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1. 发明授权

US08847154B2 Ion transfer tube for a mass spectrometer system 有权
标题翻译：用于质谱仪系统的离子转移管
公开(公告)号：US08847154B2
公开(公告)日：2014-09-30
申请号：US13333948
申请日：2011-12-21
申请人： Eloy R. Wouters , Alexander A. Makarov , R. Paul Atherton , Jean Jacques Dunyach
发明人： Eloy R. Wouters , Alexander A. Makarov , R. Paul Atherton , Jean Jacques Dunyach
IPC分类号： H01J49/26 , H01J49/42 , H01J49/04
CPC分类号： H01J49/0404 , B23H7/02 , B23H9/14
摘要： An ion transfer tube for a mass spectrometer comprises a core member and a first jacket tube member at least partially enclosing the core member and providing one or more channels therethrough. A method of forming an ion transfer tube, comprises: providing a first jacket tube member having a length and an internal bore, the internal bore passing along the length and defining an interior surface of circular cross section; removing at least one portion of the first jacket tube member adjacent to the interior surface so as to form at least one groove, channel, slot, recess or embayment of or in the interior surface; and providing a core member within the bore of the jacket tube member such that remnant portions of the interior surface of circular cross section mate against portions of an exterior surface of the core member.
摘要翻译：用于质谱仪的离子传递管包括芯构件和至少部分地包围芯构件并且提供穿过其中的一个或多个通道的第一护套管构件。一种形成离子转移管的方法，包括：提供具有长度和内孔的第一套管构件，所述内孔沿着所述长度通过并限定圆形横截面的内表面; 移除与所述内表面相邻的所述第一套管构件的至少一部分，以便形成所述内表面中或所述内表面中的至少一个凹槽，通道，槽，凹槽或沉积物; 并且在所述护套管构件的所述孔内提供芯构件，使得所述圆形横截面的内表面的残留部分与所述芯构件的外表面的部分配合。

2. 发明授权

US08309916B2 Ion transfer tube having single or multiple elongate bore segments and mass spectrometer system 有权
标题翻译：离子转移管具有单个或多个细长孔段和质谱仪系统
公开(公告)号：US08309916B2
公开(公告)日：2012-11-13
申请号：US12858726
申请日：2010-08-18
申请人： Eloy R. Wouters , Alexander A. Makarov , R. Paul Atherton , Jean Jacques Dunyach
发明人： Eloy R. Wouters , Alexander A. Makarov , R. Paul Atherton , Jean Jacques Dunyach
IPC分类号： H01J49/26
CPC分类号： H01J49/0404
摘要： An ion transfer tube for a mass spectrometer comprises a tube member having an inlet end and an outlet end; and at least one bore extending through the tube member from the inlet end to the outlet end, the at least one bore having a non-circular cross section. A method of forming an ion transfer tube comprises the steps of providing a tube member having a length and an internal bore, the internal bore having a wall of circular cross section; and etching or eroding portions of the tube member adjacent to the wall so as to form an enlarged bore having a non-circular cross section.
摘要翻译：用于质谱仪的离子转移管包括具有入口端和出口端的管构件; 以及至少一个孔，其从所述入口端延伸到所述管构件到所述出口端，所述至少一个孔具有非圆形横截面。形成离子转移管的方法包括以下步骤：提供具有长度和内孔的管构件，所述内孔具有圆形横截面的壁; 并且蚀刻或侵蚀与壁相邻的管构件的部分，以便形成具有非圆形横截面的扩大孔。

3. 发明申请

US20120043460A1 Ion Transfer Tube Having Single or Multiple Elongate Bore Segments and Mass Spectrometer System 有权
标题翻译：具有单个或多个细长孔径和质谱仪系统的离子转移管
公开(公告)号：US20120043460A1
公开(公告)日：2012-02-23
申请号：US12858726
申请日：2010-08-18
申请人： Eloy R. WOUTERS , Alexander A. Makarov , R. Paul Atherton , Jean Jacques Dunyach
发明人： Eloy R. WOUTERS , Alexander A. Makarov , R. Paul Atherton , Jean Jacques Dunyach
IPC分类号： H01J49/26 , B23H1/00 , H01J49/04
CPC分类号： H01J49/0404
摘要： An ion transfer tube for a mass spectrometer comprises a tube member having an inlet end and an outlet end; and at least one bore extending through the tube member from the inlet end to the outlet end, the at least one bore having a non-circular cross section. A method of forming an ion transfer tube comprises the steps of providing a tube member having a length and an internal bore, the internal bore having a wall of circular cross section; and etching or eroding portions of the tube member adjacent to the wall so as to form an enlarged bore having a non-circular cross section.
摘要翻译：用于质谱仪的离子转移管包括具有入口端和出口端的管构件; 以及至少一个孔，其从所述入口端延伸到所述管构件到所述出口端，所述至少一个孔具有非圆形横截面。形成离子转移管的方法包括以下步骤：提供具有长度和内孔的管构件，所述内孔具有圆形横截面的壁; 并且蚀刻或侵蚀与壁相邻的管构件的部分，以便形成具有非圆形横截面的扩大孔。

4. 发明申请

US20110260048A1 Ion Transfer Tube for a Mass Spectrometer Having a Resistive Tube Member and a Conductive Tube Member 审中-公开
标题翻译：用于具有电阻管部件和导电管部件的质谱仪的离子转移管
公开(公告)号：US20110260048A1
公开(公告)日：2011-10-27
申请号：US12765540
申请日：2010-04-22
申请人： Eloy R. WOUTERS , Alexander A. Makarov , Jean-Jacques Dunyach
发明人： Eloy R. WOUTERS , Alexander A. Makarov , Jean-Jacques Dunyach
IPC分类号： H01J49/04 , H01J49/26
CPC分类号： H01J49/0404
摘要： An ion transfer tube having an ion inlet and an ion outlet comprises: a first tube member comprising an electrically resistive material and having a first end comprising the ion inlet and a second end; a first electrode electrically coupled to the first tube member; a second tube member having a first end in leak-tight contact with the second end of the first tube member and a second end comprising the ion outlet; a second electrode electrically coupled to either the first tube member or the second tube member; and a heater thermally coupled to at least one of the tube members, wherein, in operation, an electrical potential difference applied between the electrodes produces an electric field within the first tube member that urges charged particles through the first tube member into the second tube member and the heater supplies heat to the charged particles within the ion transfer tube.
摘要翻译：具有离子入口和离子出口的离子传递管包括：第一管构件，其包括电阻材料并且具有包括离子入口的第一端和第二端; 电耦合到第一管构件的第一电极; 第二管构件，其具有与第一管构件的第二端密封接触的第一端和包括离子出口的第二端; 电耦合到第一管构件或第二管构件的第二电极; 以及加热器，其耦合到所述管构件中的至少一个，其中，在操作中，施加在所述电极之间的电位差在所述第一管构件内产生电场，所述电场将带电粒子通过所述第一管构件推入所述第二管构件并且加热器向离子传递管内的带电粒子提供热量。

5. 发明授权

US08461549B2 Multi-needle multi-parallel nanospray ionization source for mass spectrometry 有权
标题翻译：用于质谱的多针多平行纳米喷雾电离源
公开(公告)号：US08461549B2
公开(公告)日：2013-06-11
申请号：US13483806
申请日：2012-05-30
申请人： Alexander A. Makarov , Eloy R. Wouters
发明人： Alexander A. Makarov , Eloy R. Wouters
IPC分类号： H01J27/02 , H01J49/00 , B21D51/16
CPC分类号： H01J49/167 , H01J49/0018 , Y10T29/49423 , Y10T29/49433
摘要： An electrospray ion source for a mass spectrometer for generating ions of an analyte from a sample comprising the analyte dissolved in a liquid solvent comprises: an electrode receiving the sample and comprising at least a first plurality of protrusions protruding from a base, each protrusion of the at least a first plurality of protrusions having a respective tip; and a voltage source, wherein, in operation of the electrospray ion source, the sample is caused to move, in the presence of a gas or air, from the base to each protrusion tip along a respective protrusion exterior so as to form a respective stream of charged particles emitted towards an ion inlet aperture of the mass spectrometer under application of voltage applied to the electrode from the voltage source.
摘要翻译：用于从包含溶解在液体溶剂中的分析物的样品产生分析物离子的质谱仪的电喷雾离子源包括：接收样品并包含至少从基底突出的第一多个突起的电极，至少第一多个突起具有相应的末端; 以及电压源，其中，在电喷雾离子源的操作中，使样品在气体或空气的存在下沿着相应的突起外部从基部移动到每个突起尖端，以形成相应的流在施加从电压源施加到电极的电压下，向质谱仪的离子入口孔发射的带电粒子。

6. 发明授权

US08207496B2 Multi-needle multi-parallel nanospray ionization source for mass spectrometry 有权
标题翻译：用于质谱的多针多平行纳米喷雾电离源
公开(公告)号：US08207496B2
公开(公告)日：2012-06-26
申请号：US12701011
申请日：2010-02-05
申请人： Alexander A. Makarov , Eloy R. Wouters
发明人： Alexander A. Makarov , Eloy R. Wouters
IPC分类号： H01J49/26 , H01J49/10 , H01J49/04 , H01B13/00
CPC分类号： H01J49/167 , H01J49/0018 , Y10T29/49423 , Y10T29/49433
摘要： An electrospray ion source for a mass spectrometer includes an electrode comprising at least a first plurality of protrusions protruding from a base, each protrusion of the at least a first plurality of protrusions having a respective tip; a conduit for delivering an analyte-bearing liquid to the electrode; and a voltage source, wherein, in operation of the electrospray ion source, the analyte-bearing liquid is caused to move, in the presence of a gas or air, from the base to each protrusion tip along a respective protrusion exterior so as to form a respective stream of charged particles emitted towards an ion inlet aperture of the mass spectrometer under application of voltage applied to the electrode from the voltage source.
摘要翻译：用于质谱仪的电喷雾离子源包括电极，其包括从基底突出的至少第一多个突起，所述至少第一多个突起的每个突起具有相应的末端; 用于将分析物承载液体输送到电极的导管; 以及电压源，其中，在电喷雾离子源的操作中，使有分析物的液体在气体或空气的存在下沿着相应的突起外部从基部移动到每个突起尖端，以形成在施加从电压源施加到电极的电压下，向质谱仪的离子入口孔发射的相应的带电粒子流。

7. 发明申请

US20140224995A1 Ion Detection 有权
标题翻译：离子检测
公开(公告)号：US20140224995A1
公开(公告)日：2014-08-14
申请号：US14117302
申请日：2012-05-14
申请人： Alexander Kholomeev , Alexander A. Makarov
发明人： Alexander Kholomeev , Alexander A. Makarov
IPC分类号： H01J49/02 , H01J49/00
CPC分类号： H01J49/025 , H01J49/0031 , H01J49/022 , H01J49/425
摘要： A mass analyser in which ions form packets that oscillate with a period has an ion detector comprising: a detection arrangement; and compensation circuitry. The detection arrangement may comprise: a plurality of detection electrodes detecting image current signals from ions in the mass analyser; and a preamplifier, providing an output based on the image current signals. The compensation circuitry provides a compensation signal to a respective compensatory part of the detection arrangement, based on one or more of the image current signals. A capacitance between each of the compensatory parts of the detection arrangement and a signal-carrying part of the detection arrangement affects the signal-to-noise ratio of the preamplifier output. A generator may provide a trapping field defining an ion trapping volume and a shielding conductor may be positioned between two detection electrodes, with a controller applying a voltage to the shielding conductor based on a detected image current.
摘要翻译：其中离子形成具有一段时间振荡的分组的质量分析器具有离子检测器，其包括：检测装置; 和补偿电路。检测装置可以包括：多个检测电极，用于检测质量分析器中离子的图像电流信号; 和前置放大器，基于图像电流信号提供输出。补偿电路基于一个或多个图像电流信号向检测装置的相应的补偿部分提供补偿信号。检测装置的每个补偿部分和检测装置的信号承载部分之间的电容影响前置放大器输出的信噪比。发生器可以提供限定离子捕获体积的捕获场，并且屏蔽导体可以位于两个检测电极之间，其中控制器基于检测到的图像电流向屏蔽导体施加电压。

8. 发明申请

US20140191122A1 Mass Analyser 有权
标题翻译：质量分析仪
公开(公告)号：US20140191122A1
公开(公告)日：2014-07-10
申请号：US14117172
申请日：2012-05-14
申请人： Eduard V. Denisov , Alexander Kholomeev , Jan-Peter Hauschild , Alexander A. Makarov
发明人： Eduard V. Denisov , Alexander Kholomeev , Jan-Peter Hauschild , Alexander A. Makarov
IPC分类号： H01J49/26
CPC分类号： H01J49/26 , H01J49/425 , Y10T29/49117
摘要： A mass analyser comprises: an electrical field generator, providing a time-varying electric field for injection of ions to be analysed, excitation of ions to be analysed or both; first and second detection electrodes, each of which receives a respective voltage pickup due to the time-varying electric field and provides a respective detection signal based on a respective image current at the detection electrode; and a differential amplifier, providing an output based on the difference between the detection signal for the first detection electrode and the detection signal for the second detection electrode. It may also be provided that the electrical field generator comprises at least one field generating electrode without a spatially symmetrical counterpart and the capacitance between each field generating electrode and the first detection electrode is substantially the same as the capacitance between that field generating electrode and the second detection electrode.
摘要翻译：质量分析器包括：电场发生器，提供用于注入要分析的离子的时变电场，要分析的离子的激发或两者; 第一和第二检测电极，每个检测电极由于时变电场而接收相应的电压拾取器，并且基于检测电极处的各自的图像电流提供相应的检测信号; 以及差分放大器，基于第一检测电极的检测信号和第二检测电极的检测信号之间的差提供输出。还可以提供的是，电场发生器包括至少一个没有空间对称的场产生电极，并且每个场产生电极和第一检测电极之间的电容与该场产生电极和第二检测电极之间的电容基本相同检测电极。

9. 发明授权

US08735811B2 Multi-channel detection 有权
标题翻译：多通道检测
公开(公告)号：US08735811B2
公开(公告)日：2014-05-27
申请号：US13345329
申请日：2012-01-06
申请人： Alexander A. Makarov
发明人： Alexander A. Makarov
IPC分类号： H01J49/40
CPC分类号： H01J49/406 , H01J49/004 , H01J49/025 , H01J49/061 , H01J49/408
摘要： A mass spectrometer and method of mass spectrometry wherein charged particles in a beam undergo multiple changes of direction. A detection arrangement detects a first portion of the charged particle beam, and provides a first output based upon the intensity of the detected first portion of the charged particle beam. The detection arrangement detects a second portion of the charged particle beam that has traveled a greater path length through the mass spectrometer than the first portion of the charged particle beam, and provides a second output based upon the detected second portion of the charged particle beam. A controller adjusts the parameters of the charged particle beam and/or the detection arrangement, based upon the first output of the detection arrangement, so as to adjust the second output of the detection arrangement.
摘要翻译：质谱仪和质谱法，其中光束中的带电粒子经历多个方向改变。检测装置检测带电粒子束的第一部分，并且基于所检测到的带电粒子束的第一部分的强度提供第一输出。检测装置检测带电粒子束的第二部分，该第二部分已经比通过质谱仪行进了比带电粒子束的第一部分更大的路径长度，并且基于检测到的带电粒子束的第二部分提供第二输出。控制器基于检测装置的第一输出来调整带电粒子束和/或检测装置的参数，以便调整检测装置的第二输出。

10. 发明授权

US08716654B2 Electrostatic trap 有权
标题翻译：静电诱捕器
公开(公告)号：US08716654B2
公开(公告)日：2014-05-06
申请号：US13737771
申请日：2013-01-09
申请人： Alexander A. Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan R. Horning
发明人： Alexander A. Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan R. Horning
IPC分类号： H01J49/26
CPC分类号： H01J49/4245 , H01J49/0027 , H01J49/02 , H01J49/282 , H01J49/406 , H01J49/425
摘要： An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′ (r, Φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, Φ, z) is the result of a perturbation W to an ideal field U(r, Φ, z) which, for example, is hypologarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, Φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 π radians over an ion detection period Tm.
摘要翻译：公开了诸如轨道捕获器的静电捕获器，具有电极结构。产生U'（r，Φ，z）形式的静电捕获场，以捕获陷阱内的离子，使它们经历同步振荡。捕获场U'（r，Φ，z）是对于理想场U（r，Φ，z）的扰动W的结果，其在轨道捕获的情况下例如是对数的。扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，Φ，z）的等电位，或者通过添加失真场（电或磁性）。扰动的幅度使得至少一些捕获的离子具有大于零但小于2的绝对相位扩展; 弧度超过离子检测周期Tm。

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