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51. 发明授权

US07848791B2 Optical coherence tomography apparatus and methods 有权
标题翻译：光学相干断层扫描仪和方法
公开(公告)号：US07848791B2
公开(公告)日：2010-12-07
申请号：US11351896
申请日：2006-02-10
申请人： Joseph M. Schmitt , Amanda Koski , Michael Atlas , Christopher Petersen
发明人： Joseph M. Schmitt , Amanda Koski , Michael Atlas , Christopher Petersen
IPC分类号： A61B6/00
CPC分类号： G01B9/02091 , A61B5/0066 , A61B5/6852 , G01B9/0205 , G01B2290/65 , G01B2290/70 , G01N21/474 , G01N21/4795 , G01N21/8507 , G01N2021/1787 , G01N2021/8514 , G01N2021/8528 , G02B6/262
摘要： In one aspect, the invention relates to an imaging probe. The imaging probe includes an elongate body having a proximal end and distal end, the elongate body adapted to enclose a portion of a slidable optical fiber, the optical fiber having a longitudinal axis; and a first optical assembly attached to a distal end of the fiber. The first optical assembly includes a beam director adapted to direct light emitted from the fiber to a plane at a predetermined angle to the longitudinal axis, a linear actuator disposed at the proximal portion of the elongated body, the actuator adapted to affect relative linear motion between the elongate body and the optical fiber; and a second optical assembly located at the distal portion of the elongate body and attached thereto, the second optical assembly comprising a reflector in optical communication with the first optical assembly, the reflector adapted to direct the light to a position distal to the elongate body.
摘要翻译：一方面，本发明涉及一种成像探针。成像探头包括具有近端和远端的细长主体，细长主体适于包围可滑动光纤的一部分，光纤具有纵向轴线; 以及附接到纤维的远端的第一光学组件。第一光学组件包括光束引导器，其适于将从光纤发射的光引导到与纵向轴线成预定角度的平面;线性致动器，设置在细长主体的近端部分处，致动器适于影响细长体和光纤; 以及第二光学组件，其位于细长主体的远端部分并附接到其上，第二光学组件包括与第一光学组件光学连通的反射器，反射器适于将光引导到远离细长主体的位置。

52. 发明申请

US20090306520A1 Quantitative methods for obtaining tissue characteristics from optical coherence tomography images 审中-公开
标题翻译：从光学相干断层扫描图像获得组织特征的定量方法
公开(公告)号：US20090306520A1
公开(公告)日：2009-12-10
申请号：US12455523
申请日：2009-06-02
申请人： Joseph M. Schmitt , Chenyang Xu
发明人： Joseph M. Schmitt , Chenyang Xu
IPC分类号： A61B6/00
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/7264
摘要： A method and apparatus for determining properties of a tissue or tissues imaged by optical coherence tomography (OCT). In one embodiment the backscatter and attenuation of the OCT optical beam is measured and based on these measurements and indicium such as color is assigned for each portion of the image corresponding to the specific value of the backscatter and attenuation for that portion. The image is then displayed with the indicia and a user can then determine the tissue characteristics. In an alternative embodiment the tissue characteristics is classified automatically by a program given the combination of backscatter and attenuation values.
摘要翻译：用于确定通过光学相干断层摄影（OCT）成像的组织或组织的性质的方法和装置。在一个实施例中，测量OCT光束的后向散射和衰减，并且基于这些测量，并且针对对应于该部分的后向散射和衰减的特定值的图像的每个部分分配诸如颜色的标记。然后用标记显示图像，然后用户可以确定组织特征。在替代实施例中，通过给出反向散射和衰减值的组合的程序，组织特征被自动分类。

53. 发明申请

US20080161696A1 Opto-acoustic imaging devices and methods 有权
标题翻译：光声成像装置及方法
公开(公告)号：US20080161696A1
公开(公告)日：2008-07-03
申请号：US11983417
申请日：2007-11-08
申请人： Joseph M. Schmitt , Christopher Petersen , Toru Ohashi , Tetsuya Nakamatsu
发明人： Joseph M. Schmitt , Christopher Petersen , Toru Ohashi , Tetsuya Nakamatsu
IPC分类号： A61B8/00
CPC分类号： A61B5/0066 , A61B5/0095 , A61B5/6852 , A61B8/12 , A61B8/445 , A61B8/4461
摘要： In one aspect, the invention relates to a probe. The probe includes a sheath, a flexible, bi-directionally rotatable, optical subsystem positioned within the sheath, the optical subsystem comprising a transmission fiber, the optical subsystem capable of transmitting and collecting light of a predetermined range of wavelengths along a first beam having a predetermined beam size. The probe also includes an ultrasound subsystem, the ultrasound subsystem positioned within the sheath and adapted to propagate energy of a predetermined range of frequencies along a second beam having a second predetermined beam size, wherein a portion of the first and second beams overlap a region during a scan.
摘要翻译：一方面，本发明涉及一种探针。探针包括位于护套内的护套，柔性双向可旋转的光学子系统，光学子系统包括传输光纤，该光学子系统能够沿着具有第一光束的第一光束发射和收集预定波长范围的光预定的光束尺寸。所述探针还包括超声子系统，所述超声子系统位于护套内并且适于沿具有第二预定光束尺寸的第二光束传播预定频率范围的能量，其中第一和第二光束的一部分在扫描。

54. 发明授权

US06591122B2 Device and method for monitoring body fluid and electrolyte disorders 有权
公开(公告)号：US06591122B2
公开(公告)日：2003-07-08
申请号：US09810918
申请日：2001-03-16
申请人： Joseph M. Schmitt
发明人： Joseph M. Schmitt
IPC分类号： A61B500
CPC分类号： G01N21/359 , A61B5/0053 , A61B5/0059 , A61B5/02438 , A61B5/14546 , A61B5/4878
摘要： A device and a method for measuring body fluid-related metrics using spectrophotometry to facilitate therapeutic interventions aimed at restoring body fluid balance. The specific body fluid-related metrics include the absolute volume fraction of water in the extravascular and intravascular tissue compartments, as well as the shifts of water between these two compartments. The absolute volume fraction of water is determined using algorithms where received radiation measured at two or more wavelengths are combined to form either a single ratio, a sum of ratios or ratio of ratios of the form log [R(&lgr;1)/R(&lgr;2)] in which the received radiation in the numerator depends primarily on the absorbance of water and the received radiation in the denominator depends primarily on the absorbance of water and the sum of the absorbances of non-heme proteins, lipids and water in tissue. The difference between the fraction of water in the intravascular fluid volume (“IFV”) and extravascular fluid volume (“EFV”) compartments are also determined using a differential method that takes advantage of the observation that pulsations caused by expansion of blood vessels in the skin as the heart beats produce changes in the received radiation at a particular wavelength that are proportional to the difference between the effective absorption of light in the blood and the surrounding tissue. This difference, integrated over time, provides a measure of the quantity of the fluid that shifts into and out of the capillaries. A mechanism for mechanically inducing a pulse is built into the device to improve the reliability of measurements of IFV-EFV under weak-pulse conditions.

55. 发明授权

US06570659B2 Broadband light source system and method and light source combiner 有权
标题翻译：宽带光源系统及方法及光源组合器
公开(公告)号：US06570659B2
公开(公告)日：2003-05-27
申请号：US09811054
申请日：2001-03-16
申请人： Joseph M. Schmitt
发明人： Joseph M. Schmitt
IPC分类号： G01B902
CPC分类号： G02B6/4215 , G01M11/3127 , G01M11/3154 , G01M11/3181 , G02B6/2713 , G02B6/274 , G02B6/2773 , G02B6/2931 , G02B6/29349
摘要： A system for generating a source of broadband light includes, in one embodiment, a plurality of light sources such as SLEDs or edge-emitting luminescent diodes (ELEDs) whose outputs are combined in at least one combiner unit. The combiner unit combines light from a plurality of light sources into a single mode output beam. In one embodiment, the single mode output beam is the input beam to an interferometer for optical coherence tomography. In another embodiment, a time-gain compensation (TGC) unit is in communication with the plurality of light sources. The TGC unit controls the plurality of light sources independently and simultaneously. In one embodiment, control of the plurality of light sources by the TGC unit is in synchrony with the variation in optical delay in the reference arm of the interferometer. The TGC unit may feature, for example, a modulated current regulator.
摘要翻译：在一个实施例中，用于产生宽带光源的系统包括多个光源，例如SLED或边缘发光发光二极管（ELED），其输出组合在至少一个组合器单元中。组合器单元将来自多个光源的光组合成单模输出光束。在一个实施例中，单模输出光束是用于光学相干层析成像的干涉仪的输入光束。在另一个实施例中，时间增益补偿（TGC）单元与多个光源通信。 TGC单元独立地并且同时地控制多个光源。在一个实施例中，TGC单元对多个光源的控制与干涉仪的参考臂中的光学延迟的变化同步。 TGC单元可以具有例如调制电流调节器。

56. 发明授权

US08953911B1 Spectroscopic imaging probes, devices, and methods 有权
标题翻译：光谱成像探针，装置和方法
公开(公告)号：US08953911B1
公开(公告)日：2015-02-10
申请号：US13284369
申请日：2011-10-28
申请人： Chenyang Xu , Joseph M. Schmitt
发明人： Chenyang Xu , Joseph M. Schmitt
IPC分类号： G02B6/26 , G02B6/00
CPC分类号： G02B6/264 , A61B5/0066 , A61B5/0075 , A61B5/0084 , G02B6/00 , G02B6/26 , G02B6/262 , G02B6/3604 , G02B6/4206 , G02B6/4214 , G02B6/4215 , G02B6/4287 , H04B10/0775
摘要： In part, the invention relates to a single clad fiber to multi-clad optical fiber connector for use in applying excitation light to a sample and obtaining reflected light from the sample. The connector can include a dual clad optical fiber portion and a single clad optical fiber portion in optical communication with the dual clad optical fiber portion. In one embodiment, a core of the dual clad optical fiber portion and a core of the single clad optical fiber portion have substantially similar indices of refraction. In one embodiment, excitation light is propagated by the core of the dual clad optical fiber. Further, in one embodiment, light reflected by the sample is propagated by the first cladding layer of the dual clad optical fiber portion.
摘要翻译：部分地，本发明涉及用于向样品施加激发光并获得来自样品的反射光的单包层光纤到多包层光纤连接器。连接器可以包括双包层光纤部分和与双包层光纤部分光通信的单包层光纤部分。在一个实施例中，双包层光纤部分的芯和单包层光纤部分的芯具有基本相似的折射率。在一个实施例中，激发光由双包层光纤的芯传播。此外，在一个实施例中，由样品反射的光由双包层光纤部分的第一包层传播。

57. 发明授权

US08786336B1 Phase-lock loop-based clocking system, methods and apparatus 有权
标题翻译：基于锁相环的计时系统，方法和装置
公开(公告)号：US08786336B1
公开(公告)日：2014-07-22
申请号：US14046462
申请日：2013-10-04
申请人： Joseph M. Schmitt
发明人： Joseph M. Schmitt
IPC分类号： H03L7/06
CPC分类号： H03L7/104 , H03L7/07 , H03L7/0805 , H03L7/093
摘要： In part, the invention relates to an optical coherence tomography system that includes one or more phased-locked loop circuits. In one embodiment, the phased-locked loop circuit includes a phase detector, a loop filter, and a voltage controlled oscillator wherein the phased-locked loop circuit is configured to generate a sample clock. The optical coherence tomography system can include an analog to digital converter having a sample clock input, an interferometric signal input, and a sample data output, the analog to digital converter configured to receive the sample clock and sample OCT data in response thereto. In one embodiment, the phased-locked loop circuit is configured to lock on a first signal in less than or equal to about 1 microseconds.
摘要翻译：部分地，本发明涉及一种包括一个或多个锁相环电路的光学相干断层摄影系统。在一个实施例中，锁相环电路包括相位检测器，环路滤波器和压控振荡器，其中锁相环电路被配置为产生采样时钟。光学相干断层摄影系统可以包括具有采样时钟输入，干涉信号输入和采样数据输出的模数转换器，模数转换器被配置为接收采样时钟并响应于此采样OCT数据。在一个实施例中，锁相环电路被配置为在小于或等于约1微秒内锁定第一信号。

58. 发明授权

US08478384B2 Intravascular optical coherence tomography system with pressure monitoring interface and accessories 有权
标题翻译：血管内光学相干断层扫描系统具有压力监测界面和附件
公开(公告)号：US08478384B2
公开(公告)日：2013-07-02
申请号：US12689724
申请日：2010-01-19
申请人： Joseph M. Schmitt , Christopher Petroff
发明人： Joseph M. Schmitt , Christopher Petroff
IPC分类号： A61B5/00
CPC分类号： A61B5/02154 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/02007 , A61B5/0215 , A61B5/6852 , A61B5/742
摘要： An optical coherence tomography system and method with integrated pressure measurement. In one embodiment the system includes an interferometer including: a wavelength swept laser; a source arm in communication with the wavelength swept laser; a reference arm in communication with a reference reflector; a first photodetector having a signal output; a detector arm in communication with the first photodetector, a probe interface; a sample arm in communication with a first optical connector of the probe interface; an acquisition and display system comprising: an A/D converter having a signal input in communication with the first photodetector signal output and a signal output; a processor system in communication with the A/D converter signal output; and a display in communication with the processor system; and a probe comprising a pressure sensor and configured for connection to the first optical connector of the probe interface, wherein the pressure transducer comprises an optical pressure transducer.
摘要翻译：光学相干断层扫描系统和集成压力测量方法。在一个实施例中，系统包括干涉仪，包括：波长扫描激光; 与波长扫描激光器通信的源臂; 与参考反射器连通的参考臂; 具有信号输出的第一光电检测器; 与第一光电检测器连通的检测器臂，探针接口; 与所述探针接口的第一光学连接器连通的样品臂; 一种采集和显示系统，包括：具有与第一光电检测器信号输出通信的信号输入的信号输出的A / D转换器; 与A / D转换器信号输出通信的处理器系统; 以及与处理器系统通信的显示器; 以及探针，其包括压力传感器并且被配置为连接到所述探针接口的所述第一光学连接器，其中所述压力传感器包括光学压力传感器。

59. 发明申请

US20120310081A1 Multimodal Imaging System, Apparatus, and Methods 有权
标题翻译：多模式成像系统，装置和方法
公开(公告)号：US20120310081A1
公开(公告)日：2012-12-06
申请号：US13484763
申请日：2012-05-31
申请人： Desmond Adler , Joseph M. Schmitt , Mattias Dahlberg , Par Gustafsson , Ulrik Hubinette , Magnus Samuelsson , Johan Svanerudh
发明人： Desmond Adler , Joseph M. Schmitt , Mattias Dahlberg , Par Gustafsson , Ulrik Hubinette , Magnus Samuelsson , Johan Svanerudh
IPC分类号： A61B5/0215 , A61B8/12 , A61B6/02
CPC分类号： A61B5/0035 , A61B5/0044 , A61B5/0046 , A61B5/0066 , A61B5/0084 , A61B5/0215 , A61B5/6852 , A61B6/504 , A61B6/5247 , A61B8/0891 , A61B8/12 , A61B8/4416 , A61B8/4433 , A61B8/5261 , A61B8/54 , A61B2560/0437 , A61B2560/045 , A61B2560/0456 , G06F19/00
摘要： In part, the invention relates to an image data collection system. The system can include an interferometer having a reference arm that includes a first optical fiber of length of L1 and a sample arm that includes a second optical fiber of length of L2 and a first rotary coupler configured to interface with an optical tomography imaging probe, wherein the rotary coupler is in optical communication with the sample arm. In one embodiment, L2 is greater than about 5 meters. The first optical fiber and the second optical fiber can both be disposed in a common protective sheath. In one embodiment, the system further includes an optical element configured to adjust the optical path length of the reference arm, wherein the optical element is in optical communication with the reference arm and wherein the optical element is transmissive or reflective.
摘要翻译：本发明的一部分涉及图像数据收集系统。该系统可以包括具有参考臂的干涉仪，该参考臂包括长度为L1的第一光纤和包括L2长度的第二光纤的样本臂和被配置为与光学层析成像探针接口的第一旋转耦合器，其中旋转耦合器与样品臂光学连通。在一个实施例中，L2大于约5米。第一光纤和第二光纤都可以设置在共同的保护套中。在一个实施例中，该系统还包括配置成调整参考臂的光路长度的光学元件，其中光学元件与参考臂光学连通，并且其中光学元件是透射或反射的。

60. 发明申请

US20110216325A1 Methods and Apparatus for Swept-Source Optical Coherence Tomography 有权
公开(公告)号：US20110216325A1
公开(公告)日：2011-09-08
申请号：US13030886
申请日：2011-02-18
申请人： Joseph M. Schmitt
发明人： Joseph M. Schmitt
IPC分类号： G01B9/02 , H03H9/00 , G02B26/00 , H01S3/10
CPC分类号： G01B9/02091 , A61B5/0066 , A61B5/0073 , G01B9/02004 , G01B9/02043 , G01B9/02069 , G01B2290/25 , G01B2290/60 , H01S3/1062 , H01S5/141 , H01S5/146 , H01S5/5036
摘要： In one embodiment of the invention, a semiconductor optical amplifier (SOA) in a laser ring is chosen to provide low polarization-dependent gain (PDG) and a booster semiconductor optical amplifier, outside of the ring, is chosen to provide high polarization-dependent gain. The use of a semiconductor optical amplifier with low polarization-dependent gain nearly eliminates variations in the polarization state of the light at the output of the laser, but does not eliminate the intra-sweep variations in the polarization state at the output of the laser, which can degrade the performance of the SS-OCT system.

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