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1. 发明授权

US09579401B2 Staining composition 有权
标题翻译：染色组成
公开(公告)号：US09579401B2
公开(公告)日：2017-02-28
申请号：US13638105
申请日：2011-04-01
申请人： Gerrit Reinold Jacob Melles
发明人： Gerrit Reinold Jacob Melles
IPC分类号： A61K49/00 , A61K9/00
CPC分类号： A61K49/001 , A61K9/0048 , A61K49/0023 , A61K49/0028 , A61K49/003 , A61K49/0034 , A61K49/006 , A61K49/0071
摘要： The invention is directed to a staining composition and to the use of the staining composition in staining ocular tissue. In a first aspect, the invention provides a staining composition comprising a vital dye and a density increasing compound chosen from the group consisting of water soluble polymers and small inert molecules.
摘要翻译：本发明涉及染色组合物以及染色组合物在染色眼组织中的用途。在第一方面，本发明提供一种染色组合物，其包含活性染料和选自水溶性聚合物和小惰性分子的密度增加化合物。

2. 发明申请

US20150037258A1 INFECTION INDICATING MEDICAL DEVICES 审中-公开
标题翻译：感染指示医疗器械
公开(公告)号：US20150037258A1
公开(公告)日：2015-02-05
申请号：US14312541
申请日：2014-06-23
申请人： Indicator Systems International, Inc.
发明人： Gerald F. Swiss , Robert M. Moriarty , Ram W. Sabnis
IPC分类号： A61K49/00
CPC分类号： A61K49/0043 , A61B5/14539 , A61B5/412 , A61B5/686 , A61K49/0023
摘要： Provided herein is an implantable medical device capable of self-reporting microbial growth adjacent the site of the implanted device.
摘要翻译：本文提供了能够自动报告在植入装置的位置附近的微生物生长的可植入医疗装置。

3. 发明申请

US20080069776A1 HISTOFLUORESCENT STAIN FOR ENDOSCOPY 审中-公开
标题翻译：用于内窥镜的感染性皮炎
公开(公告)号：US20080069776A1
公开(公告)日：2008-03-20
申请号：US11855254
申请日：2007-09-14
申请人： Akira YAMAMOTO , Yusuke IIMORI , Mizue SAZE , Mariko ISHIGURO , Yae KUROSAWA , Hiroyuki SASAKI
发明人： Akira YAMAMOTO , Yusuke IIMORI , Mizue SAZE , Mariko ISHIGURO , Yae KUROSAWA , Hiroyuki SASAKI
IPC分类号： A61B1/06 , A61K49/00
CPC分类号： A61K49/0023
摘要： A histofluorescent stain for endoscopy having good fluorescent stainability for the inner part of tissues is provided.A histofluorescent stain composition for endoscopy, containing a compound represented by the following Formula (1) wherein R1 and R2, which may be identical or different, each represent an alkyl group having 1 to 5 carbon atoms; and X− represents an anion residue.
摘要翻译：提供了对于内部部分具有良好荧光染色性的内镜检查的组织荧光染色剂。用于内窥镜检查的组织荧光染色组合物，其含有下式（1）表示的化合物，其中R 1和R 2可以相同或不同，各自表示烷基具有1至5个碳原子的基团; 而X - 代表阴离子残基。

4. 发明授权

US06205352B1 Sentinel node identification using non-isotope means 失效
标题翻译：使用非同位素手段进行哨兵节点识别
公开(公告)号：US06205352B1
公开(公告)日：2001-03-20
申请号：US09195481
申请日：1998-11-18
申请人： Robert G. Carroll
发明人： Robert G. Carroll
IPC分类号： A61B500
CPC分类号： A61K49/0023 , A61K49/18 , A61K49/222
摘要： A method for identifying a sentinel node is provided. The method includes injecting tumor-bearing tissue with a marking composition, radiating marking-agent-targeting energy into suspect tissues potentially harboring the sentinel node, and detecting a lymph node within the suspect tissues first infiltrated by the marking agent. The method is conducted without detecting radioactivity, and thus avoids the health and environmental problems posed by methods based on detecting radiolabels. Moreover, the method obviates the need for surgical dissection to initially detect potential sentinel nodes. Also provided are systems for performing the method and compositions for use in the method.
摘要翻译：提供了一种用于识别前哨节点的方法。该方法包括用标记组合物注入具有肿瘤的组织，将潜在携带前哨淋巴结的可疑组织中的标记剂靶向能量辐射，并检测由标记剂首先渗入的可疑组织内的淋巴结。该方法在不检测放射性的情况下进行，从而避免了基于检测放射性标记的方法所产生的健康和环境问题。此外，该方法避免了手术解剖的需要，以初步检测潜在的前哨淋巴结。还提供了用于执行用于该方法的方法和组合物的系统。

5. 发明授权

US08664364B2 Optical biosensors 有权
标题翻译：光学生物传感器
公开(公告)号：US08664364B2
公开(公告)日：2014-03-04
申请号：US12524328
申请日：2008-01-24
申请人： Brigitte F. Schmidt , Christopher S. Szent-Gyorgyi , Alan S. Waggoner , Peter B. Berget , Marcel P. Bruchez , Jonathan W. Jarvik
发明人： Brigitte F. Schmidt , Christopher S. Szent-Gyorgyi , Alan S. Waggoner , Peter B. Berget , Marcel P. Bruchez , Jonathan W. Jarvik
IPC分类号： G01N33/50 , G01N33/53 , C07K16/44 , C09B23/00
CPC分类号： C07K16/00 , A61K49/0021 , A61K49/0023 , A61K49/0032 , A61K49/0056 , A61K49/0058 , C07K16/44 , C07K2317/21 , C07K2317/622 , C07K2319/00 , C09B69/00 , G01N33/52 , G01N33/5308
摘要： Provided are biosensors, compositions comprising biosensors, and methods of using biosensors in living cells and organisms. The biosensors are able to be selectively targeted to certain regions or structures within a cell. The biosensors may provide a signal when the biosensor is targeted and/or in response to a property of the cell or organism such as membrane potential, ion concentration or enzyme activity.
摘要翻译：提供了生物传感器，包含生物传感器的组合物，以及在活细胞和生物体中使用生物传感器的方法。生物传感器能够选择性地靶向细胞内的某些区域或结构。当生物传感器被靶向和/或响应于细胞或生物体的性质，例如膜电位，离子浓度或酶活性时，生物传感器可提供信号。

6. 发明申请

US20130149247A1 VIVO TUMOR TARGETING AND SPECTROSCOPIC DETECTION WITH SURFACE-ENHANCED RAMAN NANOPARTICLE TAGS 审中-公开
标题翻译： VIVO肿瘤靶向和光谱检测与表面增强拉曼纳米标签
公开(公告)号：US20130149247A1
公开(公告)日：2013-06-13
申请号：US13680524
申请日：2012-11-19
申请人： EMORY UNIVESITY
发明人： Ximei Qian , Dominic Ansari , Shuming Nie
IPC分类号： A61K49/00
CPC分类号： A61K49/0089 , A61B5/0059 , A61B5/416 , A61B2503/40 , A61K49/0023 , A61K49/0032 , A61K49/0041 , A61K49/0065 , A61K49/0093 , B82Y5/00 , G01N21/658 , Y10S977/773 , Y10S977/81
摘要： Nanostructures, methods of preparing nanostructures, methods of detecting targets in subjects, and methods of treating diseases in subjects, are disclosed. An embodiment, among others, of the nanostructure includes a metallic gold surface-enhanced Raman scattering nanoparticle, a Raman reporter and a protection structure. The protection structure may include a thiol-polyethylene glycol to which may be attached a target-specific probe.
摘要翻译：公开了纳米结构，制备纳米结构的方法，检测受试者中靶标的方法和治疗受试者疾病的方法。纳米结构的一个实施方案包括金属金表面增强拉曼散射纳米颗粒，拉曼报告物和保护结构。保护结构可以包括硫醇 - 聚乙二醇，其可以连接目标特异性探针。

7. 发明申请

US20130045167A1 Staining Composition 有权
标题翻译：染色成分
公开(公告)号：US20130045167A1
公开(公告)日：2013-02-21
申请号：US13638105
申请日：2011-04-01
申请人： Gerrit Reinold Jacob Melles
发明人： Gerrit Reinold Jacob Melles
IPC分类号： A61K49/00
CPC分类号： A61K49/001 , A61K9/0048 , A61K49/0023 , A61K49/0028 , A61K49/003 , A61K49/0034 , A61K49/006 , A61K49/0071
摘要： The invention is directed to a staining composition and to the use of the staining composition in staining ocular tissue. In a first aspect, the invention provides a staining composition comprising a vital dye and a density increasing compound chosen from the group consisting of water soluble polymers and small inert molecules.
摘要翻译：本发明涉及染色组合物以及染色组合物在染色眼组织中的用途。在第一方面，本发明提供一种染色组合物，其包含活性染料和选自水溶性聚合物和小惰性分子的密度增加化合物。

8. 发明申请

US20110165077A1 IN VIVO TUMOR TARGETING AND SPECTROSCOPIC DETECTION WITH SURFACE ENHANCED RAMAN NANOPARTICLE TAGS 审中-公开
标题翻译：在体外肿瘤定位和光谱检测与表面增强拉曼纳米标签
公开(公告)号：US20110165077A1
公开(公告)日：2011-07-07
申请号：US12593359
申请日：2008-04-02
申请人： Ximei Qian , Dominic Ansari , Shuming Nie
发明人： Ximei Qian , Dominic Ansari , Shuming Nie
IPC分类号： A61K49/00 , A61P35/00
CPC分类号： A61K49/0089 , A61B5/0059 , A61B5/416 , A61B2503/40 , A61K49/0023 , A61K49/0032 , A61K49/0041 , A61K49/0065 , A61K49/0093 , B82Y5/00 , G01N21/658 , Y10S977/773 , Y10S977/81
摘要： Nanostructures, methods of preparing nanostructures, methods of detecting targets in subjects, and methods of treating diseases in subjects, are disclosed. An embodiment, among others, of the nanostructure includes a metallic gold surface-enhanced Raman scattering nanoparticle, a Raman reporter and a protection structure. The protection structure may include a thiol-polyethylene glycol to which may be attached a target-specific probe.
摘要翻译：公开了纳米结构，制备纳米结构的方法，检测受试者中靶标的方法和治疗受试者疾病的方法。纳米结构的一个实施方案包括金属金表面增强拉曼散射纳米颗粒，拉曼报告物和保护结构。保护结构可以包括硫醇 - 聚乙二醇，其可以连接目标特异性探针。

9. 发明申请

US20170258939A1 Staining Composition 审中-公开
公开(公告)号：US20170258939A1
公开(公告)日：2017-09-14
申请号：US15422961
申请日：2017-02-02
申请人： Medical Technology Transfer Holding B.V.
发明人： Gerrit Reinold Jacob Melles
IPC分类号： A61K49/00 , A61K9/00
CPC分类号： A61K49/001 , A61K9/0048 , A61K49/0023 , A61K49/0028 , A61K49/003 , A61K49/0034 , A61K49/006 , A61K49/0071
摘要： The invention is directed to a staining composition and to the use of the staining composition in staining ocular tissue. In a first aspect, the invention provides a staining composition comprising a vital dye and a density increasing compound chosen from the group consisting of water soluble polymers and small inert molecules.

10. 发明申请

US20170240582A1 1,4,7,10-TETRAZACYCLODODECANE BASED AGENTS TO TARGET BACTERIA AND ITS USE 审中-公开
公开(公告)号：US20170240582A1
公开(公告)日：2017-08-24
申请号：US15503783
申请日：2015-08-18
申请人： HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH
发明人： Mark BROENSTRUP , Haiyu HU , Galina SERGEEV , Bushra RAIS , Kevin FERREIRA , Verena FETZ
IPC分类号： C07H17/04 , C07D403/14 , C12Q1/16 , A61K49/00 , C07D257/02 , C07D491/16
CPC分类号： C07H17/04 , A61K49/0023 , A61K49/0032 , A61K49/0052 , C07D257/02 , C07D403/14 , C07D491/16 , C12Q1/16 , G01N2800/26
摘要： The present invention relates to new compounds comprising a siderophore moiety as well as a core structure able to chelate a metal ion. Optionally, the compounds may have additionally a moiety with a functional element including a marker molecule, a bioactive agent, an activity based probe suitable to monitor the aberrant expression or activity of proteins involved in the initiation and progression of bacterial infection, or a compound useful for bacterial inhibition. In a further aspect, the present invention provides a pharmaceutical composition containing said compound, for example, said pharmaceutical composition is an antibiotic. Additionally, the present invention relates to the use of said compounds in diagnostic methods, in particular, imaging methods including SPEC, PET or MRI. In an embodiment of the present invention, the compound is part of a theranostic composition having both, therapeutic as well as diagnostic activities.

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