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1. 发明授权

US09364660B2 Electrode array device configured for placement inside the dura for direct spinal cord stimulation 有权
标题翻译：电极阵列装置配置用于放置在硬脑膜内用于直接脊髓刺激
公开(公告)号：US09364660B2
公开(公告)日：2016-06-14
申请号：US13885157
申请日：2011-11-11
申请人： Matthew Howard , Timothy Brennan , Brian Dalm , Marcel Utz , George T. Gillies , Steven Scott , Randall S. Nelson , Robert Shurig
发明人： Matthew Howard , Timothy Brennan , Brian Dalm , Marcel Utz , George T. Gillies , Steven Scott , Randall S. Nelson , Robert Shurig
IPC分类号： A61N1/05 , A61N1/36 , A61N1/372 , A61N1/375 , A61N1/378
CPC分类号： A61N1/0553 , A61N1/0558 , A61N1/36071 , A61N1/372 , A61N1/37205 , A61N1/375 , A61N1/3787 , Y10T29/49117
摘要： A method for treating intractable pain via electrical stimulation of the spinal cord. Remote, non-contact stimulation of a selected region of spinal cord is achieved by placement of a transceiver patch directly on the surface of that region of spinal cord, with said patch optionally being inductively coupled to a transmitter patch of similar size on either the outer or inner wall of the dura surrounding that region of the spinal cord. By inductively exchanging electrical power and signals between said transmitter and transceiver patches, and by carrying out the necessary electronic and stimulus signal distribution functions on the transceiver patch, the targeted dorsal column axons can be stimulated without the unintended stray stimulation of nearby dorsal rootlets. Novel configurations of a pliable surface-sheath and clamp or dentate ligament attachment features which realize undamaging attachment of the patch to the spinal cord are described.
摘要翻译：一种通过脊髓电刺激治疗难治性疼痛的方法。通过将收发器贴片直接放置在脊髓区域的表面上来实现脊髓选定区域的远程，非接触刺激，其中所述贴片可任选地感应耦合到外部类似尺寸的发射器贴片或围绕该脊髓区域的硬脑膜的内壁。通过在所述发射器和收发器贴片之间感应地交换电力和信号，并且通过在收发器贴片上执行必要的电子和刺激信号分配功能，可以刺激目标背侧轴突，而不会对附近的背根刺的无意的杂散刺激。描述了实现柔性表面鞘和夹具或齿状韧带附着特征的新颖结构，其实现了贴片对脊髓的不损伤附着。

2. 发明申请

US20120283582A1 SYSTEMS AND METHODS FOR DETERMINING LOCATION OF AN ACCESS NEEDLE IN A SUBJECT 有权
公开(公告)号：US20120283582A1
公开(公告)日：2012-11-08
申请号：US13464762
申请日：2012-05-04
申请人： Srijoy Mahapatra , George T. Gillies , Jason Tucker-Schwartz , Harutyun V. Gyurjyan
发明人： Srijoy Mahapatra , George T. Gillies , Jason Tucker-Schwartz , Harutyun V. Gyurjyan
IPC分类号： A61B5/06
CPC分类号： A61B5/065 , A61B5/02154 , A61B5/03 , A61B5/04012 , A61B5/0402 , A61B5/0456 , A61B5/06 , A61B5/6848 , A61B5/7257
摘要： Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject. A current location of the needle may be distinguished from another location based on an algorithm including the pressure frequency information and the cardiac waveform information.

3. 发明申请

US20100211064A1 Electrode Catheter for Ablation Purposes and Related Method Thereof 有权
标题翻译：消融用电极导管及其相关方法
公开(公告)号：US20100211064A1
公开(公告)日：2010-08-19
申请号：US12532233
申请日：2008-03-20
申请人： Srijoy Mahapatra , George T. Gillies
发明人： Srijoy Mahapatra , George T. Gillies
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2017/00323 , A61B2018/00029 , A61B2018/00035 , A61B2018/00279 , A61B2018/00357 , A61B2018/00363 , A61B2018/00577 , A61B2018/00916 , A61B2018/1497 , A61B2090/064 , A61B2218/002 , A61B2218/007 , A61N1/06
摘要： An electrode catheter for use with an endocardial ablation catheter, wherein the electrode catheter receives the transmitted energy for ablating a portion of the heart. The electrode catheter comprises a proximal portion, a distal portion, and a longitudinal structure there between; and an electrode in communication with said electrode catheter, wherein said electrode receives the transmitted energy from the endocardial ablation catheter, or alternatively an epicardial ablation catheter.
摘要翻译：一种与心内膜消融导管一起使用的电极导管，其中电极导管接收用于烧蚀心脏的一部分的传输能量。电极导管包括近端部分，远端部分和其间的纵向结构; 以及与所述电极导管连通的电极，其中所述电极接收来自心内膜消融导管的传输的能量，或者替代地，心外膜消融导管。

4. 发明授权

US07670327B2 Catheter systems for delivery of agents and related method thereof 有权
标题翻译：用于递送药剂的导管系统及其相关方法
公开(公告)号：US07670327B2
公开(公告)日：2010-03-02
申请号：US11105166
申请日：2005-04-13
申请人： John Kucharczyk , George T. Gillies
发明人： John Kucharczyk , George T. Gillies
IPC分类号： A61M31/00
CPC分类号： A61M25/003 , A61M25/0032 , A61M25/007 , A61M2025/0004 , A61M2025/0039
摘要： A method is disclosed for the delivery of therapeutic agents into tissues, blood vessels, and body ducts of the human body. A novel catheter enables controlled directing of emitted drug delivery to assist control of drug dwell time in targeted areas. One coaxial catheter embodiment provides capability for locating an outer lumen of the system into the target region, with localization of said outer lumen carried out by use of appropriate medical imaging modalities. In one embodiment, an inner lumen of the catheter means is primed with the agent to be delivered, and recirculated flow of the agent through pluralities of appropriately positioned port holes on the two lumens then occurs via one or more active and/or passive flow driving and guiding techniques intrinsic to the design of the coaxial catheter system. Another coaxial catheter embodiment carries and emits agent in an outer cannula and recaptures agent plus liquid or fluids in the body (such as blood, bile, serum, stable (non-flowing) liquid or kinetic liquid) in an inner cannula.
摘要翻译：公开了用于将治疗剂递送到人体的组织，血管和体导管中的方法。一种新型的导管能够控制引导排出的药物输送以帮助控制目标区域中的药物停留时间。一个同轴导管实施例提供了将系统的外腔定位到目标区域中的能力，通过使用适当的医学成像模式对所述外腔进行定位。在一个实施例中，导管装置的内腔用待传递的药剂引发，并且药剂的再循环流动通过两个流明上的多个适当定位的孔口然后经由一个或多个主动和/或被动流动驱动以及设计同轴导管系统固有的指导技术。另一个同轴导管实施例在外插管中携带并发射试剂，并在内套管中重新捕获剂体内加液体或液体（例如血液，胆汁，血清，稳定（非流动）液体或动力学液体）。

5. 发明授权

US06316181B1 Establishment of cell lines with persistent expression of a green fluorescent protein (GFP) using a pIRES/EGFP DNA vector construct 失效
标题翻译：使用pIRES / EGFP DNA载体构建体建立具有绿色荧光蛋白（GFP）的持续表达的细胞系
公开(公告)号：US06316181B1
公开(公告)日：2001-11-13
申请号：US09296808
申请日：1999-04-23
申请人： Helen Fillmore , William C. Broaddus , John S. Shurm, Jr. , George T. Gillies
发明人： Helen Fillmore , William C. Broaddus , John S. Shurm, Jr. , George T. Gillies
IPC分类号： C12Q102
CPC分类号： G01N33/5011 , C12N5/0693 , C12N2503/00 , C12N2510/00 , C12Q1/6897
摘要： The present invention provides a vector for stably transforming cells. The vector comprises the green fluorescent protein (GFP) from Aequorea victoria as a marker. The invention also provides stably transfected cell lines which may be used to assess real-time biological processes, including tumor cell migration.
摘要翻译：本发明提供了用于稳定转化细胞的载体。载体包含来自维他命A的绿色荧光蛋白（GFP）作为标记。本发明还提供可用于评估实时生物过程（包括肿瘤细胞迁移）的稳定转染的细胞系。

6. 发明授权

US09642534B2 Systems and methods for determining location of an access needle in a subject 有权
公开(公告)号：US09642534B2
公开(公告)日：2017-05-09
申请号：US13464752
申请日：2012-05-04
申请人： Srijoy Mahapatra , George T. Gillies , Jason Tucker-Schwartz
发明人： Srijoy Mahapatra , George T. Gillies , Jason Tucker-Schwartz
IPC分类号： A61B5/02 , A61B5/06
CPC分类号： A61B5/02158 , A61B5/02 , A61B5/02125 , A61B5/02154 , A61B5/04014 , A61B5/04017 , A61B5/0402 , A61B5/061 , A61B5/065 , A61B5/6848 , A61B5/7203 , A61B5/725 , A61B17/3403 , A61B17/3478 , A61B18/1492 , A61B34/20 , A61B2017/00243 , A61B2018/00351 , A61B2018/00577 , A61B2034/2055 , A61B2090/064 , A61B2562/0247 , A61B2562/0252
摘要： Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject. A current location of the needle may be distinguished from another location based on an algorithm including the pressure frequency information and the cardiac waveform information.

7. 发明申请

US20150238685A1 Method and System for Enhanced Imaging Visualization of Deep Brain Anatomy Using Infusion 审中-公开
标题翻译：使用输液增强成像可视化深层解剖学的方法与系统
公开(公告)号：US20150238685A1
公开(公告)日：2015-08-27
申请号：US14429592
申请日：2013-09-18
申请人： William J. ELIAS , Aaron E. BOND , George T. GILLIES
发明人： William J. Elias , Aaron E. Bond , George T. Gillies
IPC分类号： A61M5/00 , A61M25/10 , A61M25/00 , A61B5/055 , A61N1/36
CPC分类号： A61M5/007 , A61B5/0042 , A61B5/055 , A61B6/032 , A61B6/12 , A61B6/481 , A61B6/501 , A61M25/0026 , A61M25/007 , A61M25/0127 , A61M25/10 , A61M25/1002 , A61M31/005 , A61M2025/0037 , A61M2025/0042 , A61M2025/105 , A61M2025/1052 , A61M2025/1093 , A61N1/36139 , G01R33/285
摘要： Provided is a method and system for delivering a diagnostic agent to a site in the brain of a subject for imaging at least a portion of the brain site on a medical imaging system. The method and system includes a catheter device with associated lumens having diagnostic agent ports for delivering the diagnostic agent (e.g., infusate) through the lumens and advancing the diagnostic agent so as to exit out from the lumens to at least a portion of the brain site and while sealing a portion of the brain site thereby preventing the exited diagnostic agent from travelling proximally beyond the sealing location, and at the same time imaging at least a portion of the brain site during at least a portion of the sealing duration so that the brain site can be visualized on a medical imaging system. The diagnostic agent (infusate) is able to highlight borders and internal patterns of the deep structures of the brain thereby enabling direct targeting. Ultimately this leads to reduced complications, enhanced therapy, and the elimination of the need for awake surgery. The method and system provides the capability heretofore not possible to visualize the small, often indistinct regions, which will greatly improve clinical outcomes with therapeutic interventions.
摘要翻译：提供了一种用于将诊断剂递送到受试者脑中的位置以在医学成像系统上成像脑部位的至少一部分的方法和系统。所述方法和系统包括具有相关联腔的导管装置，所述导管装置具有诊断剂端口，用于将诊断剂（例如，输注液体）输送通过管腔并推进诊断剂以便从腔内离开至脑部位的至少一部分并且同时密封脑部位的一部分，从而防止被退出的诊断剂向近侧移动超过密封位置，并且同时在至少一部分密封持续时间期间对脑部位的至少一部分进行成像，使得大脑现场可以在医学成像系统上显现。诊断剂（输注物）能够突出大脑深层结构的边界和内部模式，从而实现直接靶向。最终导致并发症减少，治疗加强，消除了清醒手术的需要。该方法和系统提供了迄今为止不可能将小的，通常不清楚的区域可视化的能力，这将大大改善临床结果与治疗干预。

8. 发明授权

US08226694B2 Closure device for skull plates and related method thereof 有权
标题翻译：颅骨封闭装置及其相关方法
公开(公告)号：US08226694B2
公开(公告)日：2012-07-24
申请号：US12304801
申请日：2007-06-26
申请人： William C. Broaddus , Zhi-Jian Chen , George T. Gillies
发明人： William C. Broaddus , Zhi-Jian Chen , George T. Gillies
IPC分类号： A61B17/84
CPC分类号： A61F2/2875 , A61B17/688 , A61B90/39 , A61F2002/3008 , A61F2002/30113 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30225 , A61F2002/30329 , A61F2002/30438 , A61F2002/30441 , A61F2002/30448 , A61F2002/30472 , A61F2002/3052 , A61F2220/0025 , A61F2220/0041 , A61F2220/005 , A61F2230/0006 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0069 , A61F2250/0098
摘要： A method and means of cranial bone flap fixation that provides, among other things, the re-opening, resetting and/or repositioning of the bone flap during neurosurgical procedures. The instrumentation central to this method and means is MR and CT-visible to aid in imaging-based localization of it. The method and means can also be used in other types of medical procedures where certain kinds of hard or firm tissue fixation is desirable according to the method of the invention.
摘要翻译：颅骨骨瓣固定的方法和手段，其特别提供神经外科手术期间骨瓣的重新开启，重新定位和/或重新定位。该方法和手段中心的仪器是MR和CT可见，有助于其基于成像的定位。根据本发明的方法，所述方法和装置也可用于其它类型的医疗程序，其中某些种类的硬组织或固体组织固定是期望的。

9. 发明申请

US20120123461A1 ACCESS TROCAR AND RELATED METHOD THEREOF 有权
标题翻译：访问权限及其相关方法
公开(公告)号：US20120123461A1
公开(公告)日：2012-05-17
申请号：US13318450
申请日：2010-04-30
申请人： George T. Gillies , Peter Pollak , Srijoy Mahapatra
发明人： George T. Gillies , Peter Pollak , Srijoy Mahapatra
IPC分类号： A61B17/34
CPC分类号： A61B17/3423 , A61B17/3403 , A61B2017/00247 , A61B2017/3413 , A61B2017/3425 , A61B2018/00392
摘要： System and method that is directed to medical treatments of organs having anatomical spaces, such as (but not limited to) the heart and the pericardial space. Specifically, an apparatus and method is provided for safely accessing anatomical spaces with surfaces to deliver medical devices or media into such spaces, or to remove fluids from such spaces. The methods and apparatus may include a first elongated member with a sharp tip used to penetrate the surface surrounding the anatomical space with a second elongated member with a helical tine used to engage the surface and lift the surface away from the underlying anatomical space. Once the first elongated member has incised the surface, it is removed, and the incision may be used as a point of entry for delivering media or medical devices into the anatomical space, or for carrying out further medical procedures.
摘要翻译：针对具有解剖空间的器官的医学治疗的系统和方法，例如（但不限于）心脏和心包空间。具体地说，提供了一种装置和方法，用于安全地接触具有表面的解剖空间，以将医疗装置或介质输送到这样的空间中，或者从这些空间移除流体。所述方法和装置可以包括具有尖端的第一细长构件，所述第一细长构件用于用具有螺旋齿的第二细长构件穿过围绕所述解剖空间的表面，所述第二细长构件用于接合所述表面并将所述表面提升离开所述下面的解剖空间。一旦第一细长构件已经切开表面，就将其移除，并且切口可以用作将介质或医疗装置输送到解剖空间中的进入点，或者用于执行进一步的医疗程序。

10. 发明申请

US20100198137A1 Coaxial Catheter Systems for Transference of Medium 有权
标题翻译：用于传播介质的同轴导管系统
公开(公告)号：US20100198137A1
公开(公告)日：2010-08-05
申请号：US12760837
申请日：2010-04-15
申请人： William C. Broaddus , Zhi-Jian Chen , George T. Gillies
发明人： William C. Broaddus , Zhi-Jian Chen , George T. Gillies
IPC分类号： A61M25/00
CPC分类号： A61M25/0026 , A61M5/007 , A61M25/00 , A61M25/0045 , A61M25/007 , A61M27/006 , A61M2025/1013
摘要： A method, technique and system is disclosed for the delivery of therapeutic agents and/or into the bulk brain tissues and other parts, tissues and organs of the body, including vasculature. A novel form of coaxial catheter provides a means for implanting an outer tube into the brain, then inserting an inner tube into the outer tube and aligning them such that port holes on both of the tubes will overlap and permit a flux of the therapeutic agent to flow into the brain in such a way as to minimize the effects of trapped air, virtually eliminate backflow of the agent, and avoid the potential for additional damage to the brain since only one surgical placement of the outer tube is needed. Similarly, the method, technique system may be utilized to remove fluids or other medium from the brain, tissues, and organs to minimize the effects of escaped air or negative pressure.
摘要翻译：公开了用于递送治疗剂和/或进入体内的大脑组织和身体其他部位，组织和器官的方法，技术和系统，包括脉管系统。同轴导管的新颖形式提供了一种用于将外管植入大脑中的装置，然后将内管插入外管并对准它们，使得两个管上的孔口将重叠并允许治疗剂的通量流入大脑，以尽可能减少被捕获的空气的影响，实际上消除了药剂的回流，并避免了额外的损害大脑的潜力，因为只需要一个手术放置外管。类似地，该方法技术系统可用于从脑，组织和器官中除去流体或其它介质，以最小化逃逸空气或负压的影响。

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