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41. 发明授权

US06849039B2 Blood processing systems and methods for collecting plasma free or essentially free of cellular blood components 有权
标题翻译：用于收集血浆游离或基本上不含细胞血液成分的血液处理系统和方法
公开(公告)号：US06849039B2
公开(公告)日：2005-02-01
申请号：US10279765
申请日：2002-10-24
申请人： Kyungyoon Min , Richard I. Brown , Julie Moriarty
发明人： Kyungyoon Min , Richard I. Brown , Julie Moriarty
IPC分类号： A61M1/36 , A61M1/38 , B04B5/04 , B01D21/26 , B04B11/00
CPC分类号： A61M1/3693 , A61M1/3633 , A61M1/3696 , A61M1/38 , A61M2202/0429 , A61M2205/128 , B04B5/0442 , B04B2005/045
摘要： Blood separation systems and methods introduce blood into an annular separation channel between a low-G wall and a high-G wall while rotating the separation channel about an axis, for separation of the blood into blood components. The annular separation channel has an annular boundary wall. The systems and methods direct a first blood component into a constricted channel along the low-G wall. The systems and methods remove the first blood component through a first path that communicates with the separation channel through an opening that adjoins the constricted channel adjacent the low-G wall. The systems and methods direct a second blood component along a surface that extends generally in an axial direction along the high-G wall toward the annular boundary wall. The systems and methods collect the second blood component through a second path that communicates with the separation channel through an opening that adjoins the surface adjacent the high-G wall axially spaced from the annular boundary wall.
摘要翻译：血液分离系统和方法将血液引入低G壁和高G壁之间的环形分离通道，同时围绕轴线旋转分离通道，以将血液分离成血液成分。环形分隔通道具有环形边界壁。系统和方法将第一血液成分引导到沿着低G壁的收缩通道。系统和方法通过与分离通道连通的第一路径去除第一血液成分，所述第一路径通过邻近靠近低G壁的收缩通道的开口。系统和方法沿着沿着高G壁的轴向方向朝着环形边界壁延伸的表面引导第二血液成分。所述系统和方法通过第二路径收集第二血液成分，所述第二路径通过与所述环形边界壁轴向间隔开的邻近所述高G壁的表面邻接的开口与所述分离通道连通。

42. 发明授权

US06582349B1 Blood processing system 有权
标题翻译：血液处理系统
公开(公告)号：US06582349B1
公开(公告)日：2003-06-24
申请号：US09669752
申请日：2000-09-26
申请人： Robert J Cantu , Kyungyoon Min , Douglas W Reitz , Robert I Brown
发明人： Robert J Cantu , Kyungyoon Min , Douglas W Reitz , Robert I Brown
IPC分类号： B04D1100
CPC分类号： A61M1/3693 , A61M1/3696 , B01D21/262 , B01D21/32 , B01D21/34 , B01D2221/10 , B04B9/14 , B04B2005/045 , B04B2009/143
摘要： Blood processing systems and methods rotate a processing chamber on a rotating element. The processing chamber includes a first compartment and a second compartment. Blood is conveyed into the first compartment for centrifugal separation into components. A liquid free of blood occupies the second compartment to counter-balance the first compartment during rotation on the rotating element. In one embodiment, the second compartment is served by a single fluid flow access. Prior to use, the single access is coupled to tubing, through which a vacuum is drawn to remove air from the second compartment. While the vacuum exists, communication is opened between the tubing and a source of liquid. The vacuum draws the liquid into the second compartment through the single access, thereby priming the second compartment for use.
摘要翻译：血液处理系统和方法将处理室旋转在旋转元件上。处理室包括第一隔室和第二隔室。血液被输送到第一隔室中，用于离心分离成组分。没有血液的液体占据第二隔室，以在旋转元件旋转期间平衡第一隔间。在一个实施例中，第二隔室由单个流体流动进入。在使用之前，单个通道联接到管道，通过该管道吸入真空以从第二隔室移除空气。当存在真空时，在管道和液体源之间打开通信。真空通过单一进入将液体吸入第二隔室，从而启动第二隔间以供使用。

43. 发明授权

US5980760A System and methods for harvesting mononuclear cells by recirculation of packed red blood cells 失效
标题翻译：通过再循环包装的红细胞收获单核细胞的系统和方法
公开(公告)号：US5980760A
公开(公告)日：1999-11-09
申请号：US886780
申请日：1997-07-01
申请人： Kyungyoon Min , Richard I Brown , Daniel F Bischof , William H Cork , Robert J Cantu
发明人： Kyungyoon Min , Richard I Brown , Daniel F Bischof , William H Cork , Robert J Cantu
IPC分类号： A61M1/02 , A61M1/36 , B01D21/26 , B04B5/04 , B04B11/02 , B04B13/00
CPC分类号： B01D21/302 , A61M1/3696 , B01D21/262 , B04B13/00 , B04B5/0442 , B01D2221/10 , B04B2005/045
摘要： A blood separation system operates in a first mode to convey whole blood into the inlet region of a blood processing chamber for centrifugal separation into packed red blood cells, a plasma constituent, and an interface, which carries mononuclear cells, between the packed red blood cells and the plasma constituent. The system removes packed red blood cells and the plasma constituent from the chamber, while maintaining the interface within the chamber. The system operates in a second mode to remove the interface from the chamber by conveying packed red blood cells into the inlet region. An outlet path conveys the removed interface from the chamber. The outlet path includes a first sensing element to locate mononuclear cells in the removed interface and provide a sensed output upon locating mononuclear cells.
摘要翻译：血液分离系统以第一模式操作，以将全血输送到血液处理室的入口区域，用于离心分离成装填的红血细胞，血浆成分和携带单核细胞的界面，和等离子体成分。该系统在保持室内的界面的同时从腔室中去除填充的红细胞和等离子体成分。该系统以第二模式操作，以通过将填充的红血细胞输送到入口区域来从腔室去除界面。出口路径从腔室传送去除的界面。出口路径包括第一感测元件，以将去除界面中的单核细胞定位，并在定位单核细胞时提供感测输出。

44. 发明授权

US09717842B2 Disposable fluid circuits and methods for cell washing 有权
公开(公告)号：US09717842B2
公开(公告)日：2017-08-01
申请号：US14122855
申请日：2012-09-12
申请人： Kyungyoon Min , Christopher Wegener
发明人： Kyungyoon Min , Christopher Wegener
IPC分类号： A61M1/36 , A61M1/02 , A61M1/34 , A61M1/26 , C12M1/12
CPC分类号： A61M1/3692 , A61M1/0209 , A61M1/0236 , A61M1/262 , A61M1/265 , A61M1/3472 , A61M1/3496 , A61M1/3693 , C12M37/02 , F04C2270/041
摘要： Systems and methods for the washing and processing of biological fluid/biological cells are disclosed. The systems and methods utilize a disposable fluid circuit including a spinning membrane separation device to wash the biological cells.

45. 发明授权

US09176038B2 Apparatus and method for processing biological material 有权
标题翻译：用于处理生物材料的装置和方法
公开(公告)号：US09176038B2
公开(公告)日：2015-11-03
申请号：US13611211
申请日：2012-09-12
申请人： Kyungyoon Min , Thomas E. Dudar , James C. Laird
发明人： Kyungyoon Min , Thomas E. Dudar , James C. Laird
IPC分类号： B01L3/00 , B01D21/00 , B01D21/26 , C12M1/00 , G01N1/40 , G01N15/04 , G01N21/07 , B01L1/00 , G01N15/14 , G01N21/03 , G01N35/10 , A61M39/04 , A61M39/26
CPC分类号： G01N1/4077 , A61M39/045 , A61M39/26 , B01D21/26 , B01D21/262 , B01L1/00 , B01L3/502 , B01L3/5021 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L3/50825 , B01L3/5635 , B01L2200/025 , B01L2200/026 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/10 , B01L2300/044 , B01L2300/046 , B01L2300/049 , B01L2400/0409 , B01L2400/0478 , B01L2400/0481 , B01L2400/0633 , C12M47/02 , G01N1/40 , G01N15/042 , G01N21/03 , G01N21/07 , G01N33/491 , G01N2001/4083 , G01N2015/149 , G01N2035/00495 , G01N2035/1058
摘要： The application discloses an apparatus and method for processing biological material, including a suspension of cells.
摘要翻译：本申请公开了一种用于处理生物材料的装置和方法，包括细胞悬浮液。

46. 发明授权

US08448992B2 Sterile docking device, medical fluid flow system with sterile docking device and method of using same 有权
标题翻译：无菌对接装置，具有无菌对接装置的医用流体流动系统及其使用方法
公开(公告)号：US08448992B2
公开(公告)日：2013-05-28
申请号：US13028372
申请日：2011-02-16
申请人： Kyungyoon Min , William H. Cork
发明人： Kyungyoon Min , William H. Cork
IPC分类号： F16L35/00 , B32B38/04
CPC分类号： A61M39/143 , F04C2270/0421 , F16L29/005 , F16L47/02 , F16L2201/44
摘要： Method and apparatus are disclosed for forming a sealed communication between conduits or conduit subassemblies, each of which has a wall with an exterior surface, and at least one of the walls includes an electrically conductive portion. The exterior surfaces may be brought into a facing relationship, and each conductive portion is heated sufficiently to sterilize the exterior surfaces of the walls by generating electrical current in the conductive portion, such as by application of a voltage or by induction. An aperture is then provided, as by an aperture-forming member, through the facing walls to provide communication between the conduits or conduit subassemblies.
摘要翻译：公开了用于在导管或导管子组件之间形成密封连接的方法和装置，每个管子组件具有带有外表面的壁，并且至少一个壁包括导电部分。外表面可以处于面对的关系，并且每个导电部分被充分加热以通过在导电部分中产生电流来消除（例如通过施加电压或通过感应）的电流。然后，通过孔形成构件，通过面向壁提供孔，以在导管或导管组件之间提供连通。

47. 发明申请

US20100158893A1 SYSTEMS AND METHODS FOR OBTAINING IMMUNOGLOBULIN FROM BLOOD 审中-公开
标题翻译：从血液中获取免疫球蛋白的系统和方法
公开(公告)号：US20100158893A1
公开(公告)日：2010-06-24
申请号：US12339900
申请日：2008-12-19
申请人： Kyungyoon Min , Larry Backes , Francisco M. Rausa, III , Shawn F. Bairstow , Sindhu Ramachandran , Sharon Pokropinski
发明人： Kyungyoon Min , Larry Backes , Francisco M. Rausa, III , Shawn F. Bairstow , Sindhu Ramachandran , Sharon Pokropinski
IPC分类号： A61K39/395 , C07K16/18 , A61M1/34
CPC分类号： A61M1/3472 , A61M1/3486 , A61M1/38 , A61M2202/0419 , A61M2202/0057
摘要： The present disclosure relates generally to systems for obtaining a pharmaceutically acceptable immunoglobulin from blood of a donor comprising a first conduit configured to convey blood from the donor to a substrate, wherein said blood includes at least one first component and at least one second component, said first component of the blood including immunoglobulin, and wherein said substrate is adapted to bind immunoglobulin; and a second conduit configured to convey at least a portion of the second component of the blood from the first conduit to the donor.
摘要翻译：本公开一般涉及用于从供体的血液获得药学上可接受的免疫球蛋白的系统，其包括构建成将血液从供体输送到底物的第一导管，其中所述血液包括至少一种第一组分和至少一种第二组分，所述第一组分包括免疫球蛋白的血液的第一组分，并且其中所述底物适于结合免疫球蛋白; 以及第二导管，其构造成将血液的第二组分的至少一部分从第一导管输送到供体。

48. 发明申请

US20100112695A1 Apparatus And Methods For Processing Tissue to Release Cells 审中-公开
标题翻译：用于处理组织释放细胞的装置和方法
公开(公告)号：US20100112695A1
公开(公告)日：2010-05-06
申请号：US12263984
申请日：2008-11-03
申请人： Kyungyoon Min
发明人： Kyungyoon Min
IPC分类号： C12N5/06 , C12M1/00
CPC分类号： C12M45/02 , C12M47/04
摘要： An apparatus and methods for processing tissue to release biological material including cells are disclosed.
摘要翻译：公开了一种用于处理组织以释放包括细胞的生物材料的装置和方法。

49. 发明授权

US07708710B2 Method and apparatus for collecting and processing blood 有权
标题翻译：用于收集和处理血液的方法和装置
公开(公告)号：US07708710B2
公开(公告)日：2010-05-04
申请号：US10826420
申请日：2004-04-16
申请人： Kyungyoon Min , Richard I. Brown
发明人： Kyungyoon Min , Richard I. Brown
IPC分类号： A61M37/00 , C02F1/44 , B01D33/15
CPC分类号： A61M1/38 , A61M1/0209 , A61M1/302 , A61M1/3693
摘要： Methods are disclosed for collecting and separating whole blood into one or more components. A disposable blood separation fluid circuit is provided which is adapted to cooperate with a reusable separation controller. The fluid circuit includes a fluid flow path for communication with a blood source and at least one container in fluid communication with the fluid flow path. The fluid flow path is connected to a blood source and quantities of whole blood are collected in the container and one other location within the fluid circuit. The source is then disconnected from the disposable fluid circuit. The quantities of whole blood are centrifugally processed, with processing of at least a portion of one of the quantities beginning after the source is disconnected from the fluid circuit.
摘要翻译：公开了将全血收集和分离成一个或多个组分的方法。提供了一种一次性血液分离流体回路，其适于与可重复使用的分离控制器配合。流体回路包括用于与血液源连通的流体流动路径和与流体流动路径流体连通的至少一个容器。流体流动路径连接到血液源，并且全部血液的数量被收集在容器和流体回路内的另一个位置。然后将源从一次性流体回路断开。全血的量是离心处理的，处理至少一部分数量从源头与流体回路断开之后开始。

50. 发明申请

US20090211989A1 SYSTEMS AND METHODS FOR CONVEYING MULTIPLE BLOOD COMPONENTS TO A RECIPIENT 有权
标题翻译：将多个血液成分输送到受体的系统和方法
公开(公告)号：US20090211989A1
公开(公告)日：2009-08-27
申请号：US12394258
申请日：2009-02-27
申请人： Lan T. Nguyen , Kyungyoon Min , Tony Nguyen
发明人： Lan T. Nguyen , Kyungyoon Min , Tony Nguyen
IPC分类号： B01D21/30
CPC分类号： A61M1/02 , A61K35/16 , A61K35/18 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/024 , A61M1/029 , A61M1/30 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2205/128 , B01D21/262 , B01D21/302 , B01D21/34 , B01D2221/08 , B01D2221/10
摘要： Systems and methods are provided for conveying an amount of red blood cells and an amount of plasma to a blood source. Blood is conveyed from a blood source into a separation device and the separation device is operated to separate the blood into a layer containing red blood cells and a layer containing plasma. Red blood cells and plasma are removed from the separation device and volumes of the red blood cells and plasma are conveyed to the blood source. The volumes of red blood cells and plasma are alternately conveyed to the blood source for said amounts of red blood cells and plasma.
摘要翻译：提供系统和方法用于将一定量的红细胞和一定量的血浆输送到血液源。将血液从血液源输送到分离装置中，分离装置被操作以将血液分离成含有红细胞的层和含有血浆的层。从分离装置中取出红细胞和血浆，将红细胞和血浆的体积输送到血源。将红细胞和血浆的体积交替地输送到血液源中用于所述量的红细胞和血浆。

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