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51. 发明授权

US09895227B2 Prosthesis adapted for placement under external imaging 有权
公开(公告)号：US09895227B2
公开(公告)日：2018-02-20
申请号：US13444238
申请日：2012-04-11
申请人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Ray Leonard, II
发明人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Ray Leonard, II
IPC分类号： A61F2/82 , A61F2/24 , A61B90/00
CPC分类号： A61F2/2475 , A61B90/39 , A61F2/2418 , A61F2230/0026 , A61F2230/0095 , A61F2250/0098
摘要： An expandable prosthesis having an imageable structure comprising one or more elements visually distinguishable by an external (e.g., radiographic or ultrasonic) imaging system, the structure being located about a first axis that corresponds to a structural feature of the prosthesis that is configured to perform a specific function particular to that axis. The imageable structure is configured to assist in the rotational orientation of the prosthesis during placement within the implantation site. In one embodiment, the prosthesis comprises a venous valve that includes imageable elements or structure, such as a pair of radiopaque markers, that defines the orifice of the valve structure such that the orifice can be oriented with a particular anatomical feature under imaging, such as to align the orifice with the long axis of the vessel.

52. 发明申请

US20130018453A1 ARTIFICIAL VALVE PROSTHESIS WITH IMPROVED FLOW DYNAMICS 审中-公开
标题翻译：人工阀具有改进的流动动力学
公开(公告)号：US20130018453A1
公开(公告)日：2013-01-17
申请号：US13550229
申请日：2012-07-16
申请人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
发明人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2250/0037 , A61F2250/0039
摘要： An expandable venous valve having a support structure that is configured to enlarge the area adjacent to the valve structure such that the flow patterns of retrograde flow are modified in a way that facilitates the flushing of the pockets at the base of the valve area to prevent stagnation of bodily fluid, which in the venous system, can lead to thrombus formation. The enlarged pocket areas can be created by forming an artificial sinus adjacent the valve structure in an unsupported section of vessel wall between two support frame sections or the support frame can comprise an expanded-diameter intermediate or proximal section that forms an artificial sinus adjacent the valve structure.
摘要翻译：一种可膨胀静脉瓣，其具有支撑结构，所述支撑结构被构造成扩大与所述瓣膜结构相邻的区域，使得逆行流的流动模式以便于在所述瓣膜区域的底部冲洗所述凹穴以防止停滞的方式被修改的体液，其在静脉系统中可导致血栓形成。可以通过在两个支撑框架部分之间的容器壁的无支撑部分中形成邻近阀结构的人造窦来形成扩大的口袋区域，或者支撑框架可以包括形成邻近瓣膜的人造窦的扩张直径的中间或近端部分结构体。

53. 发明授权

US08292938B2 Placement of multiple intraluminal medical devices within a body vessel 有权
标题翻译：多个管腔内医疗器械放置在体内容器内
公开(公告)号：US08292938B2
公开(公告)日：2012-10-23
申请号：US11210999
申请日：2005-08-24
申请人： Brian C. Case
发明人： Brian C. Case
IPC分类号： A61M29/00
CPC分类号： A61F2/962 , A61F2/01 , A61F2/013 , A61F2/2412 , A61F2/2436 , A61F2/2475 , A61F2/95 , A61F2/966 , A61F2002/011 , A61F2002/826 , A61F2002/9522 , A61F2230/0006
摘要： Medical device delivery systems and related kits and methods for placing multiple expandable medical devices within a body vessel are provided. A delivery system includes first and second expandable medical devices having the same or different dimensions. Placement of the first and second expandable medical devices in a body vessel can be achieved without requiring withdrawal of one or more components of the delivery system and insertion of secondary components.
摘要翻译：提供用于将多个可扩展医疗装置放置在体内容器内的医疗装置输送系统和相关工具包和方法。递送系统包括具有相同或不同尺寸的第一和第二可扩张医疗装置。可以实现第一和第二可扩张医疗装置在身体容器中的放置，而不需要撤回输送系统的一个或多个部件和次要部件的插入。

54. 发明申请

US20120203327A1 INTRALUMENALLY-IMPLANTABLE FRAMES 有权
标题翻译：内部可植入框架
公开(公告)号：US20120203327A1
公开(公告)日：2012-08-09
申请号：US13447619
申请日：2012-04-16
申请人： Brian C. Case , Jacob A. Flagle , Andrew K. Hoffa , Darin G. Schaeffer , Michael L. Garrison
发明人： Brian C. Case , Jacob A. Flagle , Andrew K. Hoffa , Darin G. Schaeffer , Michael L. Garrison
IPC分类号： A61F2/86
CPC分类号： A61F2/86 , A61F2/06 , A61F2/2418 , A61F2/2475 , A61F2/91 , A61F2/915 , A61F2002/068 , A61F2002/91508 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2220/0016 , A61F2220/0058 , A61F2230/0054 , A61F2250/0037 , A61F2250/0039
摘要： Implantable frames for use in body passages are provided herein. The implantable frames can include a plurality of hoop members joined by a plurality of longitudinal connecting members to form a tubular frame defining a cylindrical lumen. The plurality of longitudinal connecting members may include first and second longitudinal connecting members joining a first hoop member to a second hoop member such that the first and second longitudinal connecting members extend across an entire space separating the first and second hoop members.
摘要翻译：本文提供了用于身体通道的植入框架。可植入框架可以包括由多个纵向连接构件连接以形成限定圆柱形管腔的管状框架的多个环形构件。多个纵向连接构件可以包括将第一箍构件连接到第二箍构件的第一和第二纵向连接构件，使得第一和第二纵向连接构件跨越分隔第一和第二箍构件的整个空间延伸。

55. 发明申请

US20090177275A1 SENSING DELIVERY SYSTEM FOR INTRALUMINAL MEDICAL DEVICES 审中-公开
标题翻译：感染输送系统用于内科医疗器械
公开(公告)号：US20090177275A1
公开(公告)日：2009-07-09
申请号：US12406678
申请日：2009-03-18
申请人： Brian C. Case
发明人： Brian C. Case
IPC分类号： A61F2/24 , A61B5/05
CPC分类号： A61B5/1076 , A61B5/0215 , A61B2090/3784 , A61F2/2412 , A61F2/2436 , A61F2/2475 , A61F2/95 , A61F2002/011
摘要： Delivery systems and methods of treatment are described. The delivery systems facilitate visualization, monitoring, or sensing of body vessel parameters, blood parameters, or an intraluminal medical device included in the delivery system prior to, during, or after deployment in a body vessel. A sensing apparatus associated with the delivery systems provide information relating to the body vessel and/or fluid within the body vessel that can be used for verification of placement, confirmation of intraluminal medical device function, and/or determination of the need for additional delivery steps, among other purposes. The information can also be used for verification of initial vessel sizing information.
摘要翻译：描述了递送系统和治疗方法。递送系统便于在部署在体内血管之前，期间或之后的体内血管参数，血液参数或包括在输送系统中的管腔内医疗装置的可视化，监测或感测。与输送系统相关联的感测装置提供与身体容器和/或身体容器内的流体相关的信息，其可用于验证放置，确认管腔内医疗装置的功能和/或确定需要额外的输送步骤，其他目的。该信息也可用于验证初始容器尺寸信息。

56. 发明申请

US20090048669A1 METHODS AND SYSTEMS FOR MODIFYING VASCULAR VALVES 有权
标题翻译：用于修补血管的方法和系统
公开(公告)号：US20090048669A1
公开(公告)日：2009-02-19
申请号：US12257720
申请日：2008-10-24
申请人： Jacob A. Flagle , Brian C. Case
发明人： Jacob A. Flagle , Brian C. Case
IPC分类号： A61F2/28 , A61B19/00
CPC分类号： A61B17/00234 , A61B17/00491 , A61B17/064 , A61B17/122 , A61B18/1492 , A61B2017/00783 , A61F2/06 , A61F2/2475 , Y10S623/904
摘要： Described are methods and systems for modifying vascular valves in order to reduce retrograde blood flow through the valves. Preferred methods include connecting vascular valve leaflets with at least one remodelable material, such that the valve leaflets become fused by the ingrowth of the patient's native tissue. Preferred remodelable materials include collagenous extracellular matrix material, such as small intestine submucosa.
摘要翻译：描述了用于修改血管瓣膜以减少通过瓣膜的逆行血流量的方法和系统。优选的方法包括将血管瓣叶与至少一种可重塑材料连接，使得瓣膜小叶由于患者的天然组织的向内生长而变得熔化。优选的可重塑材料包括胶原细胞外基质材料，例如小肠粘膜下层。

57. 发明授权

US07449027B2 Modifying fluid flow in a body vessel lumen to promote intraluminal flow-sensitive processes 有权
标题翻译：修改体内血管腔内的流体流动，以促进腔内流感敏感过程
公开(公告)号：US07449027B2
公开(公告)日：2008-11-11
申请号：US11093401
申请日：2005-03-29
申请人： James B. Hunt , Brian C. Case
发明人： James B. Hunt , Brian C. Case
IPC分类号： A61F2/06
CPC分类号： A61F2/2403 , A61B17/12022 , A61B17/12036 , A61B17/1204 , A61B17/12109 , A61B17/12131 , A61B50/30 , A61B2017/00783 , A61F2/2412 , A61F2/2475 , A61F2002/068 , A61F2250/006 , Y10S623/903
摘要： The present invention, in one embodiment, provides an implantable intraluminal fluid flow control system comprising an interface and a flow-modifying device positioned at a flow-modifying effective distance from the interface within the lumen of a body vessel. In one embodiment, the invention relates to maintaining, regulating or varying the fluid flow within a body vessel to preserve, promote, alter or enhance remodeling of tissue at the interface. Remodeling can include the resorption and replacement of implanted remodelable material with autologous tissue. The interface can comprise remodelable material such as small intestine submucosa. In one embodiment, one or more interfaces are positioned at flow-modifying effective distances from one or more flow-modifying devices. Related medical devices, kits and methods of treatment are also provided in some embodiments.
摘要翻译：本发明在一个实施例中提供了一种植入式管腔内流体流动控制系统，其包括界面和流动修改装置，所述界面和流动修改装置以与主体容器的内腔内的界面有效距离的流动修改方式定位。在一个实施方案中，本发明涉及维持，调节或改变体内容器内的流体流动以保持，促进，改变或增强组织在界面处的重塑。重塑可以包括用自体组织吸收和替换植入的可重塑材料。界面可以包括可重塑的材料，例如小肠粘膜下层。在一个实施例中，一个或多个接口被定位成与一个或多个流量修改设备的流动修改有效距离。在一些实施例中也提供了相关的医疗装置，套件和治疗方法。

58. 发明授权

US07442206B2 Methods and systems for modifying vascular valves 有权
标题翻译：改变血管瓣膜的方法和系统
公开(公告)号：US07442206B2
公开(公告)日：2008-10-28
申请号：US11260360
申请日：2005-10-27
申请人： Jacob A. Flagle , Brian C. Case
发明人： Jacob A. Flagle , Brian C. Case
IPC分类号： A61F2/24
CPC分类号： A61B17/00234 , A61B17/00491 , A61B17/064 , A61B17/122 , A61B18/1492 , A61B2017/00783 , A61F2/06 , A61F2/2475 , Y10S623/904
摘要： Described are methods and systems for modifying vascular valves in order to reduce retrograde blood flow through the valves. Preferred methods include connecting vascular valve leaflets with at least one remodelable material, such that the valve leaflets become fused by the ingrowth of the patient's native tissue. Preferred remodelable materials include collagenous extracellular matrix material, such as small intestine submucosa.
摘要翻译：描述了用于修改血管瓣膜以减少通过瓣膜的逆行血流量的方法和系统。优选的方法包括将血管瓣叶与至少一种可重塑材料连接，使得瓣膜小叶通过患者的天然组织的向内生长而变得熔化。优选的可重塑材料包括胶原细胞外基质材料，例如小肠粘膜下层。

59. 发明申请

US20080255580A1 MEDICAL DEVICE DELIVERY SYSTEM WITH SHEATH SEPARATION 有权
标题翻译：医疗器械输送系统与分离
公开(公告)号：US20080255580A1
公开(公告)日：2008-10-16
申请号：US12059241
申请日：2008-03-31
申请人： GRANT T. HOFFMAN , Brian C. Case
发明人： GRANT T. HOFFMAN , Brian C. Case
IPC分类号： A61B17/00
CPC分类号： A61F2/95 , A61F2/958 , A61F2/97
摘要： Medical device delivery systems and associated methods are provided. Delivery systems according to the invention include an elongated tubular member and a body member, such as a dilator, disposed therein. An intraluminal medical device is disposed on the dilator and within the tubular member prior to deployment. The delivery system includes a means for separating two or more portions of the distal end of the tubular member that aids in deploying the intraluminal medical device from the delivery system by separating two or more portions of the tubular member from each other to facilitate release of the intraluminal medical device from the body member. Various structures can be used for means for separating, including a cutting ring, activateable material on the tubular member, or other suitable structure. The provided devices and methods reduce friction occuring from relative movement between the sheath and dilator during deployment.
摘要翻译：提供医疗器械输送系统及相关方法。根据本发明的递送系统包括细长的管状构件和设置在其中的诸如扩张器的主体构件。在展开之前，将管腔内医疗装置设置在扩张器上并在管状构件内。递送系统包括用于分离管状构件的远端的两个或更多个部分的装置，其通过将管状构件的两个或更多个部分彼此分离来有助于将管腔内医疗装置从输送系统展开以便于释放管腔内医疗器械从身体成员。各种结构可以用于分离的装置，包括切割环，管状构件上的可激活材料或其他合适的结构。所提供的装置和方法减少在展开期间由护套和扩张器之间的相对运动发生的摩擦力。

60. 发明授权

US10413652B2 Systems and methods for use and control of an automated separator with adsorption columns 有权
公开(公告)号：US10413652B2
公开(公告)日：2019-09-17
申请号：US14110587
申请日：2011-04-13
申请人： John T. Foley , Jonathan Prendergast , Lan T. Nguyen , Brian C. Case
发明人： John T. Foley , Jonathan Prendergast , Lan T. Nguyen , Brian C. Case
IPC分类号： A61M1/36
摘要： Blood treatment systems and methods are provided for combining a blood separation system and an adsorption device. The blood separation system is configured to separate a blood component from blood, while the adsorption device is configured to receive at least a portion of the separated blood component and process it. The blood separation system includes a fluid flow element and a controller. The fluid flow element is configured for flowing the separated blood component into the adsorption device. The controller controls the fluid flow element based at least in part on one or more processing parameters. The processing parameters include a maximum flow rate of the separated blood component flowed into the adsorption device, a maximum pressure of the separated blood component flowed into the adsorption device, and/or the volume of fluid in a location of the system.

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