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1. 发明申请

US20090318309A1 Thermo-reversibly gelled colloidal suspensions and a process for making the same 审中-公开
标题翻译：热可逆胶凝胶体悬浮液及其制备方法
公开(公告)号：US20090318309A1
公开(公告)日：2009-12-24
申请号：US12386335
申请日：2009-04-16
申请人： Kyle William Kimble , Jeremy Paul Walker , Sanlord Abraham Asher
发明人： Kyle William Kimble , Jeremy Paul Walker , Sanlord Abraham Asher
IPC分类号： C40B40/14 , C40B40/04 , B01J13/00
CPC分类号： C40B40/14 , B01J13/0065
摘要： Disclosed is a thermoreversible synthesis of a new type of material made by embedding a colloidal population within a thermo-reversibly gelled polymer. The polymer may be a physically cross-linked PVA hydrogel. PVA hydrogels are non-toxic, biocompatible, mechanically robust, and elastic. The present invention TGCCA diffraction is similar to that of photo-polymerized PCCA. The present invention TGCCA can be irreversibly covalently cross-linked using glutaraldehyde. The cross-linked TGCCA can be made responsive to chemical stimuli by functionalizing the hydrogel hydroxyl groups. The diffraction of carboxyl or amine functionalized TGCCA was monitored as a function of the pH and determined diffraction wavelengths titrate with the pKa of the functional group. It was also demonstrated that TGCCA could be fabricated in arbitrarily large volumes and shapes. The present invention method fabricates inexpensive homogenously diffracting chemically modifiable TGCCA.
摘要翻译：公开了通过将胶体体嵌入热可逆胶凝聚合物制备的新型材料的热可逆合成。聚合物可以是物理交联的PVA水凝胶。 PVA水凝胶是无毒的，生物相容的，机械坚固的和弹性的。本发明TGCCA衍射与光聚合PCCA相似。本发明TGCCA可以用戊二醛不可逆地共价交联。通过官能化水凝胶羟基，交联TGCCA可以对化学刺激作出反应。监测羧基或胺官能化TGCCA的衍射作为pH的函数，并用官能团的pKa测定衍射波长滴定度。还表明，TGCCA可以以任意大的体积和形状制造。本发明方法制造廉价的均匀衍射化学修饰的TGCCA。

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