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1. 发明授权

US09364143B2 Process, arrangements and systems for providing frequency domain imaging of a sample 有权
标题翻译：用于提供样品频域成像的过程，布置和系统
公开(公告)号：US09364143B2
公开(公告)日：2016-06-14
申请号：US13465580
申请日：2012-05-07
申请人： Seok-Hyun Yun , Johannes F. de Boer
发明人： Seok-Hyun Yun , Johannes F. de Boer
IPC分类号： A61B6/00 , A61B3/10 , A61B5/00 , G01N21/45 , G01N21/47
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/1233 , A61B3/14 , A61B5/0059 , A61B5/0066 , A61B5/418 , G01N21/45 , G01N21/4795
摘要： Exemplary apparatus, arrangement and method can be provided for obtaining information associated with an anatomical structure or sample using optical microscopy. A radiation can include first electromagnetic radiation(s) directed to an anatomical sample and at least one second electromagnetic radiation directed to a reference. A wavelength of the radiation can vary over time, and the wavelength can be shorter than approximately 1150 nm. An interference can be detected between third and forth radiations associated with the first, second and fourth radiation, respectively. At least one image corresponding to portion(s) of the sample can be generated using data associated with the interference. Source arrangement(s) can be provided which is configured to provide an electromagnetic radiation having a wavelength that varies over time. A period of a variation of the wavelength of the first electromagnetic radiation(s) can be shorter than 1 millisecond, and the wavelength can be shorter than approximately 1150 nm.
摘要翻译：可以提供示例性的装置，布置和方法，以使用光学显微镜获得与解剖结构或样品相关联的信息。辐射可以包括指向解剖样品的第一电磁辐射和指向参考的至少一个第二电磁辐射。辐射的波长可以随时间变化，并且波长可以短于约1150nm。可以分别在与第一，第二和第四辐射相关联的第三和第四辐射之间检测干扰。可以使用与干扰相关联的数据来生成对应于样本的一部分的至少一个图像。可以提供源装置，其配置为提供具有随时间变化的波长的电磁辐射。第一电磁辐射的波长变化的周期可以短于1毫秒，并且波长可以短于约1150nm。

2. 发明授权

US08922781B2 Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample 有权
标题翻译：用于通过同时照射和检测样品上的多个点来执行光学成像的装置，装置，内窥镜，导管和方法
公开(公告)号：US08922781B2
公开(公告)日：2014-12-30
申请号：US11288994
申请日：2005-11-29
申请人： Guillermo J. Tearney , Johannes F. de Boer , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Johannes F. de Boer , Brett Eugene Bouma
IPC分类号： G01B9/02 , G02B21/00 , A61B5/00 , G02B23/24 , G02B23/26
CPC分类号： G02B23/2469 , A61B5/0066 , A61B5/0073 , A61B5/6852 , G01B9/02001 , G01B9/02091 , G02B21/0032 , G02B21/0056 , G02B23/2453 , G02B23/26
摘要： Devices, arrangements, endoscopes, catheters and methods adapted to propagate at least one electro-magnetic radiation are provided. In particular, a waveguide apparatus specifically configured may be utilized to split the electro-magnetic radiation into a plurality of beams that are intended to illuminate a biological sample, and impart a unique associated characteristic unto each of the beams. The beams may be intended to illuminate a biological sample at distinct locations, and impart a unique associated characteristic unto each of the beams. In addition, a control apparatus may be provided which is configured to control at least one of the fibers and which can be input to the fibers so as to modify the unique associated characteristics of the beams being propagated along the fibers, and thereby modify the characteristics of the distinct locations on the sample.
摘要翻译：提供了适于传播至少一个电磁辐射的装置，布置，内窥镜，导管和方法。特别地，可以使用专门配置的波导装置将电磁辐射分割成旨在照射生物样品的多个光束，并且向每个光束赋予独特的相关特征。光束可以用于在不同的位置照射生物样品，并且赋予每个光束唯一的相关特征。此外，可以提供控制装置，其被配置为控制光纤中的至少一个并且可以输入到光纤，以便改变沿着光纤传播的光束的独特相关特性，从而改变特性的样品上不同的位置。

3. 发明申请

US20120316434A1 PROCESS, ARRANGEMENTS AND SYSTEMS FOR PROVIDING FREQUENCY DOMAIN IMAGING OF A SAMPLE 有权
标题翻译：用于提供样品的频域成像的过程，安排和系统
公开(公告)号：US20120316434A1
公开(公告)日：2012-12-13
申请号：US13465580
申请日：2012-05-07
申请人： Seok-Hyun Yun , Johannes F. de Boer
发明人： Seok-Hyun Yun , Johannes F. de Boer
IPC分类号： A61B6/02
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/1233 , A61B3/14 , A61B5/0059 , A61B5/0066 , A61B5/418 , G01N21/45 , G01N21/4795
摘要： Exemplary apparatus, arrangement and method can be provided for obtaining information associated with an anatomical structure or sample using optical microscopy. A radiation can include first electromagnetic radiation(s) directed to an anatomical sample and at least one second electromagnetic radiation directed to a reference. A wavelength of the radiation can vary over time, and the wavelength can be shorter than approximately 1150 nm. An interference can be detected between third and forth radiations associated with the first, second and fourth radiation, respectively. At least one image corresponding to portion(s) of the sample can be generated using data associated with the interference. Source arrangement(s) can be provided which is configured to provide an electromagnetic radiation having a wavelength that varies over time. A period of a variation of the wavelength of the first electromagnetic radiation(s) can be shorter than 1 millisecond, and the wavelength can be shorter than approximately 1150 nm.
摘要翻译：可以提供示例性的装置，布置和方法，以使用光学显微镜获得与解剖结构或样品相关联的信息。辐射可以包括指向解剖样品的第一电磁辐射和指向参考的至少一个第二电磁辐射。辐射的波长可以随时间变化，并且波长可以短于约1150nm。可以分别在与第一，第二和第四辐射相关联的第三和第四辐射之间检测干扰。可以使用与干扰相关联的数据来生成对应于样本的一部分的至少一个图像。可以提供源装置，其配置为提供具有随时间变化的波长的电磁辐射。第一电磁辐射的波长变化的周期可以短于1毫秒，并且波长可以短于约1150nm。

4. 发明授权

US08175685B2 Process, arrangements and systems for providing frequency domain imaging of a sample 有权
标题翻译：用于提供样品频域成像的过程，布置和系统
公开(公告)号：US08175685B2
公开(公告)日：2012-05-08
申请号：US11744287
申请日：2007-05-04
申请人： Seok-Hyun Yun , Johannes F. de Boer
发明人： Seok-Hyun Yun , Johannes F. de Boer
IPC分类号： A61B6/00
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/1233 , A61B3/14 , A61B5/0059 , A61B5/0066 , A61B5/418 , G01N21/45 , G01N21/4795
摘要： Apparatus, arrangement and method are provided for obtaining information associated with an anatomical structure or a sample using optical microscopy. For example, a radiation can be provided which includes at least one first electromagnetic radiation directed to be provided to an anatomical sample and at least one second electro-magnetic radiation directed to a reference. A wavelength of the radiation can vary over time, and the wavelength is shorter than approximately 1150 nm. An interference can be detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. At least one image corresponding to at least one portion of the sample can be generated using data associated with the interference. In addition, at least one source arrangement can be provided which is configured to provide an electromagnetic radiation which has a wavelength that varies over time. A period of a variation of the wavelength of the first electromagnetic radiation can be shorter than 1 millisecond, and the wavelength is shorter than approximately 1150 nm.
摘要翻译：提供了用于使用光学显微镜获得与解剖结构或样品相关联的信息的装置，布置和方法。例如，可以提供辐射，其包括至少一个被引导到解剖样品的第一电磁辐射和指向参考的至少一个第二电磁辐射。辐射的波长可随时间变化，波长比约1150nm短。可以在与第一辐射相关联的至少一个第三辐射与与第二辐射相关联的至少一个第四辐射之间检测干扰。可以使用与干扰相关联的数据来生成对应于样本的至少一部分的至少一个图像。此外，可以提供至少一个源装置，其被配置为提供具有随时间变化的波长的电磁辐射。第一电磁辐射的波长变化的周期可以短于1毫秒，并且波长比约1150nm短。

5. 发明申请

US20120002686A1 PROCESS AND APPARATUS FOR A WAVELENGTH TUNING SOURCE 有权
标题翻译：波长调谐源的过程和装置
公开(公告)号：US20120002686A1
公开(公告)日：2012-01-05
申请号：US13160335
申请日：2011-06-14
申请人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
发明人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
IPC分类号： H01S3/10
CPC分类号： G01J3/10 , A61B5/0059 , A61B5/0066 , G01B9/02004 , G01B9/02091 , G01J3/12 , G01J9/0215 , G01N21/4795 , G02B27/48 , H01S3/08009 , H01S3/08063 , H01S3/105 , H01S5/141 , H01S5/146 , H01S5/4087
摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.
摘要翻译：可以提供用于过滤电磁辐射的装置和源装置，其可以包括被配置为基于电磁辐射的频率物理地分离电磁辐射的一个或多个部件的至少一个光谱分离装置。装置和源装置还可以具有至少一个连续旋转的光学布置，其被配置为接收与一个或多个部件相关联的至少一个信号。此外，装置和源装置可以包括被配置为接收信号的至少一个波束选择装置。

6. 发明授权

US07864822B2 Process and apparatus for a wavelength tuning source 有权
标题翻译：用于波长调谐源的过程和装置
公开(公告)号：US07864822B2
公开(公告)日：2011-01-04
申请号：US12369556
申请日：2009-02-11
申请人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
发明人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
IPC分类号： H01S3/10
CPC分类号： G01J3/10 , A61B5/0059 , A61B5/0066 , G01B9/02004 , G01B9/02091 , G01J3/12 , G01J9/0215 , G01N21/4795 , G02B27/48 , H01S3/08009 , H01S3/08063 , H01S3/105 , H01S5/141 , H01S5/146 , H01S5/4087
摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.
摘要翻译：可以提供用于过滤电磁辐射的装置和源装置，其可以包括被配置为基于电磁辐射的频率物理地分离电磁辐射的一个或多个部件的至少一个光谱分离装置。装置和源装置还可以具有至少一个连续旋转的光学布置，其被配置为接收与一个或多个部件相关联的至少一个信号。此外，装置和源装置可以包括被配置为接收信号的至少一个波束选择装置。

7. 发明授权

US07797119B2 Apparatus and method for rangings and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands 有权
标题翻译：用于低相干干涉测量LCI和光学相干断层扫描的脉冲和降噪的装置和方法通过光谱带的并行检测
公开(公告)号：US07797119B2
公开(公告)日：2010-09-14
申请号：US11956129
申请日：2007-12-13
申请人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01R35/00
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译：通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。信号保持不变。喷射噪声的降低增加了系统的动态范围和灵敏度。

8. 发明授权

US07782464B2 Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images 有权
标题翻译：基于光学相干断层图像提供纤维层厚度图的方法，布置和系统
公开(公告)号：US07782464B2
公开(公告)日：2010-08-24
申请号：US11744412
申请日：2007-05-04
申请人： Mircea Mujat , Raymond C. Chan , Johannes F. de Boer
发明人： Mircea Mujat , Raymond C. Chan , Johannes F. de Boer
IPC分类号： G01B9/02
CPC分类号： A61B3/102 , G06T7/12 , G06T7/149 , G06T2207/10101 , G06T2207/20116 , G06T2207/30041
摘要： A system, arrangement, computer-accessible medium and process are provided for determining information associated with at least one portion of an anatomical structure. For example, an interference between at least one first radiation associated with a radiation directed to the anatomical structure and at least one second radiation associated with a radiation directed to a reference can be detected. Three-dimensional volumetric data can be generated for the at least one portion as a function of the interference. Further, the information can be determined which is at least one geometrical characteristic and/or at least one intensity characteristic of the portion based on the volumetric data.
摘要翻译：提供了一种用于确定与解剖结构的至少一部分相关联的信息的系统，布置，计算机可访问介质和过程。例如，可以检测到与指向解剖结构的辐射相关联的至少一个第一辐射与定向到参考的辐射相关联的至少一个第二辐射之间的干扰。作为干扰的函数，可以针对至少一个部分生成三维体积数据。此外，可以基于体积数据来确定哪个是该部分的至少一个几何特征和/或至少一个强度特性。

9. 发明授权

US07643153B2 Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands 有权
标题翻译：低相干干涉测量和降噪的装置和方法LCI和光学相干断层扫描OCT信号通过光谱带的并行检测
公开(公告)号：US07643153B2
公开(公告)日：2010-01-05
申请号：US11956079
申请日：2007-12-13
申请人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02044 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45
摘要： Apparatus, method, logic arrangement and storage medium are provided for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source can be split into N spectral bands. The N spectral bands can be individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band may be detected by a separate photo detector and amplified. For each spectral band, the signal can be band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is likely reduced by a factor equal to the number of spectral bands, while the signal amplitude can remain the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译：提供装置，方法，逻辑布置和存储介质，用于通过检测光谱带的并行组来提高光学相干断层扫描和低相干干涉测量（“LCI”）信号的检测灵敏度，每个频带是光频率的唯一组合。 LCI宽带宽源可以分为N个光谱带。可以单独地检测和处理N个频谱带，以使信噪比增加N倍。每个频谱带可以由单独的光检测器检测并被放大。对于每个光谱带，信号可以通过模拟电子装置在信号带周围进行带通滤波，并被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。结果，对信号的散粒噪声贡献可能降低等于光谱带数的因子，而信号幅度可以保持相同。喷射噪声的降低增加了系统的动态范围和灵敏度。

10. 发明授权

US07630083B2 Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands 有权
标题翻译：低相干干涉测量和降噪的装置和方法LCI和光学相干断层扫描OCT信号通过光谱带的并行检测
公开(公告)号：US07630083B2
公开(公告)日：2009-12-08
申请号：US11955834
申请日：2007-12-13
申请人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B11/02 , G01B9/02
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译：通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。信号保持不变。喷射噪声的降低增加了系统的动态范围和灵敏度。

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