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31. 发明授权

US06274361B1 pth 失效
标题翻译：第
公开(公告)号：US06274361B1
公开(公告)日：2001-08-14
申请号：US09080662
申请日：1998-05-18
申请人： Sanjoy Biswas , Martin K. R. Burnham , Andrew P. Fosberry , John E Hodgson , Elizabeth J Lawlor , Tong Li , Damien McDevitt , Christopher Michael Traini , Martin Rosenberg , Judith Ward , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , Martin K. R. Burnham , Andrew P. Fosberry , John E Hodgson , Elizabeth J Lawlor , Tong Li , Damien McDevitt , Christopher Michael Traini , Martin Rosenberg , Judith Ward , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12N916
CPC分类号： C12N9/18
摘要： The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供第p多肽和编码第p多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用第p多肽筛选抗菌化合物的方法。

32. 发明授权

US06828135B2 Phosphodiester &agr;-GlcNAcase of the lysosomal targeting pathway 有权
标题翻译： Phosphodiester alpha-GlcNAcase的溶酶体靶向途径
公开(公告)号：US06828135B2
公开(公告)日：2004-12-07
申请号：US10306686
申请日：2002-11-29
申请人： William M. Canfield
发明人： William M. Canfield
IPC分类号： C12N916
CPC分类号： C12N9/1288 , A61K38/00 , C12N9/1205 , C12N9/16 , C12Y301/04045
摘要： The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme phosphodiester &agr;-GlcNAcase, methods of producing and methods of purifying this enzyme.
摘要翻译：本发明提供了溶酶体靶向途径酶磷酸二酯α-GlcNAcase的核苷酸和氨基序列，其生产方法和纯化该酶的方法。

33. 发明授权

US06780627B1 22438, 23553, 25278, and 26212 novel human sulfatases 失效
公开(公告)号：US06780627B1
公开(公告)日：2004-08-24
申请号：US09495823
申请日：2000-01-31
申请人： Maria Alexandra Glucksmann , Mark Williamson
发明人： Maria Alexandra Glucksmann , Mark Williamson
IPC分类号： C12N916
CPC分类号： C12N9/16 , A61K38/00
摘要： The present invention relates to newly identified human sulfatases. In particular, the invention relates to sulfatase polypeptides and polynucleotides, methods of detecting the sulfatase polypeptides and polynucleotides, and methods of diagnosing and treating sulfatase-related disorders. Also provided are vectors, host cells, and recombinant methods for making and using the novel molecules.

34. 发明授权

US06762043B1 Motor proteins and methods for their use 失效
标题翻译：运动蛋白及其使用方法
公开(公告)号：US06762043B1
公开(公告)日：2004-07-13
申请号：US10093317
申请日：2002-03-06
申请人： Christophe Beraud
发明人： Christophe Beraud
IPC分类号： C12N916
CPC分类号： C12N9/14
摘要： The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence of absorbance readouts.
摘要翻译：本发明提供用于鉴定可用于治疗细胞增殖障碍的化合物的高通量筛选系统。该方法可以与吸光度读数的荧光同时进行。

35. 发明授权

US06734003B2 Phosphodiesterase 10 失效
标题翻译：磷酸二酯酶10
公开(公告)号：US06734003B2
公开(公告)日：2004-05-11
申请号：US10034015
申请日：2001-12-20
申请人： Kate Loughney
发明人： Kate Loughney
IPC分类号： C12N916
CPC分类号： C12N9/16 , A61K38/00
摘要： The present invention provides novel human PDE10 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE10 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE10 polypeptides. The invention further provides methods to identify binding partners of PDE10, and more particularly, binding partners that modulate PDE10 enzyme activity.
摘要翻译：本发明提供新的人PDE10多肽，编码多肽的多核苷酸，包含多核苷酸的表达构建体，用表达构建体转化的宿主细胞; 生产PDE10多肽的方法; 反义多核苷酸; 和与PDE10多肽特异性免疫反应的抗体。本发明进一步提供鉴定PDE10的结合配偶体的方法，更具体地，涉及调节PDE10酶活性的结合配偶体。

36. 发明授权

US06720174B1 Phytases 失效
标题翻译：植酸酶
公开(公告)号：US06720174B1
公开(公告)日：2004-04-13
申请号：US09488265
申请日：2000-01-20
申请人： Martin Lehmann
发明人： Martin Lehmann
IPC分类号： C12N916
CPC分类号： C07H21/04 , C12N9/16
摘要： This invention relates to improved phytases, preferably phytases of an increased thermostability, and a process of producing them. In particular, stabilizing amino acid mutations are introduced into a homologous protein, or the active site of a phytase is replaced in part or in toto. The corresponding DNA sequences and methods of preparing them are also disclosed, as are methods of producing the improved phytases, and the use thereof. Specific variants of Aspergillus fumigatus phytase and of consensus phytases are disclosed.
摘要翻译：本发明涉及改进的植酸酶，优选植酸酶的增加的热稳定性，以及它们的生产方法。特别地，将稳定的氨基酸突变引入同源蛋白质中，或者植酸酶的活性位点被部分或者替代。还公开了相应的DNA序列及其制备方法，以及生产改良的植酸酶的方法及其用途。公开了烟曲霉植酸酶和共有植酸酶的具体变体。

37. 发明授权

US06699704B1 Heat tolerant phytases 有权
标题翻译：耐热植酸酶
公开(公告)号：US06699704B1
公开(公告)日：2004-03-02
申请号：US09635504
申请日：2000-08-09
申请人： Adolphus van Loon , David Mitchell
发明人： Adolphus van Loon , David Mitchell
IPC分类号： C12N916
CPC分类号： A23K20/147 , A23K20/168 , C12N9/16
摘要： The present invention relates to heat tolerant phytases and DNA sequences which code therefor. The phytases are useful in hydrolyzing phytate to inositol and inorganic phosphates. The phytases are valuable feed additives.
摘要翻译：本发明涉及编码耐热植酸酶和DNA序列。肌醇六磷酸酶可以将植酸盐水解成肌醇和无机磷酸盐。植酸酶是有价值的饲料添加剂。

38. 发明授权

US06686189B2 Polypeptides having lipase activity and nucleic acids encoding same 失效
标题翻译：具有脂肪酶活性的多肽和编码相同的核酸
公开(公告)号：US06686189B2
公开(公告)日：2004-02-03
申请号：US10171229
申请日：2002-06-12
申请人： Michael W. Rey , Elizabeth J. Golightly
发明人： Michael W. Rey , Elizabeth J. Golightly
IPC分类号： C12N916
CPC分类号： A21D8/042 , C11D3/38627 , C12N9/20 , Y10S435/929
摘要： The present invention relates to isolated polypeptides having lipase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
摘要翻译：本发明涉及具有脂肪酶活性的分离的多肽和分离的编码多肽的核酸序列。本发明还涉及包含核酸序列的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

39. 发明授权

US06673587B1 Histone deacetylase, and uses therefor 有权
标题翻译：新组蛋白脱乙酰酶，并用于此
公开(公告)号：US06673587B1
公开(公告)日：2004-01-06
申请号：US09637145
申请日：2000-08-11
申请人： Ronald M. Evans , Hung-Ying Kao , Michael Downes , Peter Ordentlich
发明人： Ronald M. Evans , Hung-Ying Kao , Michael Downes , Peter Ordentlich
IPC分类号： C12N916
CPC分类号： C12N9/16
摘要： The present invention relates to the identification, isolation, sequencing and characterization of a new member of the histone deacetylase family, as well as its transcripts, gene products, associated sequence information, and related genes. The present invention also relates to methods for detecting and diagnosing carriers of normal and mutant alleles of these genes, methods for detecting and diagnosing diseases, methods of identifying genes and proteins related to or interacting with such genes and proteins, methods of screening for potential therapeutics for diseases, methods of treatment for diseases, and to cell lines and animal models useful in screening for and evaluating potentially useful therapies for diseases. In a particular aspect of the present invention, a novel family member, HDAC7, is described and its interaction with SMRT/N-CoR and mSin3A, its biochemical properties and subcellular localization are characterized. In addition, evidence is provided that the HDAC4, 5, and 7 deacetylases may mediate nuclear receptor repression. The findings described here indicate that two or more classes of histone deacetylases can collectively contribute to SMRT/N-CoR action and that at least some deacetylases may directly associate with SMRT/N-CoR in a mSin3A independent fashion.
摘要翻译：本发明涉及组蛋白脱乙酰酶家族的新成员以及其转录物，基因产物，相关序列信息和相关基因的鉴定，分离，测序和表征。本发明还涉及用于检测和诊断这些基因的正常和突变等位基因的载体的方法，用于检测和诊断疾病的方法，鉴定与这些基因和蛋白质相关或与之相互作用的基因和蛋白质的方法，筛选潜在治疗剂的方法用于疾病的治疗方法，以及用于筛选和评估潜在有用的疾病疗法的细胞系和动物模型。在本发明的特定方面，描述了新型家族成员HDAC7，并且与SMRT / N-CoR和mSin3A的相互作用，其生物化学性质和亚细胞定位被表征。此外，证据表明HDAC4,5和7脱乙酰酶可能介导核受体抑制。这里描述的发现表明，两种或更多类组蛋白脱乙酰酶可以共同促进SMRT / N-CoR作用，并且至少一些脱乙酰酶可以以独立于mSin3A的方式直接与SMRT / N-CoR相关联。

40. 发明授权

US06667169B2 Polypeptides having acid phosphatase activity and nucleic acids encoding same 失效
公开(公告)号：US06667169B2
公开(公告)日：2003-12-23
申请号：US09957156
申请日：2001-09-19
申请人： Debbie S. Yaver , Randy M. Berka , Michael W. Rey
发明人： Debbie S. Yaver , Randy M. Berka , Michael W. Rey
IPC分类号： C12N916
CPC分类号： C12N9/16 , C07K14/37 , C12Y301/03002
摘要： The present invention relates to isolated polypeptides having acid phosphatase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.

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