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41. 发明授权

US08355138B2 Method and apparatus for performing optical imaging using frequency-domain interferometry 有权
公开(公告)号：US08355138B2
公开(公告)日：2013-01-15
申请号：US13191885
申请日：2011-07-27
申请人： Seok-Hyun Yun , Brett Eugene Bouma , Guillermo J. Tearney , Johannes Fitzgerald De Boer
发明人： Seok-Hyun Yun , Brett Eugene Bouma , Guillermo J. Tearney , Johannes Fitzgerald De Boer
IPC分类号： G01B11/02 , G01B9/02
CPC分类号： H01S5/5045 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02002 , G01B9/02004 , G01B9/02043 , G01B9/02075 , G01B9/02081 , G01B9/02083 , G01B9/02084 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/0218 , G01J3/0264 , G01J3/453 , G01J9/0215 , G01N21/4795 , G02B6/3604 , G02B26/12 , G02B27/48 , G02F1/093 , G02F1/11 , H01S3/0071 , H01S3/0078 , H01S3/08009 , H01S3/08063 , H01S3/105 , H01S3/1068 , H01S5/0071 , H01S5/0078 , H01S5/1025 , H01S5/14 , H01S5/141 , H01S5/146
摘要： An apparatus and method are provided. In particular, at least one first electro-magnetic radiation may be provided to a sample and at least one second electro-magnetic radiation can be provided to a non-reflective reference. A frequency of the first and/or second radiations varies over time. An interference is detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. Alternatively, the first electro-magnetic radiation and/or second electro-magnetic radiation have a spectrum which changes over time. The spectrum may contain multiple frequencies at a particular time. In addition, it is possible to detect the interference signal between the third radiation and the fourth radiation in a first polarization state. Further, it may be preferable to detect a further interference signal between the third and fourth radiations in a second polarization state which is different from the first polarization state. The first and/or second electro-magnetic radiations may have a spectrum whose mean frequency changes substantially continuously over time at a tuning speed that is greater than 100 Tera Hertz per millisecond.

42. 再颁专利

USRE43875E1 System and method for optical coherence imaging 有权
标题翻译：光学相干成像系统和方法
公开(公告)号：USRE43875E1
公开(公告)日：2012-12-25
申请号：US12323228
申请日：2008-11-25
申请人： Milen Shishkov , Brett Eugene Bouma , Guillermo J. Tearney
发明人： Milen Shishkov , Brett Eugene Bouma , Guillermo J. Tearney
IPC分类号： G02B6/32 , G02B6/12 , G02B6/26 , G02B6/42 , G02B6/44 , G02B6/02 , G02B6/028 , G02B6/032 , G02B6/036
CPC分类号： H04J14/0267 , A61B5/0066 , A61B5/0084 , A61B5/6852 , G02B6/2552 , G02B6/262 , G02B6/2856
摘要： Apparatus and method are provided for transmitting at least one electro-magnetic radiation is provided. In particular, at least one optical fiber having at least one end extending along a first axis may be provided. Further, a light transmissive optical arrangement may be provided in optical cooperation with the optical fiber. The optical arrangement may have a first surface having a portion that is perpendicular to a second axis, and a second surface which includes a curved portion. The first axis can be provided at a particular angle that is more than 0° and less than 90° with respect to the second axis.
摘要翻译：提供了用于传送至少一个电磁辐射的装置和方法。特别地，可以提供至少一个具有沿着第一轴线延伸的至少一个端部的光纤。此外，可以与光纤光学协作地提供透光的光学装置。光学装置可以具有第一表面，其具有垂直于第二轴线的部分，以及包括弯曲部分的第二表面。第一轴可以相对于第二轴线以大于0°且小于90°的特定角度设置。

43. 发明申请

US20120101374A1 SYSTEMS, DEVICES, METHODS, APPARATUS AND COMPUTER-ACCESSIBLE MEDIA FOR PROVIDING OPTICAL IMAGING OF STRUCTURES AND COMPOSITIONS 有权
标题翻译：用于提供结构和组成的光学成像的系统，设备，方法，装置和计算机可访问介质
公开(公告)号：US20120101374A1
公开(公告)日：2012-04-26
申请号：US13114845
申请日：2011-05-24
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Hongki Yoo , Milen Shishkov , Joseph Gardecki , Roman Shubochkin , Theodore Morse , Farouc Amin Jaffer
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Hongki Yoo , Milen Shishkov , Joseph Gardecki , Roman Shubochkin , Theodore Morse , Farouc Amin Jaffer
IPC分类号： A61B6/00
CPC分类号： A61B5/0084 , A61B5/0066 , A61B5/0071 , A61B5/6852 , G01B9/02029 , G01B9/0205 , G01B9/02091 , G01N21/4795 , G01N21/64 , G01N21/6456 , G01N21/65 , G01N2201/0866
摘要： Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.
摘要翻译：描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。例如，一种布置可以向解剖结构提供至少一个电磁辐射。这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。光纤芯和包层之间的区域可以具有与光纤芯和包层的折射率不同的折射率。该装置还可以包括至少一个被配置成经由光学核和包层传播辐射到解剖结构的装置。

44. 发明申请

US20120002686A1 PROCESS AND APPARATUS FOR A WAVELENGTH TUNING SOURCE 有权
标题翻译：波长调谐源的过程和装置
公开(公告)号：US20120002686A1
公开(公告)日：2012-01-05
申请号：US13160335
申请日：2011-06-14
申请人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
发明人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
IPC分类号： H01S3/10
CPC分类号： G01J3/10 , A61B5/0059 , A61B5/0066 , G01B9/02004 , G01B9/02091 , G01J3/12 , G01J9/0215 , G01N21/4795 , G02B27/48 , H01S3/08009 , H01S3/08063 , H01S3/105 , H01S5/141 , H01S5/146 , H01S5/4087
摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.
摘要翻译：可以提供用于过滤电磁辐射的装置和源装置，其可以包括被配置为基于电磁辐射的频率物理地分离电磁辐射的一个或多个部件的至少一个光谱分离装置。装置和源装置还可以具有至少一个连续旋转的光学布置，其被配置为接收与一个或多个部件相关联的至少一个信号。此外，装置和源装置可以包括被配置为接收信号的至少一个波束选择装置。

45. 发明授权

US08045177B2 Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy 有权
标题翻译：使用光谱编码的内窥镜检查来测量振动的装置和方法
公开(公告)号：US08045177B2
公开(公告)日：2011-10-25
申请号：US12104689
申请日：2008-04-17
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Saumil Merchant , John Rosowski
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Saumil Merchant , John Rosowski
IPC分类号： G01B11/02
CPC分类号： A61B1/227 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/4504
摘要： An apparatus and method according to an exemplary embodiment of to the present invention can provide imaging information associated with at least one portion of a sample. For example, at least two first different wavelengths of at least one first electro-magnetic radiation within a first wavelength range may be provided on the portion of the sample so as to determine at least one first transverse location of the portion. At least two second different wavelengths of at least one second electro-magnetic radiation may also be provided within a second wavelength range provided on the portion so as to determine at least one second transverse location of the portion. It is possible to obtain a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference to determine a motion of the portion or of particles within or on the portion, whereas the motion is effectuated by at least one of a sound wave. Further, the imaging information of the portion can be provided based on the first transverse location, the second transverse location and the motion.
摘要翻译：根据本发明的示例性实施例的装置和方法可以提供与样本的至少一部分相关联的成像信息。例如，可以在样品的部分上提供在第一波长范围内的至少一个第一电磁辐射的至少两个第一不同波长，以便确定该部分的至少一个第一横向位置。还可以在设置在该部分上的第二波长范围内提供至少两个第二不同波长的至少一个第二电磁辐射，以便确定该部分的至少一个第二横向位置。可以获得从样品返回的至少一个第三电磁辐射电磁辐射和从参考返回的至少一个第四电磁辐射之间的相对相位，以确定该部分或颗粒的运动或者在该部分上，而运动由声波中的至少一个来实现。此外，可以基于第一横向位置，第二横向位置和运动来提供该部分的成像信息。

46. 发明申请

US20110201924A1 Method and Apparatus for Improving Image Clarity and Sensitivity in Optical Tomography Using Dynamic Feedback to Control Focal Properties and Coherence Gating 审中-公开
标题翻译：使用动态反馈来改善光学层析成像中的图像清晰度和灵敏度以控制焦点特性和连贯门控的方法和装置
公开(公告)号：US20110201924A1
公开(公告)日：2011-08-18
申请号：US12845575
申请日：2010-07-28
申请人： Guillermo J. Tearney , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： A61B6/00
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/6853 , G01B9/0205 , G01B9/02063 , G01B9/02068 , G01B9/02085 , G01B9/02091 , G01B2290/35 , G01N21/4795
摘要： Methods for optical imaging, particularly with optical coherence tomography, using a low coherence light beam reflected from a sample surface and compared to a reference light beam, wherein real time dynamic optical feedback is used to detect the surface position of a tissue sample with respect to a reference point and the necessary delay scan range. The delay is provided by a tilting/rotating mirror actuated by a voltage adjustable galvanometer. An imaging probe apparatus for implementing the method is provided. The probe initially scans along one line until it finds the tissue surface, identifiable as a sharp transition from no signal to a stronger signal. The next time the probe scans the next line it adjusts the waveform depending on the previous scan. An algorithm is disclosed for determining the optimal scan range.
摘要翻译：光学成像的方法，特别是使用光学相干断层摄影，使用从样品表面反射并与参考光束反射的低相干光束，其中使用实时动态光学反馈来检测组织样品相对于参考点和必要的延迟扫描范围。延迟由通过电压可调电流计驱动的倾斜/旋转镜提供。提供了一种用于实现该方法的成像探针装置。探头首先沿着一条线扫描，直到发现组织表面，被认为是从无信号到较强信号的急剧转变。下一次探头扫描下一行时，会根据先前的扫描调整波形。公开了一种用于确定最佳扫描范围的算法。

47. 发明申请

US20110178398A1 METHOD AND APPARATUS FOR IMAGING OF VESSEL SEGMENTS 有权
标题翻译：用于成像船舶部分的方法和装置
公开(公告)号：US20110178398A1
公开(公告)日：2011-07-21
申请号：US12946725
申请日：2010-11-15
申请人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma
IPC分类号： A61B6/00
CPC分类号： A61B5/6852 , A61B5/0062 , A61B5/0066 , A61B5/0084 , A61B5/02007
摘要： An apparatus, method and software arrangement for imaging a surface of a structure that is in contact with an opaque fluid is provided. The apparatus includes an article of manufacture (e.g., a housing), a fluid delivery arrangement and an imaging arrangement. The housing includes an aperture formed in the article of manufacture. The fluid delivery arrangement is configured to deliver a volume of substantially transparent fluid to the aperture formed in the housing. The imaging arrangement is configured to image the surface of the structure using an imaging modality after the volume of the transparent fluid is delivered to the aperture, wherein the imaging arrangement and/or the article of manufacture is translated along the surface of the structure while imaging the surface of the structure.
摘要翻译：提供了一种用于对与不透明流体接触的结构的表面进行成像的装置，方法和软件装置。该装置包括制品（例如，壳体），流体输送装置和成像装置。壳体包括形成在制品中的孔。流体输送装置构造成将一定体积的基本上透明的流体输送到形成在壳体中的孔。成像装置被配置为在将透明流体的体积传送到孔之后使用成像模态来对结构的表面进行成像，其中成像装置和/或制品在结构的表面上被平移，而成像结构的表面。

48. 发明授权

US07911621B2 Apparatus and method for controlling ranging depth in optical frequency domain imaging 有权
标题翻译：用于控制光频域成像中测距深度的装置和方法
公开(公告)号：US07911621B2
公开(公告)日：2011-03-22
申请号：US12016303
申请日：2008-01-18
申请人： S. M. Reza Motaghiannezam , Guillermo J. Tearney , Brett Eugene Bouma
发明人： S. M. Reza Motaghiannezam , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： G01B9/02004 , G01B9/02002 , G01B9/02028 , G01B9/02078 , G01B9/02091 , G01B2290/70
摘要： Exemplary embodiments of an apparatus are provided. For example, the exemplary apparatus can include at least one first arrangement providing at least one first electro-magnetic radiation to a sample, at least one second electro-magnetic radiation to a first reference and at least one third electro-magnetic radiation to a second reference. A frequency of radiation provided by the first arrangement generally varies over time. The exemplary apparatus may also include at least one second arrangement which is configured to detect a first interference between at least one fourth electro-magnetic radiation associated with the first electro-magnetic radiation and at least one fifth electro-magnetic radiation associated with the second radiation. The second arrangement is also configured to detect a second interference between at least one sixth electro-magnetic radiation associated with the first electro-magnetic radiation and at least one seventh electro-magnetic radiation associated with the third radiation.
摘要翻译：提供了一种装置的示例性实施例。例如，示例性设备可以包括至少一个第一布置，其向样品提供至少一个第一电磁辐射，至少一个第二电磁辐射到第一参考和至少一个第三电磁辐射到第二参考参考。由第一装置提供的辐射频率通常随时间而变化。示例性装置还可以包括至少一个第二装置，其被配置为检测与第一电磁辐射相关联的至少一个第四电磁辐射与至少一个与第二辐射相关联的第五电磁辐射之间的第一干涉。第二布置还被配置为检测与第一电磁辐射相关联的至少一个第六电磁辐射与与第三辐射相关联的至少一个第七电磁辐射之间的第二干涉。

49. 发明授权

US07864822B2 Process and apparatus for a wavelength tuning source 有权
标题翻译：用于波长调谐源的过程和装置
公开(公告)号：US07864822B2
公开(公告)日：2011-01-04
申请号：US12369556
申请日：2009-02-11
申请人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
发明人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
IPC分类号： H01S3/10
CPC分类号： G01J3/10 , A61B5/0059 , A61B5/0066 , G01B9/02004 , G01B9/02091 , G01J3/12 , G01J9/0215 , G01N21/4795 , G02B27/48 , H01S3/08009 , H01S3/08063 , H01S3/105 , H01S5/141 , H01S5/146 , H01S5/4087
摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.
摘要翻译：可以提供用于过滤电磁辐射的装置和源装置，其可以包括被配置为基于电磁辐射的频率物理地分离电磁辐射的一个或多个部件的至少一个光谱分离装置。装置和源装置还可以具有至少一个连续旋转的光学布置，其被配置为接收与一个或多个部件相关联的至少一个信号。此外，装置和源装置可以包括被配置为接收信号的至少一个波束选择装置。

50. 发明授权

US07847949B2 Method and apparatus for optical imaging via spectral encoding 有权
标题翻译：通过频谱编码进行光学成像的方法和装置
公开(公告)号：US07847949B2
公开(公告)日：2010-12-07
申请号：US11537048
申请日：2006-09-29
申请人： Guillermo J. Tearney , Dvir Yelin , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Dvir Yelin , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for generating an image of at least one portion of an anatomical structure. For example, the portion can have an area greater than about 1 mm2, and the image can have a resolution a transverse resolution that is below about 10 μm. For example, light can be scanned over such portion so as to generate first information which is related to the portion, where the light may be provided through a diffraction arrangement to generate a spectrally dispersed line. Method, apparatus and arrangement according to a further exemplary embodiment of the present invention can be provided for positioning a radiation or optical beam within an anatomical structure based on signals generated by scanning a portion of the structure using the same or a different beam.
摘要翻译：可以提供根据本发明的示例性实施例的方法，装置和装置，用于生成解剖结构的至少一部分的图像。例如，该部分可以具有大于约1mm 2的面积，并且图像可以具有低于约10μm的横向分辨率的分辨率。例如，可以在这样的部分上扫描光，以便产生与该部分相关的第一信息，其中可以通过衍射装置提供光以产生光谱分散的线。可以提供根据本发明的另一示例性实施例的方法，装置和装置，用于基于通过使用相同或不同的束扫描结构的一部分而产生的信号来将辐射或光束定位在解剖结构内。

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