专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明授权

US08674293B2 Multireflection time-of-flight mass spectrometer 有权
标题翻译：多重反射飞行时间质谱仪
公开(公告)号：US08674293B2
公开(公告)日：2014-03-18
申请号：US13790760
申请日：2013-03-08
申请人： Alexander A. Makarov , Dmitry E. Grinfeld , Mikhail A. Monastyrskiy
发明人： Alexander A. Makarov , Dmitry E. Grinfeld , Mikhail A. Monastyrskiy
IPC分类号： H01J49/40 , H01J49/26 , B01D59/44
CPC分类号： H01J49/406 , H01J49/061 , H01J49/405
摘要： A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.
摘要翻译：公开了一种在多反射飞行时间质谱仪中反射离子的方法。该方法包括将离子导向具有多个电极的离子反射镜，并向离子镜电极施加电压以产生电场，使得离子的平均轨迹与离子反射镜的对称平面相交并离开离子反射镜，其中离子由反射镜在空间上聚焦到第一位置并且在时间上聚焦到与第一位置不同的第二位置。还公开了用于执行该方法的装置。

42. 发明授权

US08461549B2 Multi-needle multi-parallel nanospray ionization source for mass spectrometry 有权
标题翻译：用于质谱的多针多平行纳米喷雾电离源
公开(公告)号：US08461549B2
公开(公告)日：2013-06-11
申请号：US13483806
申请日：2012-05-30
申请人： Alexander A. Makarov , Eloy R. Wouters
发明人： Alexander A. Makarov , Eloy R. Wouters
IPC分类号： H01J27/02 , H01J49/00 , B21D51/16
CPC分类号： H01J49/167 , H01J49/0018 , Y10T29/49423 , Y10T29/49433
摘要： An electrospray ion source for a mass spectrometer for generating ions of an analyte from a sample comprising the analyte dissolved in a liquid solvent comprises: an electrode receiving the sample and comprising at least a first plurality of protrusions protruding from a base, each protrusion of the at least a first plurality of protrusions having a respective tip; and a voltage source, wherein, in operation of the electrospray ion source, the sample is caused to move, in the presence of a gas or air, from the base to each protrusion tip along a respective protrusion exterior so as to form a respective stream of charged particles emitted towards an ion inlet aperture of the mass spectrometer under application of voltage applied to the electrode from the voltage source.
摘要翻译：用于从包含溶解在液体溶剂中的分析物的样品产生分析物离子的质谱仪的电喷雾离子源包括：接收样品并包含至少从基底突出的第一多个突起的电极，至少第一多个突起具有相应的末端; 以及电压源，其中，在电喷雾离子源的操作中，使样品在气体或空气的存在下沿着相应的突起外部从基部移动到每个突起尖端，以形成相应的流在施加从电压源施加到电极的电压下，向质谱仪的离子入口孔发射的带电粒子。

43. 发明申请

US20120043460A1 Ion Transfer Tube Having Single or Multiple Elongate Bore Segments and Mass Spectrometer System 有权
标题翻译：具有单个或多个细长孔径和质谱仪系统的离子转移管
公开(公告)号：US20120043460A1
公开(公告)日：2012-02-23
申请号：US12858726
申请日：2010-08-18
申请人： Eloy R. WOUTERS , Alexander A. Makarov , R. Paul Atherton , Jean Jacques Dunyach
发明人： Eloy R. WOUTERS , Alexander A. Makarov , R. Paul Atherton , Jean Jacques Dunyach
IPC分类号： H01J49/26 , B23H1/00 , H01J49/04
CPC分类号： H01J49/0404
摘要： An ion transfer tube for a mass spectrometer comprises a tube member having an inlet end and an outlet end; and at least one bore extending through the tube member from the inlet end to the outlet end, the at least one bore having a non-circular cross section. A method of forming an ion transfer tube comprises the steps of providing a tube member having a length and an internal bore, the internal bore having a wall of circular cross section; and etching or eroding portions of the tube member adjacent to the wall so as to form an enlarged bore having a non-circular cross section.
摘要翻译：用于质谱仪的离子转移管包括具有入口端和出口端的管构件; 以及至少一个孔，其从所述入口端延伸到所述管构件到所述出口端，所述至少一个孔具有非圆形横截面。形成离子转移管的方法包括以下步骤：提供具有长度和内孔的管构件，所述内孔具有圆形横截面的壁; 并且蚀刻或侵蚀与壁相邻的管构件的部分，以便形成具有非圆形横截面的扩大孔。

44. 发明授权

US07985950B2 Parallel mass analysis 有权
标题翻译：平行质量分析
公开(公告)号：US07985950B2
公开(公告)日：2011-07-26
申请号：US12521688
申请日：2007-12-27
申请人： Alexander A. Makarov , Stevan Horning
发明人： Alexander A. Makarov , Stevan Horning
IPC分类号： H01J49/26 , H01J27/02
CPC分类号： H01J49/009 , H01J49/425
摘要： A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap.
摘要翻译：提供了一种质谱系统和方法。来自离子源的离子存储在第一离子存储装置和第二离子存储装置中。在第一喷射时间段期间，离子从第一离子存储装置喷射到第一质量分析装置，以在第一分析时间段期间进行分析。在第二喷射时间段期间，离子从第二离子存储装置喷射到第二质量分析装置。离子存储装置串联连接，使得第一离子存储装置的离子传送孔与第二离子存储装置的离子传送孔连通。第一分析时间段和第二喷射时间段至少部分重叠。

45. 发明申请

US20100038533A1 Ion Transfer Arrangement with Spatially Alternating DC and Viscous Ion Flow 有权
标题翻译：离子转移布置与空间交替DC和粘性离子流
公开(公告)号：US20100038533A1
公开(公告)日：2010-02-18
申请号：US12513954
申请日：2007-11-07
申请人： Alexander A. Makarov , Reinhold Pesch , Robert Malek , Viacheslav Kozlovskiy
发明人： Alexander A. Makarov , Reinhold Pesch , Robert Malek , Viacheslav Kozlovskiy
IPC分类号： H01J49/02
CPC分类号： H01J49/062 , H01J3/14
摘要： A method of transporting gas and entrained ions between higher and lower pressure regions of a mass spectrometer comprises providing an ion transfer conduit 60 between the higher and lower pressure regions. The ion transfer conduit 60 includes an electrode assembly 300 which defines an ion transfer channel. The electrode assembly 300 has a first set of ring electrodes 305 of a first width D1, and a second set of ring electrodes of a second width D2 (≧D1) and interleaved with the first ring electrodes 305. A DC voltage of magnitude V1 and a first polarity is supplied to the first ring electrodes 205 and a DC voltage of magnitude V2 which may be less than or equal to the magnitude of V1 but with an opposed polarity is applied to the second ring electrodes 310. The pressure of the ion transfer conduit 60 is controlled so as to maintain viscous flow of gas and ions within the ion transfer channel.
摘要翻译：在质谱仪的较高压力区域和较低压力区域之间输送气体和夹带离子的方法包括在较高压力区域和较低压力区域之间提供离子转移导管60。离子传递管道60包括限定离子传递通道的电极组件300。电极组件300具有第一组宽度为D1的环形电极305和第二组宽度D2（≧D1）的第二组环形电极，并与第一环形电极305交错。将第一极性提供给第一环形电极205，并且可以将小于或等于V1的大小但具有相对极性的幅度为V2的DC电压施加到第二环形电极310.离子转移的压力管道60被控制以便保持气体和离子在离子传递通道内的粘性流动。

46. 发明授权

US09196469B2 Constraining arcuate divergence in an ion mirror mass analyser 有权
公开(公告)号：US09196469B2
公开(公告)日：2015-11-24
申请号：US13989697
申请日：2011-11-24
申请人： Alexander A. Makarov
发明人： Alexander A. Makarov
IPC分类号： H01J49/34 , H01J49/40 , H01J49/42
CPC分类号： H01J49/405 , H01J49/4245 , H01J49/425 , H01J49/427
摘要： A method of selecting ions of interest from a beam of ions using an analyzer, the method comprising: (i) providing an analyzer comprising two opposing ion mirrors each mirror comprising inner and outer field-defining electrode systems elongated along an analyzer axis z, each system comprising one or more electrodes, the outer system surrounding the inner; (ii) causing the beam of ions to fly through the analyzer along a main flight path in the presence of an analyzer field so as to undergo within the analyzer at least one full oscillation in the direction of the analyzer axis while orbiting about or oscillating between one or more electrodes of the inner field defining electrode system; (iii) providing one or more sets of electrodes adjacent the main flight path; (iv) constraining the arcuate divergence from the main flight path of ions of interest by applying one set of voltages to one or more of the sets of electrodes adjacent the main flight path when the ions of interest are in the vicinity of at least one of said one or more sets of electrodes adjacent the main flight path and applying one or more different sets of voltages to the said one or more sets of electrodes adjacent the main flight path when the ions of interest are not in the vicinity of at least one of said one or more sets of electrodes adjacent the main flight path; and: (v) ejecting the ions of interest from the analyzer. Also provided is a charged particle analyzer comprising the two opposing ion mirrors comprising inner and outer field-defining electrode systems elongated along an analyzer axis z; and at least one arcuate focusing lens for constraining the arcuate divergence of a beam of charged particles within the analyzer while the beam orbits around the axis z, the analyzer further comprising a disc having two faces at least partly spanning the space between the inner and outer field defining electrode systems and lying in a plane perpendicular to the axis z, the disc having resistive coating upon both faces.

47. 发明授权

US08637815B2 Charged particle analysers and methods of separating charged particles 有权
标题翻译：带电粒子分析仪和分离带电粒子的方法
公开(公告)号：US08637815B2
公开(公告)日：2014-01-28
申请号：US13375150
申请日：2010-05-27
申请人： Alexander A. Makarov , Anastassios Giannakopulos
发明人： Alexander A. Makarov , Anastassios Giannakopulos
IPC分类号： H01J49/40
CPC分类号： H01J49/40 , H01J49/406 , H01J49/4245
摘要： Methods and analysers useful for time of flight mass spectrometry are provided. A method of separating charged particles comprises the steps of: providing an analyser comprising two opposing mirrors each mirror comprising inner and outer field-defining electrode systems elongated along an axis z, the outer system surrounding the inner and defining therebetween an analyser volume, the mirrors creating an electrical field within the analyser volume comprising opposing electrical fields along z, the strength along z of the electrical field being a minimum at a plane z=0; causing a beam of charged particles to fly through the analyser, orbiting around the z axis within the analyser volume, reflecting from one mirror to the other at least once thereby defining a maximum turning point within a mirror; the strength along z of the electrical field at the maximum turning point being X and the absolute strength along z of the electrical field being less than |X|/2 for not more than ⅔ of the distance along z between the plane z=0 and the maximum turning point in each mirror; separating the charged particles according to their flight times; and ejecting at least some of the charged particles having a plurality of m/z from the analyser or detecting the at least some of charged particles having a plurality of m/z, the ejecting or detecting being performed after the particles have undergone the same number of orbits around the axis z.
摘要翻译：提供了可用于飞行时间质谱的方法和分析仪。分离带电粒子的方法包括以下步骤：提供包括两个相对的反射镜的分析器，每个反射镜包括沿着轴线z细长的内部和外部场限定电极系统，外部系统围绕内部并且在其间限定分析器体积，在分析器体积内产生包括沿着z的相对电场的电场，在z = 0的平面处电场z的强度是最小的; 使得带电粒子束飞过分析器，围绕分析器体积内的z轴轨道运动，从一个反射镜至另一个反射镜至少一次，从而限定了反射镜内的最大转折点; 在最大转折点处的电场z的强度为X，电场z的绝对强度小于| X | / 2，不超过z = z = 0和每个镜中的最大转折点; 根据飞行时间分离带电粒子; 并且从分析器中排出具有多个m / z的至少一些带电粒子或者检测至少一些具有多个m / z的带电粒子，在粒子经历相同数目之后执行喷射或检测绕z轴的轨道。

48. 发明授权

US08546754B2 Ion trap 有权
标题翻译：离子阱
公开(公告)号：US08546754B2
公开(公告)日：2013-10-01
申请号：US13204043
申请日：2011-08-05
申请人： Alexander A. Makarov , Mikhail A. Monastyrskiy , Dmitry E. Grinfeld
发明人： Alexander A. Makarov , Mikhail A. Monastyrskiy , Dmitry E. Grinfeld
IPC分类号： H01J49/42 , H01J49/26
CPC分类号： H01J49/423 , H01J49/427
摘要： An ion trap comprises substantially elongate electrodes 10, 20 some of which are curved along their axis of elongation and which define a trapping volume between them. The sectional area of this trapping volume towards the extremities of the trap in the direction of elongation is different to the sectional area away from its extremities (eg towards the middle of the trap). In a preferred embodiment, the trap has a plurality of elongate electrodes, wherein opposed electrodes have different radii of curvature so that the trap splays towards its extremities. Thereby, a wider mass range of ions can be trapped and ejected, a higher space charge capacity (for a given trap length) is provided, and sharper ion beam focussing on ejection is possible.
摘要翻译：离子阱包括基本上细长的电极10,20，其中一些电极10,10沿着其伸长轴线弯曲并且在它们之间限定捕获体积。该捕集体向伸长方向截面的横截面面积与远离其末端的截面积（例如朝向捕集阱的中部）不同。在优选实施例中，陷阱具有多个细长电极，其中相对电极具有不同的曲率半径，使得陷阱向其四肢展开。因此，可以捕获并喷射更宽质量范围的离子，提供更高的空间电荷容量（对于给定的陷阱长度），并且能够在喷射时聚焦更清晰的离子束。

49. 发明授权

US08507852B2 Apparatus and methods for ion mobility spectrometry 有权
标题翻译：用于离子迁移谱的装置和方法
公开(公告)号：US08507852B2
公开(公告)日：2013-08-13
申请号：US13327396
申请日：2011-12-15
申请人： Alexander A. Makarov
发明人： Alexander A. Makarov
IPC分类号： H01J49/36 , H01J49/26 , H01J49/00
CPC分类号： G01N27/622 , H01J49/004
摘要： There is provided of an on mobility spectrometer for separating ions according to their on mobility comprising, in various aspects: a drift tube having therein a drift space and in the drift space at least two on separation paths of different lengths: a straight drift tube having therein a helical ion separation path; a helical on separation path surrounding an axially extending inner electrode assembly; and a drift tube for separating ions according to their ion mobility wherein a rotating arcuate electric field is applied in operation to separate ions having an ion mobility such that their rotational velocity in the drift tube is matched to the rotational velocity of the rotating arcuate electric field. Various methods for separating ions according to their on mobility are also provided.
摘要翻译：提供了一种用于根据其移动性分离离子的移动光谱仪，其包括在各个方面：其中具有漂移空间的漂移管和在漂移空间中至少两个在不同长度的分离路径上的漂移管：具有其中有螺旋离子分离路径; 围绕轴向延伸的内部电极组件的分离路径上的螺旋; 以及用于根据其离子迁移率分离离子的漂移管，其中在操作中施加旋转弓形电场以分离具有离子迁移率的离子，使得它们在漂移管中的旋转速度与旋转弧形电场的旋转速度相匹配。还提供了根据其流动性分离离子的各种方法。

50. 发明申请

US20120091332A1 Charged Particle Analysers and Methods of Separating Charged Particles 有权
标题翻译：带电粒子分析仪和分离带电粒子的方法
公开(公告)号：US20120091332A1
公开(公告)日：2012-04-19
申请号：US13375187
申请日：2010-05-27
申请人： Alexander A. Makarov , Anastassios Giannakopulos
发明人： Alexander A. Makarov , Anastassios Giannakopulos
IPC分类号： H01J49/40 , H01J49/26 , H01J49/06
CPC分类号： H01J49/40 , H01J49/406 , H01J49/4245
摘要： A method of separating charged particles using an analyser is provided, the method comprising: causing a beam of charged particles to fly through the analyser and undergo within the analyser at least one full oscillation in the direction of an analyser axis (z) of the analyser whilst orbiting about the axis (z) along a main flight path; constraining the arcuate divergence of the beam as it flies through the analyser; and separating the charged particles according to their flight time. An analyser for performing the method is also provided. At least one arcuate focusing lens is preferably used to constrain the divergence, which may comprise a pair of opposed electrodes located either side of the beam. An array of arcuate focusing lenses may be used which are located at substantially the same z coordinate, the arcuate focusing lenses in the array being spaced apart in the arcuate direction and the array extending at least partially around the z axis, thereby constraining the arcuate divergence of the beam a plurality of times as it flies through the analyser.
摘要翻译：提供了一种使用分析器分离带电粒子的方法，所述方法包括：使带电粒子束飞过分析器，并在分析器内沿分析器轴线（z）的方向进行至少一次全部振荡，同时沿着主飞行路径围绕轴线（z）绕行驶; 约束梁在其穿过分析器时的弓形发散; 并根据飞行时间分离带电粒子。还提供了用于执行该方法的分析器。优选地使用至少一个弧形聚焦透镜来限制发散，其可以包括位于光束的任一侧的一对相对的电极。可以使用位于基本上相同z坐标处的弧形聚焦透镜阵列，阵列中的弧形聚焦透镜在弧形方向上间隔开，并且阵列至少部分地围绕z轴延伸，从而约束弓形散度的光束多次通过分析仪。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式