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1. 发明申请

US20090218277A1 SEPARATION APPARATUS AND METHOD 有权
标题翻译：分离装置和方法
公开(公告)号：US20090218277A1
公开(公告)日：2009-09-03
申请号：US12399545
申请日：2009-03-06
申请人： Kyungyoon Min , Richard I. Brown , Alp Akonur , Julie Moriarty
发明人： Kyungyoon Min , Richard I. Brown , Alp Akonur , Julie Moriarty
IPC分类号： B01D17/038
CPC分类号： A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2205/128 , B04B5/0442 , B04B2005/045
摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.
摘要翻译：使用分离装置和方法来使用用于围绕轴线旋转的分离通道。这种通道包括径向间隔开的内侧壁部分和外侧壁部分以及端壁部分。入口将流体输送到通道中。屏障位于内外侧壁部分的通道中间。第一流动路径在屏障的上游侧和下游侧之间连通。收集区域可以位于屏障的下游，用于与第一流动路径通信。通道的外侧壁部分可以位于其上游部分的径向外侧。屏障可以沿着通道的轴向长度的大部分连接外侧壁部分。第一和第二出口流动路径可以允许在障碍物的上游或下游与两者的通道进行通信。

2. 发明授权

US07918350B2 Separation apparatus and method 有权
标题翻译：分离装置及方法
公开(公告)号：US07918350B2
公开(公告)日：2011-04-05
申请号：US12399545
申请日：2009-03-06
申请人： Kyungyoon Min , Richard I. Brown , Alp Akonur , Julie Moriarty
发明人： Kyungyoon Min , Richard I. Brown , Alp Akonur , Julie Moriarty
IPC分类号： B04B3/00 , B04B1/06 , B04B1/12 , B04B7/10 , B01D21/26 , B01D45/12
CPC分类号： A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2205/128 , B04B5/0442 , B04B2005/045
摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.
摘要翻译：使用分离装置和方法来使用用于围绕轴线旋转的分离通道。这种通道包括径向间隔开的内侧壁部分和外侧壁部分以及端壁部分。入口将流体输送到通道中。屏障位于内外侧壁部分的通道中间。第一流动路径在屏障的上游侧和下游侧之间连通。收集区域可以位于屏障的下游，用于与第一流动路径通信。通道的外侧壁部分可以位于其上游部分的径向外侧。屏障可以沿着通道的轴向长度的大部分连接外侧壁部分。第一和第二出口流动路径可以允许在障碍物的上游或下游与两者的通道进行通信。

3. 发明授权

US06849039B2 Blood processing systems and methods for collecting plasma free or essentially free of cellular blood components 有权
标题翻译：用于收集血浆游离或基本上不含细胞血液成分的血液处理系统和方法
公开(公告)号：US06849039B2
公开(公告)日：2005-02-01
申请号：US10279765
申请日：2002-10-24
申请人： Kyungyoon Min , Richard I. Brown , Julie Moriarty
发明人： Kyungyoon Min , Richard I. Brown , Julie Moriarty
IPC分类号： A61M1/36 , A61M1/38 , B04B5/04 , B01D21/26 , B04B11/00
CPC分类号： A61M1/3693 , A61M1/3633 , A61M1/3696 , A61M1/38 , A61M2202/0429 , A61M2205/128 , B04B5/0442 , B04B2005/045
摘要： Blood separation systems and methods introduce blood into an annular separation channel between a low-G wall and a high-G wall while rotating the separation channel about an axis, for separation of the blood into blood components. The annular separation channel has an annular boundary wall. The systems and methods direct a first blood component into a constricted channel along the low-G wall. The systems and methods remove the first blood component through a first path that communicates with the separation channel through an opening that adjoins the constricted channel adjacent the low-G wall. The systems and methods direct a second blood component along a surface that extends generally in an axial direction along the high-G wall toward the annular boundary wall. The systems and methods collect the second blood component through a second path that communicates with the separation channel through an opening that adjoins the surface adjacent the high-G wall axially spaced from the annular boundary wall.
摘要翻译：血液分离系统和方法将血液引入低G壁和高G壁之间的环形分离通道，同时围绕轴线旋转分离通道，以将血液分离成血液成分。环形分隔通道具有环形边界壁。系统和方法将第一血液成分引导到沿着低G壁的收缩通道。系统和方法通过与分离通道连通的第一路径去除第一血液成分，所述第一路径通过邻近靠近低G壁的收缩通道的开口。系统和方法沿着沿着高G壁的轴向方向朝着环形边界壁延伸的表面引导第二血液成分。所述系统和方法通过第二路径收集第二血液成分，所述第二路径通过与所述环形边界壁轴向间隔开的邻近所述高G壁的表面邻接的开口与所述分离通道连通。

4. 发明授权

US09533089B2 Centrifugation system with red blood cell barrier 有权
标题翻译：具有红细胞屏障的离心系统
公开(公告)号：US09533089B2
公开(公告)日：2017-01-03
申请号：US14008651
申请日：2012-03-28
申请人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
发明人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
IPC分类号： A61M1/36 , B04B5/04
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3331 , A61M2205/3337 , B04B5/0442 , B04B2005/045 , C12N5/0634 , C12N5/0641 , C12N5/0644
摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.
摘要翻译：提供离心系统和方法用于将血液分离成其组成部分。离心机的内壁和外壁各自包括朝向另一壁延伸的突起。分离室被容纳在离心机之间的壁之间，其中腔室包括用于使血液进入腔室的入口端口，用于使等离子体流出腔室的等离子体出口和用于使红细胞流出的红细胞出口的房间。随着室中的离心机容纳在壁之间，第一突出部延伸到分离的血液成分流向等离子体出口端口的路径中，并防止细胞血液成分流入等离子体出口。第二突出部延伸到朝向红细胞出口流动的分离的血液成分的路径中，并防止血浆流入红细胞出口。

5. 发明申请

US20140045671A1 CENTRIFUGATION SYSTEM WITH RED BLOOD CELL BARRIER 有权
标题翻译：红血球细胞分离系统
公开(公告)号：US20140045671A1
公开(公告)日：2014-02-13
申请号：US14008651
申请日：2012-03-28
申请人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
发明人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
IPC分类号： A61M1/36
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3331 , A61M2205/3337 , B04B5/0442 , B04B2005/045 , C12N5/0634 , C12N5/0641 , C12N5/0644
摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.
摘要翻译：提供离心系统和方法用于将血液分离成其组成部分。离心机的内壁和外壁各自包括朝向另一壁延伸的突起。分离室被容纳在离心机之间的壁之间，其中腔室包括用于使血液进入腔室的入口端口，用于使等离子体流出腔室的等离子体出口和用于使红细胞流出的红细胞出口的房间。随着室中的离心机容纳在壁之间，第一突出部延伸到分离的血液成分流向等离子体出口端口的路径中，并防止细胞血液成分流入等离子体出口。第二突出部延伸到朝向红细胞出口流动的分离的血液成分的路径中，并防止血浆流入红细胞出口。

6. 发明授权

US08075468B2 Systems and methods for mid-processing calculation of blood composition 有权
标题翻译：血液成分中期计算的系统和方法
公开(公告)号：US08075468B2
公开(公告)日：2011-12-13
申请号：US12394375
申请日：2009-02-27
申请人： Kyungyoon Min , Richard I. Brown
发明人： Kyungyoon Min , Richard I. Brown
IPC分类号： B01D21/26 , B04B3/00
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/3696 , A61M2205/3306 , B01D21/262 , B01D21/302 , B01D21/34 , B01D2221/08 , B01D2221/10
摘要： Blood separation methods are provided for mid-processing calculation of blood composition. Blood is conveyed into a device having an outlet line and the device is spun to separate platelets from the blood. A flow of platelets is conveyed from the device by the outlet line and the platelets in the outlet line are optically measured. With said optical measurement, a current platelet yield, a platelet pre-count, the volume of blood to process to collect a target amount of platelets, and/or the processing time required to collect a target amount of platelets is calculated. The optical measurement can also be used to calculate an amount of storage fluid to convey into a collection container with the platelets.
摘要翻译：提供血液分离方法用于血液成分的中间处理计算。将血液输送到具有出口管线的装置中，并且将该装置旋转以将血小板与血液分开。通过出口管线从装置输送血小板流，并且光学测量出口管线中的血小板。通过所述光学测量，计算目前的血小板产量，血小板预计数，用于收集目标量的血小板的血液的体积和/或收集目标量的血小板所需的处理时间。光学测量还可用于计算与血小板一起输送到收集容器中的储存液体的量。

7. 发明申请

US20090215602A1 SYSTEMS AND METHODS FOR MID-PROCESSING CALCULATION OF BLOOD COMPOSITION 有权
标题翻译：用于中间体计算血液组合物的系统和方法
公开(公告)号：US20090215602A1
公开(公告)日：2009-08-27
申请号：US12394375
申请日：2009-02-27
申请人： Kyungyoon Min , Richard I. Brown
发明人： Kyungyoon Min , Richard I. Brown
IPC分类号： A61M1/36 , B01D17/038 , B01D21/26 , B04B1/00 , B04B1/18
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/3696 , A61M2205/3306 , B01D21/262 , B01D21/302 , B01D21/34 , B01D2221/08 , B01D2221/10
摘要： Blood separation methods and systems are provided for mid-processing calculation of blood composition. Blood is conveyed into a device having an outlet line and the device is spun to separate a blood component from the blood. A flow of blood component is conveyed from the device by the outlet line and the blood component in the outlet line is optically measured. With said optical measurement, a current blood component yield, a blood component pre-count, the volume of blood to process to collect a target amount of said blood component, and/or the processing time required to collect a target amount of said blood component is calculated. The optical measurement can also be used to calculate an amount of storage fluid to convey into a collection container with the blood component.
摘要翻译：提供血液分离方法和系统用于血液成分的中间处理计算。将血液输送到具有出口管线的装置中，并且将该装置旋转以将血液成分与血液分离。通过出口管路从装置输送血液成分流，并且光学测量出口管线中的血液成分。通过所述光学测量，当前的血液成分收率，血液成分预计数，用于收集目标量的所述血液成分的血液的体积和/或收集目标量的所述血液成分所需的处理时间被计算。光学测量还可以用于计算要输送到具有血液成分的收集容器中的存储流体的量。

8. 发明授权

US5750039A Blood processing systems and methods for collecting mono nuclear cells 失效
标题翻译：用于收集单核细胞的血液处理系统和方法
公开(公告)号：US5750039A
公开(公告)日：1998-05-12
申请号：US745779
申请日：1996-11-08
申请人： Richard I. Brown , Kyungyoon Min
发明人： Richard I. Brown , Kyungyoon Min
IPC分类号： A61K35/14 , A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D21/24 , B01D21/26 , B04B5/04 , B04B7/08 , B04B13/00
CPC分类号： A61M1/0209 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3603 , A61M1/3624 , A61M1/3693 , A61M1/3696 , B01D17/0217 , B01D21/003 , B01D21/0087 , B01D21/2405 , B01D21/245 , B01D21/262 , B01D21/32 , B01D21/34 , B04B13/00 , B04B5/0442 , B04B7/08 , A61M1/025 , A61M1/30 , A61M2202/0427 , A61M2205/331 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3393 , B01D2221/10 , B04B2005/045
摘要： Systems and methods centrifugally separate mono nuclear cells from whole blood in a separation chamber. The systems and methods control the exit hematocrit value of red blood cells separated in the chamber by recirculating a portion of the red blood cells removed from the chamber for mixing whole blood entering the separation chamber. The systems and methods also control the entry hematocrit value of whole blood entering the separation chamber by recirculating a portion of the plasma constituent removed from the separation chamber for mixing whole blood entering the separation chamber.
摘要翻译：系统和方法在分离室中离心分离单核细胞与全血。系统和方法通过再循环从腔室中取出的一部分红细胞来控制在腔室中分离的红细胞的出血血细胞比值，用于混合进入分离室的全血。系统和方法还通过再循环从分离室除去的等离子体成分的一部分来混合进入分离室的全血，从而控制进入分离室的全血进入血细胞比容值。

9. 发明授权

US5980760A System and methods for harvesting mononuclear cells by recirculation of packed red blood cells 失效
标题翻译：通过再循环包装的红细胞收获单核细胞的系统和方法
公开(公告)号：US5980760A
公开(公告)日：1999-11-09
申请号：US886780
申请日：1997-07-01
申请人： Kyungyoon Min , Richard I Brown , Daniel F Bischof , William H Cork , Robert J Cantu
发明人： Kyungyoon Min , Richard I Brown , Daniel F Bischof , William H Cork , Robert J Cantu
IPC分类号： A61M1/02 , A61M1/36 , B01D21/26 , B04B5/04 , B04B11/02 , B04B13/00
CPC分类号： B01D21/302 , A61M1/3696 , B01D21/262 , B04B13/00 , B04B5/0442 , B01D2221/10 , B04B2005/045
摘要： A blood separation system operates in a first mode to convey whole blood into the inlet region of a blood processing chamber for centrifugal separation into packed red blood cells, a plasma constituent, and an interface, which carries mononuclear cells, between the packed red blood cells and the plasma constituent. The system removes packed red blood cells and the plasma constituent from the chamber, while maintaining the interface within the chamber. The system operates in a second mode to remove the interface from the chamber by conveying packed red blood cells into the inlet region. An outlet path conveys the removed interface from the chamber. The outlet path includes a first sensing element to locate mononuclear cells in the removed interface and provide a sensed output upon locating mononuclear cells.
摘要翻译：血液分离系统以第一模式操作，以将全血输送到血液处理室的入口区域，用于离心分离成装填的红血细胞，血浆成分和携带单核细胞的界面，和等离子体成分。该系统在保持室内的界面的同时从腔室中去除填充的红细胞和等离子体成分。该系统以第二模式操作，以通过将填充的红血细胞输送到入口区域来从腔室去除界面。出口路径从腔室传送去除的界面。出口路径包括第一感测元件，以将去除界面中的单核细胞定位，并在定位单核细胞时提供感测输出。

10. 发明授权

US07708710B2 Method and apparatus for collecting and processing blood 有权
标题翻译：用于收集和处理血液的方法和装置
公开(公告)号：US07708710B2
公开(公告)日：2010-05-04
申请号：US10826420
申请日：2004-04-16
申请人： Kyungyoon Min , Richard I. Brown
发明人： Kyungyoon Min , Richard I. Brown
IPC分类号： A61M37/00 , C02F1/44 , B01D33/15
CPC分类号： A61M1/38 , A61M1/0209 , A61M1/302 , A61M1/3693
摘要： Methods are disclosed for collecting and separating whole blood into one or more components. A disposable blood separation fluid circuit is provided which is adapted to cooperate with a reusable separation controller. The fluid circuit includes a fluid flow path for communication with a blood source and at least one container in fluid communication with the fluid flow path. The fluid flow path is connected to a blood source and quantities of whole blood are collected in the container and one other location within the fluid circuit. The source is then disconnected from the disposable fluid circuit. The quantities of whole blood are centrifugally processed, with processing of at least a portion of one of the quantities beginning after the source is disconnected from the fluid circuit.
摘要翻译：公开了将全血收集和分离成一个或多个组分的方法。提供了一种一次性血液分离流体回路，其适于与可重复使用的分离控制器配合。流体回路包括用于与血液源连通的流体流动路径和与流体流动路径流体连通的至少一个容器。流体流动路径连接到血液源，并且全部血液的数量被收集在容器和流体回路内的另一个位置。然后将源从一次性流体回路断开。全血的量是离心处理的，处理至少一部分数量从源头与流体回路断开之后开始。

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