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1. 发明授权

US06288082B1 Substituted 3-cyanoquinolines 有权
公开(公告)号：US06288082B1
公开(公告)日：2001-09-11
申请号：US09406573
申请日：1999-09-24
申请人： Allan Wissner , Hwei-Ru Tsou , Dan M. Berger , Middleton B. Floyd, Jr. , Philip R. Hamann , Nan Zhang , Mark E. Salvati , Philip Frost
发明人： Allan Wissner , Hwei-Ru Tsou , Dan M. Berger , Middleton B. Floyd, Jr. , Philip R. Hamann , Nan Zhang , Mark E. Salvati , Philip Frost
IPC分类号： A61K3147
CPC分类号： C07D401/12 , C07D215/48 , C07D417/12
摘要： This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.

2. 发明授权

US06297258B1 Substituted 3-cyanoquinolines 有权
标题翻译：取代的3-氰基喹啉
公开(公告)号：US06297258B1
公开(公告)日：2001-10-02
申请号：US09630270
申请日：2000-08-01
申请人： Allan Wissner , Hwei-Ru Tsou , Dan M. Berger , Middleton B. Floyd, Jr. , Philip R. Hamann , Nan Zhang , Philip Frost
发明人： Allan Wissner , Hwei-Ru Tsou , Dan M. Berger , Middleton B. Floyd, Jr. , Philip R. Hamann , Nan Zhang , Philip Frost
IPC分类号： A61K3147
CPC分类号： C07D215/54 , C07D215/44 , C07D215/56
摘要： This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
摘要翻译：本发明提供了具有其结构的式I化合物，其中G1，G2，R1，R4，Z，n和X在本说明书或其药学上可接受的盐中定义，其可用作抗肿瘤药物和治疗多囊肾病。

3. 再颁专利

USRE42376E1 Substituted 3-cyanoquinolines 有权
标题翻译：取代的3-氰基喹啉
公开(公告)号：USRE42376E1
公开(公告)日：2011-05-17
申请号：US12785269
申请日：2010-05-21
申请人： Allan Wissner , Hwei-Ru Tsou , Dan M. Berger , Middleton B. Floyd, Jr. , Philip R. Hamann , Nan Zhang , Philip Frost
发明人： Allan Wissner , Hwei-Ru Tsou , Dan M. Berger , Middleton B. Floyd, Jr. , Philip R. Hamann , Nan Zhang , Philip Frost
IPC分类号： A61K31/47 , C07D215/44
CPC分类号： C07D215/54 , C07D215/44 , C07D215/56
摘要： This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
摘要翻译：本发明提供具有以下结构的式I化合物：其中G1，G2，R1，R4，Z，n和X在本说明书中定义，或其药学上可接受的盐，其可用作抗肿瘤剂和治疗多囊肾病。

4. 发明授权

US06432979B1 Method of treating or inhibiting colonic polyps and colorectal cancer 失效
标题翻译：治疗或抑制结肠息肉和结肠直肠癌的方法
公开(公告)号：US06432979B1
公开(公告)日：2002-08-13
申请号：US09634787
申请日：2000-08-09
申请人： Philip Frost , Carolyn M. Discafani-Marro
发明人： Philip Frost , Carolyn M. Discafani-Marro
IPC分类号： A61K3147
CPC分类号： A61K31/19 , A61K31/47 , A61K2300/00
摘要： This invention provides a method of treating or inhibiting colonic polyps or treating or inhibiting colorectal cancer in a mammal in need thereof which comprises administering to said mammal an NSAID and an EFGR kinase inhibitor.
摘要翻译：本发明提供了治疗或抑制结肠息肉或治疗或抑制有需要的哺乳动物的结肠直肠癌的方法，其包括对所述哺乳动物施用NSAID和EFGR激酶抑制剂。

5. 发明授权

US06323209B1 Method of treating or inhibiting colonic polyps 失效
标题翻译：治疗或抑制结肠息肉的方法
公开(公告)号：US06323209B1
公开(公告)日：2001-11-27
申请号：US09185066
申请日：1998-11-03
申请人： Philip Frost
发明人： Philip Frost
IPC分类号： A61K31505
CPC分类号： A61K31/505 , Y10S514/885
摘要： This invention provides a method of treating or inhibiting colonic polyps in a mammal in need thereof which comprises administering to said mammal a compound having the formula wherein: X is phenyl which is optionally substituted; R and R1 are each, independently, hydrogen, halogen, alkyl, alkoxy, hydroxy, or trifluoromethyl; R2 is hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl; Y is a radical selected from the group consisting of R3 is independently hydrogen, alkyl, carboxy, carboalkoxy, phenyl, or carboalkyl; n=2-4; or a pharmaceutically acceptable salt thereof, with the proviso that each R3 of Y may be the same or different.
摘要翻译：本发明提供了治疗或抑制有需要的哺乳动物中的结肠息肉的方法，该方法包括对所述哺乳动物施用具有下式的化合物：X是任选被取代的苯基; R和R 1各自独立地是氢，卤素，烷基烷氧基，羟基或三氟甲基; R 2是氢，烷基，烷氧基，羟基，三氟甲基; Y是选自R 3独立地是氢，烷基，羧基，烷氧羰基，苯基或烷基烷基的基团; n = 2-4 ;或其药学上可接受的盐，条件是Y的每个R 3可以相同或不同。

6. 发明申请

US20060079515A1 Method for the treatment of polycystic kidney disease 审中-公开
标题翻译：多囊肾病的治疗方法
公开(公告)号：US20060079515A1
公开(公告)日：2006-04-13
申请号：US11243932
申请日：2005-10-05
申请人： Philip Frost
发明人： Philip Frost
IPC分类号： A61K31/5513 , A61K31/537 , A61K31/47 , A61K31/4035 , A61K31/336 , A61K31/19
CPC分类号： A61K31/54 , A61K31/18 , A61K31/47 , A61K31/5513 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method for treating, inhibiting the progression of, or eradicating polycystic kidney disease of in a patient in need thereof which comprises providing to said patient an effective amount of a TACE inhibitor compound in combination with an effective amount of a Src kinase inhibitor, a HER-2 kinase inhibitor, or a combination of Src and HER-2 inhibitor.
摘要翻译：本发明提供了在有需要的患者中治疗，抑制多囊肾病进展或消除多囊肾病的方法，该方法包括向所述患者提供有效量的TACE抑制剂化合物与有效量的Src激酶抑制剂，HER-2激酶抑制剂或Src和HER-2抑制剂的组合。

7. 发明授权

US06511986B2 Method of treating estrogen receptor positive carcinoma 失效
公开(公告)号：US06511986B2
公开(公告)日：2003-01-28
申请号：US09923217
申请日：2001-08-06
申请人： Yixian Zhang , Tammy M. Sadler , Philip Frost , Lee Martin Greenberger
发明人： Yixian Zhang , Tammy M. Sadler , Philip Frost , Lee Martin Greenberger
IPC分类号： A61K3144
CPC分类号： A61K31/4745 , A61K31/135 , A61K31/55 , A61K31/70 , A61K45/06 , Y10S514/874 , Y10S514/922 , A61K2300/00
摘要： This invention provides a method of treating or inhibiting an estrogen receptor positive carcinoma in a mammal in need thereof, which comprises providing said mammal with an effective amount of a combination of a rapamycin and an antiestrogen.

8. 发明申请

US20160367555A1 Use of a Receptor-Type Kinase Modulator for Treating Polycystic Kidney Disease 有权
标题翻译：使用受体型激酶调节剂治疗多囊肾病
公开(公告)号：US20160367555A1
公开(公告)日：2016-12-22
申请号：US15158171
申请日：2016-05-18
申请人： Philip Frost , William W. N. Liao , Eric K. Rowinsky
发明人： Philip Frost , William W. N. Liao , Eric K. Rowinsky
IPC分类号： A61K31/517 , A61K9/08 , A61K9/20
CPC分类号： A61K31/517 , A61K9/08 , A61K9/20 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054
摘要： The invention comprises a method of treating polycystic kidney disease (PKD) in a mammal, such as a human or feline (e.g., Persian cat), comprising administering a therapeutically effective amount of the compound of formula to the mammal. Also provided are uses of the compound for preparation of a medicament for treating PKD and the above compound and compositions comprising it for treating PKD.
摘要翻译：给哺乳动物。还提供了该化合物用于制备用于治疗PKD的药物和上述化合物及其组合物用于治疗PKD的用途。

9. 发明申请

US20130217711A1 Use of a Receptor-Type Kinase Modulator for Treating Polycystic Kidney Disease 有权
标题翻译：使用受体型激酶调节剂治疗多囊肾病
公开(公告)号：US20130217711A1
公开(公告)日：2013-08-22
申请号：US13818844
申请日：2011-08-25
申请人： Philip Frost , William W. N. Liao , Eric K. Rowinsky
发明人： Philip Frost , William W. N. Liao , Eric K. Rowinsky
IPC分类号： A61K31/517
CPC分类号： A61K31/517 , A61K9/08 , A61K9/20 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054
摘要： The invention comprises use of a therapeutically effective amount of the compound of the formula below for preparation of a medicament for treating polycystic kidney diseases (PKD) in a mammal, such as human or feline (e.g., Persian cat).Formula (I). Also provided are the above compound and compositions comprising it for treating PKD.
摘要翻译：本发明包括使用治疗有效量的下式化合物来制备用于治疗哺乳动物如人或猫（例如波斯猫）的多囊肾病（PKD）的药物。（I）。还提供了上述化合物和包含其用于治疗PKD的组合物。

10. 发明申请

US20070142425A1 Use of CCI-779 as an antineoplastic agent 有权
公开(公告)号：US20070142425A1
公开(公告)日：2007-06-21
申请号：US11701109
申请日：2007-02-01
申请人： Gary Dukart , James Gibbons , Lisa Speicher , Philip Frost , Carolyn Discafani-Marro
发明人： Gary Dukart , James Gibbons , Lisa Speicher , Philip Frost , Carolyn Discafani-Marro
IPC分类号： A61K31/4745
CPC分类号： A61K31/4745 , A61K31/436
摘要： This invention provides the use of CCI-779 in the treatment of neoplasms.

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