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1. 发明申请

US20050112643A1 Atr-2 cell cycle checkpoint 审中-公开
标题翻译： Atr-2细胞周期检查点
公开(公告)号：US20050112643A1
公开(公告)日：2005-05-26
申请号：US10954723
申请日：2004-09-30
申请人： Kate Loughney , Kathleen Keegan
发明人： Kate Loughney , Kathleen Keegan
IPC分类号： C12N9/12 , C12N15/54 , C12Q1/68 , C07H21/04 , G01N33/574
CPC分类号： C12N9/12
摘要： Polynucleotides encoding novel Atr-2 cell cycle checkpoint polypeptides are disclosed, along with expression constructs comprising the polynucleotides, host cells transformed with the expression constructs, methods to make the Atr-2 polypeptides using the host cells, Atr-2 polypeptides, and binding partners of the Atr-2 polypeptides.
摘要翻译：公开了编码新型Atr-2细胞周期检查点多肽的多核苷酸，以及包含多核苷酸的表达构建体，用表达构建体转化的宿主细胞，使用宿主细胞制备Atr-2多肽的方法，Atr-2多肽和结合配偶体的Atr-2多肽。

2. 发明授权

US5932465A Phosphodiesterase 8A 失效
公开(公告)号：US5932465A
公开(公告)日：1999-08-03
申请号：US951648
申请日：1997-10-16
申请人： Kate Loughney
发明人： Kate Loughney
IPC分类号： G01N33/53 , A61K38/46 , A61P43/00 , C07K16/40 , C07K16/42 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/68 , G01N33/566 , C12N15/63
CPC分类号： C12N9/16
摘要： The present invention provides novel human PDE8 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE8 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE8 polypeptides.

3. 发明授权

US06864070B2 Phosphodiesterase 10 失效
标题翻译：磷酸二酯酶10
公开(公告)号：US06864070B2
公开(公告)日：2005-03-08
申请号：US10083620
申请日：2002-02-26
申请人： Kate Loughney
发明人： Kate Loughney
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61P43/00 , C07K16/40 , C07K16/42 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/566
CPC分类号： C12N9/16 , A61K38/00
摘要： The present invention provides novel human PDE10 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE10 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE10 polypeptides. The invention further provides methods to identify binding partners of PDE 10, and more particularly, binding partners that modulate PDE10 enzyme activity.
摘要翻译：本发明提供新的人PDE10多肽，编码多肽的多核苷酸，包含多核苷酸的表达构建体，用表达构建体转化的宿主细胞; 生产PDE10多肽的方法; 反义多核苷酸; 和与PDE10多肽特异性免疫反应的抗体。本发明还提供了鉴定PDE10的结合配偶体的方法，更具体地，涉及调节PDE10酶活性的结合配偶体。

4. 发明授权

US06734003B2 Phosphodiesterase 10 失效
标题翻译：磷酸二酯酶10
公开(公告)号：US06734003B2
公开(公告)日：2004-05-11
申请号：US10034015
申请日：2001-12-20
申请人： Kate Loughney
发明人： Kate Loughney
IPC分类号： C12N916
CPC分类号： C12N9/16 , A61K38/00
摘要： The present invention provides novel human PDE10 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE10 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE10 polypeptides. The invention further provides methods to identify binding partners of PDE10, and more particularly, binding partners that modulate PDE10 enzyme activity.
摘要翻译：本发明提供新的人PDE10多肽，编码多肽的多核苷酸，包含多核苷酸的表达构建体，用表达构建体转化的宿主细胞; 生产PDE10多肽的方法; 反义多核苷酸; 和与PDE10多肽特异性免疫反应的抗体。本发明进一步提供鉴定PDE10的结合配偶体的方法，更具体地，涉及调节PDE10酶活性的结合配偶体。

5. 发明授权

US06566087B1 Phosphodiesterase 8A 失效
公开(公告)号：US06566087B1
公开(公告)日：2003-05-20
申请号：US09686055
申请日：2000-10-11
申请人： Kate Loughney
发明人： Kate Loughney
IPC分类号： C12Q100
CPC分类号： C12N9/16
摘要： The present invention provides novel human PDE8 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE8 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE8 polypeptides.

6. 发明授权

US5955583A Antibodies to cGMP-binding, cGMP-specific phospodiesterase 失效
标题翻译： cGMP结合的抗体，cGMP特异性磷酸二酯酶
公开(公告)号：US5955583A
公开(公告)日：1999-09-21
申请号：US463949
申请日：1995-06-05
申请人： Joseph A. Beavo , Jackie D. Corbin , Kenneth M. Ferguson , Sharron H. Francis , Ann Kadlecek , Kate Loughney , Linda M. McAllister-Lucas , William K. Sonnenburg , Melissa K. Thomas
发明人： Joseph A. Beavo , Jackie D. Corbin , Kenneth M. Ferguson , Sharron H. Francis , Ann Kadlecek , Kate Loughney , Linda M. McAllister-Lucas , William K. Sonnenburg , Melissa K. Thomas
IPC分类号： C12N15/02 , C07H21/04 , C07K16/40 , C12N1/21 , C12N5/10 , C12N5/12 , C12N9/16 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/02 , C12Q1/44 , C12Q1/68 , C12R1/645
CPC分类号： C12N9/16
摘要： The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Antibodies to the cGMP-binding, cGMP-stimulated phosphodiesterase are disclosed. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
摘要翻译：本发明提供编码cGMP结合，命名为cGB-PDE的cGMP特异性磷酸二酯酶的新型纯化和分离的核苷酸序列。公开了cGMP结合的抗体，cGMP刺激的磷酸二酯酶。本发明还提供了用于重组生产cGB-PDE多肽产物的方法和材料以及用于鉴定调节cGB-PDE多肽的酶活性的化合物的方法。

7. 发明申请

US20060222647A1 Methods and compositions for modulating the activity of PDE5 审中-公开
标题翻译：调节PDE5活性的方法和组合物
公开(公告)号：US20060222647A1
公开(公告)日：2006-10-05
申请号：US10352534
申请日：2003-01-28
申请人： Joseph Beavo , Jackie Corbin , Kenneth Ferguson , Sharron Francis , Ann Kadlecek , Linda McAllister-Lucas , Kate Loughney , William Sonnenburg , Melissa Thomas , Sergei Rybalkin
发明人： Joseph Beavo , Jackie Corbin , Kenneth Ferguson , Sharron Francis , Ann Kadlecek , Linda McAllister-Lucas , Kate Loughney , William Sonnenburg , Melissa Thomas , Sergei Rybalkin
IPC分类号： A61K48/00 , A61K38/54 , A61K39/395
CPC分类号： C12N9/16
摘要： The present invention provides agents such as agonists, antibodies, antagonists or inhibitors to modulate the activity of PDE5 proteins. These compositions and methods are useful for the diagnosis or treatment of conditions associated with the presence, the deficiency, altered levels, or altered activity of PDE5 proteins.
摘要翻译：本发明提供了诸如激动剂，抗体，拮抗剂或调节PDE5蛋白活性的抑制剂的药剂。这些组合物和方法可用于诊断或治疗与PDE5蛋白的存在，缺乏，改变的水平或改变的活性相关的病症。

8. 发明授权

US06350603B1 Phosphodiesterase 10 失效
标题翻译：磷酸二酯酶10
公开(公告)号：US06350603B1
公开(公告)日：2002-02-26
申请号：US09256000
申请日：1999-02-23
申请人： Kate Loughney
发明人： Kate Loughney
IPC分类号： C12N916
CPC分类号： C12N9/16 , A61K38/00
摘要： The present invention provides novel human PDE10 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE10 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE10 polypeptides. The invention further provides methods to identify binding partners of PDE10, and more particularly, binding partners that modulate PDE10 enzyme activity.
摘要翻译：本发明提供新的人PDE10多肽，编码多肽的多核苷酸，包含多核苷酸的表达构建体，用表达构建体转化的宿主细胞; 生产PDE10多肽的方法; 反义多核苷酸; 和与PDE10多肽特异性免疫反应的抗体。本发明进一步提供鉴定PDE10的结合配偶体的方法，更具体地，涉及调节PDE10酶活性的结合配偶体。

9. 发明授权

US6133007A Phosphodiesterase 8A 失效
公开(公告)号：US6133007A
公开(公告)日：2000-10-17
申请号：US174437
申请日：1998-10-16
申请人： Kate Loughney
发明人： Kate Loughney
IPC分类号： G01N33/53 , A61K38/46 , A61P43/00 , C07K16/40 , C07K16/42 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/68 , G01N33/566
CPC分类号： C12N9/16
摘要： The present invention provides novel human PDE8 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE8 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE8 polypeptides.

10. 发明授权

US5652131A Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods 失效
公开(公告)号：US5652131A
公开(公告)日：1997-07-29
申请号：US480547
申请日：1995-06-07
申请人： Joseph A. Beavo , Jackie D. Corbin , Kenneth M. Ferguson , Sharron H. Francis , Ann Kadlecek , Kate Loughney , Linda M. McAllister-Lucas , William K. Sonnenburg , Melissa K. Thomas
发明人： Joseph A. Beavo , Jackie D. Corbin , Kenneth M. Ferguson , Sharron H. Francis , Ann Kadlecek , Kate Loughney , Linda M. McAllister-Lucas , William K. Sonnenburg , Melissa K. Thomas
IPC分类号： C12N15/02 , C07H21/04 , C07K16/40 , C12N1/21 , C12N5/10 , C12N5/12 , C12N9/16 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/02 , C12Q1/44 , C12Q1/68 , C12R1/645 , C12N15/63
CPC分类号： C12N9/16
摘要： The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.

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