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41. 发明授权

US09302043B2 Socketed portal anchors and methods of using same 有权
标题翻译：插座门户锚和使用方法
公开(公告)号：US09302043B2
公开(公告)日：2016-04-05
申请号：US13795937
申请日：2013-03-12
申请人： Medtronic, Inc.
发明人： Brian D. Nelson
IPC分类号： A61M25/02 , A61M5/158 , A61M39/02 , A61M25/00 , A61M5/142
CPC分类号： A61M5/158 , A61M5/14276 , A61M25/02 , A61M39/0247 , A61M2025/0042 , A61M2025/024 , A61M2025/0246 , A61M2025/0273 , A61M2025/028 , A61M2025/0286 , A61M2039/025 , A61M2039/027 , A61M2039/0273 , A61N1/0539
摘要： Anchors for securing a medical device relative to a body portal, wherein the anchors may accommodate most any implantation trajectory through the portal. Such anchors may further secure the device along any such trajectory without imparting undesirable biasing forces that may shift the device from its intended implanted location. In some embodiments, the anchor is configured as a burr hole anchor including a spherical member contained in a socket of the anchor wherein the socket may be collapsed to lock the spherical member along a particular trajectory.
摘要翻译：用于固定医疗装置相对于身体门静脉的锚点，其中所述锚可以适应大部分通过所述入口的任何植入轨迹。这样的锚固件可以沿着任何这样的轨迹进一步固定装置，而不会施加不期望的偏置力，这可能使装置从其预期的植入位置移动。在一些实施例中，锚固件被构造为钻孔锚固件，其包括包含在锚固件的插座中的球形构件，其中插座可以被折叠以沿着特定轨迹锁定球形构件。

42. 发明授权

US09295735B2 Liposomal composition for convection-enhanced delivery to the central nervous centre 有权
标题翻译：用于对流增强输送到中枢神经中心的脂质体组成
公开(公告)号：US09295735B2
公开(公告)日：2016-03-29
申请号：US13130525
申请日：2009-11-23
申请人： Thomas Redelmeier , Matthias Luz
发明人： Thomas Redelmeier , Matthias Luz
IPC分类号： A61K9/127 , A61K49/00 , A61K9/00 , A61K31/4745 , A61M25/00
CPC分类号： A61K49/0084 , A61K9/0019 , A61K9/127 , A61K31/4745 , A61K49/0023 , A61K49/0041 , A61M25/007 , A61M2025/0042
摘要： Convection-enhanced delivery (CED) is used as a method to deliver a direct infusion of therapeutic agents to the central nervous center thus circumventing the blood-blood barrier. A non-PEGylated liposomal composition comprising at least one saturated neutral phospholipid and at least one saturated anionic phospholipid and a therapeutic or diagnostic agent encapsulated therein is used to overcome toxicity associated with high peak drug concentration delivered locally CED as well as to increase tissue distribution volume for an improved sustained drug release. In one embodiment, the liposome composition comprises a molar ratio of DSPC:DSPG:CHOL of 7:2:1 and the therapeutic or diagnostic agent is selected from topotecan, conotoxin, gadodiamide or rhodamine, and is used in the treatment of epilepsy.
摘要翻译：对流增强递送（CED）用作将治疗剂直接输注到中枢神经中枢的方法，从而绕过血液屏障。使用包含至少一种饱和中性磷脂和至少一种饱和阴离子磷脂和其中包封的治疗或诊断剂的非PEG化脂质体组合物来克服与局部CED递送的高峰药物浓度相关的毒性以及增加组织分布体积用于改善持续的药物释放。在一个实施方案中，脂质体组合物包含7:2:1的DSPC:DSPG:CHOL的摩尔比，治疗或诊断剂选自拓扑替康，芋螺毒素，钆二胺或罗丹明，并用于治疗癫痫。

43. 发明授权

US09295540B2 Dynamic microvalve protection device with associated balloon element for therapeutic intravascular procedures 有权
标题翻译：动态微型阀保护装置与相关联的气囊元件用于治疗性血管内手术
公开(公告)号：US09295540B2
公开(公告)日：2016-03-29
申请号：US14164988
申请日：2014-01-27
申请人： Surefire Medical, Inc.
发明人： James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally , Brett E. Naglreiter , Norman R. Weldon , Bryan M. Pinchuk
IPC分类号： A61F2/24 , A61F2/01 , A61M25/00 , A61M25/06
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0076 , A61F2230/008 , A61M25/005 , A61M25/0075 , A61M2025/0004 , A61M2025/0042 , A61M2025/0076 , A61M2025/0681
摘要： An apparatus includes a delivery catheter having a deployable dynamic valve that rapidly opens and closes in response to relative fluid pressure thereabout. The valve is maintained in a collapsed configuration during introduction to a treatment site. A balloon element is provided between the delivery catheter and the valve and is adapted such that upon inflation it can move the valve from the collapsed configuration to a deployed configuration.
摘要翻译：一种装置包括具有可展开的动态阀的输送导管，其响应于其周围的相对流体压力快速地打开和关闭。在引入治疗部位期间，瓣膜保持收缩构型。气囊元件设置在输送导管和阀之间，并且适于使得在充气时，其可将阀从折叠构型移动到展开构型。

44. 发明授权

US09271833B2 Transcatheter coronary sinus mitral valve annuloplasty procedure and coronary artery and myocardial protection device 有权
标题翻译：经导管冠状窦二尖瓣瓣环成形术和冠状动脉及心肌保护装置
公开(公告)号：US09271833B2
公开(公告)日：2016-03-01
申请号：US13468761
申请日：2012-05-10
申请人： June-Hong Kim , Robert J. Lederman , Ozgur Kocaturk
发明人： June-Hong Kim , Robert J. Lederman , Ozgur Kocaturk
IPC分类号： A61F2/24 , A61F2/06 , A61M25/00
CPC分类号： A61F2/2451 , A61F2/06 , A61F2002/068 , A61F2210/0014 , A61F2220/0075 , A61F2230/0045 , A61F2250/0037 , A61F2250/0065 , A61M25/0041 , A61M2025/0042 , A61M2025/0059
摘要： A protective device or bridge comprising a central arch is suitable to be placed between an annuplasty device placed in the coronary sinus and an underlying coronary artery to inhibit transmission of compressive force on the coronary artery by the annuplasty device.
摘要翻译：包括中央拱形物的保护装置或桥梁适于放置在放置在冠状窦内的平喘装置和下面的冠状动脉之间，以通过平喘装置阻止冠状动脉上的压力传递。

45. 发明申请

US20150335345A1 METHOD AND APPARATUS FOR PLACING A CATHETER WITHIN A VASCULATURE 审中-公开
标题翻译：用于在血管中放置导管的方法和装置
公开(公告)号：US20150335345A1
公开(公告)日：2015-11-26
申请号：US14813173
申请日：2015-07-30
申请人： Roxwood Medical, Inc.
发明人： Mehrdad FARHANGNIA , John MILLER , Mark TABER , Mark C. YANG
IPC分类号： A61B17/3207 , A61M25/10 , A61B17/22 , A61M25/09
CPC分类号： A61B17/3207 , A61B2017/22042 , A61B2017/22044 , A61B2017/22069 , A61B2017/22094 , A61M25/04 , A61M25/104 , A61M2025/0042 , A61M2025/09175 , A61M2025/09183
摘要： A catheter for insertion into vasculature of a patient to a target area in the vasculature includes a hollow inner shaft, a non-occluding self-expandable scaffold coupled to the distal end of the inner shaft and disposed at the distal end of the inner shaft, and a hollow outer shaft. The outer shaft is slidable over the inner shaft and scaffold such that the scaffold is in a non-expanded state when the outer shaft is around the scaffold. The outer shaft has a state where the distal end of the outer shaft remains near the target area without the inner shaft and the scaffold being within the outer shaft. The inner shaft and the scaffold are removable through the proximal end of the outer shaft while the distal end of the outer shaft remains near the target area.
摘要翻译：将用于插入脉管系统的患者的导管插入脉管系统中的目标区域包括中空内轴，联接到内轴的远端并设置在内轴的远端处的非闭塞自扩张式脚手架，和中空的外轴。外轴可以在内轴和支架上滑动，使得当外轴在支架周围时，支架处于非膨胀状态。外轴具有外轴的远端保持在目标区域附近而没有内轴并且支架位于外轴内的状态。内轴和支架可以通过外轴的近端移除，而外轴的远端保持在目标区域附近。

46. 发明申请

US20150238685A1 Method and System for Enhanced Imaging Visualization of Deep Brain Anatomy Using Infusion 审中-公开
标题翻译：使用输液增强成像可视化深层解剖学的方法与系统
公开(公告)号：US20150238685A1
公开(公告)日：2015-08-27
申请号：US14429592
申请日：2013-09-18
申请人： William J. ELIAS , Aaron E. BOND , George T. GILLIES
发明人： William J. Elias , Aaron E. Bond , George T. Gillies
IPC分类号： A61M5/00 , A61M25/10 , A61M25/00 , A61B5/055 , A61N1/36
CPC分类号： A61M5/007 , A61B5/0042 , A61B5/055 , A61B6/032 , A61B6/12 , A61B6/481 , A61B6/501 , A61M25/0026 , A61M25/007 , A61M25/0127 , A61M25/10 , A61M25/1002 , A61M31/005 , A61M2025/0037 , A61M2025/0042 , A61M2025/105 , A61M2025/1052 , A61M2025/1093 , A61N1/36139 , G01R33/285
摘要： Provided is a method and system for delivering a diagnostic agent to a site in the brain of a subject for imaging at least a portion of the brain site on a medical imaging system. The method and system includes a catheter device with associated lumens having diagnostic agent ports for delivering the diagnostic agent (e.g., infusate) through the lumens and advancing the diagnostic agent so as to exit out from the lumens to at least a portion of the brain site and while sealing a portion of the brain site thereby preventing the exited diagnostic agent from travelling proximally beyond the sealing location, and at the same time imaging at least a portion of the brain site during at least a portion of the sealing duration so that the brain site can be visualized on a medical imaging system. The diagnostic agent (infusate) is able to highlight borders and internal patterns of the deep structures of the brain thereby enabling direct targeting. Ultimately this leads to reduced complications, enhanced therapy, and the elimination of the need for awake surgery. The method and system provides the capability heretofore not possible to visualize the small, often indistinct regions, which will greatly improve clinical outcomes with therapeutic interventions.
摘要翻译：提供了一种用于将诊断剂递送到受试者脑中的位置以在医学成像系统上成像脑部位的至少一部分的方法和系统。所述方法和系统包括具有相关联腔的导管装置，所述导管装置具有诊断剂端口，用于将诊断剂（例如，输注液体）输送通过管腔并推进诊断剂以便从腔内离开至脑部位的至少一部分并且同时密封脑部位的一部分，从而防止被退出的诊断剂向近侧移动超过密封位置，并且同时在至少一部分密封持续时间期间对脑部位的至少一部分进行成像，使得大脑现场可以在医学成像系统上显现。诊断剂（输注物）能够突出大脑深层结构的边界和内部模式，从而实现直接靶向。最终导致并发症减少，治疗加强，消除了清醒手术的需要。该方法和系统提供了迄今为止不可能将小的，通常不清楚的区域可视化的能力，这将大大改善临床结果与治疗干预。

47. 发明申请

US20150209063A1 SYSTEMS, METHODS AND DEVICES FOR ABLATION, CROSSING, AND CUTTING OF OCCLUSIONS 审中-公开
标题翻译：系统，消除，交叉和切割的系统，方法和设备
公开(公告)号：US20150209063A1
公开(公告)日：2015-07-30
申请号：US14682782
申请日：2015-04-09
申请人： ReFlow Medical, Inc.
发明人： Isa Rizk , John Fulkerson
IPC分类号： A61B17/3207
CPC分类号： A61B17/3207 , A61B2017/22094 , A61F2/95 , A61M25/0021 , A61M29/02 , A61M2025/0042
摘要： Ablation, crossing, and cutting systems, devices and associated methods, including a crossing device, comprising, in combination: a spring-enhanced handle and body configured to controllably extend and retract a blade within a microcatheter for addressing an occlusion within a vessel of a patient to provide improved access for supplemental treatment and reperfusion.
摘要翻译：消融，交叉和切割系统，装置和相关方法，包括交叉装置，其组合包括：弹簧增强的手柄和主体，其构造成可控制地延伸和缩回微导管内的叶片，用于解决在一个患者为补充治疗和再灌注提供改进的途径。

48. 发明授权

US09067332B2 Micro-fabricated catheter devices formed with hybrid materials 有权
标题翻译：用混合材料形成的微型导管装置
公开(公告)号：US09067332B2
公开(公告)日：2015-06-30
申请号：US12753831
申请日：2010-04-02
申请人： John Lippert , Edward J. Snyder
发明人： John Lippert , Edward J. Snyder
IPC分类号： A61M25/00 , B26F1/00 , A61M25/09 , B26D5/20
CPC分类号： A61M25/09 , A61M25/0009 , A61M25/0013 , A61M25/0045 , A61M25/0051 , A61M25/0053 , A61M25/0097 , A61M2025/0042 , A61M2025/0081 , A61M2025/09091 , A61M2025/09108 , A61M2025/09133 , B26D5/20 , B26F1/0053 , B26F1/0061
摘要： A catheter device is disclosed including an elongated outer member having a plurality of resultant beams of substantially identical thickness along a length of the outer member, where each resultant beam from among the plurality of resultant beams is formed between two simultaneously cut fenestrations on substantially opposite sides of the outer member, the outer member having an outer surface and an interior surface forming a lumen extending from a proximal end to a distal end, where the outer member is formed from two or more different stock materials.
摘要翻译：公开了一种导管装置，其包括细长外部构件，其具有沿外部构件的长度具有基本相同厚度的多个合成梁，其中来自多个合成梁的每个合成梁形成在基本上相对的两侧的两个同时切割的开窗所述外部构件具有外表面和形成从近端延伸到远端的内腔的内表面，其中所述外部构件由两种或更多种不同的原料形成。

49. 发明申请

US20150173782A1 Methods and Systems for Treatment of Acute Ischemic Stroke 有权
标题翻译：治疗急性缺血性卒中的方法与系统
公开(公告)号：US20150173782A1
公开(公告)日：2015-06-25
申请号：US14576953
申请日：2014-12-19
申请人： Silk Road Medical, Inc.
发明人： Michi E. Garrison , Tony M. Chou
IPC分类号： A61B17/22 , A61M25/06 , A61M25/00 , A61M29/00
CPC分类号： A61M25/0054 , A61B17/22 , A61B17/320758 , A61B17/3417 , A61B2017/00867 , A61B2017/00991 , A61B2017/22034 , A61B2017/22038 , A61B2017/22039 , A61B2017/22042 , A61B2017/22054 , A61B2017/22062 , A61B2017/22067 , A61B2017/22072 , A61B2017/22074 , A61B2017/22079 , A61B2017/22082 , A61B2017/22084 , A61B2017/22094 , A61B2017/2212 , A61B2017/2215 , A61B2017/2217 , A61B2017/320775 , A61B2017/3484 , A61B2017/3486 , A61B2090/062 , A61F2/013 , A61M25/0023 , A61M25/0041 , A61M25/0043 , A61M25/0068 , A61M25/007 , A61M25/01 , A61M25/0662 , A61M29/00 , A61M2025/0004 , A61M2025/0037 , A61M2025/0042 , A61M2025/0175 , A61M2025/0681 , A61M2025/1052 , A61M2210/12
摘要： A system of devices for treating an artery includes an arterial access sheath adapted to introduce an interventional catheter into an artery and an elongated dilator positionable within the internal lumen of the sheath body. The system also includes a catheter formed of an elongated catheter body sized and shaped to be introduced via a carotid artery access site into a common carotid artery through the internal lumen of the arterial access sheath. The catheter has an overall length and a distal most section length such that the distal most section can be positioned in an intracranial artery and at least a portion of the proximal most section is positioned in the common carotid artery during use.
摘要翻译：用于治疗动脉的装置系统包括适于将介入导管引入动脉的动脉通路鞘和可定位在鞘体的内腔内的细长扩张器。该系统还包括由细长的导管体形成的导管，该导管的尺寸和形状被设计成经由颈动脉进入部位通过动脉通路鞘的内腔引入颈总动脉。导管具有整体长度和最远端部分长度，使得最远侧部分可以定位在颅内动脉中，并且最近部分的至少一部分在使用期间位于颈总动脉中。

50. 发明授权

US08979801B2 Microcatheter devices and methods for targeted substance delivery 有权
标题翻译：用于靶向物质输送的微导管装置和方法
公开(公告)号：US08979801B2
公开(公告)日：2015-03-17
申请号：US11279771
申请日：2006-04-14
申请人： Theodore Lamson , Patrick Macaulay
发明人： Theodore Lamson , Patrick Macaulay
IPC分类号： A61M5/178 , A61M25/00 , A61B18/14 , A61B17/00 , A61B18/00
CPC分类号： A61M25/007 , A61B18/1477 , A61B2017/00247 , A61B2018/00392 , A61B2018/1425 , A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M25/0069 , A61M25/0082 , A61M25/0084 , A61M2025/0042 , A61M2025/0092 , A61M2025/0096
摘要： Delivery catheters useable to deliver substances, articles or devices to target locations within the bodies of human or animal subjects. The delivery catheter generally comprises a catheter having a tissue penetrating distal tip member on the distal end and one or more delivery aperture(s) whereby a substance, article or device may be delivered through the lumen of the catheter body and out of the delivery aperture(s). In some applications, the substance delivery catheter is used in combination with a transluminal tissue penetrating catheter having a penetrator that is advanced to a first location. The delivery catheter is then advanced through (or over) the penetrator, through intervening tissue, to a desired target location.
摘要翻译：输送导管可用于将物质，物品或装置输送到目标人体或动物体内的位置。输送导管通常包括导管，该导管具有远端上的组织穿透远侧末端构件和一个或多个输送孔，从而可将物质，制品或装置通过导管主体的内腔输送出输送孔（s）。在一些应用中，物质输送导管与具有前进到第一位置的穿透器的经管组织穿透导管组合使用。然后将输送导管穿过（或越过）穿透器通过介入组织推进到期望的目标位置。

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