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1. 发明授权

US09533089B2 Centrifugation system with red blood cell barrier 有权
标题翻译：具有红细胞屏障的离心系统
公开(公告)号：US09533089B2
公开(公告)日：2017-01-03
申请号：US14008651
申请日：2012-03-28
申请人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
发明人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
IPC分类号： A61M1/36 , B04B5/04
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3331 , A61M2205/3337 , B04B5/0442 , B04B2005/045 , C12N5/0634 , C12N5/0641 , C12N5/0644
摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.
摘要翻译：提供离心系统和方法用于将血液分离成其组成部分。离心机的内壁和外壁各自包括朝向另一壁延伸的突起。分离室被容纳在离心机之间的壁之间，其中腔室包括用于使血液进入腔室的入口端口，用于使等离子体流出腔室的等离子体出口和用于使红细胞流出的红细胞出口的房间。随着室中的离心机容纳在壁之间，第一突出部延伸到分离的血液成分流向等离子体出口端口的路径中，并防止细胞血液成分流入等离子体出口。第二突出部延伸到朝向红细胞出口流动的分离的血液成分的路径中，并防止血浆流入红细胞出口。

2. 发明申请

US20140045671A1 CENTRIFUGATION SYSTEM WITH RED BLOOD CELL BARRIER 有权
标题翻译：红血球细胞分离系统
公开(公告)号：US20140045671A1
公开(公告)日：2014-02-13
申请号：US14008651
申请日：2012-03-28
申请人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
发明人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
IPC分类号： A61M1/36
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3331 , A61M2205/3337 , B04B5/0442 , B04B2005/045 , C12N5/0634 , C12N5/0641 , C12N5/0644
摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.
摘要翻译：提供离心系统和方法用于将血液分离成其组成部分。离心机的内壁和外壁各自包括朝向另一壁延伸的突起。分离室被容纳在离心机之间的壁之间，其中腔室包括用于使血液进入腔室的入口端口，用于使等离子体流出腔室的等离子体出口和用于使红细胞流出的红细胞出口的房间。随着室中的离心机容纳在壁之间，第一突出部延伸到分离的血液成分流向等离子体出口端口的路径中，并防止细胞血液成分流入等离子体出口。第二突出部延伸到朝向红细胞出口流动的分离的血液成分的路径中，并防止血浆流入红细胞出口。

3. 发明授权

US08075468B2 Systems and methods for mid-processing calculation of blood composition 有权
标题翻译：血液成分中期计算的系统和方法
公开(公告)号：US08075468B2
公开(公告)日：2011-12-13
申请号：US12394375
申请日：2009-02-27
申请人： Kyungyoon Min , Richard I. Brown
发明人： Kyungyoon Min , Richard I. Brown
IPC分类号： B01D21/26 , B04B3/00
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/3696 , A61M2205/3306 , B01D21/262 , B01D21/302 , B01D21/34 , B01D2221/08 , B01D2221/10
摘要： Blood separation methods are provided for mid-processing calculation of blood composition. Blood is conveyed into a device having an outlet line and the device is spun to separate platelets from the blood. A flow of platelets is conveyed from the device by the outlet line and the platelets in the outlet line are optically measured. With said optical measurement, a current platelet yield, a platelet pre-count, the volume of blood to process to collect a target amount of platelets, and/or the processing time required to collect a target amount of platelets is calculated. The optical measurement can also be used to calculate an amount of storage fluid to convey into a collection container with the platelets.
摘要翻译：提供血液分离方法用于血液成分的中间处理计算。将血液输送到具有出口管线的装置中，并且将该装置旋转以将血小板与血液分开。通过出口管线从装置输送血小板流，并且光学测量出口管线中的血小板。通过所述光学测量，计算目前的血小板产量，血小板预计数，用于收集目标量的血小板的血液的体积和/或收集目标量的血小板所需的处理时间。光学测量还可用于计算与血小板一起输送到收集容器中的储存液体的量。

4. 发明申请

US20090215602A1 SYSTEMS AND METHODS FOR MID-PROCESSING CALCULATION OF BLOOD COMPOSITION 有权
标题翻译：用于中间体计算血液组合物的系统和方法
公开(公告)号：US20090215602A1
公开(公告)日：2009-08-27
申请号：US12394375
申请日：2009-02-27
申请人： Kyungyoon Min , Richard I. Brown
发明人： Kyungyoon Min , Richard I. Brown
IPC分类号： A61M1/36 , B01D17/038 , B01D21/26 , B04B1/00 , B04B1/18
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/3696 , A61M2205/3306 , B01D21/262 , B01D21/302 , B01D21/34 , B01D2221/08 , B01D2221/10
摘要： Blood separation methods and systems are provided for mid-processing calculation of blood composition. Blood is conveyed into a device having an outlet line and the device is spun to separate a blood component from the blood. A flow of blood component is conveyed from the device by the outlet line and the blood component in the outlet line is optically measured. With said optical measurement, a current blood component yield, a blood component pre-count, the volume of blood to process to collect a target amount of said blood component, and/or the processing time required to collect a target amount of said blood component is calculated. The optical measurement can also be used to calculate an amount of storage fluid to convey into a collection container with the blood component.
摘要翻译：提供血液分离方法和系统用于血液成分的中间处理计算。将血液输送到具有出口管线的装置中，并且将该装置旋转以将血液成分与血液分离。通过出口管路从装置输送血液成分流，并且光学测量出口管线中的血液成分。通过所述光学测量，当前的血液成分收率，血液成分预计数，用于收集目标量的所述血液成分的血液的体积和/或收集目标量的所述血液成分所需的处理时间被计算。光学测量还可以用于计算要输送到具有血液成分的收集容器中的存储流体的量。

5. 发明授权

US5750039A Blood processing systems and methods for collecting mono nuclear cells 失效
标题翻译：用于收集单核细胞的血液处理系统和方法
公开(公告)号：US5750039A
公开(公告)日：1998-05-12
申请号：US745779
申请日：1996-11-08
申请人： Richard I. Brown , Kyungyoon Min
发明人： Richard I. Brown , Kyungyoon Min
IPC分类号： A61K35/14 , A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D21/24 , B01D21/26 , B04B5/04 , B04B7/08 , B04B13/00
CPC分类号： A61M1/0209 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3603 , A61M1/3624 , A61M1/3693 , A61M1/3696 , B01D17/0217 , B01D21/003 , B01D21/0087 , B01D21/2405 , B01D21/245 , B01D21/262 , B01D21/32 , B01D21/34 , B04B13/00 , B04B5/0442 , B04B7/08 , A61M1/025 , A61M1/30 , A61M2202/0427 , A61M2205/331 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3393 , B01D2221/10 , B04B2005/045
摘要： Systems and methods centrifugally separate mono nuclear cells from whole blood in a separation chamber. The systems and methods control the exit hematocrit value of red blood cells separated in the chamber by recirculating a portion of the red blood cells removed from the chamber for mixing whole blood entering the separation chamber. The systems and methods also control the entry hematocrit value of whole blood entering the separation chamber by recirculating a portion of the plasma constituent removed from the separation chamber for mixing whole blood entering the separation chamber.
摘要翻译：系统和方法在分离室中离心分离单核细胞与全血。系统和方法通过再循环从腔室中取出的一部分红细胞来控制在腔室中分离的红细胞的出血血细胞比值，用于混合进入分离室的全血。系统和方法还通过再循环从分离室除去的等离子体成分的一部分来混合进入分离室的全血，从而控制进入分离室的全血进入血细胞比容值。

6. 发明申请

US20090211962A1 PROCESSING CHAMBERS FOR USE WITH APHERESIS DEVICES 审中-公开
标题翻译：加工中心与APHERESIS设备一起使用
公开(公告)号：US20090211962A1
公开(公告)日：2009-08-27
申请号：US12392952
申请日：2009-02-25
申请人： Kyungyoon Min , Richard I. Brown
发明人： Kyungyoon Min , Richard I. Brown
IPC分类号： B01D33/74
CPC分类号： A61M1/3693 , A61M1/0218 , A61M1/0231 , A61M1/3652 , A61M1/3696 , A61M1/38 , A61M2205/128
摘要： Processing chamber for use with apheresis devices are described herein. An example centrifugal processing chamber includes first and second lateral walls spaced at a distance from one another. Additionally, the example centrifugal processing chamber includes a channel at least partially defined by the first and second lateral walls. Further, the centrifugal processing chamber includes an inlet fluidly coupled to the channel to convey blood to the channel. Further still, the centrifugal processing chamber includes a first outlet fluidly coupled to the channel having a first opening adjacent the first lateral wall. The first outlet is to convey separated plasma from the channel. Additionally, the centrifugal processing chamber includes a second fluid outlet fluidly coupled to the channel having a second opening adjacent the second lateral wall. The second outlet is to convey separated red blood cells from the channel. Additionally, the processing chamber includes a barrier formed along the second lateral wall to intercept platelets. The first and second lateral walls are spaced such that the distance between the first and second lateral walls enables at least one therapeutic unit of single dose platelets to pool adjacent the barrier without spilling into the first outlet or the second outlet.
摘要翻译：本文描述了与分离装置一起使用的处理室。一个示例性离心处理室包括彼此间隔一定距离的第一和第二侧壁。另外，示例性离心处理室包括至少部分地由第一和第二侧壁限定的通道。此外，离心处理室包括流体耦合到通道以将血液输送到通道的入口。此外，离心处理室包括流体耦合到通道的第一出口，其具有与第一侧壁相邻的第一开口。第一个出口是从通道传送分离的等离子体。此外，离心处理室包括流体地联接到通道的第二流体出口，其具有邻近第二侧壁的第二开口。第二个出口是从通道传送分离的红细胞。另外，处理室包括沿着第二侧壁形成的屏障，以拦截血小板。第一和第二侧壁间隔开，使得第一和第二侧壁之间的距离使得单剂量血小板的至少一个治疗单元能够在不渗入第一出口或第二出口的情况下相邻隔离池。

7. 发明授权

US06706008B2 Automated system and method for withdrawing compounds from blood 有权
标题翻译：自动化系统和从血液中提取化合物的方法
公开(公告)号：US06706008B2
公开(公告)日：2004-03-16
申请号：US09800133
申请日：2001-03-06
申请人： Rohit Vishnoi , Richard I. Brown , Kyungyoon Min , Tom Westberg
发明人： Rohit Vishnoi , Richard I. Brown , Kyungyoon Min , Tom Westberg
IPC分类号： A61M3700
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/342 , A61M1/3441 , A61M1/3672 , A61M1/3675 , A61M1/3679 , A61M1/3687 , A61M1/3692 , A61M1/3696 , A61M2205/12
摘要： Automated systems and methods for withdrawing a selected compound from blood are disclosed. The systems and methods utilize a disposable fluid circuit mounted on a re-usable hardware component or module. The system withdraws blood from a donor or patient, separates the blood into two or more components and further combines the separated component with a solvent so as to remove a compound from the blood component.
摘要翻译：公开了用于从血液中取出选定化合物的自动化系统和方法。系统和方法利用安装在可重复使用的硬件部件或模块上的一次性流体回路。系统从供体或患者抽出血液，将血液分离成两个或更多个组分，并进一步将分离的组分与溶剂组合，以从血液组分中除去化合物。

8. 发明授权

US07708710B2 Method and apparatus for collecting and processing blood 有权
标题翻译：用于收集和处理血液的方法和装置
公开(公告)号：US07708710B2
公开(公告)日：2010-05-04
申请号：US10826420
申请日：2004-04-16
申请人： Kyungyoon Min , Richard I. Brown
发明人： Kyungyoon Min , Richard I. Brown
IPC分类号： A61M37/00 , C02F1/44 , B01D33/15
CPC分类号： A61M1/38 , A61M1/0209 , A61M1/302 , A61M1/3693
摘要： Methods are disclosed for collecting and separating whole blood into one or more components. A disposable blood separation fluid circuit is provided which is adapted to cooperate with a reusable separation controller. The fluid circuit includes a fluid flow path for communication with a blood source and at least one container in fluid communication with the fluid flow path. The fluid flow path is connected to a blood source and quantities of whole blood are collected in the container and one other location within the fluid circuit. The source is then disconnected from the disposable fluid circuit. The quantities of whole blood are centrifugally processed, with processing of at least a portion of one of the quantities beginning after the source is disconnected from the fluid circuit.
摘要翻译：公开了将全血收集和分离成一个或多个组分的方法。提供了一种一次性血液分离流体回路，其适于与可重复使用的分离控制器配合。流体回路包括用于与血液源连通的流体流动路径和与流体流动路径流体连通的至少一个容器。流体流动路径连接到血液源，并且全部血液的数量被收集在容器和流体回路内的另一个位置。然后将源从一次性流体回路断开。全血的量是离心处理的，处理至少一部分数量从源头与流体回路断开之后开始。

9. 发明授权

US07396452B2 Apparatus for determining flow rates of biological fluids 有权
标题翻译：用于确定生物流体流速的装置
公开(公告)号：US07396452B2
公开(公告)日：2008-07-08
申请号：US11427402
申请日：2006-06-29
申请人： Kyungyoon Min , Richard I. Brown
发明人： Kyungyoon Min , Richard I. Brown
IPC分类号： B01D21/30 , B01D21/26 , G01F1/00 , B01D21/32 , B04B11/00
CPC分类号： A61M1/3693 , A61M1/3696
摘要： An apparatus comprises an inlet to convey a first fluid comprising first and second components having different density into a rotating chamber such that an interface forms between at least portions of such components at a first location. At least one outlet removes at least one of the first and second components. A controller is adapted to introduce the first fluid and is operable to move the interface from the first location to a second location and to move the interface from the second location in a direction toward the first location and to return the interface to the second location. The controller is operable to determine a flow rate of the first or second component based, at least in part, on the time interval between when the interface moves from and returns to the second location. At least one sensing assembly is adapted to sense the location of the interface.
摘要翻译：一种装置包括将包含具有不同密度的第一和第二组分的第一流体输送到旋转室中的入口，使得界面在第一位置处在这些部件的至少部分之间形成。至少一个出口去除第一和第二组分中的至少一个。控制器适于引入第一流体并且可操作以将界面从第一位置移动到第二位置，并且将界面从朝向第一位置的方向从第二位置移动并将界面返回到第二位置。该控制器可操作以至少部分地基于界面从第二位置移动到第二位置之间的时间间隔来确定第一或第二组件的流量。至少一个感测组件适于感测界面的位置。

10. 发明授权

US06884228B2 Automated system adaptable for use with different fluid circuits 有权
标题翻译：自动化系统适用于不同流体回路
公开(公告)号：US06884228B2
公开(公告)日：2005-04-26
申请号：US09800206
申请日：2001-03-06
申请人： Richard I. Brown , Kyungyoon Min , Rohit Vishnoi , Sandra Thom , Liam Farrell , Tom Westberg
发明人： Richard I. Brown , Kyungyoon Min , Rohit Vishnoi , Sandra Thom , Liam Farrell , Tom Westberg
IPC分类号： A61M1/02 , A61M1/36 , A61M1/38 , A61M37/00 , C02F1/44
CPC分类号： A61M1/38 , A61M1/0209 , A61M1/0218 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3692 , A61M1/3696 , A61M2205/12 , A61M2209/082 , A61M2209/084
摘要： Automated systems and method for processing blood and other fluids are disclosed. The systems and methods utilize a disposable fluid circuit selected from one of two or more circuits. The circuits are mounted on a re-usable hardware component or module. The system includes a programmable controller including programs for use with the fluid circuits.
摘要翻译：公开了用于处理血液和其它流体的自动化系统和方法。该系统和方法利用从两个或更多个电路中的一个中选择的一次性流体回路。电路安装在可重复使用的硬件组件或模块上。该系统包括可编程控制器，其包括与流体回路一起使用的程序。

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