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1. 发明授权

US09121893B2 Combined PET/MR imaging system and APD-based pet detector for use in simultaneous PET/MR imaging 有权
标题翻译：组合PET / MR成像系统和基于APD的宠物检测器，用于同时PET / MR成像
公开(公告)号：US09121893B2
公开(公告)日：2015-09-01
申请号：US11532665
申请日：2006-09-18
申请人： Matthias J. Schmand , Ron Grazioso , Ronald Nutt , Robert E. Nutt , Nan Zhang , James Luke Corbeil , Ralf Ladebeck , Markus Vester , Günter Schnur , Wolfgang Renz , Hubertus Fischer , Bernd J. Pichler
发明人： Matthias J. Schmand , Ron Grazioso , Ronald Nutt , Robert E. Nutt , Nan Zhang , James Luke Corbeil , Ralf Ladebeck , Markus Vester , Günter Schnur , Wolfgang Renz , Hubertus Fischer , Bernd J. Pichler
IPC分类号： G01T1/164 , G01T1/166 , G01R33/28 , G01R33/26 , G01R33/381 , G01R33/48 , G01T1/16 , G01T1/29 , A61B6/03 , A61B8/08
CPC分类号： G01R33/481 , A61B6/037 , A61B8/5261 , G01R33/26 , G01R33/28 , G01R33/307 , G01R33/381 , G01T1/1603 , G01T1/2018 , G01T1/2985
摘要： APD-based PET modules are provided for use in combined PET/MR imaging. Each module includes a number of independent, optically isolated detectors. Each detector includes an array of scintillator (e.g. LSO) crystals read out by an array of APDs. The modules are positioned in the tunnel of a MR scanner. Simultaneous, artifact-free images can be acquired with the APD-based PET and MR system resulting in a high-resolution and cost-effective integrated PET/MR system.
摘要翻译：提供基于APD的PET模块，用于组合PET / MR成像。每个模块包括多个独立的光隔离探测器。每个检测器包括由APD阵列读出的闪烁体阵列（例如LSO）晶体。模块位于MR扫描仪的通道中。基于APD的PET和MR系统可以获得同时，无伪影的图像，从而产生高分辨率和成本效益的集成PET / MR系统。

2. 发明申请

US20070102641A1 Combined PET/MR Imaging System and APD-Based PET Detector For Use In Simultaneous PET/MR Imaging 有权
标题翻译：组合PET / MR成像系统和基于APD的PET检测器，用于同时PET / MR成像
公开(公告)号：US20070102641A1
公开(公告)日：2007-05-10
申请号：US11532665
申请日：2006-09-18
申请人： Matthias Schmand , Ron Grazioso , Ronald Nutt , Robert Nutt , Nan Zhang , James Corbeil , Ralf Ladebeck , Markus Vester , Gunter Schnur , Wolfgang Renz , Hubertus Fischer , Bernd Pichler
发明人： Matthias Schmand , Ron Grazioso , Ronald Nutt , Robert Nutt , Nan Zhang , James Corbeil , Ralf Ladebeck , Markus Vester , Gunter Schnur , Wolfgang Renz , Hubertus Fischer , Bernd Pichler
IPC分类号： G01T1/164 , G01T1/166 , A61B5/05
CPC分类号： G01R33/481 , A61B6/037 , A61B8/5261 , G01R33/26 , G01R33/28 , G01R33/307 , G01R33/381 , G01T1/1603 , G01T1/2018 , G01T1/2985
摘要： APD-based PET modules are provided for use in combined PET/MR imaging. Each module includes a number of independent, optically isolated detectors. Each detector includes an array of scintillator (e.g. LSO) crystals read out by an array of APDs. The modules are positioned in the tunnel of a MR scanner. Simultaneous, artifact-free images can be acquired with the APD-based PET and MR system resulting in a high-resolution and cost-effective integrated PET/MR system.
摘要翻译：提供基于APD的PET模块，用于组合PET / MR成像。每个模块包括多个独立的光隔离探测器。每个检测器包括由APD阵列读出的闪烁体阵列（例如LSO）晶体。模块位于MR扫描仪的通道中。基于APD的PET和MR系统可以获得同时，无伪影的图像，从而产生高分辨率和成本效益的集成PET / MR系统。

3. 发明授权

US07218113B2 Magnetic resonance system and operating method for RF pulse optimization 有权
标题翻译：用于RF脉冲优化的磁共振系统和操作方法
公开(公告)号：US07218113B2
公开(公告)日：2007-05-15
申请号：US11036727
申请日：2005-01-14
申请人： Thorsten Feiweier , Ralf Ladebeck , Ralph Oppelt , Wolfgang Renz , Markus Vester
发明人： Thorsten Feiweier , Ralf Ladebeck , Ralph Oppelt , Wolfgang Renz , Markus Vester
IPC分类号： G01V3/00
CPC分类号： G01R33/5612 , G01R33/246 , G01R33/543 , G01R33/5659
摘要： In a magnetic resonance system and an operating method therefor, a B1 field distribution of a radio-frequency antenna is measured in at least one part of a examination volume of the magnetic resonance system, and then the RF pulses emitted by the radio-frequency antenna are optimized, based on the determined B1 field distribution, for homogenization in a specific volume. An effective volume within the examination volume is determined beforehand for each applied RF pulse and, based on the determined B1 field distribution, the appertaining RF pulse is individually adjusted such that the B1 field is homogenized within the effective volume of the RF pulse.
摘要翻译：在磁共振系统及其操作方法中，在磁共振系统的检查体积的至少一部分中测量射频天线的B 1场分布，然后RF 基于确定的B SUB场分布来优化由射频天线发射的脉冲用于在特定体积中的均匀化。对于每个施加的RF脉冲，预先确定检查体积内的有效体积，并且基于所确定的B SUB场分布，分别调整相应的RF脉冲，使得B <1> SUB>场在RF脉冲的有效体积内均匀化。

4. 发明申请

US20060250133A1 Combined positron emission tomography and magnetic resonance tomography unit 失效
标题翻译：组合正电子发射断层扫描和磁共振断层扫描单元
公开(公告)号：US20060250133A1
公开(公告)日：2006-11-09
申请号：US11395251
申请日：2006-04-03
申请人： Robert Krieg , Rainer Kuth , Ralf Ladebeck , Ralph Oppelt , Wolfgang Renz , Sebastian Schmidt , Markus Vester
发明人： Robert Krieg , Rainer Kuth , Ralf Ladebeck , Ralph Oppelt , Wolfgang Renz , Sebastian Schmidt , Markus Vester
IPC分类号： G06K9/00
CPC分类号： G01R33/481 , G01T1/1603
摘要： A positron emission tomography unit (PET), having a unit part assigned to an examination space and a first evaluation unit, is combined with a magnetic resonance tomography unit (MRT). The unit part of the PRT includes at least two gamma ray detector units with in each case an assigned electronics unit. The MRT includes a second evaluation unit, a gradient coil system and a high frequency antenna device formed as a stripline antenna device having at least two conductors. The high frequency antenna device is arranged nearer to the examination space than the gradient coil system with a high frequency shield between the gradient coil system and the high frequency antenna device. Each conductor of the stripline antenna device respectively includes a gamma ray detector unit with an assigned electronics unit. The conductors of the stripline antenna device are configured for the respective gamma ray detector units and their assigned electronics units as shielding covers that are caused by the high frequency antenna device and are opaque to high frequency radiation. An examination object in the examination space can be imaged by the combined positron emission tomography and magnetic resonance tomography unit.
摘要翻译：将具有分配给检查空间的单位部分和第一评估单元的正电子发射断层摄影单元（PET）与磁共振断层摄影单元（MRT）组合。 PRT的单位部分包括至少两个伽马射线检测器单元，在每种情况下都是分配的电子单元。 MRT包括第二评估单元，梯度线圈系统和形成为具有至少两个导体的带状线天线装置的高频天线装置。高频天线装置布置成比梯度线圈系统和高频天线装置之间具有高频屏蔽的梯度线圈系统更靠近检查空间。带状线天线装置的每个导体分别包括具有分配的电子单元的伽马射线检测器单元。带状线天线装置的导体被配置用于相应的伽马射线检测器单元及其分配的电子单元作为由高频天线装置引起并且对高频辐射不透明的屏蔽盖。检查空间中的检查对象可以通过组合的正电子发射断层摄影和磁共振断层摄影单元成像。

5. 发明授权

US07522952B2 Combined positron emission tomography and magnetic resonance tomography unit 有权
标题翻译：组合正电子发射断层扫描和磁共振断层扫描单元
公开(公告)号：US07522952B2
公开(公告)日：2009-04-21
申请号：US11395267
申请日：2006-04-03
申请人： Robert Krieg , Rainer Kuth , Ralf Ladebeck , Ralph Oppelt , Wolfgang Renz , Sebastian Schmidt , Markus Vester
发明人： Robert Krieg , Rainer Kuth , Ralf Ladebeck , Ralph Oppelt , Wolfgang Renz , Sebastian Schmidt , Markus Vester
IPC分类号： A61B5/055
CPC分类号： G01T1/1603 , A61B6/037 , A61B6/4417 , A61B6/5247 , G01R33/481 , G01T1/2985
摘要： A combined PET/MRI tomography unit has a PET unit with a unit part assigned to the examination space, and a first evaluation unit for evaluating the PET electric signals. The unit part has a gamma ray detector. The combined unit has an MRI unit and a second evaluation unit for evaluating MRI signals. The MRI unit has a high frequency antenna as well as a gradient coil system, the high frequency antenna device being arranged nearer to the examination space than the gradient coil system, as well as a high frequency shield arranged between the gradient coil system and the high frequency antenna device. The PET unit part is arranged between the high frequency shield and the high frequency antenna device. A shielding cover for the high frequency antenna device faces the high frequency antenna device. The shielding cover is opaque to high frequency radiation.
摘要翻译：组合的PET / MRI断层摄影单元具有分配给检查空间的单位部分的PET单元和用于评估PET电信号的第一评估单元。单位部件具有伽马射线检测器。组合单元具有用于评估MRI信号的MRI单元和第二评估单元。 MRI单元具有高频天线以及梯度线圈系统，高频天线装置布置成比梯度线圈系统更靠近检查空间，以及布置在梯度线圈系统和高电平之间的高频屏蔽频率天线装置。 PET单元部分布置在高频屏蔽和高频天线装置之间。用于高频天线装置的屏蔽罩面向高频天线装置。屏蔽罩对高频辐射是不透明的。

6. 发明申请

US20050189940A1 Magnetic resonance system and operating method for RF pulse optimization 有权
标题翻译：用于RF脉冲优化的磁共振系统和操作方法
公开(公告)号：US20050189940A1
公开(公告)日：2005-09-01
申请号：US11036727
申请日：2005-01-14
申请人： Thorsten Feiweier , Ralf Ladebeck , Ralph Oppelt , Wolfgang Renz , Markus Vester
发明人： Thorsten Feiweier , Ralf Ladebeck , Ralph Oppelt , Wolfgang Renz , Markus Vester
IPC分类号： A61B5/055 , G01R33/34 , G01R33/3415 , G01R33/36 , G01V3/00
CPC分类号： G01R33/5612 , G01R33/246 , G01R33/543 , G01R33/5659
摘要： In a magnetic resonance system and an operating method therefor, a B1 field distribution of a radio-frequency antenna is measured in at least one part of a examination volume of the magnetic resonance system, and then the RF pulses emitted by the radio-frequency antenna are optimized, based on the determined B1 field distribution, for homogenization in a specific volume. An effective volume within the examination volume is determined beforehand for each applied RF pulse and, based on the determined B1 field distribution, the appertaining RF pulse is individually adjusted such that the B1 field is homogenized within the effective volume of the RF pulse.
摘要翻译：在磁共振系统及其操作方法中，在磁共振系统的检查体积的至少一部分中测量射频天线的B 1场分布，然后RF 基于确定的B SUB场分布来优化由射频天线发射的脉冲用于在特定体积中的均匀化。对于每个施加的RF脉冲，预先确定检查体积内的有效体积，并且基于所确定的B SUB场分布，分别调整相应的RF脉冲，使得B <1> SUB>场在RF脉冲的有效体积内均匀化。

7. 发明授权

US07323874B2 Combined positron emission tomography and magnetic resonance tomography unit 失效
标题翻译：组合正电子发射断层扫描和磁共振断层扫描单元
公开(公告)号：US07323874B2
公开(公告)日：2008-01-29
申请号：US11395251
申请日：2006-04-03
申请人： Robert Krieg , Rainer Kuth , Ralf Ladebeck , Ralph Oppelt , Wolfgang Renz , Sebastian Schmidt , Markus Vester
发明人： Robert Krieg , Rainer Kuth , Ralf Ladebeck , Ralph Oppelt , Wolfgang Renz , Sebastian Schmidt , Markus Vester
IPC分类号： G01V3/00
CPC分类号： G01R33/481 , G01T1/1603
摘要： A positron emission tomography unit (PET), having a unit part assigned to an examination space and a first evaluation unit, is combined with a magnetic resonance tomography unit (MRT). The unit part of the PRT includes at least two gamma ray detector units with in each case an assigned electronics unit. The MRT includes a second evaluation unit, a gradient coil system and a high frequency antenna device formed as a stripline antenna device having at least two conductors. The high frequency antenna device is arranged nearer to the examination space than the gradient coil system with a high frequency shield between the gradient coil system and the high frequency antenna device. Each conductor of the stripline antenna device respectively includes a gamma ray detector unit with an assigned electronics unit. The conductors of the stripline antenna device are configured for the respective gamma ray detector units and their assigned electronics units as shielding covers that are caused by the high frequency antenna device and are opaque to high frequency radiation. An examination object in the examination space can be imaged by the combined positron emission tomography and magnetic resonance tomography unit.
摘要翻译：将具有分配给检查空间的单位部分和第一评估单元的正电子发射断层摄影单元（PET）与磁共振断层摄影单元（MRT）组合。 PRT的单位部分包括至少两个伽马射线检测器单元，在每种情况下都是分配的电子单元。 MRT包括第二评估单元，梯度线圈系统和形成为具有至少两个导体的带状线天线装置的高频天线装置。高频天线装置布置成比梯度线圈系统和高频天线装置之间具有高频屏蔽的梯度线圈系统更靠近检查空间。带状线天线装置的每个导体分别包括具有分配的电子单元的伽马射线检测器单元。带状线天线装置的导体被配置用于相应的伽马射线检测器单元及其分配的电子单元作为由高频天线装置引起并且对高频辐射不透明的屏蔽盖。检查空间中的检查对象可以通过组合的正电子发射断层摄影和磁共振断层摄影单元成像。

8. 发明申请

US20060251312A1 Combined positron emission tomography and magnetic resonance tomography unit 有权
标题翻译：组合正电子发射断层扫描和磁共振断层扫描单元
公开(公告)号：US20060251312A1
公开(公告)日：2006-11-09
申请号：US11395267
申请日：2006-07-03
申请人： Robert Krieg , Rainer Kuth , Ralf Ladebeck , Ralph Oppelt , Wolfgang Renz , Sebastian Schmidt , Markus Vester
发明人： Robert Krieg , Rainer Kuth , Ralf Ladebeck , Ralph Oppelt , Wolfgang Renz , Sebastian Schmidt , Markus Vester
IPC分类号： G01V3/00
CPC分类号： G01T1/1603 , A61B6/037 , A61B6/4417 , A61B6/5247 , G01R33/481 , G01T1/2985
摘要： Combined positron emission tomography and magnetic resonance tomography unit for imaging an examination object in an examination space, comprising a positron emission tomography unit that has a unit part assigned to the examination space, and a first evaluation unit for evaluating the electric signals for a positron emission tomography image of the examination object. The unit part in this case comprises a gamma ray detector with an assigned electronics unit. Furthermore, the combined unit comprises a magnetic resonance tomography unit and a second evaluation unit for evaluating the magnetic resonance signals for a magnetic resonance image of the examination object. The magnetic resonance unit in this case has a high frequency antenna device as well as a gradient coil system, the high frequency antenna device being arranged nearer to the examination space than the gradient coil system, as well as a high frequency shield arranged between the gradient coil system and the high frequency antenna device. The positron emission tomography unit part is arranged in this case between the high frequency shield and the high frequency antenna device, and is provided, at least on the side facing the high frequency antenna device, with a shielding cover that is caused by the high frequency antenna device and is opaque to high frequency radiation.
摘要翻译：组合正电子发射断层摄影和磁共振断层摄影单元，用于对检查空间中的检查对象进行成像，包括具有分配给检查空间的单位部分的正电子发射断层摄影单元和用于评估正电子发射的电信号的第一评估单元检查对象的断层扫描图像。这种情况下的单元部分包括具有分配的电子单元的伽马射线检测器。此外，组合单元包括磁共振断层摄影单元和用于评估检查对象的磁共振图像的磁共振信号的第二评估单元。在这种情况下，磁共振单元具有高频天线装置以及梯度线圈系统，高频天线装置布置成比梯度线圈系统更靠近检查空间，以及布置在梯度之间的高频屏蔽线圈系统和高频天线装置。在这种情况下，正电子发射断层摄影单元部分布置在高频屏蔽和高频天线装置之间，并且至少在面向高频天线装置的一侧上设置有由高频天线装置引起的屏蔽罩天线装置，对高频辐射是不透明的。

9. 发明申请

US20090114827A1 Method for stabilizing the gain of a pet detection system 有权
标题翻译：稳定宠物检测系统增益的方法
公开(公告)号：US20090114827A1
公开(公告)日：2009-05-07
申请号：US12232451
申请日：2008-09-17
申请人： Ziad Burbar , James Corbeil , Gregory Hayzen , Sridhar Kuppuswamy , Ralf Ladebeck , Matthew E. Martin , Matthias J. Schmand
发明人： Ziad Burbar , James Corbeil , Gregory Hayzen , Sridhar Kuppuswamy , Ralf Ladebeck , Matthew E. Martin , Matthias J. Schmand
IPC分类号： G01T1/164 , G01T1/20
CPC分类号： G01T1/1603 , A61B6/037 , G01T7/005
摘要： A method is disclosed for stabilizing the gain of a PET detection system with a cooling unit. The method includes determining the temperature of at least one component of the PET detection system, comparing the actual gain with a reference value, and actuating the cooling unit to influence the temperature such that the gain tends to the reference value. In at least one embodiment, the reference value is determined by determining the temperature of the at least one component during a test measurement, determining the gain during the test measurement, determining a functional dependence of the gain on the temperature, and selecting the reference value based on the gain to be stabilized. Advantageously, in at least one embodiment the gain can be kept constant using the described method in a simple manner, with the influence of the temperature of the components being taken into account.
摘要翻译：公开了一种用于通过冷却单元稳定PET检测系统的增益的方法。该方法包括确定PET检测系统的至少一个部件的温度，将实际增益与参考值进行比较，以及致动冷却单元以影响温度，使得增益趋于参考值。在至少一个实施例中，参考值通过在测试测量期间确定至少一个组件的温度，确定测试测量期间的增益，确定增益对温度的功能依赖性以及选择参考值来确定基于要稳定的收益。有利地，在至少一个实施例中，利用所述方法以简单的方式，可以将增益保持恒定，同时考虑组件的温度的影响。

10. 发明申请

US20100108895A1 Background signal suppression in pet spectrums 有权
标题翻译：宠物光谱背景信号抑制
公开(公告)号：US20100108895A1
公开(公告)日：2010-05-06
申请号：US12591003
申请日：2009-11-04
申请人： Ralf Ladebeck , Markus Vester
发明人： Ralf Ladebeck , Markus Vester
IPC分类号： G01T1/164
CPC分类号： G01T1/00
摘要： A method and a facility are disclosed for imaging a PET spectrum with a PET detector, especially a PE-MR tomograph, and evaluation of the PET spectrum. To improve the correction of the base line in PET and thereby to improve the energy resolution for the PET images, at least one embodiment of the facility includes: a sampling facility for sampling the output signal of the PET detector at a predetermined sampling rate; an edge discriminator for recognizing at least one edge of a PET pulse; a background signal discriminator for estimating a background signal under the PET pulse; and an integrator device for determining the energy of the PET pulse in the PET spectrum above of the background signal from the sample values of the sampling facility.
摘要翻译：公开了一种利用PET检测器，特别是PE-MR断层摄影仪对PET光谱进行成像并评估PET光谱的方法和设备。为了改善PET中基线的校正，从而提高PET图像的能量分辨率，设备的至少一个实施例包括：采样设备，用于以预定采样率对PET检测器的输出信号进行采样; 用于识别PET脉冲的至少一个边缘的边缘鉴别器; 背景信号鉴别器，用于估计PET脉冲下的背景信号; 以及积分器装置，用于根据来自采样设备的样本值的背景信号确定PET谱中PET脉冲的能量。

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