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41. 发明申请

US20100056380A1 COMBINATORIAL BIOMINERALIZATION ARRAYS 审中-公开
标题翻译：组合生物自动化阵列
公开(公告)号：US20100056380A1
公开(公告)日：2010-03-04
申请号：US12200893
申请日：2008-08-28
申请人： Dong June Ahn
发明人： Dong June Ahn
IPC分类号： C40B30/00 , C40B40/04 , C40B40/08 , C40B40/10
CPC分类号： C40B40/04 , B01J19/0046 , B01J2219/00527 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2219/0074 , B01J2219/00756 , C40B60/12
摘要： Systems and methods employing combinatorial arrays for revealing factors which control biomineralization processes. An understanding of such control factors may be expected to allow those of skill in the art to mimic biomineralization processes so as to allow manufacture of engineered synthetic biomineralized products, such as artificial bones. Such products would be expected to have structure and properties similar or identical to natural products (e.g., bones), and exhibit improved immunological acceptance when implanted as compared to existing synthetic engineered products.
摘要翻译：使用组合阵列揭示控制生物矿化过程的因素的系统和方法。可以预期了解这些控制因素可以使本领域技术人员模拟生物矿化过程，以便制造工程化的合成生物矿化产品，如人造骨。预期这样的产品将具有与天然产物（例如骨骼）相似或相同的结构和性质，并且与现有的合成工程产品相比，在植入时表现出改善的免疫接受性。

42. 发明申请

US20100048421A1 NANOCOMPOSITE STRUCTURES AND RELATED METHODS AND SYSTEMS 有权
标题翻译：纳米复合结构及相关方法和系统
公开(公告)号：US20100048421A1
公开(公告)日：2010-02-25
申请号：US12540027
申请日：2009-08-12
申请人： Si-Ping HAN , Hareem Maune , Robert D. Barish , William A. Goddard, III
发明人： Si-Ping HAN , Hareem Maune , Robert D. Barish , William A. Goddard, III
IPC分类号： C40B40/04 , C07H21/00 , C40B50/14
CPC分类号： B82B1/00 , B82Y30/00
摘要： The disclosure relates to nanotube composite structures and related methods and systems. In particular, structures, methods and systems are provided herein to allow for precise, tunable separation between nanomaterials such as carbon nanotubes.
摘要翻译：本公开涉及纳米管复合结构及相关方法和系统。特别地，本文提供了结构，方法和系统，以允许诸如碳纳米管之类的纳米材料之间的精确的，可调节的分离。

43. 发明申请

US20100022414A1 Droplet Libraries 审中-公开
标题翻译：液滴图书馆
公开(公告)号：US20100022414A1
公开(公告)日：2010-01-28
申请号：US12504764
申请日：2009-07-17
申请人： Darren Link , Brian Hutchison , Michael Samuels , Michael Weiner
发明人： Darren Link , Brian Hutchison , Michael Samuels , Michael Weiner
IPC分类号： C40B40/10 , C40B40/04 , C40B50/08
CPC分类号： B01F3/0807 , B01F5/0646 , B01F5/0653 , B01F13/0062 , B01F2215/0037 , B01J19/0046 , B01J2219/00286 , B01J2219/00351 , B01J2219/00418 , B01J2219/00479 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00599 , B01J2219/0065 , B01J2219/00657 , B01J2219/00664 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/0074 , B01J2219/00743 , B01L3/502761 , B01L7/52 , B01L2200/027 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0681 , B01L2300/0864 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , C40B40/04 , C40B50/08 , G01N15/1459 , G01N33/5008 , G01N2015/1006 , G01N2500/00 , Y02A90/26
摘要： The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.
摘要翻译：本发明一般涉及液滴库以及用于形成液滴库的系统和方法。本发明还涉及在各种生物，化学或诊断测定中利用这些液滴文库的方法。

44. 发明申请

US20100016286A1 Anti-Inflammatory Agents 失效
标题翻译：抗炎药
公开(公告)号：US20100016286A1
公开(公告)日：2010-01-21
申请号：US11922277
申请日：2006-06-14
申请人： David J. Grainger , David John Fox
发明人： David J. Grainger , David John Fox
IPC分类号： A61K31/55 , C40B40/04 , A61K31/44 , A61K31/40 , C07D223/12 , C07D211/00 , C07D207/00 , A61P29/00
CPC分类号： C07D223/12 , A61K31/4015 , A61K31/45 , A61K31/55 , C07D207/267 , C07D207/273 , C07D211/76
摘要： The invention provides compounds, pharmaceutical compositions and uses of compounds and salts thereof of general formula (I), for the preparation of a medicament for treatment of an inflammatory disorder, but excluding (S)-3-(r-methylcyclohexyl-carbonylamino)-caprolactam: wherein z is 1, 2, 3 or 4; A is —CO— or —SO2-; Q is linear or branched alkyl, alkenyl, alkynyl, alkoxy, oxyalkyl, aminoalkyl, alkylamino, alkylaminoalkyl, haloalkyl, aryl or substituted aryl; T1 and T2 together constitute a cycloalkyl, cycloalkenyl or polycycloalkyl radical composed of n additional carbon atoms, where n is between 2 and 7; and each hydrogen atom bonded to the carbon atoms in the ring generated by T1 and T2 may be independently be substituted by a group R1, where R1 is independently selected from an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radical of 1 to 20 carbon atoms; or each R1 is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl or aminodialkyl radical.
摘要翻译：本发明提供了通式（I）化合物及其盐的化合物，药物组合物及其用途，用于制备治疗炎症性疾病但不包括（S）-3-（R-甲基环己基 - 羰基氨基） - 己内酰胺：其中z为1,2,3或4; A是-CO-或-SO 2 - ; Q是直链或支链烷基，烯基，炔基，烷氧基，烷氧基，氨基烷基，烷基氨基，烷基氨基烷基，卤代烷基，芳基或取代的芳基; T1和T2一起构成由n个另外的碳原子组成的环烷基，环烯基或多环烷基，其中n在2和7之间; 并且与由T1和T2生成的环中与碳原子键合的每个氢原子可以独立地被基团R 1取代，其中R 1独立地选自烷基，卤代烷基，烷氧基，卤代烷氧基，烯基，炔基或烷基氨基至20个碳原子; 或每个R 1独立地选自氟，氯，溴，碘，羟基，氧烷基，氨基，氨基烷基或氨基二烷基。

45. 发明申请

US20090318309A1 Thermo-reversibly gelled colloidal suspensions and a process for making the same 审中-公开
标题翻译：热可逆胶凝胶体悬浮液及其制备方法
公开(公告)号：US20090318309A1
公开(公告)日：2009-12-24
申请号：US12386335
申请日：2009-04-16
申请人： Kyle William Kimble , Jeremy Paul Walker , Sanlord Abraham Asher
发明人： Kyle William Kimble , Jeremy Paul Walker , Sanlord Abraham Asher
IPC分类号： C40B40/14 , C40B40/04 , B01J13/00
CPC分类号： C40B40/14 , B01J13/0065
摘要： Disclosed is a thermoreversible synthesis of a new type of material made by embedding a colloidal population within a thermo-reversibly gelled polymer. The polymer may be a physically cross-linked PVA hydrogel. PVA hydrogels are non-toxic, biocompatible, mechanically robust, and elastic. The present invention TGCCA diffraction is similar to that of photo-polymerized PCCA. The present invention TGCCA can be irreversibly covalently cross-linked using glutaraldehyde. The cross-linked TGCCA can be made responsive to chemical stimuli by functionalizing the hydrogel hydroxyl groups. The diffraction of carboxyl or amine functionalized TGCCA was monitored as a function of the pH and determined diffraction wavelengths titrate with the pKa of the functional group. It was also demonstrated that TGCCA could be fabricated in arbitrarily large volumes and shapes. The present invention method fabricates inexpensive homogenously diffracting chemically modifiable TGCCA.
摘要翻译：公开了通过将胶体体嵌入热可逆胶凝聚合物制备的新型材料的热可逆合成。聚合物可以是物理交联的PVA水凝胶。 PVA水凝胶是无毒的，生物相容的，机械坚固的和弹性的。本发明TGCCA衍射与光聚合PCCA相似。本发明TGCCA可以用戊二醛不可逆地共价交联。通过官能化水凝胶羟基，交联TGCCA可以对化学刺激作出反应。监测羧基或胺官能化TGCCA的衍射作为pH的函数，并用官能团的pKa测定衍射波长滴定度。还表明，TGCCA可以以任意大的体积和形状制造。本发明方法制造廉价的均匀衍射化学修饰的TGCCA。

46. 发明申请

US20090286693A1 MICROARRAYS OF TAGGED COMBINATORIAL TRIAZINE LIBRARIES 审中-公开
标题翻译：标签组合图书馆的微观
公开(公告)号：US20090286693A1
公开(公告)日：2009-11-19
申请号：US12469517
申请日：2009-05-20
申请人： Young-Tae CHANG , Ho-Sang Moon
发明人： Young-Tae CHANG , Ho-Sang Moon
IPC分类号： C40B30/04 , C40B40/04
CPC分类号： C07D251/40 , C07B2200/11 , C07D251/48 , C07D251/54 , C40B40/04 , G01N33/54353 , G01N33/6803
摘要： Triazine linkers can be used to prepare universal small molecule chips for functional proteomics and sensors. These triazine linker compounds are prepared by making a first building block by adding a first amine by reductive amination of triazine, making a second building block by adding a second amine to cyanuric chloride, and combining the first and second building blocks by aminating the first building block onto one of the chloride positions of the second building block. These triazine linkers are then linked to a substrate for determining binding affinity of proteins.
摘要翻译：三嗪接头可用于制备功能蛋白质组学和传感器的通用小分子芯片。这些三嗪连接体化合物是通过通过三嗪的还原胺化加入第一胺制备第一组合物来制备的，通过向氰尿酰氯中加入第二种胺而形成第二种结构单元，并将第一和第二组合物通过胺化第一建筑物阻挡在第二构建块的氯化物位置之一上。然后将这些三嗪接头连接到底物以确定蛋白质的结合亲和力。

47. 发明申请

US20090264317A1 Functionalized nanostructure, methods of manufacture thereof and articles comprising the same 审中-公开
标题翻译：官能化纳米结构体，其制造方法和包含其的制品
公开(公告)号：US20090264317A1
公开(公告)日：2009-10-22
申请号：US12421259
申请日：2009-04-09
申请人： Yuval Ofir , Vincent Martin Rotello , Brian John Jordan , Kenneth Raymond Carter
发明人： Yuval Ofir , Vincent Martin Rotello , Brian John Jordan , Kenneth Raymond Carter
IPC分类号： C40B50/14 , C40B30/00 , C40B40/04 , C40B40/06 , C40B40/10 , B29C35/08 , B32B3/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y30/00 , B82Y40/00 , H05K3/102 , H05K3/389 , H05K2201/0257 , H05K2203/0108 , H05K2203/0522 , Y10T428/24802
摘要： Disclosed is a method comprising disposing a functionalized patternable material on a substrate, wherein the functionalized patternable material comprises a first click chemical moiety; patterning the functionalized patternable material; and reacting the first click chemical moiety with a complementary reactant to form an functionalized patterned surface, the complementary reactant comprising a second click chemical moiety that reacts with the first click chemical moiety; the complementary reactant comprising an functional group.
摘要翻译：公开了一种方法，包括将功能化的可图案材料设置在基底上，其中所述官能化可图案材料包括第一点击化学部分; 图案化功能化图案化材料; 并且使所述第一点击化学部分与互补反应物反应以形成官能化图案化表面，所述互补反应物包含与所述第一点击化学部分反应的第二点击化学部分; 包含官能团的互补反应物。

48. 发明申请

US20090137411A1 Methods and biochips for detecting small molecule compounds 审中-公开
标题翻译：检测小分子化合物的方法和生物芯片
公开(公告)号：US20090137411A1
公开(公告)日：2009-05-28
申请号：US10593908
申请日：2005-03-28
申请人： Yimin Sun , Wanli Xing , Guoqing Wang , Hongwu Du , Rong Zhang , Yuan Lu , Yan Wang , Jing Cheng
发明人： Yimin Sun , Wanli Xing , Guoqing Wang , Hongwu Du , Rong Zhang , Yuan Lu , Yan Wang , Jing Cheng
IPC分类号： C40B30/04 , C40B40/04 , C40B50/18
CPC分类号： G01N33/543 , B01J2219/00387 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00659 , B01J2219/0072 , C40B60/14 , G01N33/54366
摘要： The present invention discloses methods for detection of small molecule compounds and its specific biochips. Biochips of the present invention comprise a solid support and carrier-linked small molecules immobilized onto the solid support. The invention also provides methods and kits for detection of small molecule compounds using the biochips of the invention.
摘要翻译：本发明公开了小分子化合物及其特定生物芯片的检测方法。本发明的生物芯片包含固体支持物和固定在固体支持物上的载体连接的小分子。本发明还提供了使用本发明的生物芯片检测小分子化合物的方法和试剂盒。

49. 发明申请

US20090136932A1 FIBERS WITH ISOLATED BIOMOLECULES AND USES THEREOF 审中-公开
标题翻译：具有分离生物分子的纤维及其用途
公开(公告)号：US20090136932A1
公开(公告)日：2009-05-28
申请号：US12049149
申请日：2008-03-14
申请人： Harold G. Craighead , Leon M. Bellan
发明人： Harold G. Craighead , Leon M. Bellan
IPC分类号： C12Q1/68 , C07H21/00 , C07H21/02 , C07H21/04 , C07K2/00 , C07C53/00 , B32B5/02 , C40B40/04 , B01J19/00 , G01N21/00 , B29C47/00 , C07H1/00 , C07K1/00
CPC分类号： C12Q1/6874 , B01J2219/00511 , B01J2219/00524 , B01J2219/00576 , B01J2219/00596 , B01J2219/00657 , B01J2219/00666 , B01J2219/00702 , B01J2219/00722 , C07H1/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K1/14 , D01D5/0007 , G01N2021/6432 , G01N2021/7723 , G01N2021/773 , G01N2021/7786 , H01J47/00 , Y10T428/298
摘要： The present invention relates to compositions, methods, and uses for isolated biomolecule-containing fibers. The invention also relates to isolated, elongated biopolymers such as nucleic acids, polypeptides, lipids, and carbohydrates within fibers. The invention relates to methods of detecting and analyzing biomolecules in fibers using light, electrons, and neutrons. The invention further relates to methods of determining the sequence, structure, and properties of isolated, elongated biopolymers fixed within fibers.
摘要翻译：本发明涉及用于分离的含有生物分子的纤维的组合物，方法和用途。本发明还涉及分离的细长生物聚合物，例如纤维内的核酸，多肽，脂质和碳水化合物。本发明涉及使用光，电子和中子检测和分析纤维中生物分子的方法。本发明还涉及确定固定在纤维内的分离的细长生物聚合物的顺序，结构和性质的方法。

50. 发明申请

US20090048123A1 Reagentless and Reusable Biosensors with Tunable Differential Binding Affinities and Methods of Making 有权
标题翻译：具有可调节差异结合亲和力的制剂和可重复使用的生物传感器和制备方法
公开(公告)号：US20090048123A1
公开(公告)日：2009-02-19
申请号：US12103778
申请日：2008-04-16
申请人： Igor L. Medintz , Ellen R. Goldman , George P. Anderson , J. Matthew Mauro
发明人： Igor L. Medintz , Ellen R. Goldman , George P. Anderson , J. Matthew Mauro
IPC分类号： C40B40/04 , G01N21/64 , C12M1/00 , C40B50/00
CPC分类号： C12Q1/6818 , B82Y5/00 , B82Y10/00 , C12Q1/6825 , G01N21/6428 , G01N2021/6441 , C12Q2565/607 , C12Q2565/101
摘要： The biosensor comprises a modular biorecognition element and a modular flexible arm element. The biorecognition element and the flexible arm element are each labeled with a signaling element. The flexible arm contains an analog of an analyte of interest that binds with the biorecognition element, bringing the two signaling elements in close proximity, which establishes a baseline fluorescence resonance energy transfer (FRET). When an analyte of interest is provided to the biosensor, the analyte will displace the analyte analog, and with it, the signaling module of the modular flexible arm, causing a measurable change in the FRET signal in a analyte concentration dependent manner. The modularity of different portions of the biosensor allows functional flexibility. The biosensor operates without additional development reagents, requiring only the presence of analyte or target for function.
摘要翻译：生物传感器包括模块化生物识别元件和模块化柔性臂元件。生物识别元件和柔性臂元件各自用信号元件标记。柔性臂包含与生物识别元件结合的感兴趣分析物的类似物，使得两个信号元件紧密相邻，这建立了基线荧光共振能量转移（FRET）。当感兴趣的分析物被提供给生物传感器时，分析物将置换分析物类似物，并且借助于该模块化柔性臂的信号模块，以分析物浓度依赖的方式引起FRET信号的可测量的变化。生物传感器的不同部分的模块化允许功能灵活性。生物传感器无需额外的开发试剂即可运行，仅需要分析物或靶标的存在才能发挥作用。

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