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1. 发明授权

US06582349B1 Blood processing system 有权
标题翻译：血液处理系统
公开(公告)号：US06582349B1
公开(公告)日：2003-06-24
申请号：US09669752
申请日：2000-09-26
申请人： Robert J Cantu , Kyungyoon Min , Douglas W Reitz , Robert I Brown
发明人： Robert J Cantu , Kyungyoon Min , Douglas W Reitz , Robert I Brown
IPC分类号： B04D1100
CPC分类号： A61M1/3693 , A61M1/3696 , B01D21/262 , B01D21/32 , B01D21/34 , B01D2221/10 , B04B9/14 , B04B2005/045 , B04B2009/143
摘要： Blood processing systems and methods rotate a processing chamber on a rotating element. The processing chamber includes a first compartment and a second compartment. Blood is conveyed into the first compartment for centrifugal separation into components. A liquid free of blood occupies the second compartment to counter-balance the first compartment during rotation on the rotating element. In one embodiment, the second compartment is served by a single fluid flow access. Prior to use, the single access is coupled to tubing, through which a vacuum is drawn to remove air from the second compartment. While the vacuum exists, communication is opened between the tubing and a source of liquid. The vacuum draws the liquid into the second compartment through the single access, thereby priming the second compartment for use.
摘要翻译：血液处理系统和方法将处理室旋转在旋转元件上。处理室包括第一隔室和第二隔室。血液被输送到第一隔室中，用于离心分离成组分。没有血液的液体占据第二隔室，以在旋转元件旋转期间平衡第一隔间。在一个实施例中，第二隔室由单个流体流动进入。在使用之前，单个通道联接到管道，通过该管道吸入真空以从第二隔室移除空气。当存在真空时，在管道和液体源之间打开通信。真空通过单一进入将液体吸入第二隔室，从而启动第二隔间以供使用。

2. 发明授权

US6027441A Systems and methods providing a liquid-primed, single flow access chamber 失效
标题翻译：提供液体注射的单流入口室的系统和方法
公开(公告)号：US6027441A
公开(公告)日：2000-02-22
申请号：US886179
申请日：1997-07-01
申请人： Robert J Cantu , Kyungyoon Min , Douglas W Reitz
发明人： Robert J Cantu , Kyungyoon Min , Douglas W Reitz
IPC分类号： A61K35/14 , A61M1/36 , B01D21/26 , B04B9/14 , B04B11/00 , B04B11/04
CPC分类号： A61M1/3693 , A61M1/3696 , B01D21/262 , B01D21/32 , B01D21/34 , B04B9/14 , B01D2221/10 , B04B2005/045 , B04B2009/143
摘要： Blood processing systems and methods rotate a processing chamber on a rotating element. The processing chamber includes a first compartment and a second compartment. Blood is conveyed into the first compartment for centrifugal separation into components. A liquid free of blood occupies the second compartment to counter-balance the first compartment during rotation on the rotating element. In one embodiment, the second compartment is served by a single fluid flow access. Prior to use, the single access is coupled to tubing, through which a vacuum is drawn to remove air from the second compartment. While the vacuum exists, communication is opened between the tubing and a source of liquid. The vacuum draws the liquid into the second compartment through the single access, thereby priming the second compartment for use.
摘要翻译：血液处理系统和方法将处理室旋转在旋转元件上。处理室包括第一隔室和第二隔室。血液被输送到第一隔室中，用于离心分离成组分。没有血液的液体占据第二隔室，以在旋转元件旋转期间平衡第一隔间。在一个实施例中，第二隔室由单个流体流动进入。在使用之前，单个通道联接到管道，通过该管道吸入真空以从第二隔室移除空气。当存在真空时，在管道和液体源之间打开通信。真空通过单一进入将液体吸入第二隔室，从而启动第二隔间以供使用。

3. 发明授权

US06168561A Blood processing chamber counter-balanced with blood-free liquid 失效
标题翻译：血液处理室与无血液反应
公开(公告)号：US06168561A
公开(公告)日：2001-01-02
申请号：US09377339
申请日：1999-08-19
申请人： Robert J Cantu , Kyungyoon Min , Douglas W Reitz
发明人： Robert J Cantu , Kyungyoon Min , Douglas W Reitz
IPC分类号： B01D2126
CPC分类号： A61M1/3693 , A61M1/3696 , B01D21/262 , B01D21/32 , B01D21/34 , B01D2221/10 , B04B9/14 , B04B2005/045 , B04B2009/143
摘要： Blood processing systems and methods rotate a processing chamber on a rotating element. The processing chamber includes a first compartment and a second compartment. Blood is conveyed into the first compartment for centrifugal separation into components. A liquid free of blood occupies the second compartment to counter-balance the first compartment during rotation on the rotating element. In one embodiment, the second compartment is served by a single fluid flow access. Prior to use, the single access is coupled to tubing, through which a vacuum is drawn to remove air from the second compartment. While the vacuum exists, communication is opened between the tubing and a source of liquid. The vacuum draws the liquid into the second compartment through the single access, thereby priming the second compartment for use.
摘要翻译：血液处理系统和方法将处理室旋转在旋转元件上。处理室包括第一隔室和第二隔室。血液被输送到第一隔室中，用于离心分离成组分。没有血液的液体占据第二隔室，以在旋转元件旋转期间平衡第一隔间。在一个实施例中，第二隔室由单个流体流动进入。在使用之前，单个通道联接到管道，通过该管道吸入真空以从第二隔室移除空气。当存在真空时，在管道和液体源之间打开通信。真空通过单一进入将液体吸入第二隔室，从而启动第二隔间以供使用。

4. 发明授权

US5980760A System and methods for harvesting mononuclear cells by recirculation of packed red blood cells 失效
标题翻译：通过再循环包装的红细胞收获单核细胞的系统和方法
公开(公告)号：US5980760A
公开(公告)日：1999-11-09
申请号：US886780
申请日：1997-07-01
申请人： Kyungyoon Min , Richard I Brown , Daniel F Bischof , William H Cork , Robert J Cantu
发明人： Kyungyoon Min , Richard I Brown , Daniel F Bischof , William H Cork , Robert J Cantu
IPC分类号： A61M1/02 , A61M1/36 , B01D21/26 , B04B5/04 , B04B11/02 , B04B13/00
CPC分类号： B01D21/302 , A61M1/3696 , B01D21/262 , B04B13/00 , B04B5/0442 , B01D2221/10 , B04B2005/045
摘要： A blood separation system operates in a first mode to convey whole blood into the inlet region of a blood processing chamber for centrifugal separation into packed red blood cells, a plasma constituent, and an interface, which carries mononuclear cells, between the packed red blood cells and the plasma constituent. The system removes packed red blood cells and the plasma constituent from the chamber, while maintaining the interface within the chamber. The system operates in a second mode to remove the interface from the chamber by conveying packed red blood cells into the inlet region. An outlet path conveys the removed interface from the chamber. The outlet path includes a first sensing element to locate mononuclear cells in the removed interface and provide a sensed output upon locating mononuclear cells.
摘要翻译：血液分离系统以第一模式操作，以将全血输送到血液处理室的入口区域，用于离心分离成装填的红血细胞，血浆成分和携带单核细胞的界面，和等离子体成分。该系统在保持室内的界面的同时从腔室中去除填充的红细胞和等离子体成分。该系统以第二模式操作，以通过将填充的红血细胞输送到入口区域来从腔室去除界面。出口路径从腔室传送去除的界面。出口路径包括第一感测元件，以将去除界面中的单核细胞定位，并在定位单核细胞时提供感测输出。

5. 发明授权

US5961842A Systems and methods for collecting mononuclear cells employing control of packed red blood cell hematocrit 失效
标题翻译：采用控制包装的红细胞血细胞比容收集单核细胞的系统和方法
公开(公告)号：US5961842A
公开(公告)日：1999-10-05
申请号：US886350
申请日：1997-07-01
申请人： Kyungyoon Min , Richard I Brown , Robert J Cantu , Daniel F Bischof , William H Cork
发明人： Kyungyoon Min , Richard I Brown , Robert J Cantu , Daniel F Bischof , William H Cork
IPC分类号： A61M1/30 , A61M1/36 , B04B5/04 , B04B13/00 , B01D21/26
CPC分类号： B04B5/0442 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , B04B13/00 , A61M1/30 , A61M2205/331 , B04B2005/045
摘要： Blood separation systems and methods employ a rotating chamber. The chamber includes an inlet region where whole blood enters for centrifugal separation into packed red blood cells, a plasma constituent, and an interface carrying mononuclear cells between the packed red blood cells and the plasma constituent. The packed red blood cells in the chamber have a hematocrit value H.sub.PRBC. A controller operates in a first mode to convey whole blood into the inlet region while removing packed red blood cells and the plasma constituent from the chamber and while maintaining the interface within the chamber. The controller also operates in the first mode to maintain a set H.sub.PRBC by conveying packed red blood cells into the inlet region.
摘要翻译：血液分离系统和方法采用旋转室。所述腔室包括全血进入的入口区域，用于离心分离成包装的红细胞，血浆成分，以及在填充的红细胞和血浆成分之间携带单核细胞的界面。室内包装的红细胞具有红细胞比容值HPRBC。控制器以第一模式操作，以将全血输送到入口区域，同时从室中去除填充的红细胞和等离子体成分，同时保持室内的界面。控制器还在第一模式下操作以通过将填充的红细胞输送到入口区域来维持一组HPRBC。

6. 发明授权

US6027657A Systems and methods for collecting diluted mononuclear cells 失效
标题翻译：用于收集稀释的单核细胞的系统和方法
公开(公告)号：US6027657A
公开(公告)日：2000-02-22
申请号：US886732
申请日：1997-07-01
申请人： Kyungyoon Min , Richard I Brown , Robert J Cantu
发明人： Kyungyoon Min , Richard I Brown , Robert J Cantu
IPC分类号： A61K35/14 , A61M1/36 , A61M1/38 , B01D21/26 , B04B5/04
CPC分类号： B01D21/302 , A61M1/3693 , A61M1/3696 , A61M1/38 , B01D21/262 , B04B5/0442 , B01D2221/10 , B04B2005/045
摘要： Systems and methods rotate a chamber, in which whole blood is centrifugally separated into packed red blood cells, a plasma constituent, and an interface between the packed red blood cells and the plasma constituent. The interface carries platelets and mononuclear cells. The systems and methods include an interface control unit. The interface control unit is operative in a first state to enable removal of platelet-poor plasma in a first container for use as a diluting liquid. In a second state, the interface control unit retains mononuclear cells in the chamber, while removing platelet-rich plasma from the chamber, bypassing the platelet-poor collection container, thereby maintaining its platelet-poor character. In a third state, the interface control unit enables the removal of mononuclear cells from the chamber in a path that leads to a second container, where the mononuclear cells are collected. The systems and methods direct platelet-poor plasma from the first container to the second container to dilute the removed mononuclear cells in the second container.
摘要翻译：系统和方法旋转室，其中全血离心分离成包装的红细胞，血浆成分以及填充的红细胞和血浆成分之间的界面。界面携带血小板和单核细胞。系统和方法包括接口控制单元。界面控制单元在第一状态下操作以使得能够在用作稀释液体的第一容器中移除贫血小血浆。在第二状态下，界面控制单元在腔室中保留单核细胞，同时从腔室中除去富含血小板的血浆，绕过血小板收集容器，从而维持其血小板减少的特征。在第三状态下，界面控制单元能够在通向收集单核细胞的第二容器的路径中从腔室去除单核细胞。系统和方法将血小板从第一容器直接引导到第二容器，以稀释第二容器中去除的单核细胞。

7. 发明授权

US09603986B2 Device and method for processing and producing autologous platelet-rich plasma 有权
公开(公告)号：US09603986B2
公开(公告)日：2017-03-28
申请号：US14014542
申请日：2013-08-30
申请人： Benjamin E. Kusters , Christopher J. Wegener , Kyungyoon Min
发明人： Benjamin E. Kusters , Christopher J. Wegener , Kyungyoon Min
IPC分类号： B01D63/16 , A61M1/34 , A61M1/26 , A61M1/02
CPC分类号： A61M1/3496 , A61M1/0218 , A61M1/265 , A61M2205/103 , A61M2205/75 , B01D63/16 , B01D2317/02 , B01D2319/02 , B01D2319/06
摘要： A system and method are provided, including an integrated single-use kit, for processing whole blood to produce platelet rich plasma. A two stage spinning membrane separator, has a first stage for receiving whole blood and separating substantially all red blood cells from plasma and platelets, and a second stage for further separating platelet rich plasma from plasma. A first waste container is in fluid communication with the first stage of the separator for receiving separated red blood cells, while a second waste container is in fluid communication with the second stage of the separator for receiving separated plasma. An outlet line is in fluid communication with the second stage of the separator for receiving platelet rich plasma, and a reinfusion container is removably connected to the outlet line for receiving platelet rich plasma from the second stage of the separator.

8. 发明授权

US09533089B2 Centrifugation system with red blood cell barrier 有权
标题翻译：具有红细胞屏障的离心系统
公开(公告)号：US09533089B2
公开(公告)日：2017-01-03
申请号：US14008651
申请日：2012-03-28
申请人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
发明人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
IPC分类号： A61M1/36 , B04B5/04
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3331 , A61M2205/3337 , B04B5/0442 , B04B2005/045 , C12N5/0634 , C12N5/0641 , C12N5/0644
摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.
摘要翻译：提供离心系统和方法用于将血液分离成其组成部分。离心机的内壁和外壁各自包括朝向另一壁延伸的突起。分离室被容纳在离心机之间的壁之间，其中腔室包括用于使血液进入腔室的入口端口，用于使等离子体流出腔室的等离子体出口和用于使红细胞流出的红细胞出口的房间。随着室中的离心机容纳在壁之间，第一突出部延伸到分离的血液成分流向等离子体出口端口的路径中，并防止细胞血液成分流入等离子体出口。第二突出部延伸到朝向红细胞出口流动的分离的血液成分的路径中，并防止血浆流入红细胞出口。

9. 发明授权

US09408961B2 Membrane separation devices, systems and methods employing same and data management systems and methods 有权
标题翻译：膜分离装置，采用相同的系统和方法以及数据管理系统和方法
公开(公告)号：US09408961B2
公开(公告)日：2016-08-09
申请号：US14003281
申请日：2012-03-09
申请人： Christopher J. Wegener , Kyungyoon Min , Laurent Forcioli , Mark J. Brierton , Daniel R. Boggs
发明人： Christopher J. Wegener , Kyungyoon Min , Laurent Forcioli , Mark J. Brierton , Daniel R. Boggs
IPC分类号： A61M1/34 , A61M1/02 , B01D61/18 , B01D63/06 , B01D63/16 , A61M1/38 , A61M1/26 , A61M1/36
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
摘要翻译：公开了膜分离装置以及在血液处理程序中采用该装置的系统和方法。在一个实施例中，提供了一种纺丝膜分离器，其中在膜和壳体之间的间隙中产生至少两个区域或区域，使得两个区域之间的流体的混合被与膜相关联的径向肋这减小了膜和壳体之间的间隙以限定两个流体区域，脊部分离两个区域中的流体以最小化两者之间的混合。公开了自动化系统和方法，用于将先前收集的全血的单元分离成诸如浓红细胞和血浆的组分，用于在单次通过中从供体直接收集红细胞和血浆，以及用于细胞洗涤。还公开了数据管理系统和方法以及启动方法。

10. 发明授权

US09131268B2 Display device, display method, and multimedia transmission method 有权
标题翻译：显示设备，显示方式和多媒体传输方式
公开(公告)号：US09131268B2
公开(公告)日：2015-09-08
申请号：US13643734
申请日：2011-09-28
申请人： Kyungyoon Min
发明人： Kyungyoon Min
IPC分类号： G06F3/038 , G09G5/00 , H04N21/4363 , H04N5/765 , G06F3/14
CPC分类号： H04N21/43635 , G06F3/1446 , G09G5/006 , G09G2358/00 , G09G2370/04 , G09G2370/10 , G09G2370/12 , H04N5/765
摘要： Provided are a display device configuring a multi-display and a display method. The multi-media display receives a DisplayPort signal from outside, converts the received signal into a set of LVTTL signals, converts a portion of the LVTTL signals into a high-quality image signal capable of using HDMI to display multimedia on a corresponding display device, and converts another portion of the LVTTL signals into a DisplayPort signal to transmit the DisplayPort signal to another display device. Accordingly, an infinite multi-display can display high quality multimedia.
摘要翻译：提供了构成多显示器和显示方法的显示装置。多媒体显示器从外部接收DisplayPort信号，将接收到的信号转换为一组LVTTL信号，将一部分LVTTL信号转换为能够使用HDMI在相应显示装置上显示多媒体的高质量图像信号，并将LVTTL信号的另一部分转换成DisplayPort信号，以将DisplayPort信号传输到另一显示设备。因此，无限多显示器可以显示高质量的多媒体。

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