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1. 发明授权

US5630946A Method for processing a biological fluid including leukocyte removal in an extracorporeal circuit 失效
标题翻译：用于在体外循环中处理包括白细胞去除的生物流体的方法
公开(公告)号：US5630946A
公开(公告)日：1997-05-20
申请号：US392358
申请日：1995-02-21
申请人： Stephen Hart , Frank R. Pascale , Vlado I. Matkovich
发明人： Stephen Hart , Frank R. Pascale , Vlado I. Matkovich
IPC分类号： A61M1/36 , A61M1/38
CPC分类号： A61M1/3621 , A61M1/3603 , A61M1/3643 , A61M2202/0439 , A61M2205/366
摘要： A method for removing undesirable material including leukocytes from a biological fluid in an extracorporeal circuit comprises passing a leukocyte containing biological fluid from a patient into a container; passing a portion of biological fluid from the container through a recirculation loop including a filter assembly for removing leukocytes to leukocyte deplete the biological fluid and to pass the portion of leukocyte-depleted biological fluid into the container; passing additional leukocyte containing biological fluid from a patient into the container so that the additional fluid is mixed with leukocyte depleted biological fluid in the container to provide a mixture including leukocyte depleted and non-leukocyte depleted biological fluid; passing the mixture of biological fluid from the container; passing a portion of the mixture to the patient while passing another portion of the mixture through the recirculation loop.
摘要翻译：一种用于从体外循环中从生物流体除去包括白细胞的不需要的物质的方法包括将含有生物流体的白细胞从患者送入容器中; 使来自容器的生物流体的一部分通过包括用于将白细胞去除白细胞的过滤器组件的再循环回路消耗生物流体并使白细胞贫乏的生物流体的一部分通过到容器中; 将含有来自患者的含有生物液体的另外的白细胞携带到容器中，使得额外的流体与容器中的白细胞贫化的生物流体混合，以提供包含白细胞贫化和非白细胞贫化的生物流体的混合物; 使来自容器的生物流体的混合物通过; 将混合物的一部分通过患者，同时使另一部分混合物通过再循环回路。

2. 发明申请

US20120325399A1 IMPACT RESISTANT DOOR SKIN, DOOR INCLUDING THE SAME, AND METHOD OF MANUFACTURING AN IMPACT RESISTANT DOOR SKIN FROM A PRE-FORMED DOOR SKIN 有权
标题翻译：抗冲击皮肤皮肤，包括其的门，以及从预先形成的门皮制造抗冲击性皮肤的方法
公开(公告)号：US20120325399A1
公开(公告)日：2012-12-27
申请号：US13600901
申请日：2012-08-31
申请人： James PFAU , Stephen Hart , James Bryant
发明人： James PFAU , Stephen Hart , James Bryant
IPC分类号： B32B33/00
CPC分类号： E06B3/7001 , B29D99/0021 , B29L2031/724 , B32B5/26 , B32B17/02 , B32B37/24 , B32B2309/02 , B32B2309/04 , B32B2375/00 , B32B2419/00 , B32B2607/00 , E06B3/80 , E06B3/822 , E06B2003/7023 , E06B2003/7051 , Y10T156/1031 , Y10T442/10
摘要： An impact resistant door skin, a door including the same, and a method of manufacturing an impact resistant door skin from a pre-formed door skin are provided. The method includes the steps of providing at least one preformed door skin and applying adhesive to a rear side of the at least one preformed door skin. A fiberglass mesh mat is pressed onto the rear side of the at least one preformed door skin. Then, chopped glass fibers coated with adhesive are sprayed onto the rear side of the at least one preformed door skin using a chopper gun to form a layer of chopped glass fibers on the fiberglass mesh mat. The performed door skin may be a molded door skin having at least one recessed panel formed therein.
摘要翻译：提供了抗冲击门皮，包括该门的门，以及从预先形成的门皮制造抗冲击门皮的方法。该方法包括以下步骤：提供至少一个预成型门皮，并将粘合剂施加到至少一个预成型门皮的后侧。将玻璃纤维网垫压在至少一个预制门皮的后侧。然后，使用切割枪将涂有粘合剂的切碎的玻璃纤维喷涂到至少一个预成型门皮的后侧，以在玻璃纤维网垫上形成切碎的玻璃纤维层。所执行的门皮可以是其中形成有至少一个凹板的模制门皮。

3. 发明授权

US4774102A Method of electrostatic powder spray coating 失效
标题翻译：静电粉末喷涂方法
公开(公告)号：US4774102A
公开(公告)日：1988-09-27
申请号：US871972
申请日：1986-06-09
申请人： Steven L. Kiefer , Stephen Hart , Ronald G. Creech
发明人： Steven L. Kiefer , Stephen Hart , Ronald G. Creech
IPC分类号： B05B5/03 , B05B5/053 , B05B5/08 , B05D1/06
CPC分类号： B05D1/06 , B05B5/032 , B05B5/0533 , B05B5/0535 , B05B5/087
摘要： An electrostatic powder spray coating method and apparatus for producing evenly coated continuous films of thermoplastic and thermosetting powders on substrates or parts having electrically conductive geometric complex surfaces and enables the use, without the occurrence of "cobwebbing," of significantly higher charging voltages for the spray gun in the spray coating of preheated substrates and parts, thus allowing faster coating lines. The invention features the use of a grounded electrically conductive ring for grounding the ionized field in the powder discharge region of the spray gun.
摘要翻译：一种静电粉末喷涂方法和装置，用于在具有导电几何复合表面的基底或部件上制备均匀涂布的热塑性和热固性粉末的连续膜，并且能够使用，而不会发生“蜘蛛网”（smwebbing）“显着更高的喷射充电电压在预热的基材和部件的喷涂中喷枪，从而允许更快的涂布线。本发明的特征在于使用接地的导电环来将喷枪的粉末放电区域中的电离场接地。

4. 发明授权

US09272441B2 Method of sealing a porous fibrous substrate, and method of making a door 有权
标题翻译：密封多孔纤维基材的方法和制造门的方法
公开(公告)号：US09272441B2
公开(公告)日：2016-03-01
申请号：US12377448
申请日：2007-08-28
申请人： James Pfau , Stephen Hart
发明人： James Pfau , Stephen Hart
IPC分类号： B27N1/00 , B27N3/00 , B27N7/00 , B29C44/12 , E06B3/72
CPC分类号： B27N1/006 , B27N3/005 , B27N7/005 , B29C44/1209 , E06B3/72 , Y10T428/249958 , Y10T442/20
摘要： A method of surface sealing a porous fibrous substrate is provided. According to the method, a porous fibrous substrate possessing a moisture content and a surface with pores is provided. A sealant composition is applied to a surface of the porous fibrous substrate and permitted to penetrate the surface pores of the porous fibrous substrate and undergo cure while participating in a foaming reaction with the moisture content to establish a water-resistant polymeric foam sealant impregnated into the porous fibrous substrate. The water-resistant polymeric foam sealant contains a polyurethane and/or polyurea.
摘要翻译：提供了表面密封多孔纤维基材的方法。根据该方法，提供具有水分含量的多孔纤维基材和具有孔的表面。将密封剂组合物施加到多孔纤维基材的表面并允许穿透多孔纤维基材的表面孔，并在参与具有水分含量的发泡反应的同时进行固化，以建立浸渍到多孔纤维基材中的耐水聚合物泡沫密封剂多孔纤维基材。耐水聚合物泡沫密封剂含有聚氨酯和/或聚脲。

5. 发明申请

US20090082250A1 Control of gene expression using a complex of an oligonucleotide and a regulatory peptide 审中-公开
标题翻译：使用寡核苷酸和调节肽的复合物控制基因表达
公开(公告)号：US20090082250A1
公开(公告)日：2009-03-26
申请号：US12152175
申请日：2008-05-13
申请人： Stephen Hart , Simak Ali , Boris Tumi PuFong , Andrew C. G. Porter , Laki Buluwela , Satu Vainikka , John David Jenkinson , Patrick Kanda
发明人： Stephen Hart , Simak Ali , Boris Tumi PuFong , Andrew C. G. Porter , Laki Buluwela , Satu Vainikka , John David Jenkinson , Patrick Kanda
IPC分类号： C12N15/11 , A61K38/02 , A01H1/06 , G01N33/53 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/1138 , C12N15/63 , C12N2310/15 , C12N2310/335 , C12N2310/336 , C12N2310/3513
摘要： A method for suppressing the expression of a selected gene in a cell the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.
摘要翻译：一种抑制细胞中所选择的基因表达的方法，包括向细胞中引入分子，所述分子包含（1）核酸结合部分，所述核酸结合部分结合位点或与所选基因相关联，所述基因存在于基因组中，（2）表达阻遏物部分，其中所述核酸结合部分包含寡核苷酸或寡核苷酸模拟物或类似物，并且其中所述阻遏物部分包含多肽或肽模拟物。提供了用于本发明方法的分子。阻遏物可以是能够募集组蛋白脱乙酰酶或DNA甲基化酶的组蛋白脱乙酰酶或DNA甲基化酶或多肽的一部分。

6. 发明授权

US08864926B2 Method of manufacturing an impact resistant door skin from a pre-formed door skin 有权
标题翻译：从预成型门皮制造耐冲击门皮的方法
公开(公告)号：US08864926B2
公开(公告)日：2014-10-21
申请号：US13600901
申请日：2012-08-31
申请人： James Pfau , Stephen Hart , James Bryant
发明人： James Pfau , Stephen Hart , James Bryant
IPC分类号： B32B17/02 , E06B3/82 , B32B5/26 , E06B3/70
CPC分类号： E06B3/7001 , B29D99/0021 , B29L2031/724 , B32B5/26 , B32B17/02 , B32B37/24 , B32B2309/02 , B32B2309/04 , B32B2375/00 , B32B2419/00 , B32B2607/00 , E06B3/80 , E06B3/822 , E06B2003/7023 , E06B2003/7051 , Y10T156/1031 , Y10T442/10
摘要： An impact resistant door skin, a door including the same, and a method of manufacturing an impact resistant door skin from a pre-formed door skin are provided. The method includes the steps of providing at least one preformed door skin and applying adhesive to a rear side of the at least one preformed door skin. A fiberglass mesh mat is pressed onto the rear side of the at least one preformed door skin. Then, chopped glass fibers coated with adhesive are sprayed onto the rear side of the at least one preformed door skin using a chopper gun to form a layer of chopped glass fibers on the fiberglass mesh mat. The performed door skin may be a molded door skin having at least one recessed panel formed therein.
摘要翻译：提供了抗冲击门皮，包括该门的门，以及从预先形成的门皮制造抗冲击门皮的方法。该方法包括以下步骤：提供至少一个预成型门皮，并将粘合剂施加到至少一个预成型门皮的后侧。将玻璃纤维网垫压在至少一个预制门皮的后侧。然后，使用切割枪将涂有粘合剂的切碎的玻璃纤维喷涂到至少一个预成型门皮的后侧，以在玻璃纤维网垫上形成切碎的玻璃纤维层。所执行的门皮可以是其中形成有至少一个凹板的模制门皮。

7. 发明申请

US20050245446A1 Materials for the delivery of biologically-active material to cells 有权
标题翻译：用于将生物活性物质递送到细胞的材料
公开(公告)号：US20050245446A1
公开(公告)日：2005-11-03
申请号：US10983464
申请日：2004-11-08
申请人： Helen Hailes , Alethea Tabor , John Wong , Michael Pilkington-Miksa , Stephen Hart , Christopher Hurley
发明人： Helen Hailes , Alethea Tabor , John Wong , Michael Pilkington-Miksa , Stephen Hart , Christopher Hurley
IPC分类号： A61K38/17 , A61K48/00 , C12N15/87
CPC分类号： C12N15/87 , A61K38/1709 , A61K48/00 , A61K2300/00
摘要： The invention provides a lipid of general formula (I) or (II): wherein X1, X2 and R1 to R5 are as defined herein. Such lipids are used to form complexes with a biologically-active material such as a nucleic acid, peptide or small molecule for delivering the biologically-active material to cells. The complexes may incorporate an integrin-binding peptide and, when the biologically-active material is DNA, thereby constitute a LID complex.
摘要翻译：本发明提供通式（I）或（II）的脂质：其中X 1，X 2和R 1至R 0 > 5 如本文所定义。这种脂质用于与生物活性物质如核酸，肽或小分子形成复合物，用于将生物活性物质递送至细胞。复合物可以结合整联蛋白结合肽，并且当生物活性物质是DNA时，由此构成LID复合物。

8. 发明授权

US5609378A Automatic crane hook safety latch 失效
标题翻译：自动吊钩安全锁
公开(公告)号：US5609378A
公开(公告)日：1997-03-11
申请号：US519190
申请日：1995-08-25
申请人： Peter Bowers , Stephen Hart
发明人： Peter Bowers , Stephen Hart
IPC分类号： B66C1/36
CPC分类号： B66C1/36 , Y10S294/905
摘要： A device for remotely opening the safety latch of a hook characterized by an actuating link attached to the safety latch that is selectively movable between a first position, opening the safety latch, and a second position, closing the safety latch. The device further includes actuator, a transmitter and a receiver. The actuator engages the actuating link and selectively moves the actuating link between the first position and the second position. The transmitter transmits operating commands, inputted by the user, to the receiver. The receiver controls the actuator and causes the actuator to selectively move the actuating link between the first position and the second position in response to operating commands from the transmitter.
摘要翻译：一种用于远程打开钩的安全闩锁的装置，其特征在于，附接到安全闩锁的致动连杆可选择性地在第一位置，打开安全闩锁和第二位置之间移动，从而闭合安全闩锁。该装置还包括致动器，发射器和接收器。致动器接合致动连杆并选择性地使致动连杆在第一位置和第二位置之间移动。发射机将由用户输入的操作命令发送到接收机。接收器控制致动器并使致动器响应于来自发射器的操作命令而选择性地将致动连杆在第一位置和第二位置之间移动。

9. 发明申请

US20120077270A1 Control of Gene Expression Using a Complex of an Oligonucleotide and a Regulatory Peptide 审中-公开
标题翻译：使用寡核苷酸和调节肽的复合物控制基因表达
公开(公告)号：US20120077270A1
公开(公告)日：2012-03-29
申请号：US13251627
申请日：2011-10-03
申请人： Stephen Hart , Simak Ali , Boris Tumi PuFong , Andrew C.G. Porter , Laki Buluwela , Satu Vainikka , John David Jenkinson , Patrick Kanda
发明人： Stephen Hart , Simak Ali , Boris Tumi PuFong , Andrew C.G. Porter , Laki Buluwela , Satu Vainikka , John David Jenkinson , Patrick Kanda
IPC分类号： C12N5/071 , C07K1/00 , C07K14/00 , C12N5/04 , C12N1/20
CPC分类号： C12N15/113 , C12N15/1138 , C12N15/63 , C12N2310/15 , C12N2310/335 , C12N2310/336 , C12N2310/3513
摘要： A method for suppressing the expression of a selected gene in a cell, the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.
摘要翻译：一种用于抑制细胞中所选基因表达的方法，所述方法包括向细胞中引入包含（1）结合位点或与选定基因相关的核酸结合部分的分子，该位点存在于基因组中和（2）表达阻遏物部分，其中所述核酸结合部分包含寡核苷酸或寡核苷酸模拟物或类似物，并且其中所述阻遏物部分包含多肽或肽模拟物。提供了用于本发明方法的分子。阻遏物可以是能够募集组蛋白脱乙酰酶或DNA甲基化酶的组蛋白脱乙酰酶或DNA甲基化酶或多肽的一部分。

10. 发明申请

US20090249716A1 IMPACT RESISTANT DOOR SKIN, DOOR INCLUDING THE SAME, AND METHOD OF MANUFACTURING AN IMPACT RESISTANT DOOR SKIN FROM A PRE-FORMED DOOR SKIN 有权
标题翻译：抗冲击皮肤皮肤，包括其的门，以及从预先形成的门皮制造抗冲击性皮肤的方法
公开(公告)号：US20090249716A1
公开(公告)日：2009-10-08
申请号：US12401207
申请日：2009-03-10
申请人： James PFAU , Stephen Hart , James Bryant
发明人： James PFAU , Stephen Hart , James Bryant
IPC分类号： E04C2/02 , B32B37/22 , E06B1/52
CPC分类号： E06B3/7001 , B29D99/0021 , B29L2031/724 , B32B5/26 , B32B17/02 , B32B37/24 , B32B2309/02 , B32B2309/04 , B32B2375/00 , B32B2419/00 , B32B2607/00 , E06B3/80 , E06B3/822 , E06B2003/7023 , E06B2003/7051 , Y10T156/1031 , Y10T442/10
摘要： An impact resistant door skin, a door including the same, and a method of manufacturing an impact resistant door skin from a pre-formed door skin are provided. The method includes the steps of providing at least one preformed door skin and applying adhesive to a rear side of the at least one preformed door skin. A fiberglass mesh mat is pressed onto the rear side of the at least one preformed door skin. Then, chopped glass fibers coated with adhesive are sprayed onto the rear side of the at least one preformed door skin using a chopper gun to form a layer of chopped glass fibers on the fiberglass mesh mat. The performed door skin may be a molded door skin having at least one recessed panel formed therein.
摘要翻译：提供了抗冲击门皮，包括该门的门，以及从预先形成的门皮制造抗冲击门皮的方法。该方法包括以下步骤：提供至少一个预成型门皮，并将粘合剂施加到至少一个预成型门皮的后侧。将玻璃纤维网垫压在至少一个预制门皮的后侧。然后，使用切割枪将涂有粘合剂的切碎的玻璃纤维喷涂到至少一个预成型门皮的后侧，以在玻璃纤维网垫上形成切碎的玻璃纤维层。所执行的门皮可以是其中形成有至少一个凹板的模制门皮。

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