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41. 发明授权

US5258127A Leucocyte depleting filter device and method of use 失效
标题翻译：白细胞消耗过滤装置及其使用方法
公开(公告)号：US5258127A
公开(公告)日：1993-11-02
申请号：US756567
申请日：1991-09-11
申请人： Thomas C. Gsell , Thomas Bormann , Vlado I. Matkovich
发明人： Thomas C. Gsell , Thomas Bormann , Vlado I. Matkovich
IPC分类号： A61M1/36 , B01D39/16 , B01D67/00 , B29C59/14 , B01D37/00 , B01D19/00 , B01D39/04
CPC分类号： B01D67/009 , A61M1/3633 , B01D39/1623 , B29C59/142 , A61M2202/025 , A61M2202/0275 , A61M2202/0291 , A61M2202/0439 , A61M2205/7536 , A61M2206/16 , B29K2105/04
摘要： Leucocyte depletion filter assemblies decrease the leucocyte content of a biological fluid in an extracorporeal circuit. These filter assemblies are suitable for use in an extracorporeal circuit. Methods for removing leucocytes and other deleterious matter are also disclosed. The removal medium used in these assemblies and methods may be pleated structures which have been subjected to gas plasma treatment, improving the amount of leucocytes removed and increasing the amount of platelets which pass through the medium.
摘要翻译：白细胞消耗过滤器组件减少体外循环中生物液体的白细胞含量。这些过滤器组件适用于体外循环。还公开了除去白细胞和其它有害物质的方法。用于这些组合物和方法的去除介质可以是经过气体等离子体处理的褶皱结构，改善去除的白细胞的量并增加通过介质的血小板的量。

42. 发明授权

US5217627A System and method for processing biological fluid 失效
标题翻译：用于处理生物液体的系统和方法
公开(公告)号：US5217627A
公开(公告)日：1993-06-08
申请号：US788787
申请日：1991-11-06
申请人： David B. Pall , Thomas C. Gsell , Vlado I. Matkovich , Thomas Bormann
发明人： David B. Pall , Thomas C. Gsell , Vlado I. Matkovich , Thomas Bormann
IPC分类号： A61J1/00 , A61J1/05 , A61M1/02 , A61M1/34 , A61M1/36 , A61M5/148 , B01D61/14 , B01D61/16 , B01D61/20 , B01D61/22 , B01D63/08 , B01D65/08
CPC分类号： B01D63/087 , A61J1/05 , A61M1/02 , A61M1/0209 , A61M1/0218 , A61M1/0227 , A61M1/0231 , A61M1/025 , A61M1/029 , A61M1/3472 , A61M1/3633 , A61M1/3646 , A61M1/3652 , B01D61/145 , B01D61/147 , B01D61/16 , B01D61/20 , B01D61/22 , B01D65/08 , A61J1/10 , A61M1/3693 , A61M2202/0413 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439 , A61M2206/12 , A61M5/1486 , B01D2321/2083
摘要： A system for collecting and processing donated blood comprises a first porous medium interposed between a blood collection bag and a satellite bag and a second porous medium interposed between the blood collection bag and another satellite bag. The porous media are leucocyte depletion media. The system may also include one or more of the following: a red cell barrier medium, a separation medium, a gas inlet, and a gas outlet. The system can be used to centrifuge whole blood into one or more components, and includes a means for protecting the system during centrifugation.
摘要翻译：用于收集和处理捐赠血液的系统包括介于血液收集袋和卫星袋之间的第一多孔介质和介于血液收集袋和另一卫星袋之间的第二多孔介质。多孔介质是白细胞消耗介质。该系统还可以包括以下一种或多种：红细胞阻挡介质，分离介质，气体入口和气体出口。该系统可用于将全血离心成一个或多个组分，并且包括在离心过程中保护系统的手段。

43. 发明授权

US4479874A Convoluted plural layer filter assembly 失效
标题翻译：旋转式多层过滤器组件
公开(公告)号：US4479874A
公开(公告)日：1984-10-30
申请号：US422238
申请日：1982-09-23
申请人： David J. Rosenberg , Vlado I. Matkovich
发明人： David J. Rosenberg , Vlado I. Matkovich
IPC分类号： B01D35/02 , B01D27/06 , B01D29/01 , B01D29/07 , B01D29/11 , B01D35/00 , B01D35/28 , B01D46/12 , B01D29/06
CPC分类号： B01D46/12 , B01D29/012 , B01D29/111 , B01D35/00
摘要： A filter assembly is provided comprising a housing; a fluid inlet and a fluid outlet in the housing, each opening into a fluid chamber; and, disposed in the fluid chamber across the line of fluid flow from the inlet to the outlet so that all flow from the fluid inlet to the fluid outlet must pass therethrough, a filter element composite comprising a filter sheet material sandwiched between layers of foraminous spacer sheet material. The filter element composite has an upstream side and a downstream side and separates the chamber into a first portion on one side of the filter element composite communicating with the fluid inlet, and a second portion on the other side of the filter element composite communicating with the fluid outlet. The filter element composite is folded on itself in at least a double layer defining therebetween an open interior space in fluid communication with one of the first and second portions of the fluid chamber, the outer side of the filter element composite being in fluid communication with the other of the first and second portions of the fluid chamber; and the double layer filter element composite is arranged in a plurality of convolutions extending transversely across the fluid chamber back and forth across the line of fluid flow from the fluid inlet to the fluid outlet.
摘要翻译：提供了一种过滤器组件，包括壳体; 壳体中的流体入口和流体出口，每个开口进入流体室; 并且设置在流体室中，穿过从入口到出口的流体流，使得从流体入口到流体出口的所有流动必须通过其中，过滤元件复合材料包括夹在有孔间隔物层之间的过滤片材料片材。所述过滤元件复合体具有上游侧和下游侧，并且将所述室分离成与所述流体入口连通的所述过滤元件复合体的一侧的第一部分，并且所述过滤元件复合体的另一侧的第二部分与流体出口。过滤元件复合材料至少在双层之间折叠，在其间限定了与流体室的第一和第二部分中的一个流体连通的开放内部空间，过滤元件复合材料的外侧与流体室的第一和第二部分中的另一个; 并且所述双层过滤元件复合材料布置成以横向流过所述流体室的横向从所述流体入口到所述流体出口的流体流线路横向延伸的多个卷积。

44. 发明授权

US5630946A Method for processing a biological fluid including leukocyte removal in an extracorporeal circuit 失效
标题翻译：用于在体外循环中处理包括白细胞去除的生物流体的方法
公开(公告)号：US5630946A
公开(公告)日：1997-05-20
申请号：US392358
申请日：1995-02-21
申请人： Stephen Hart , Frank R. Pascale , Vlado I. Matkovich
发明人： Stephen Hart , Frank R. Pascale , Vlado I. Matkovich
IPC分类号： A61M1/36 , A61M1/38
CPC分类号： A61M1/3621 , A61M1/3603 , A61M1/3643 , A61M2202/0439 , A61M2205/366
摘要： A method for removing undesirable material including leukocytes from a biological fluid in an extracorporeal circuit comprises passing a leukocyte containing biological fluid from a patient into a container; passing a portion of biological fluid from the container through a recirculation loop including a filter assembly for removing leukocytes to leukocyte deplete the biological fluid and to pass the portion of leukocyte-depleted biological fluid into the container; passing additional leukocyte containing biological fluid from a patient into the container so that the additional fluid is mixed with leukocyte depleted biological fluid in the container to provide a mixture including leukocyte depleted and non-leukocyte depleted biological fluid; passing the mixture of biological fluid from the container; passing a portion of the mixture to the patient while passing another portion of the mixture through the recirculation loop.
摘要翻译：一种用于从体外循环中从生物流体除去包括白细胞的不需要的物质的方法包括将含有生物流体的白细胞从患者送入容器中; 使来自容器的生物流体的一部分通过包括用于将白细胞去除白细胞的过滤器组件的再循环回路消耗生物流体并使白细胞贫乏的生物流体的一部分通过到容器中; 将含有来自患者的含有生物液体的另外的白细胞携带到容器中，使得额外的流体与容器中的白细胞贫化的生物流体混合，以提供包含白细胞贫化和非白细胞贫化的生物流体的混合物; 使来自容器的生物流体的混合物通过; 将混合物的一部分通过患者，同时使另一部分混合物通过再循环回路。

45. 发明授权

US5587070A System for processing biological fluid 失效
标题翻译：生物液体处理系统
公开(公告)号：US5587070A
公开(公告)日：1996-12-24
申请号：US071495
申请日：1993-06-04
申请人： David B. Pall , Thomas C. Gsell , Vlado I. Matkovich , Thomas Bormann
发明人： David B. Pall , Thomas C. Gsell , Vlado I. Matkovich , Thomas Bormann
IPC分类号： A61J1/00 , A61J1/05 , A61M1/02 , A61M1/34 , A61M1/36 , A61M5/148 , B01D61/14 , B01D61/16 , B01D61/20 , B01D61/22 , B01D63/08 , B01D65/08 , B01D36/00 , B01D36/02
CPC分类号： B01D63/087 , A61J1/05 , A61M1/02 , A61M1/0209 , A61M1/0218 , A61M1/0227 , A61M1/0231 , A61M1/025 , A61M1/029 , A61M1/3472 , A61M1/3633 , A61M1/3646 , A61M1/3652 , B01D61/145 , B01D61/147 , B01D61/16 , B01D61/20 , B01D61/22 , B01D65/08 , A61J1/10 , A61M1/3693 , A61M2202/0413 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439 , A61M2206/12 , A61M5/1486 , B01D2321/2083
摘要： A system for collecting and processing donated blood comprises a first porous medium interposed between a blood collection bag and a satellite bag and a second porous medium interposed between the blood collection bag and another satellite bag. The porous media are leucocyte depletion media. The system may also include one or more of the following: a red cell barrier medium, a separation medium, a gas inlet, and a gas outlet. The system can be used to centrifuge whole blood into one or more components, and includes a means for protecting the system during centrifugation.
摘要翻译：用于收集和处理捐赠血液的系统包括介于血液收集袋和卫星袋之间的第一多孔介质和介于血液收集袋和另一卫星袋之间的第二多孔介质。多孔介质是白细胞消耗介质。该系统还可以包括以下一种或多种：红细胞阻挡介质，分离介质，气体入口和气体出口。该系统可用于将全血离心成一个或多个组分，并且包括在离心过程中保护系统的方法。

46. 发明授权

US5393101A Connector assembly 失效
标题翻译：连接器组件
公开(公告)号：US5393101A
公开(公告)日：1995-02-28
申请号：US956854
申请日：1992-10-02
申请人： Vlado I. Matkovich
发明人： Vlado I. Matkovich
IPC分类号： F16L37/08 , A61J1/05 , A61J1/10 , A61M5/14 , A61M5/31 , A61M39/00 , A61M39/02 , A61M39/10 , A61M39/14 , F16L29/00 , F16L37/098 , F16L37/30 , F16L37/38 , F16L55/00 , A61M5/00 , F16L47/00
CPC分类号： A61M39/18 , A61M39/1011 , A61M39/14 , F16L29/005 , F16L37/0985 , F16L37/30 , F16L37/38 , A61J1/10 , A61J1/1475 , A61M2039/1027 , A61M2039/1072 , Y10S285/915 , Y10S604/905
摘要： A connector assembly includes first and second fittings and first and second membrane assemblies. Each fitting defines a respective aperture. Each membrane assembly has a layer sealing the aperture and a removable contamination containment layer overlying a respective sealing layer. The first and second fittings may be resiliently coupled in biased opposition to urge positive contact between the first and second removable contamination containment layers and/or the first and second sealing layers. In one application, a connector assembly according to the invention may define a fluid communication path for handling a fluid without allowing the level of contaminants in the fluid to increase. A connector assembly according to the invention may be used to handle a biological fluid while maintaining the fluid free of viable contaminating microorganisms or preserving its sterility, for example.
摘要翻译：连接器组件包括第一和第二配件以及第一和第二膜组件。每个配件限定相应的孔。每个膜组件具有密封孔的层和覆盖相应的密封层的可移除的污染物容纳层。第一和第二配件可以以偏置的相反方式弹性耦合，以推动第一和第二可移除污染物容纳层和/或第一和第二密封层之间的正接触。在一个应用中，根据本发明的连接器组件可以限定用于处理流体的流体连通路径，而不允许流体中的污染物水平增加。根据本发明的连接器组件可以用于处理生物流体，同时保持流体不含活的污染微生物或保持其不育。

47. 发明授权

US5151192A Method for removing heparin from blood or plasma 失效
标题翻译：从血液或血浆中去除肝素的方法
公开(公告)号：US5151192A
公开(公告)日：1992-09-29
申请号：US552138
申请日：1990-07-13
申请人： Vlado I. Matkovich , Peter J. Degen , Thomas C. Gsell , Thomas Bormann , Isaac Rothman
发明人： Vlado I. Matkovich , Peter J. Degen , Thomas C. Gsell , Thomas Bormann , Isaac Rothman
IPC分类号： A61M1/36 , B01D15/00 , B01J20/26 , B01J41/04 , B01J41/14 , B01J47/00 , G01N1/10 , G01N33/48
CPC分类号： A61M1/3675 , B01D15/00 , B01J20/26 , B01J41/04 , B01J41/14 , B01J47/007 , Y10T436/25375 , Y10T436/255
摘要： A porous medium having a positive surface change removes heparin from a heparin-containing liquid, without removing other proteinaceous components from the liquid. Methods and devices are disclosed.
摘要翻译：具有正表面电荷的多孔介质从含肝素的液体中除去肝素，而不从液体中除去其它蛋白质成分。公开了方法和装置。

48. 发明授权

US5070899A Check valve 失效
标题翻译：止回阀
公开(公告)号：US5070899A
公开(公告)日：1991-12-10
申请号：US357676
申请日：1989-05-26
申请人： Vlado I. Matkovich , Sidney Krakauer
发明人： Vlado I. Matkovich , Sidney Krakauer
IPC分类号： A61M39/24
CPC分类号： A61M39/24 , Y10T137/3021 , Y10T137/4643 , Y10T137/7722
摘要： The disclosure describes a check valve comprising a structure for channeling a flow of a first fluid and first and second porous elements for permitting flow of the first fluid and substantially preventing flow of a second fluid. The first and second porous elements extend across the channeling structure, engaging and sealing against the channeling structure to define a pocket between the first and second porous elements. The pocket contains the second fluid.
摘要翻译：本公开描述了一种止回阀，其包括用于引导第一流体和第一和第二多孔元件的流动的结构，用于允许第一流体的流动并且基本上防止第二流体的流动。第一和第二多孔元件延伸穿过沟槽结构，与沟槽结构接合并密封以限定第一和第二多孔元件之间的凹穴。口袋包含第二液体。

49. 发明授权

US4976926A Vacuum diagnostic device 失效
标题翻译：真空诊断装置
公开(公告)号：US4976926A
公开(公告)日：1990-12-11
申请号：US225023
申请日：1988-07-28
申请人： Vlado I. Matkovich
发明人： Vlado I. Matkovich
IPC分类号： B01D61/18 , B01L3/00 , G01N33/543
CPC分类号： B01L3/502 , B01D61/18 , G01N33/54366 , Y10T436/255
摘要： A diagnostic device is provided comprising a housing including a chamber having one portion open to the exterior of the housing and another portion which is closed to the exterior of the housing; a porous structure, such as a hydrophilic membrane, having at least one wettable layer, disposed across the open portion of the chamber and hermetically sealed to the housing; a valve in a wall of the housing; and a means for increasing the volume of the closed portion of the chamber to thereby decrease the pressure within the closed portion of the chamber such that after the wettable layer is wetted, the diagnostic device is capable of maintaining a pressure differential across the porous structure after the volume of the closed portion of the chamber has been increased by the volume increasing means to create a pressure differential across the porous structure.
摘要翻译：提供了一种诊断装置，包括壳体，该壳体包括具有朝向壳体的外部敞开的一部分的腔室和封闭于壳体外部的另一部分; 多孔结构，例如具有至少一个可润湿层的亲水膜，横跨腔室的敞开部分设置并密封到壳体; 在壳体的壁中的阀; 以及用于增加室的封闭部分的体积的装置，从而降低室的封闭部分内的压力，使得在可润湿层被润湿之后，诊断装置能够在多孔结构之后保持跨越多孔结构的压力差腔室的封闭部分的体积通过体积增加装置增加，以在多孔结构上产生压差。

50. 发明授权

US4861617A Method of reducing the adhesion of bubbles in medical equipment 失效
标题翻译：减少医疗设备中气泡粘附的方法
公开(公告)号：US4861617A
公开(公告)日：1989-08-29
申请号：US075658
申请日：1987-07-20
申请人： David B. Pall , Peter J. Degen , Vlado I. Matkovich , Thomas C. Gsell
发明人： David B. Pall , Peter J. Degen , Vlado I. Matkovich , Thomas C. Gsell
IPC分类号： A61L29/08 , A61M5/36
CPC分类号： A61M5/36 , A61L29/085
摘要： A method of reducing the adhesion of bubbles to the surfaces of a medical administration set with which a parenteral liquid comes in contact prior to its introduction into a patient by treating the surfaces of the medical administration set with which the liquid comes in contact to increase the critical surface tension thereof prior to contacting the surfaces of the medical administration set with the liquid, preferably by radiation grafting with a solution of a monofunctional monomer compound.
摘要翻译：通过对与液体接触的医疗管理装置的表面进行处理而将气泡粘附到肠胃外液体在其被引入患者体内之前与其接触的医疗管理装置的表面的方法，在将药物给药装置的表面与液体接触之前，优选通过用单官能单体化合物的溶液进行辐射接枝之前，其临界表面张力。

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