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1. 发明授权

US5616254A System and method for processing biological fluid 失效
标题翻译：用于处理生物液体的系统和方法
公开(公告)号：US5616254A
公开(公告)日：1997-04-01
申请号：US451494
申请日：1995-05-26
申请人： David B. Pall , Thomas C. Gsell , Vlado I. Matkovich , Thomas Bormann
发明人： David B. Pall , Thomas C. Gsell , Vlado I. Matkovich , Thomas Bormann
IPC分类号： A61J1/00 , A61J1/05 , A61M1/02 , A61M1/34 , A61M1/36 , A61M5/148 , B01D61/14 , B01D61/16 , B01D61/20 , B01D61/22 , B01D63/08 , B01D65/08 , B01D37/00 , A61M1/00 , B01D21/26 , B01D39/00
CPC分类号： B01D63/087 , A61J1/05 , A61M1/02 , A61M1/0209 , A61M1/0218 , A61M1/0227 , A61M1/0231 , A61M1/025 , A61M1/029 , A61M1/3472 , A61M1/3633 , A61M1/3646 , A61M1/3652 , B01D61/145 , B01D61/147 , B01D61/16 , B01D61/20 , B01D61/22 , B01D65/08 , A61J1/10 , A61M1/3693 , A61M2202/0413 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439 , A61M2206/12 , A61M5/1486 , B01D2321/2083
摘要： A system for collecting and processing donated blood comprises a first porous medium interposed between a blood collection bag and a satellite bag and a second porous medium interposed between the blood collection bag and another satellite bag. The porous media are leucocyte depletion media. The system may also include one or more of the following: a red cell barrier medium, a separation medium, a gas inlet, and a gas outlet. The system can be used to centrifuge whole blood into one or more components, and includes a means for protecting the system during centrifugation.
摘要翻译：用于收集和处理捐赠血液的系统包括介于血液收集袋和卫星袋之间的第一多孔介质和介于血液收集袋和另一卫星袋之间的第二多孔介质。多孔介质是白细胞消耗介质。该系统还可以包括以下一种或多种：红细胞阻挡介质，分离介质，气体入口和气体出口。该系统可用于将全血离心成一个或多个组分，并且包括在离心过程中保护系统的方法。

2. 发明授权

US5217627A System and method for processing biological fluid 失效
标题翻译：用于处理生物液体的系统和方法
公开(公告)号：US5217627A
公开(公告)日：1993-06-08
申请号：US788787
申请日：1991-11-06
申请人： David B. Pall , Thomas C. Gsell , Vlado I. Matkovich , Thomas Bormann
发明人： David B. Pall , Thomas C. Gsell , Vlado I. Matkovich , Thomas Bormann
IPC分类号： A61J1/00 , A61J1/05 , A61M1/02 , A61M1/34 , A61M1/36 , A61M5/148 , B01D61/14 , B01D61/16 , B01D61/20 , B01D61/22 , B01D63/08 , B01D65/08
CPC分类号： B01D63/087 , A61J1/05 , A61M1/02 , A61M1/0209 , A61M1/0218 , A61M1/0227 , A61M1/0231 , A61M1/025 , A61M1/029 , A61M1/3472 , A61M1/3633 , A61M1/3646 , A61M1/3652 , B01D61/145 , B01D61/147 , B01D61/16 , B01D61/20 , B01D61/22 , B01D65/08 , A61J1/10 , A61M1/3693 , A61M2202/0413 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439 , A61M2206/12 , A61M5/1486 , B01D2321/2083
摘要： A system for collecting and processing donated blood comprises a first porous medium interposed between a blood collection bag and a satellite bag and a second porous medium interposed between the blood collection bag and another satellite bag. The porous media are leucocyte depletion media. The system may also include one or more of the following: a red cell barrier medium, a separation medium, a gas inlet, and a gas outlet. The system can be used to centrifuge whole blood into one or more components, and includes a means for protecting the system during centrifugation.
摘要翻译：用于收集和处理捐赠血液的系统包括介于血液收集袋和卫星袋之间的第一多孔介质和介于血液收集袋和另一卫星袋之间的第二多孔介质。多孔介质是白细胞消耗介质。该系统还可以包括以下一种或多种：红细胞阻挡介质，分离介质，气体入口和气体出口。该系统可用于将全血离心成一个或多个组分，并且包括在离心过程中保护系统的手段。

3. 发明授权

US5587070A System for processing biological fluid 失效
标题翻译：生物液体处理系统
公开(公告)号：US5587070A
公开(公告)日：1996-12-24
申请号：US071495
申请日：1993-06-04
申请人： David B. Pall , Thomas C. Gsell , Vlado I. Matkovich , Thomas Bormann
发明人： David B. Pall , Thomas C. Gsell , Vlado I. Matkovich , Thomas Bormann
IPC分类号： A61J1/00 , A61J1/05 , A61M1/02 , A61M1/34 , A61M1/36 , A61M5/148 , B01D61/14 , B01D61/16 , B01D61/20 , B01D61/22 , B01D63/08 , B01D65/08 , B01D36/00 , B01D36/02
CPC分类号： B01D63/087 , A61J1/05 , A61M1/02 , A61M1/0209 , A61M1/0218 , A61M1/0227 , A61M1/0231 , A61M1/025 , A61M1/029 , A61M1/3472 , A61M1/3633 , A61M1/3646 , A61M1/3652 , B01D61/145 , B01D61/147 , B01D61/16 , B01D61/20 , B01D61/22 , B01D65/08 , A61J1/10 , A61M1/3693 , A61M2202/0413 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439 , A61M2206/12 , A61M5/1486 , B01D2321/2083
摘要： A system for collecting and processing donated blood comprises a first porous medium interposed between a blood collection bag and a satellite bag and a second porous medium interposed between the blood collection bag and another satellite bag. The porous media are leucocyte depletion media. The system may also include one or more of the following: a red cell barrier medium, a separation medium, a gas inlet, and a gas outlet. The system can be used to centrifuge whole blood into one or more components, and includes a means for protecting the system during centrifugation.
摘要翻译：用于收集和处理捐赠血液的系统包括介于血液收集袋和卫星袋之间的第一多孔介质和介于血液收集袋和另一卫星袋之间的第二多孔介质。多孔介质是白细胞消耗介质。该系统还可以包括以下一种或多种：红细胞阻挡介质，分离介质，气体入口和气体出口。该系统可用于将全血离心成一个或多个组分，并且包括在离心过程中保护系统的方法。

4. 发明授权

US5601727A Device and method for separating plasma from a biological fluid 失效
标题翻译：用于从生物流体分离血浆的装置和方法
公开(公告)号：US5601727A
公开(公告)日：1997-02-11
申请号：US232174
申请日：1994-08-02
申请人： Thomas J. Bormann , Vlado I. Matkovich , Thomas C. Gsell , David B. Pall
发明人： Thomas J. Bormann , Vlado I. Matkovich , Thomas C. Gsell , David B. Pall
IPC分类号： A61M1/34 , A61M1/36 , A61M5/145 , A61M5/148 , B01D61/14 , B01D63/08 , B01D37/00 , B01D61/00
CPC分类号： B01D61/147 , A61M1/34 , A61M1/3603 , B01D63/08 , A61M2202/0415 , A61M2202/0439 , A61M5/1452 , A61M5/1486
摘要： A device and method for processing a biological fluid comprises directing the biological fluid tangentially or parallel to the face of a separation medium in at least one serpentine fluid flow channel such that a plasma-rich fluid passes through the separation medium and a plasma-depleted fluid passes tangentially to the surface of the separation medium.
摘要翻译： PCT No.PCT / US92 / 09542 Sec。 371日期1994年8月2日 102（e）日期1994年8月2日PCT提交1992年11月3日PCT公布。出版物WO93 / 08904 日期1993年5月13日用于处理生物流体的装置和方法包括在至少一个蛇形流体流动通道中将生物流体切向或平行于分离介质的表面引导，使得富含血浆的流体通过分离介质和等离子体耗尽的液体切向地传递到分离介质的表面。

5. 发明授权

US5266219A Device and method for separating plasma from blood 失效
标题翻译：血液分离装置及方法
公开(公告)号：US5266219A
公开(公告)日：1993-11-30
申请号：US745166
申请日：1991-08-15
申请人： David B. Pall , Thomas C. Gsell , Vlado I. Matkovich , Harvey Brandwein
发明人： David B. Pall , Thomas C. Gsell , Vlado I. Matkovich , Harvey Brandwein
IPC分类号： B01D39/16 , G01N33/49 , B01D37/00
CPC分类号： B01D39/163 , G01N33/491 , Y10T436/25375
摘要： A device for separating plasma from blood is provided comprising a synthetic polymeric fibrous structure having a CWST in excess of 65 dynes/cm, the structure having a first region for receiving a blood sample and a second region for accumulating plasma.
摘要翻译：提供了一种用于从血液中分离血浆的装置，其包括具有超过65达因/厘米的CWST的合成聚合物纤维结构，所述结构具有用于接收血液样品的第一区域和用于积聚血浆的第二区域。

6. 发明授权

US4861617A Method of reducing the adhesion of bubbles in medical equipment 失效
标题翻译：减少医疗设备中气泡粘附的方法
公开(公告)号：US4861617A
公开(公告)日：1989-08-29
申请号：US075658
申请日：1987-07-20
申请人： David B. Pall , Peter J. Degen , Vlado I. Matkovich , Thomas C. Gsell
发明人： David B. Pall , Peter J. Degen , Vlado I. Matkovich , Thomas C. Gsell
IPC分类号： A61L29/08 , A61M5/36
CPC分类号： A61M5/36 , A61L29/085
摘要： A method of reducing the adhesion of bubbles to the surfaces of a medical administration set with which a parenteral liquid comes in contact prior to its introduction into a patient by treating the surfaces of the medical administration set with which the liquid comes in contact to increase the critical surface tension thereof prior to contacting the surfaces of the medical administration set with the liquid, preferably by radiation grafting with a solution of a monofunctional monomer compound.
摘要翻译：通过对与液体接触的医疗管理装置的表面进行处理而将气泡粘附到肠胃外液体在其被引入患者体内之前与其接触的医疗管理装置的表面的方法，在将药物给药装置的表面与液体接触之前，优选通过用单官能单体化合物的溶液进行辐射接枝之前，其临界表面张力。

7. 发明授权

US5252222A Filter for parenteral systems and method of using thereof 失效
标题翻译：肠胃外系统的过滤器及其使用方法
公开(公告)号：US5252222A
公开(公告)日：1993-10-12
申请号：US620775
申请日：1990-12-03
申请人： Vlado I. Matkovich , Thomas C. Gsell , Thomas Bormann
发明人： Vlado I. Matkovich , Thomas C. Gsell , Thomas Bormann
IPC分类号： A61K9/00 , A61M5/165 , B01D19/00 , B01D36/00 , B01D39/16 , B01D61/14 , B01D61/18 , B01D63/08 , B01D69/12 , B01D61/00 , B01D39/00
CPC分类号： A61K9/0029 , A61M5/165 , B01D19/0031 , B01D36/001 , B01D39/1623 , B01D61/147 , B01D61/18 , B01D63/087 , B01D69/12 , A61M2005/1657
摘要： A filter device and method are provided for treating parenteral nutrient fluids, particularly TNA systems containing lipids, glucose, and amino acids. The filter device comprises a housing and a microporous medium in the form of a synthetic polymeric microporous structure having a pore rating of less than 1.2 micrometers. A preferred microporous medium comprises, in series, a matrix of microfibers which has been radiation grafted to render the matrix wettable by parenteral nutrient fluids followed by a microporous membrane, also wettable by parenteral nutrient fluids, and having a finer pore rating than the microfibrous matrix.

8. 发明授权

US5744047A Leucocyte depleting filter device and method of use 失效
标题翻译：白细胞消耗过滤装置及其使用方法
公开(公告)号：US5744047A
公开(公告)日：1998-04-28
申请号：US294051
申请日：1994-08-24
申请人： Thomas C. Gsell , Vlado I. Matkovich , Thomas Bormann
发明人： Thomas C. Gsell , Vlado I. Matkovich , Thomas Bormann
IPC分类号： A61M1/36 , B01D39/16 , B01D19/00 , A61M1/38 , B01D37/00 , B01D39/00
CPC分类号： B01D39/1623 , A61M1/3633 , A61M2202/0439 , A61M2205/7536 , A61M2206/16
摘要： Leucocyte depletion filter assemblies decrease the leucocyte content of a leucocyte-containing liquid at a flow rate of greater than about 25 milliliters per minute. These filter assemblies are suitable for use in an extracorporeal circuit. Methods for removing leucocytes and other deleterious matter are also disclosed.
摘要翻译：白细胞消耗过滤器组件以大于约25毫升/分钟的流速降低含白细胞液体的白细胞含量。这些过滤器组件适用于体外循环。还公开了除去白细胞和其它有害物质的方法。

9. 发明授权

US5362406A Leucocyte depleting filter device and method of use 失效
标题翻译：白细胞消耗过滤装置及其使用方法
公开(公告)号：US5362406A
公开(公告)日：1994-11-08
申请号：US221983
申请日：1994-03-09
申请人： Thomas C. Gsell , Vlado I. Matkovich , Thomas Bormann
发明人： Thomas C. Gsell , Vlado I. Matkovich , Thomas Bormann
IPC分类号： A61M1/36 , B01D39/16 , B01D19/00 , B01D35/01 , B01D39/00
CPC分类号： B01D39/1623 , A61M1/3633 , A61M2202/0439 , A61M2205/7536 , A61M2206/16
摘要： Leucocyte depletion filter assemblies and methods for removing leucocytes and other deleterious matter from a leucocyte-containing liquid are disclosed. Leucocyte depletion filter assemblies have a generally cylindrical housing having first and second chambers and an inlet into the first chamber and an outlet from the second chamber and a vent. A porous degassing element is positioned between the first and second chambers to remove gas from the liquid and the degassing element communicates with a vent covered with a liquophobic membrane which allows gas but not the liquid to flow through the vent. A hollow, cylindrical filter element is positioned in the second chamber and comprises a fibrous mass of microfibers capable of decreasing the leucocyte content of the liquid at a flow rate capacity of six liters per minute at a differential pressure of less than 15 psi. The mass of microfibers have a CWST of at least 53 dynes/cm and a graded pore size over at least a substantial radial portion of the microfibrous mass. The interior of the hollow filter element communicates with the outlet. These filter assemblies are suitable for use in an extracorporeal circuit. Leucocytes and other deleterious matter are removed from the leucocyte-containing liquid by passing the leucocyte-containing liquid through these filter assemblies.
摘要翻译：公开了白细胞消耗过滤器组件和从含白细胞的液体中除去白细胞和其它有害物质的方法。白细胞消耗过滤器组件具有大致圆柱形的壳体，其具有第一和第二腔室以及进入第一腔室的入口以及来自第二腔室的出口和排气口。多孔脱气元件位于第一和第二腔室之间以从液体中除去气体，并且脱气元件与允许气体而不是液体流过通气孔的透明膜覆盖的通气口连通。中空的圆柱形过滤器元件定位在第二室中，并且包括纤维质的微纤维，其能够在小于15psi的压差下以6升/分钟的流速容量降低液体的白细胞含量。微纤维的质量具有至少53达因/厘米的CWST和在微纤维块的至少基本径向部分上的分级孔径。中空过滤元件的内部与出口连通。这些过滤器组件适用于体外循环。通过使含白细胞的液体通过这些过滤器组件，从含白细胞的液体中除去白细胞和其它有害物质。

10. 发明授权

US5258127A Leucocyte depleting filter device and method of use 失效
标题翻译：白细胞消耗过滤装置及其使用方法
公开(公告)号：US5258127A
公开(公告)日：1993-11-02
申请号：US756567
申请日：1991-09-11
申请人： Thomas C. Gsell , Thomas Bormann , Vlado I. Matkovich
发明人： Thomas C. Gsell , Thomas Bormann , Vlado I. Matkovich
IPC分类号： A61M1/36 , B01D39/16 , B01D67/00 , B29C59/14 , B01D37/00 , B01D19/00 , B01D39/04
CPC分类号： B01D67/009 , A61M1/3633 , B01D39/1623 , B29C59/142 , A61M2202/025 , A61M2202/0275 , A61M2202/0291 , A61M2202/0439 , A61M2205/7536 , A61M2206/16 , B29K2105/04
摘要： Leucocyte depletion filter assemblies decrease the leucocyte content of a biological fluid in an extracorporeal circuit. These filter assemblies are suitable for use in an extracorporeal circuit. Methods for removing leucocytes and other deleterious matter are also disclosed. The removal medium used in these assemblies and methods may be pleated structures which have been subjected to gas plasma treatment, improving the amount of leucocytes removed and increasing the amount of platelets which pass through the medium.
摘要翻译：白细胞消耗过滤器组件减少体外循环中生物液体的白细胞含量。这些过滤器组件适用于体外循环。还公开了除去白细胞和其它有害物质的方法。用于这些组合物和方法的去除介质可以是经过气体等离子体处理的褶皱结构，改善去除的白细胞的量并增加通过介质的血小板的量。

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