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51. 发明授权

US09968931B2 Rapid and efficient filtering whole blood in capillary flow device 有权
公开(公告)号：US09968931B2
公开(公告)日：2018-05-15
申请号：US12288159
申请日：2008-10-15
申请人： Nan Zhang , Zhiliang Wan
发明人： Nan Zhang , Zhiliang Wan
IPC分类号： B01D33/00 , B01D35/00 , B01L3/00
CPC分类号： B01L3/502753 , B01L2300/0681 , B01L2400/0406
摘要： This invention provides lateral flow filters with pore size gradients and with features to prevent peripheral flows around the filter. The filters can be laminated composites of two or more planar filter layers. Cartridges employing the filters can include a filtration chamber configured to retain the lateral flow filters including a port for sample application and a capillary channel for filtrate egress. The fluid egress port can be positioned to receive filtrate from one filter layer but not another.

52. 发明授权

US09121893B2 Combined PET/MR imaging system and APD-based pet detector for use in simultaneous PET/MR imaging 有权
标题翻译：组合PET / MR成像系统和基于APD的宠物检测器，用于同时PET / MR成像
公开(公告)号：US09121893B2
公开(公告)日：2015-09-01
申请号：US11532665
申请日：2006-09-18
申请人： Matthias J. Schmand , Ron Grazioso , Ronald Nutt , Robert E. Nutt , Nan Zhang , James Luke Corbeil , Ralf Ladebeck , Markus Vester , Günter Schnur , Wolfgang Renz , Hubertus Fischer , Bernd J. Pichler
发明人： Matthias J. Schmand , Ron Grazioso , Ronald Nutt , Robert E. Nutt , Nan Zhang , James Luke Corbeil , Ralf Ladebeck , Markus Vester , Günter Schnur , Wolfgang Renz , Hubertus Fischer , Bernd J. Pichler
IPC分类号： G01T1/164 , G01T1/166 , G01R33/28 , G01R33/26 , G01R33/381 , G01R33/48 , G01T1/16 , G01T1/29 , A61B6/03 , A61B8/08
CPC分类号： G01R33/481 , A61B6/037 , A61B8/5261 , G01R33/26 , G01R33/28 , G01R33/307 , G01R33/381 , G01T1/1603 , G01T1/2018 , G01T1/2985
摘要： APD-based PET modules are provided for use in combined PET/MR imaging. Each module includes a number of independent, optically isolated detectors. Each detector includes an array of scintillator (e.g. LSO) crystals read out by an array of APDs. The modules are positioned in the tunnel of a MR scanner. Simultaneous, artifact-free images can be acquired with the APD-based PET and MR system resulting in a high-resolution and cost-effective integrated PET/MR system.
摘要翻译：提供基于APD的PET模块，用于组合PET / MR成像。每个模块包括多个独立的光隔离探测器。每个检测器包括由APD阵列读出的闪烁体阵列（例如LSO）晶体。模块位于MR扫描仪的通道中。基于APD的PET和MR系统可以获得同时，无伪影的图像，从而产生高分辨率和成本效益的集成PET / MR系统。

53. 发明授权

US08791514B2 Providing variable cell density and sizes in a radiation detector 有权
标题翻译：在辐射检测器中提供可变细胞密度和尺寸
公开(公告)号：US08791514B2
公开(公告)日：2014-07-29
申请号：US13540079
申请日：2012-07-02
申请人： Debora Henseler , Ronald Grazioso , Nan Zhang
发明人： Debora Henseler , Ronald Grazioso , Nan Zhang
IPC分类号： H01L27/146 , G01T1/24
CPC分类号： G01T1/248 , H01L27/14658
摘要： An apparatus and method to decrease light saturation in a photosensor array and increase detection efficiency uses a light distribution profile from a scintillator-photodetector geometry to configure the photosensor array to have a non-uniform sensor cell pattern, with varying cell density and/or varying cell size and shape. A solid-state photosensor such as a SiPM sensor having such a non-uniform cell structure realizes improved energy resolution, higher efficiency and increased signal linearity. In addition the non-uniform sensor cell array can have improved timing resolution due to improvements in statistical fluctuations. A particular embodiment for such photosensors is in PET medical imaging.
摘要翻译：降低光传感器阵列中的光饱和度并提高检测效率的装置和方法使用来自闪烁体 - 光电检测器几何形状的光分布分布来配置光传感器阵列具有不均匀的传感器单元图案，具有变化的单元密度和/或变化细胞大小和形状。诸如具有这种非均匀单元结构的SiPM传感器的固态光电传感器实现了改进的能量分辨率，更高的效率和更高的信号线性度。此外，由于统计波动的改善，非均匀传感器单元阵列可以改善时序分辨率。这种感光器的特定实施例是在PET医学成像中。

54. 发明申请

US20130116265A1 COMPOUND FOR INHIBITING TYPE 5 PHOSPHODIESTERASE AND PREPARATION METHOD THEREOF 有权
标题翻译：用于抑制5型磷酸酯酶的化合物及其制备方法
公开(公告)号：US20130116265A1
公开(公告)日：2013-05-09
申请号：US13512524
申请日：2010-07-30
申请人： Nan Zhang , Rong Zhong
发明人： Nan Zhang , Rong Zhong
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/519 , C07C59/265
摘要： The present invention discloses a compound of formula (I) and citrate thereof as type 5 phosphodiesterase inhibitor, a preparation method thereof, and a pharmaceutical composition including the compound of formula (I) and citrate thereof. The experimental results of the present invention prove that the compound of formula (I) and citrate thereof can inhibit activity of type 5 phosphodiesterase, and can be used for treating erectile dysfunction, inhibiting platelet aggregation and treating thrombosis, decreasing pulmonary hypertension and treating cardiovascular diseases, treating asthma and treating diabetes gastroparesis.
摘要翻译：本发明公开了式（I）化合物及其柠檬酸盐作为5型磷酸二酯酶抑制剂及其制备方法，以及含有式（I）化合物及其柠檬酸盐的药物组合物。本发明的实验结果证明，式（I）化合物及其柠檬酸盐可抑制5型磷酸二酯酶的活性，可用于治疗勃起功能障碍，抑制血小板聚集和治疗血栓形成，降低肺动脉高压和治疗心血管疾病治疗哮喘和治疗糖尿病胃轻瘫。

55. 发明申请

US20130009063A1 System and Method for Improving Detection of Gamma Interactions in a Positron Emission Tomography System 有权
标题翻译：用于改善正电子发射断层扫描系统中伽马相互作用检测的系统和方法
公开(公告)号：US20130009063A1
公开(公告)日：2013-01-10
申请号：US13539915
申请日：2012-07-02
申请人： Debora Henseler , Ronald Grazioso , Nan Zhang , Matthias J. Schmand , Sanghee Cho
发明人： Debora Henseler , Ronald Grazioso , Nan Zhang , Matthias J. Schmand , Sanghee Cho
IPC分类号： G01T1/164
CPC分类号： G01T1/2985 , A61B6/00 , A61B6/037 , G01T1/00
摘要： A system and method are provided for determining the onset of gamma interactions for positron emission tomography (PET) imaging more accurately than with existing techniques. The timing of a sequence of primary trigger events is obtained and used to determine a weighted combination, which mixes the timing information from the various primary trigger events to compute an overall event trigger timing with improved time resolution. Numerical simulations demonstrate that the invention improves time resolution by approximately 10% over state-of-the-art methods. This improved time resolution directly benefits the imaging performance of the PET scanner, especially in time-of-flight (TOF) mode, where a high time resolution directly translates to a reduction in image noise at the same dose—or, alternatively, a reduction of dose to the patient or scan time for the same image quality.
摘要翻译：提供了一种系统和方法，用于比现有技术更准确地确定正电子发射断层摄影（PET）成像的γ相互作用的发生。获得主要触发事件序列的定时并用于确定加权组合，其混合来自各种主要触发事件的定时信息以通过改进的时间分辨率计算总体事件触发时序。数值模拟表明，本发明使用最先进的方法将时间分辨率提高约10％。这种改进的时间分辨率直接有利于PET扫描仪的成像性能，特别是在飞行时间（TOF）模式下，其中高时间分辨率直接转换为以相同剂量降低图像噪声，或者替代地，减少给予患者剂量或扫描时间相同的图像质量。

56. 发明申请

US20120294904A1 POLYSIALIC ACID-BASED N-TRIMETHYL CHITOSAN GEL NANOPARTICLES FOR SYSTEMIC DRUG DELIVERY 有权
标题翻译：用于系统药物输送的基于多肽的N-三甲基氯化钠凝胶纳米颗粒
公开(公告)号：US20120294904A1
公开(公告)日：2012-11-22
申请号：US13474749
申请日：2012-05-18
申请人： Rebecca A. Bader , Nan Zhang
发明人： Rebecca A. Bader , Nan Zhang
IPC分类号： A61K31/726 , A61K9/00 , B82Y15/00
CPC分类号： A61K9/5161 , A61K31/519 , B82Y30/00
摘要： Gel nanoparticles for encapsulating and delivering a pharmaceutical compound to a patient. The nanoparticles are formed from N-trimethyl chitosan and polysialic acid, preferably in the presence of sodium tripolyphosphate. A ratio of polysialic acid to N-trimethyl chitosan of about 0.5 to 1 produces nanoparticles having diameter of about 100 nm (plus or minus 25 nm) and a zero potential above 30 milivolts that can stability contain a pharmaceutical compound, such as methotrexate, for delivery to a patient.
摘要翻译：用于将药物化合物包封并递送至患者的凝胶纳米颗粒。纳米颗粒由N-三甲基壳聚糖和聚唾液酸形成，优选在三聚磷酸钠存在下形成。聚唾液酸与N-三甲基壳聚糖的比例为约0.5:1，产生直径约100nm（正或负25nm）和零电位高于30毫升的纳米颗粒，其稳定性含有药物化合物，例如甲氨蝶呤，用于送到病人身上

57. 再颁专利

USRE42376E1 Substituted 3-cyanoquinolines 有权
标题翻译：取代的3-氰基喹啉
公开(公告)号：USRE42376E1
公开(公告)日：2011-05-17
申请号：US12785269
申请日：2010-05-21
申请人： Allan Wissner , Hwei-Ru Tsou , Dan M. Berger , Middleton B. Floyd, Jr. , Philip R. Hamann , Nan Zhang , Philip Frost
发明人： Allan Wissner , Hwei-Ru Tsou , Dan M. Berger , Middleton B. Floyd, Jr. , Philip R. Hamann , Nan Zhang , Philip Frost
IPC分类号： A61K31/47 , C07D215/44
CPC分类号： C07D215/54 , C07D215/44 , C07D215/56
摘要： This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
摘要翻译：本发明提供具有以下结构的式I化合物：其中G1，G2，R1，R4，Z，n和X在本说明书中定义，或其药学上可接受的盐，其可用作抗肿瘤剂和治疗多囊肾病。

58. 发明授权

US07924079B2 Baseline restore based on diode star configuration and transformer coupling 失效
标题翻译：基于二极管星形配置和变压器耦合的基线恢复
公开(公告)号：US07924079B2
公开(公告)日：2011-04-12
申请号：US12558007
申请日：2009-09-11
申请人： Matthias J. Schmand , Nan Zhang
发明人： Matthias J. Schmand , Nan Zhang
IPC分类号： H03L5/00
CPC分类号： G01T1/248
摘要： A simple, low cost circuit with only passive components, and thus low power consumption, is provided for baseline restoration of an AC coupled signal. The circuit includes a passive network of diodes arranged in a star configuration and an RF-transformer. A differential signal strategy may be employed by including a differential amplifier at the input and output of the passive network.
摘要翻译：提供了一种简单的低成本电路，仅具有无源组件，因此具有低功耗，用于AC耦合信号的基线恢复。该电路包括以星形结构布置的二极管的无源网络和RF变压器。可以通过在无源网络的输入和输出处包括差分放大器来采用差分信号策略。

59. 发明申请

US20100074396A1 MEDICAL IMAGING WITH BLACK SILICON PHOTODETECTOR 审中-公开
标题翻译：用黑色硅胶片进行医学成像
公开(公告)号：US20100074396A1
公开(公告)日：2010-03-25
申请号：US12498101
申请日：2009-07-06
申请人： Matthias J. Schmand , Debora Henseler , Ronald Grazioso , Nan Zhang , Mark S. Andreaco
发明人： Matthias J. Schmand , Debora Henseler , Ronald Grazioso , Nan Zhang , Mark S. Andreaco
IPC分类号： A61B6/03 , G01T1/24 , G01T1/20
CPC分类号： G01T1/1644 , A61B6/032 , A61B6/037
摘要： Medical imaging may be accomplished with a high photoconductive gain at a relatively low operating voltage by employing a black silicon photodetector and integrating CMOS components with elements of the photodetector.
摘要翻译：通过采用黑硅光电检测器并将CMOS部件与光电检测器的元件集成，可以在相对低的工作电压下以高的光电导增益实现医学成像。

60. 发明授权

US07579599B2 Parameter adjustment for medical device 有权
标题翻译：医疗器械参数调整
公开(公告)号：US07579599B2
公开(公告)日：2009-08-25
申请号：US11941562
申请日：2007-11-16
申请人： Nan Zhang , Volker Matschl , Niraj K. Doshi , Matthias J. Schmand
发明人： Nan Zhang , Volker Matschl , Niraj K. Doshi , Matthias J. Schmand
IPC分类号： G01T1/164
CPC分类号： A61B6/037 , A61B6/56
摘要： A medical device with a high voltage connection line for carrying a high DC supply voltage has a control unit generating said high DC supply voltage which is fed through a first AC block unit to said high voltage connection line and generating a digital control signal fed through a first AC coupling unit to said high voltage connection line, and a remotely located unit a second AC block unit coupled to said high voltage connection line for receiving said high DC supply voltage and a second AC coupling unit coupled to said high voltage connection line for receiving said digital control signal.
摘要翻译：具有用于承载高直流电源电压的高压连接线的医疗装置具有产生所述高直流电源电压的控制单元，所述高直流电源电压通过第一AC块单元馈送到所述高压连接线，并产生通过第一AC耦合单元连接到所述高压连接线，以及远程定位单元，耦合到所述高压连接线的第二AC块单元，用于接收所述高DC电源电压;以及第二AC耦合单元，耦合到所述高压连接线，用于接收所述数字控制信号。

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