US10815264
申请日：2004-03-31
申请人： Narayanan Sundararajan , Lei Sun , Yuegang Zhang , Xing Su , Selena Chan , Tae-Woong Koo , Andrew A. Berlin
发明人： Narayanan Sundararajan , Lei Sun , Yuegang Zhang , Xing Su , Selena Chan , Tae-Woong Koo , Andrew A. Berlin
IPC分类号： G01N21/65 , G01J3/44 , G01N33/48
CPC分类号： C12Q1/6827 , C12Q1/6869 , G01N21/658 , Y10T436/11 , Y10T436/117497 , Y10T436/143333 , C12Q2565/629 , C12Q2521/319 , C12Q2565/632 , C12Q2565/619
摘要： Disclosed herein are methods, apparatuses, and systems for performing nucleic acid sequencing reactions and molecular binding reactions in a microfluidic channel. The methods, apparatuses, and systems can include a restriction barrier to restrict movement of a particle to which a nucleic acid is attached. Furthermore, the methods, apparatuses, and systems can include hydrodynamic focusing of a delivery flow. In addition, the methods, apparatuses, and systems can reduce non-specific interaction with a surface of the microfluidic channel by providing a protective flow between the surface and a delivery flow.
摘要翻译：本文公开了用于在微流体通道中进行核酸测序反应和分子结合反应的方法，装置和系统。方法，装置和系统可以包括限制核酸附着的颗粒运动的限制障碍。此外，方法，装置和系统可以包括输送流的流体动力聚焦。此外，方法，装置和系统可以通过在表面和输送流之间提供保护流来减少与微流体通道的表面的非特异性相互作用。

59. 发明授权

US07400395B2 Metal coated nanocrystalline silicon as an active surface enhanced raman spectroscopy (SERS) substrate 有权
标题翻译：金属涂层纳米晶硅作为活性表面增强拉曼光谱（SERS）底物
公开(公告)号：US07400395B2
公开(公告)日：2008-07-15
申请号：US11264433
申请日：2005-10-31
申请人： Selena Chan , Andrew A. Berlin , Sunghoon Kwon , Narayanan Sundararajan , Mineo Yamakawa
发明人： Selena Chan , Andrew A. Berlin , Sunghoon Kwon , Narayanan Sundararajan , Mineo Yamakawa
IPC分类号： G01J3/44
CPC分类号： C12Q1/6825 , B82Y15/00 , B82Y30/00 , G01J3/44 , G01N21/658 , G01N2021/6439 , G01N2021/653 , G01N2021/655 , G01N2021/656 , C12Q2565/632 , C12Q2563/155
摘要： The disclosed methods and apparatus concern Raman spectroscopy using metal coated nanocrystalline porous silicon substrates. Porous silicon substrates may be formed by anodic etching in dilute hydrofluoric acid. A thin coating of a Raman active metal, such as gold or silver, may be coated onto the porous silicon by cathodic electromigration or any known technique. In certain alternatives, the metal coated porous silicon substrate comprises a plasma-oxidized, dip and decomposed porous silicon substrate. The metal-coated substrate provides an extensive, metal rich environment for SERS, SERRS, hyper-Raman and/or CARS Raman spectroscopy. In certain alternatives, metal nanoparticles may be added to the metal-coated substrate to further enhance the Raman signals. Raman spectroscopy may be used to detect, identify and/or quantify a wide variety of analytes, using the disclosed methods and apparatus. In some disclosed methods, Raman spectroscopy may be used to detect nucleotides, purines or pyrimidines at the single molecule level.
摘要翻译：所公开的方法和装置涉及使用金属涂覆的纳米晶体多孔硅衬底的拉曼光谱。多孔硅衬底可以通过在稀氢氟酸中的阳极蚀刻形成。拉曼活性金属（例如金或银）的薄涂层可以通过阴极电迁移或任何已知技术涂覆在多孔硅上。在某些替代方案中，金属涂覆的多孔硅衬底包括等离子体氧化的，浸渍和分解的多孔硅衬底。金属涂层的基底为SERS，SERRS，超拉曼和/或CARS拉曼光谱提供了广泛的金属丰富的环境。在某些替代方案中，可以将金属纳米颗粒加入到金属涂覆的基底中以进一步增强拉曼信号。使用所公开的方法和装置，可以使用拉曼光谱来检测，鉴定和/或定量各种分析物。在一些公开的方法中，可以使用拉曼光谱法在单一分子水平检测核苷酸，嘌呤或嘧啶。

60. 发明授权

US07312155B2 Forming self-aligned nano-electrodes 有权
标题翻译：形成自对准纳米电极
公开(公告)号：US07312155B2
公开(公告)日：2007-12-25
申请号：US10819790
申请日：2004-04-07
申请人： Valery M. Dubin , Swaminathan Sivakumar , Andrew A. Berlin , Mark Bohr
发明人： Valery M. Dubin , Swaminathan Sivakumar , Andrew A. Berlin , Mark Bohr
IPC分类号： H01L21/44 , H01L21/00 , H01L21/336
CPC分类号： H01L21/76838 , B82Y10/00 , H01L21/76852 , H01L51/0021 , H01L51/0048 , H01L51/0052 , H01L2221/1094 , Y10S977/742 , Y10S977/936
摘要： A nano-electrode or nano-wire may be etched centrally to form a gap between nano-electrode portions. The portions may ultimately constitute a single electron transistor. The source and drain formed from the electrode portions are self-aligned with one another. Using spacer technology, the gap between the electrodes may be made very small.
摘要翻译：可以将纳米电极或纳米线中心蚀刻以形成纳米电极部分之间的间隙。这些部分可以最终构成单个电子晶体管。由电极部分形成的源极和漏极彼此自对准。使用间隔技术，可以使电极之间的间隙非常小。

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