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    • 41. 发明授权
    • Pitot-static tube tester system
    • 皮托静电管测试仪系统
    • US4384469A
    • 1983-05-24
    • US249255
    • 1981-03-30
    • William J. Murphy
    • William J. Murphy
    • G01F1/46G01F25/00
    • G01F1/46G01F25/0007
    • A system for testing, on the ground, an aircraft pitot-static pressure tube, its pitot and static pressure passageways and inlets, and the air pressure-sensitive flight instruments attached to the pitot-static pressure tube. The system includes a hollow adapter assembly into which the tip of the pitot-static pressure tube is inserted. When the tip is as far as it can go into the hollow adapter system, the pitot and static pressure inlets of the pitot-static tube are automatically in communication with their respective corresponding outlets in the hollow adapter assembly, irrespective of the orientation either of the pitot-static tube or of the hollow adapter assembly. This is accomplished with the use of a plurality of hollow spacers, internal of the hollow adapter body, which have flanged ends and form annular chambers that are intermediate of and in communication with the inlets and with the respective outlets. The hollow adapter assembly is releasably secured to the pitot-static tube by the use of rubber seals which, when compressed, expand, contact the tube, and hold it.
    • 一种用于在地面上测试飞行器静压压力管,其皮托管和静压通道和入口以及附着在皮托静压管上的空气压敏飞行仪器的系统。 该系统包括中空适配器组件,皮托静压管的尖端插入其中。 当尖端尽可能地进入中空适配器系统时,皮托管静压管的皮托管和静压入口自动地与中空适配器组件中各自对应的出口连通,而不管 皮托管静电管或中空适配器组件。 这是通过使用多个中空的间隔件,中空适配器本体的内部,其具有法兰端并形成环形室,其与入口和相应的出口中间并与其连通。 中空适配器组件通过使用橡胶密封件可释放地固定到皮托管静电管,橡胶密封件在被压缩时膨胀,与管接触并保持。
    • 45. 发明申请
    • MAGNETORHEOLOGICAL FLUIDS AND THERAPEUTIC USES THEREOF
    • 磁流体流体及其治疗用途
    • US20100063346A1
    • 2010-03-11
    • US12300843
    • 2007-05-17
    • William J. MurphyLisbeth A. WelniakCahit EvrenselAlan FuchsFaramarz Gordaninejad
    • William J. MurphyLisbeth A. WelniakCahit EvrenselAlan FuchsFaramarz Gordaninejad
    • A61N2/00
    • A61K33/26A61K38/2013A61K41/0052A61K45/06
    • In some embodiments, the present disclosure provides methods for stimulating a subject's immune system. Particular methods provide a tumor specific immune response by injecting a tumor with a magnetorheological fluid and applying a magnetic field to the tumor. The immune response can be used to treat disseminated tumors or metastatic cells. Further methods induce a general immune response, such as by treating a section of tissue, such as healthy tissue, with a magnetorheological fluid and applying a magnetic field to the treated tissue. The immune response can be used to treat illness or disease or to enhance the effect of a therapeutic agent. In particular examples, the disclosed methods are used to enhance the effect of immuno stimulants. Also provided are methods for causing necrosis of a cell mass, such as a tumor, by injecting a magnetorheological fluid into a section of tissue and applying a magnetic field to the tissue.
    • 在一些实施方案中,本公开提供了刺激受试者的免疫系统的方法。 特定的方法通过用磁流变流体注射肿瘤并向肿瘤施加磁场来提供肿瘤特异性免疫应答。 免疫应答可用于治疗弥漫性肿瘤或转移细胞。 其它方法诱导一般的免疫应答,例如通过用磁流变流体处理一部分组织,例如健康组织,并向处理的组织施加磁场。 免疫应答可用于治疗疾病或疾病或增强治疗剂的作用。 在具体实例中,所公开的方法用于增强免疫兴奋剂的效果。 还提供了通过将磁流变流体注射到组织的一部分并向组织施加磁场来引起细胞块如肿瘤的坏死的方法。
    • 48. 发明授权
    • Use of a promoter of T-cell expansion and an inducer of CD40 stimulation in the treatment or prevention of a pathologic state
    • 使用T细胞扩增启动子和CD40刺激诱导剂治疗或预防病理状态
    • US07368106B2
    • 2008-05-06
    • US11608873
    • 2006-12-11
    • William J. MurphyRobert WiltroutBruce BlazarSusan Wilson
    • William J. MurphyRobert WiltroutBruce BlazarSusan Wilson
    • A61K39/395A61K38/20
    • A61K38/2013A61K39/395A61K2039/505A61K2300/00
    • The invention provides a method of treating or preventing a pathologic state in a mammal. The method comprises administering to the mammal a promoter of T-cell expansion and an inducer of CD40 stimulation, wherein CD40 is stimulated on cells of the immune system. The promoter of T-cell expansion and inducer of CD40 stimulation are administered in synergistically effective amounts to treat or prevent the pathologic state in the mammal. The invention also provides a method of assessing the effectiveness of treatment of a pathologic state in a mammal, wherein the mammal has been administered a promoter of T-cell expansion and an inducer of CD40 stimulation, wherein CD40 is stimulated on cells of the immune system. The method comprises measuring the level of at least one antibody in a test sample obtained from the mammal, which at least one antibody is specific for an antigen that is known to be associated with the pathologic state, and wherein the level of the at least one antibody is indicative of the effectiveness of treatment of the pathologic state in the mammal.
    • 本发明提供了治疗或预防哺乳动物病理状态的方法。 所述方法包括向哺乳动物施用T细胞扩增的启动子和CD40刺激的诱导物,其中CD40在免疫系统的细胞上被刺激。 以协同有效量施用T细胞扩增的启动子和CD40刺激诱导物,以治疗或预防哺乳动物的病理状态。 本发明还提供了评估哺乳动物病理状态治疗有效性的方法,其中哺乳动物已经给予T细胞扩增启动子和CD40刺激诱导剂,其中CD40在免疫系统的细胞上被刺激 。 该方法包括测量从哺乳动物获得的测试样品中至少一种抗体的水平,至少一种抗体对于已知与病理状态相关的抗原是特异性的,并且其中至少一种 抗体指示治疗哺乳动物病理状态的有效性。
    • 50. 发明授权
    • Plasma enhanced liner
    • 等离子增强衬管
    • US06882052B2
    • 2005-04-19
    • US10665322
    • 2003-09-20
    • William J. Murphy
    • William J. Murphy
    • C23C16/02H01L21/285H01L21/768H01L23/485H01L23/522H01L23/48
    • H01L21/76846C23C16/0281H01L21/28512H01L21/76856H01L23/485H01L23/5226H01L2924/0002H01L2924/00
    • A method and structure for forming a refractory metal liner, includes depositing a layer of refractory metal on a first conductive layer, at least half of the depositing being carried out in the presence of an amount of passivating agent that is sufficient to impede subsequent reaction of at least a top half of the layer of refractory metal with the first conductive layer and is less than an amount of passivating agent necessary to form a stoichiometric refractory metal with the passivating agent, and annealing the refractory metal and the first conductive layer in a first element ambient, thereby forming a stoichiometric refractory metal with the first element in at least a portion of the top half of the layer of refractory metal.
    • 一种用于形成难熔金属衬垫的方法和结构,包括在第一导电层上沉积难熔金属层,至少一半的沉积在一定量的钝化剂的存在下进行,所述钝化剂足以阻止随后的反应 至少具有所述第一导电层的难熔金属层的上半部分,并且小于与所述钝化剂形成化学计量的难熔金属所需的钝化剂的量,以及第一导电层对所述难熔金属和所述第一导电层进行退火 从而在难熔金属层的上半部分的至少一部分中形成具有第一元素的化学计量的难熔金属。