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41. 发明申请

US20070043069A1 HETEROCYCLIC AMIDE DERIVATIVES AS INHIBITORS OF GLYCOGEN PHOSPHORYLASE 失效
标题翻译：作为GLYCOGEN PHOSPHORYLASE的抑制剂的杂环酰胺衍生物
公开(公告)号：US20070043069A1
公开(公告)日：2007-02-22
申请号：US11463144
申请日：2006-08-08
申请人： Alan Birch , Andrew Morley , Andrew Stocker , Paul Whittamore
发明人： Alan Birch , Andrew Morley , Andrew Stocker , Paul Whittamore
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D495/04
摘要： Heterocyclic amides of formula (1) wherein: X is N or CH; R4 and R5 together are either —S—C(R6)═C(R7)— or —C(R7)═C(R6)—S—; R6 and R7 are independently selected from, for example hydrogen, halo and C1-4alkyl; A is phenylene or heteroarylene; n is 0, 1 or 2; R1 is selected from for example halo, nitro, cyano, hydroxy, carboxy; R2 is hydrogen, hydroxy or carboxy; R3 is selected from for example hydrogen, hydroxy, aryl, heterocyclyl and C1-4alkyl(optionally substituted by 1 or 2 R8 groups); R8 is selected from for example hydroxy, —COCOOR9, —C(O)N(R9)(R10), —NHC(O)R9, (R9)(R10)N— and —COOR9; R9 and R10 are selected from for example hydrogen, hydroxy, C1-4alkyl (optionally substituted by 1 or 2 R13); R13 is selected from hydroxy, halo, trihalomethyl and C1-4alkoxy; or a pharmaceutically acceptable salt or pro-drug thereof, possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity. Processes for the manufacture of said heterocyclic amide derivatives and pharmaceutical compositions containing them are described.
摘要翻译：式（1）的杂环酰胺其中：X是N或CH; R 4和R 5一起是-SC（R 6）-C（R 7） - 或 -C（R 7）C（R 6）-S-; R 6和R 7独立地选自，例如氢，卤素和C 1-4烷基; A是亚苯基或亚杂芳基; n为0,1或2; R 1选自例如卤素，硝基，氰基，羟基，羧基; R 2是氢，羟基或羧基; R 3选自例如氢，羟基，芳基，杂环基和C 1-4烷基（任选被1或2个R 8取代）组）; R 8选自例如羟基，-COCOOR 9，-C（O）N（R 9）（R 10）），-NHC（O）R 9，（R 9）（R 10）N - 和-COOR ^{9 ; R 9和R 10选自例如氢，羟基，C 1-4烷基（任选被1或2个R SUP取代 > 13 ）; R 13选自羟基，卤素，三卤代甲基和C 1-4烷氧基; 或其药学上可接受的盐或前药具有糖原磷酸化酶抑制活性，因此在治疗与增加的糖原磷酸化酶活性相关的疾病状态方面具有价值。描述了制备所述杂环酰胺衍生物和含有它们的药物组合物的方法。}

42. 发明授权

US07173025B1 Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents 失效
标题翻译：氨基杂环衍生物作为抗血栓形成或抗凝血剂
公开(公告)号：US07173025B1
公开(公告)日：2007-02-06
申请号：US09117436
申请日：1997-01-31
申请人： Andrew Stocker , John Preston , Michael James Smithers
发明人： Andrew Stocker , John Preston , Michael James Smithers
IPC分类号： A61K31/55 , A61K31/495 , C07D401/00 , C07D223/00
CPC分类号： C07D401/14 , C07D213/74 , C07D237/20 , C07D239/42 , C07D401/04 , C07D401/12
摘要： Compounds of formula (I), wherein G1 is CH or N; G2 is CH or N; R1 is a variety of optional substituents; L1 is (1-4C)alkylene; T1 is CH or N; R2 and R3 are independently hydrogen or (1-4C)alkyl or are joined to form a ring; X1 and X2 represent various linking groups; Ar is phenylene or certain heteroaryl rings and Q represents a variety of aromatic or heterocyclic rings systems, and pharmaceutically acceptable salts thereof are described as useful antithrombotic and anticoagulant agents, and are selective Factor Xa inhibitors. Processes for their preparation and pharmaceutical compositions containing them are also described.
摘要翻译：式（I）的化合物，其中G 1是CH或N; G 是CH或N; R 1是各种任选的取代基; L 1是（1-4C）亚烷基; T 1是CH或N; R 2和R 3独立地是氢或（1-4C）烷基或连接形成环; X 1和X 2代表各种连接基团; Ar是亚苯基或某些杂芳基环，Q表示各种芳族或杂环体系，其药学上可接受的盐被描述为有用的抗血栓形成和抗凝血剂，并且是选择性因子Xa抑制剂。还描述了其制备方法和含有它们的药物组合物。

43. 发明授权

US06936610B2 Heterocyclic derivatives 失效
标题翻译：杂环衍生物
公开(公告)号：US06936610B2
公开(公告)日：2005-08-30
申请号：US09963686
申请日：2001-09-27
申请人： Andrew Stocker , John Preston , John Wall Rayner , Michael James Smithers , Paul Turner
发明人： Andrew Stocker , John Preston , John Wall Rayner , Michael James Smithers , Paul Turner
IPC分类号： A61K31/44 , A61K31/444 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61P7/02 , C07D213/00 , C07D213/56 , C07D213/61 , C07D213/73 , C07D213/84 , C07D213/89 , C07D237/08 , C07D239/26 , C07D241/00 , C07D307/77 , C07D401/10 , C07D405/12
CPC分类号： C07D213/73 , A61K31/44 , A61K31/505 , C07D213/56 , C07D213/61 , C07D213/84 , C07D213/89 , C07D237/08 , C07D239/26
摘要： The invention relates to heterocyclic derivatives of formula (I) A—B—X1—T1(R2)—L1—T2(R3)—X2—Q (I) or pharmaceutically-acceptable salts thereof, which possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the heterocyclic derivatives, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect.
摘要翻译：本发明涉及式（I）的杂环衍生物<？in-line-formula description =“In-line Formulas”end =“lead”？> ABX
（R 2） - L 1 - （R 2） - X 2（R 3） - X 2 -Q（I）<？in-line-formula description =“In-line Formulas”end =“tail”？>或其药学上可接受的盐，其具有抗血栓形成和抗凝血性质，因此可用于方法治疗人或动物。本发明还涉及制备杂环衍生物的方法，含有它们的药物组合物及其在制备用于产生抗血栓形成或抗凝血作用的药物中的用途。

44. 发明授权

US06881130B1 Edge grinding 失效
标题翻译：边磨
公开(公告)号：US06881130B1
公开(公告)日：2005-04-19
申请号：US10018767
申请日：2000-04-20
申请人： Mark Andrew Stocker
发明人： Mark Andrew Stocker
IPC分类号： B24B53/00 , B23H1/04 , B23H9/00 , B24B1/00 , B24B9/00 , B24B9/06 , B24B47/22 , B24B49/04 , B24B53/065 , B25J9/16 , H01L21/304
CPC分类号： B24B1/00 , B23H1/04 , B23H9/00 , B24B9/065 , B24B47/22 , B24B49/04 , B24B53/065 , B25J9/1602 , H01L21/304
摘要： A method of positioning a grooved grinding wheel relative to a disc-like circular workpiece for edge grinding the workpiece using the groove in the wheel includes the steps of mounting the workpiece for rotation about a first axis, mounting the grinding wheel for rotation about a second parallel axis, effecting relative movement between the workpiece and the wheel to engage the rim of the wheel within the groove and performing a preliminary grind. The position of the wheel is axially adjusted in accordance with the measurements made on the profile of the rim produced by the preliminary grind, and the rim is ground again with a second preliminary grind with the grinding wheel located at the axially shifted position. The steps of grinding and measuring the periphery of the workpiece are repeated until the rim profile possesses the desired accuracy. The final position of the grooved grinding wheel is then utilized for grinding future wafers.
摘要翻译：相对于盘状圆形工件定位带槽砂轮的方法，用于使用车轮中的槽边缘研磨工件的步骤包括以下步骤：将工件安装在第一轴线周围，将砂轮安装在第二轴上平行的轴线，影响工件和车轮之间的相对运动，以使车轮轮缘在槽内啮合并进行预磨。轮的位置根据由预研磨产生的轮辋轮廓上的测量值进行轴向调节，并且轮辋再次用第二初步磨削研磨，砂轮位于轴向位移位置。重复磨削和测量工件的周边的步骤，直到轮辋轮廓具有期望的精度。然后利用开槽砂轮的最终位置研磨未来的晶圆。

45. 发明授权

US08500934B2 Methods and apparatus for forming a slurry polishing pad 失效
标题翻译：用于形成浆料抛光垫的方法和装置
公开(公告)号：US08500934B2
公开(公告)日：2013-08-06
申请号：US13048399
申请日：2011-03-15
申请人： Raymond Charles Cady , Michael John Moore , Mark Alex Shalkey , Mark Andrew Stocker
发明人： Raymond Charles Cady , Michael John Moore , Mark Alex Shalkey , Mark Andrew Stocker
IPC分类号： B24B7/00
CPC分类号： B24B37/26 , B24B13/02 , B24B37/20 , B24D18/0009 , Y10T29/53796 , Y10T156/1028 , Y10T156/1031
摘要： Methods and apparatus for forming a semi-spherical polishing pad for polishing semiconductor surfaces, provide for: placing a polishing pad pre-form on a dome-shaped forming surface, the polishing pad pre-form including a circular body having a center and an outer peripheral edge, and a plurality of slots extending from the outer peripheral edge towards the center; disposing a bladder opposite to the dome-shaped forming surface and the polishing pad pre-form; inflating the bladder with a fluid such that the dome-shaped forming surface of the bonnet form presses against the polishing pad pre-form from one side and the bladder presses against the polishing pad pre-form from an opposite side; and maintaining the pressing step for a predetermined period of time to achieve the semi-spherical polishing pad.
摘要翻译：用于形成用于抛光半导体表面的半球形抛光垫的方法和装置提供：将抛光垫预成型放置在圆顶形成形表面上，所述抛光垫预成型件包括具有中心和外部的圆形主体周缘，以及从外周缘向中心延伸的多个槽; 设置与圆顶形状表面相对的囊和抛光垫预成型件; 用流体使气囊膨胀，使得发动机罩形状的圆顶形成表面从一侧挤压抛光垫预成型件，并且气囊从相对侧压靠抛光垫预成型件; 并且保持按压步骤达预定时间以实现半球形抛光垫。

46. 发明授权

US08016009B2 Method and apparatus for sealing a glass package 有权
标题翻译：密封玻璃包装的方法和装置
公开(公告)号：US08016009B2
公开(公告)日：2011-09-13
申请号：US12958640
申请日：2010-12-02
申请人： Jeffrey Michael Amsden , James Joseph Bernas , John Joseph Costello, III , Margaret Helen Gentile , Mark Andrew Stocker , Lu Zhang
发明人： Jeffrey Michael Amsden , James Joseph Bernas , John Joseph Costello, III , Margaret Helen Gentile , Mark Andrew Stocker , Lu Zhang
IPC分类号： B29C65/00 , B29C65/16 , B32B37/10
CPC分类号： H05B33/04 , C03C23/001 , C03C23/002 , C03C23/0025 , C03C27/06 , C09J5/00 , C09J2205/31 , C09J2400/143 , H01L51/5246 , H05B33/10 , Y10T156/1066 , Y10T156/1374
摘要： An apparatus for sealing a substrate assembly by applying a force to the assembly while simultaneously exposing the substrate assembly, and in particular a sealing material disposed between two substrates of the substrate assembly, to an irradiating beam of electromagnetic energy. The beam heats, cures and/or melts the sealing material, depending upon the sealing material to form the seal. The force is applied by directing a flow of fluid against the substrate assembly, and beneficially improves contact between the substrates of the substrate assembly and the sealing material during the sealing process, therefore assisting in achieving a hermetic seal between the substrates.
摘要翻译：一种用于通过向组件施加力同时将衬底组件，特别是设置在衬底组件的两个衬底之间的密封材料同时暴露于电磁能的照射束来密封衬底组件的装置。梁根据密封材料加热，固化和/或熔化密封材料以形成密封。通过将流体流引导到衬底组件来施加力，并且有利地改善在密封过程期间衬底组件的衬底与密封材料之间的接触，从而有助于实现衬底之间的气密密封。

47. 发明申请

US20090221663A1 PYRAZOLE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS 失效
标题翻译：作为11-BETA-HSD1抑制剂的吡唑衍生物
公开(公告)号：US20090221663A1
公开(公告)日：2009-09-03
申请号：US12259562
申请日：2008-10-28
申请人： Martin John Packer , James Stewart Scott , Andrew Stocker , Paul Robert Owen Whittamore
发明人： Martin John Packer , James Stewart Scott , Andrew Stocker , Paul Robert Owen Whittamore
IPC分类号： A61K31/4155 , C07D405/12
CPC分类号： C07D231/18 , C07D231/14 , C07D403/06 , C07D405/12
摘要： A compound of Formula (I): and pharmaceutically-acceptable salts thereof wherein the variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are also described.
摘要翻译：式（I）的化合物及其药学上可接受的盐，其中定义可变基团; 还描述了其用于抑制11betaHSD1的用途，其制备方法和包含它们的药物组合物。

48. 发明申请

US20090170416A1 Methods and Apparatus for Forming a Slurry Polishing Pad 有权
标题翻译：用于形成浆料抛光垫的方法和装置
公开(公告)号：US20090170416A1
公开(公告)日：2009-07-02
申请号：US11967818
申请日：2007-12-31
申请人： Raymond Charles Cady , Michael John Moore , Mark Alex Shalkey , Mark Andrew Stocker
发明人： Raymond Charles Cady , Michael John Moore , Mark Alex Shalkey , Mark Andrew Stocker
IPC分类号： B24B7/00 , B23P19/04
CPC分类号： B24B37/26 , B24B13/02 , B24B37/20 , B24D18/0009 , Y10T29/53796 , Y10T156/1028 , Y10T156/1031
摘要： Methods and apparatus for forming a semi-spherical polishing pad for polishing semiconductor surfaces, provide for: placing a polishing pad pre-form on a dome-shaped forming surface, the polishing pad pre-form including a circular body having a center and an outer peripheral edge, and a plurality of slots extending from the outer peripheral edge towards the center; disposing a bladder opposite to the dome-shaped forming surface and the polishing pad pre-form; inflating the bladder with a fluid such that the dome-shaped forming surface of the bonnet form presses against the polishing pad pre-form from one side and the bladder presses against the polishing pad pre-form from an opposite side; and maintaining the pressing step for a predetermined period of time to achieve the semi-spherical polishing pad.
摘要翻译：用于形成用于抛光半导体表面的半球形抛光垫的方法和装置提供：将抛光垫预成型放置在圆顶形成形表面上，所述抛光垫预成型件包括具有中心和外部的圆形主体周缘，以及从外周缘向中心延伸的多个槽; 设置与圆顶形状表面相对的囊和抛光垫预成型件; 用流体使气囊膨胀，使得发动机罩形状的圆顶形成表面从一侧挤压抛光垫预成型件，并且气囊从相对侧压靠抛光垫预成型件; 并且保持按压步骤达预定时间以实现半球形抛光垫。

49. 发明申请

US20050272938A1 Process and intermediates for the preparation of thienopyrrole derivatives 失效
标题翻译：制备噻吩并吡咯衍生物的方法和中间体
公开(公告)号：US20050272938A1
公开(公告)日：2005-12-08
申请号：US10528612
申请日：2003-09-29
申请人： Michael Butters , Paul Schofield , Andrew Stocker
发明人： Michael Butters , Paul Schofield , Andrew Stocker
IPC分类号： C07D333/36 , C07D495/04 , C07D497/02
CPC分类号： C07D495/04 , C07D333/36 , Y02P20/55
摘要： Novel Process and Intermediates. A process for preparing a compound of formula (I) where R4 and R5 are as defined in the specification; and R6 is hydrogen or a protecting group, which process comprises cyclisation of a compound of formula (II) where R4 and R5 and R6 are as defined in relation to formula (I), and R7 is nitrogen protecting group, and removing the group R7, and thereafter if desired, removing any protecting group R6. Novel intermediates and the use of these in the formation of pharmaceutical compounds is also described and claimed.
摘要翻译：新工艺和中间体。制备其中R 4和R 5的式（I）化合物的方法如说明书中所定义; 和R 6是氢或保护基，该方法包括式（II）化合物的环化，其中R 4和R 5和R 5和 R 6如关于式（I）所定义，R 7为氮保护基，除去基团R 7，和此后如果需要，除去任何保护基团R 6。还描述和要求保护新型中间体及其在药物化合物形成中的用途。

50. 发明授权

US06730672B2 Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents 失效
标题翻译：氨基杂环衍生物作为抗血栓形成或抗凝血剂
公开(公告)号：US06730672B2
公开(公告)日：2004-05-04
申请号：US09800745
申请日：2001-03-08
申请人： Alan Wellington Faull , Andrew Stocker , Colette Marie Mayo , John Preston
发明人： Alan Wellington Faull , Andrew Stocker , Colette Marie Mayo , John Preston
IPC分类号： C07D40114
CPC分类号： C07D213/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The invention concerns compounds of formula (I) wherein each of G1, G2 and G3 is CH or N; m is 1 or 2; R1 includes hydrogen, halogeno and (1-4C)alkyl; M1 is a group of the formula: NR2—L1—T1R3 in which R2 and R3 together form a (1-4C)alkylene group, L1 includes (1-4C)alkylene, and T1 is CH or N; A may be a direct link; M2 is a group of the formula: (T2R4)r—L2—T3R5 in which r is 0 or 1, each of T2 and T3 is CH or N, each of R4 and R5 is hydrogen or (1-4C)alkyl, or R4 and R5 together form a (1-4C)alkylene group, and L2 includes (1-4C)alkylene; M3 may be a direct link to X; X includes sulphonyl; and Q includes naphthyl and a heterocyclic moiety; or a pharmaceutically-acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use as antithrombotic or anticoagulant agents.
摘要翻译：本发明涉及式（I）化合物，其中G 1，G 2和G 3各自为CH或N; m为1或2; R 1包括氢，卤素和（1-4C）烷基; M 1是下式的基团：其中R 2和R 3一起形成（1-4C）亚烷基，其中R 2，R 2，R 3，R 3，，L 1包括（1-4C）亚烷基，T 1是CH或N; A可能是直接链接; M 2是下式的基团：（T 2 R 4）r L 2 -T 3 R 5，其中r是0或1，每个T 2和T R 3和R 5分别是氢或（1-4C）烷基，或者R 4和R 5一起形成（1-4C）亚烷基，和L 2包括（1-4C）亚烷基; M 3可以直接连接到X; X包括磺酰基; 且Q包括萘基和杂环部分; 或其药学上可接受的盐; 其制备方法，含有它们的药物组合物及其作为抗血栓形成或抗凝血剂的用途。

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