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1. 发明授权

US06673587B1 Histone deacetylase, and uses therefor 有权
标题翻译：新组蛋白脱乙酰酶，并用于此
公开(公告)号：US06673587B1
公开(公告)日：2004-01-06
申请号：US09637145
申请日：2000-08-11
申请人： Ronald M. Evans , Hung-Ying Kao , Michael Downes , Peter Ordentlich
发明人： Ronald M. Evans , Hung-Ying Kao , Michael Downes , Peter Ordentlich
IPC分类号： C12N916
CPC分类号： C12N9/16
摘要： The present invention relates to the identification, isolation, sequencing and characterization of a new member of the histone deacetylase family, as well as its transcripts, gene products, associated sequence information, and related genes. The present invention also relates to methods for detecting and diagnosing carriers of normal and mutant alleles of these genes, methods for detecting and diagnosing diseases, methods of identifying genes and proteins related to or interacting with such genes and proteins, methods of screening for potential therapeutics for diseases, methods of treatment for diseases, and to cell lines and animal models useful in screening for and evaluating potentially useful therapies for diseases. In a particular aspect of the present invention, a novel family member, HDAC7, is described and its interaction with SMRT/N-CoR and mSin3A, its biochemical properties and subcellular localization are characterized. In addition, evidence is provided that the HDAC4, 5, and 7 deacetylases may mediate nuclear receptor repression. The findings described here indicate that two or more classes of histone deacetylases can collectively contribute to SMRT/N-CoR action and that at least some deacetylases may directly associate with SMRT/N-CoR in a mSin3A independent fashion.
摘要翻译：本发明涉及组蛋白脱乙酰酶家族的新成员以及其转录物，基因产物，相关序列信息和相关基因的鉴定，分离，测序和表征。本发明还涉及用于检测和诊断这些基因的正常和突变等位基因的载体的方法，用于检测和诊断疾病的方法，鉴定与这些基因和蛋白质相关或与之相互作用的基因和蛋白质的方法，筛选潜在治疗剂的方法用于疾病的治疗方法，以及用于筛选和评估潜在有用的疾病疗法的细胞系和动物模型。在本发明的特定方面，描述了新型家族成员HDAC7，并且与SMRT / N-CoR和mSin3A的相互作用，其生物化学性质和亚细胞定位被表征。此外，证据表明HDAC4,5和7脱乙酰酶可能介导核受体抑制。这里描述的发现表明，两种或更多类组蛋白脱乙酰酶可以共同促进SMRT / N-CoR作用，并且至少一些脱乙酰酶可以以独立于mSin3A的方式直接与SMRT / N-CoR相关联。

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