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51. 发明授权

US08500658B2 Nickel-titanium core guide wire 有权
标题翻译：镍钛芯导丝
公开(公告)号：US08500658B2
公开(公告)日：2013-08-06
申请号：US12914049
申请日：2010-10-28
申请人： William J. Boyle , Wayne E. Cornish , Raleigh A. Purtzer
发明人： William J. Boyle , Wayne E. Cornish , Raleigh A. Purtzer
IPC分类号： A61B5/00
CPC分类号： A61M25/09 , A61M2025/09175 , Y10T29/49986 , Y10T29/5187
摘要： A guide wire for use in a medical procedure having a shapeable tip integral with and made from the distal end of a superelastic nitinol distal section of the guide wire, wherein the shapeable tip can be finger kinked. Such a guide wire includes an elongated core made from a superelastic nitinol alloy at the distal end, the distal end of the elongated core having a tapered section leading to a shapeable distal tip. The shapeable tip is an extension of the distal end of the nitinol distal section, and includes permanent strain hardening from at least two different radial directions imparting crystallographic texture in the radial directions that eliminate superelasticity so that permanent deformation can be achieved with finger pressure.
摘要翻译：一种用于医疗过程的导丝，其具有与引导线的超弹性镍钛诺远端部分的远端一体并由远端制成的可成形尖端，其中可成形尖端可以被扭曲。这种导丝包括在远端由超弹性镍钛诺合金制成的细长芯，细长芯的远端具有通向可成形的远端的锥形部分。可成形尖端是镍钛诺骨远端部分的远端的延伸部，并且包括从至少两个不同径向方向的永久性应变硬化，其赋予径向方向上的结晶学结构，从而消除超弹性，从而可以用手指压力实现永久变形。

52. 发明申请

US20120109108A1 NICKEL-TITANIUM CORE GUIDE WIRE 有权
标题翻译：镍铁芯指导线
公开(公告)号：US20120109108A1
公开(公告)日：2012-05-03
申请号：US12914049
申请日：2010-10-28
申请人： William J. Boyle , Wayne E. Cornish , Raleigh A. Purtzer
发明人： William J. Boyle , Wayne E. Cornish , Raleigh A. Purtzer
IPC分类号： A61M25/09 , B21C1/00 , B23P17/00
CPC分类号： A61M25/09 , A61M2025/09175 , Y10T29/49986 , Y10T29/5187
摘要： A guide wire for use in a medical procedure having a shapeable tip integral with and made from the distal end of a superelastic nitinol distal section of the guide wire, wherein the shapeable tip can be finger kinked. Such a guide wire includes an elongated core made from a superelastic nitinol alloy at the distal end, the distal end of the elongated core having a tapered section leading to a shapeable distal tip. The shapeable tip is an extension of the distal end of the nitinol distal section, and includes permanent strain hardening from at least two different radial directions imparting crystallographic texture in the radial directions that eliminate superelasticity so that permanent deformation can be achieved with finger pressure.
摘要翻译：一种用于医疗过程的导丝，其具有与引导线的超弹性镍钛诺远端部分的远端一体并由远端制成的可成形尖端，其中可成形尖端可以被扭曲。这种导丝包括在远端由超弹性镍钛诺合金制成的细长芯，细长芯的远端具有通向可成形的远端的锥形部分。可成形尖端是镍钛诺骨远端部分的远端的延伸部，并且包括从至少两个不同径向方向的永久性应变硬化，其赋予径向方向上的结晶学结构，从而消除超弹性，从而可以用手指压力实现永久变形。

53. 发明授权

US07815660B2 Guide wire with embolic filtering attachment 有权
标题翻译：导丝与栓塞过滤附件
公开(公告)号：US07815660B2
公开(公告)日：2010-10-19
申请号：US12025404
申请日：2008-02-04
申请人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
发明人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008
摘要： A separate deliverable embolic protection device filter that attaches to a helical coil at a distal end of a conventional guide, for use in a blood vessel when an interventional procedure is being performed to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filter assembly with a proximal end and a distal end, and a guide wire connector attached to the distal end of the filter assembly. The guide wire connector is able to couple with the helical coil of the guide wire. A restraining sheath placed over the filter assembly in a coaxial arrangement maintains the filter assembly in a collapsed position and delivers the filter assembly separately to the helical coil of the guide wire, and then the guide wire connector is joined to the helical coil. Alternatively, the guide wire can include a rotatable coil section forming a portion of the distal tip coil on the guide wire which is adapted to be coupled to the filter assembly. This arrangement allows the filter assembly to be rotatably mounted onto the guide wire.
摘要翻译：一种单独的可输送栓塞保护装置过滤器，其连接到常规引导件的远端处的螺旋线圈，用于血管中，当进行介入手术以捕获可能产生并释放到血流中的任何栓塞物质时步骤。该装置包括具有近端和远端的过滤器组件和连接到过滤器组件的远端的导丝连接器。导丝连接器能够与导丝的螺旋线圈耦合。以同轴布置放置在过滤器组件上方的限制护套将过滤器组件保持在折叠位置并将过滤器组件分别输送到导丝的螺旋线圈，然后导丝连接器连接到螺旋线圈。或者，引导线可以包括可旋转的线圈部分，其形成导丝上的远端尖端线圈的一部分，其适于联接到过滤器组件。这种布置允许过滤器组件可旋转地安装在导丝上。

54. 发明授权

US07645242B1 Composite guidewire with drawn and filled tube construction 有权
标题翻译：复合导丝带有拉丝和填充管结构
公开(公告)号：US07645242B1
公开(公告)日：2010-01-12
申请号：US09470874
申请日：1999-12-22
申请人： Marc Mehrzad Jalisi , David M. Anderson , Wayne E. Cornish , Nancy A. Nicotra , Mark T. Richardson
发明人： Marc Mehrzad Jalisi , David M. Anderson , Wayne E. Cornish , Nancy A. Nicotra , Mark T. Richardson
IPC分类号： A61B5/00
CPC分类号： A61M25/09 , A61M2025/09175
摘要： The present invention is directed to an intracorporeal device, preferably a guidewire, and method for making the device. The guidewire of the present invention is formed, at least in part, of a composite elongate core formed, at least in part, of precipitation hardened material. The elongate core members of the present invention will have an ultimate tensile strength and modulus of elasticity greater than the same for an identically dimensioned elongate member formed from superelastic NITINOL alone.
摘要翻译：本发明涉及体内装置，优选导丝，以及制造该装置的方法。本发明的导丝至少部分地形成有至少部分由沉淀硬化材料形成的复合细长芯。对于由超弹性NITINOL单独形成的相同尺寸的细长构件，本发明的细长芯构件将具有大于相同尺寸的极限拉伸强度和弹性模量。

55. 发明申请

US20090131971A1 GUIDE WIRE WITH EMBOLIC FILTERING ATTACHMENT 有权
标题翻译：导线与导线连接
公开(公告)号：US20090131971A1
公开(公告)日：2009-05-21
申请号：US12025404
申请日：2008-02-04
申请人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
发明人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008
摘要： A separate deliverable embolic protection device filter that attaches to a helical coil at a distal end of a conventional guide, for use in a blood vessel when an interventional procedure is being performed to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filter assembly with a proximal end and a distal end, and a guide wire connector attached to the distal end of the filter assembly. The guide wire connector is able to couple with the helical coil of the guide wire. A restraining sheath placed over the filter assembly in a coaxial arrangement maintains the filter assembly in a collapsed position and delivers the filter assembly separately to the helical coil of the guide wire, and then the guide wire connector is joined to the helical coil. Alternatively, the guide wire can include a rotatable coil section forming a portion of the distal tip coil on the guide wire which is adapted to be coupled to the filter assembly. This arrangement allows the filter assembly to be rotatably mounted onto the guide wire.
摘要翻译：一种单独的可输送栓塞保护装置过滤器，其连接到常规引导件的远端处的螺旋线圈，用于血管中，当进行介入手术以捕获可能产生并释放到血流中的任何栓塞物质时步骤。该装置包括具有近端和远端的过滤器组件和连接到过滤器组件的远端的导丝连接器。导丝连接器能够与导丝的螺旋线圈耦合。以同轴布置放置在过滤器组件上方的限制护套将过滤器组件保持在折叠位置并将过滤器组件分别输送到导丝的螺旋线圈，然后导丝连接器连接到螺旋线圈。或者，引导线可以包括可旋转的线圈部分，其形成导丝上的远端尖端线圈的一部分，其适于联接到过滤器组件。这种布置允许过滤器组件可旋转地安装在导丝上。

56. 发明授权

US07455646B2 Polymer coated guide wire 有权
标题翻译：聚合物涂层导丝
公开(公告)号：US07455646B2
公开(公告)日：2008-11-25
申请号：US11768794
申请日：2007-06-26
申请人： Mark T. Richardson , David M. Anderson , Emmanuel C. Biagtan , Lawrence E. Brennan , David H. Burkett , Wayne E. Cornish , Robert C. Esselstein , James Jacobs , Marc M. Jalisi , Daryush P. Mirzaee , Olin J. Palmer , John Schreiner , Kent C. Stalker
发明人： Mark T. Richardson , David M. Anderson , Emmanuel C. Biagtan , Lawrence E. Brennan , David H. Burkett , Wayne E. Cornish , Robert C. Esselstein , James Jacobs , Marc M. Jalisi , Daryush P. Mirzaee , Olin J. Palmer , John Schreiner , Kent C. Stalker
IPC分类号： A61B5/00 , A61M25/00
CPC分类号： A61M25/09 , A61L31/10 , A61L31/18 , A61M25/0045 , A61M25/0054 , A61M2025/09083 , A61M2025/09133 , A61M2025/09166
摘要： A guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal portion of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that is configured to produce a linear change in stiffness of the core over a longitudinal portion of the device. An embodiment has a plurality of radiopaque elements that may be intermittent, continuous or in the form of a helical ribbon for scaled measurement of intracorporeal structure under flouroscopic imaging. Another embodiment has at least one layer of polymer over the distal end of the device.
摘要翻译：具有芯构件等的导丝或其一部分具有多个具有锥形角度的相邻锥形段的构造，以在该装置的纵向部分上产生线性的刚度变化。该装置还可以具有连续变化的锥角的芯部，以产生曲线轮廓，其被配置成在装置的纵向部分上产生芯的刚度的线性变化。一个实施例具有多个不透射线的元件，其可以是间歇的，连续的或以螺旋带的形式，用于在荧光成像下对体内结构进行缩放测量。另一个实施方案在装置的远端上具有至少一层聚合物。

57. 发明授权

US06652472B2 Guidewire with smoothly tapered segment 有权
公开(公告)号：US06652472B2
公开(公告)日：2003-11-25
申请号：US10186858
申请日：2002-07-01
申请人： Mo Jafari , Sepehr Fariabi , Lawrence E. Brennan , Wayne E. Cornish , Marc M. Jalisi , David M. Anderson
发明人： Mo Jafari , Sepehr Fariabi , Lawrence E. Brennan , Wayne E. Cornish , Marc M. Jalisi , David M. Anderson
IPC分类号： A61B500
CPC分类号： A61M25/09 , A61M2025/09175
摘要： A guidewire for intraluminal advancement of a medical device within a patient which has an elongate core member with a flexible body member disposed on a distal section thereof. In one embodiment, the distal section of the elongate core member has at least one flexible segment with at least one pair of opposed tapered or parallel faces. Preferably the flexible segment with the tapered or parallel faces is disposed at the distal end of the elongate core and forms a shapable segment.

58. 发明授权

US06524301B1 Guidewire with an intermediate variable stiffness section 有权
标题翻译：导丝具有中间可变刚度部分
公开(公告)号：US06524301B1
公开(公告)日：2003-02-25
申请号：US09748294
申请日：2000-12-21
申请人： W. Stan Wilson , Robert C. Esselstein , Wayne E. Cornish , Mark T. Richardson
发明人： W. Stan Wilson , Robert C. Esselstein , Wayne E. Cornish , Mark T. Richardson
IPC分类号： A61M2500
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09133
摘要： The invention is directed to an guide wire for intraluminal deployment of a medical device within a patient, the guide wire having an elongate core member with an intermediate core section comprising a plurality of contiguous segments in alignment with the longitudinal axis of the core member with alternating flexible and rigid core segments, so that the articulated section bends in a discontinuous, discrete manner when advanced through a curved blood vessel or other body lumen within the patient. When an obstruction on a vessel wall causes the catheter or other coaxial device to be impeded, the guide wire and intermediate core section may alternately be advanced and retracted a short distance through the catheter distal tip causing a “nodding” motion of the catheter tip while the catheter is pushed through the vessel, so as to avoid and bypass the vessel obstruction.
摘要翻译：本发明涉及一种用于在患者体内腔内部署医疗装置的导丝，所述导丝具有细长的芯部件，所述细长的芯部件具有中间的芯部分，所述中间纤芯部分包括与所述芯部件的纵向轴线对准的多个连续部分，柔性和刚性的芯段，使得铰接部分在通过患者体内的弯曲血管或其他体腔前进时以不连续的离散方式弯曲。当血管壁上的阻塞物导致导管或其它同轴装置被阻碍时，引导线和中间芯部分可以交替地前进并缩回穿过导管远端的短距离，导致导管末端的“点头”运动，同时导管被推过血管，以避免和绕过血管阻塞。

59. 发明授权

US06508781B1 Ultrasonic ablation catheter transmission wire connector assembly 有权
标题翻译：超声波消融导管传输线连接器组件
公开(公告)号：US06508781B1
公开(公告)日：2003-01-21
申请号：US09476749
申请日：1999-12-30
申请人： Lawrence Brennan , Wayne E. Cornish , Douglas H. Gesswein , Martinos Tran
发明人： Lawrence Brennan , Wayne E. Cornish , Douglas H. Gesswein , Martinos Tran
IPC分类号： A61B1720
CPC分类号： A61B17/22012 , A61B2017/00477 , A61B2017/22015
摘要： An ultrasonic angioplasty device includes a catheter and a connector assembly for interconnecting an ultrasound transmission member to an ultrasound transducer. A rotation control device is provided that prevents the ultrasound transmission member from rotating relative to the catheter. Rotation is prevented by a fastener aligning the connector assembly with the elongated catheter body, or a key member that fits in a correspondingly shaped slot in a proximal shaft portion of the catheter, for preventing rotation of the connector assembly relative to the catheter.
摘要翻译：超声波血管成形术装置包括导管和用于将超声波传输构件与超声换能器互连的连接器组件。提供了一种防止超声波传输构件相对于导管旋转的旋转控制装置。通过紧固件将连接器组件与细长的导管主体或者配合在导管的近侧轴部分中的对应形状的槽中的键构件对齐，以防止连接器组件相对于导管的旋转来防止旋转。

60. 发明授权

US06402706B2 Guide wire with multiple polymer jackets over distal and intermediate core sections 有权
标题翻译：导丝与多个聚合物外套在远端和中间芯部分之间
公开(公告)号：US06402706B2
公开(公告)日：2002-06-11
申请号：US09223223
申请日：1998-12-30
申请人： Mark Richardson , Emmanuel C. Biagtan , Wayne E. Cornish
发明人： Mark Richardson , Emmanuel C. Biagtan , Wayne E. Cornish
IPC分类号： A61B500
CPC分类号： A61M25/09 , A61M2025/09091 , A61M2025/09133
摘要： The invention is directed to a guide wire having at least two different polymeric jackets that impart different handling characteristics to the portions of the guide wire they surround. Preferably, the guide wire may have jackets of different grades of polymer, such as polyurethane 55 D and 90 A. Alternatively, the guide wire may have jackets of different types of polymers such as polyurethane and polytetrafluoroethylene, or may have a single polymeric jacket with continuously varying properties along its length. The invention also comprises methods of making such guide wires.
摘要翻译：本发明涉及一种导丝，其具有至少两种不同的聚合物夹克，其赋予它们围绕的导丝的部分不同的处理特性。优选地，导丝可以具有不同等级的聚合物的夹套，例如聚氨酯55D和90A。或者，导丝可以具有不同类型聚合物的夹克，例如聚氨酯和聚四氟乙烯，或者可以具有单个聚合物护套，沿其长度连续变化的特性。本发明还包括制造这种导丝的方法。

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