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31. 发明授权

US09546646B2 Pump and injector for liquid chromatography 有权
标题翻译：泵和注射器用于液相色谱
公开(公告)号：US09546646B2
公开(公告)日：2017-01-17
申请号：US14156197
申请日：2014-01-15
申请人： Valco Instruments Company, L.P.
发明人： Stanley D. Stearns , Ales Plistil
IPC分类号： G01N30/20 , F04B19/00 , F04B7/00 , F04B13/00
CPC分类号： F04B19/006 , F04B7/0007 , F04B13/00 , G01N30/20
摘要： A combined pump-injector valve utilizing a single piece as the barrel of the pump and as the stator of the valve, thus eliminating any need for connections between a pump and a valve, and therefore the potential for high-pressure leaks or pressure reductions. The combined pump-injector valve permits injection of nanoliter-sized samples into a chromatographic column, which is sealed during loading of the sample and filling of the pump, such that complete analyses can be completed with microliters of mobile phase with nanoliters of a sample.
摘要翻译：组合的泵 - 注射器阀，其使用单件作为泵的桶和作为阀的定子，因此消除了对泵和阀之间的连接的任何需要，并因此消除了高压泄漏或减压的可能性。组合的泵 - 注射器阀允许将纳升尺寸的样品注入色谱柱，其在样品加载和泵的填充期间被密封，使得可以用微量的流动相与纳升的样品完成完整的分析。

32. 发明授权

US09496125B2 Interfacing with a digital microfluidic device 有权
标题翻译：与数字微流体装置接口
公开(公告)号：US09496125B2
公开(公告)日：2016-11-15
申请号：US12919570
申请日：2009-03-03
申请人： Bernard Bunner , Geoff C. Gerhardt , Joseph A. Jarrell
发明人： Bernard Bunner , Geoff C. Gerhardt , Joseph A. Jarrell
IPC分类号： H01J49/00 , H01J49/16 , B01L3/00 , B03C5/02 , G01N30/06 , G01N30/20 , B01L3/02
CPC分类号： H01J49/167 , B01L3/0268 , B01L3/502792 , B01L2200/026 , B01L2300/0819 , B01L2300/089 , B01L2400/0427 , B03C5/024 , B03C2201/26 , G01N30/06 , G01N30/20 , G01N2030/201
摘要： Described are techniques for use in connection with analyzing a droplet. One or more droplets of a sample are formed on a surface of a digital microfluidic device. The droplets are manipulated to perform processing using said one or more droplets generating one or more resulting droplets. The one or more resulting droplets may be transferred from the microfluidic device to another device for analysis. The one or more droplets may also be provided to the digital microfluidic device from yet another device or analysis instrument.
摘要翻译：描述了与分析液滴有关的技术。在数字微流体装置的表面上形成一个或多个样品液滴。操纵液滴以使用所述一个或多个液滴产生一个或多个所产生的液滴进行处理。所产生的一个或多个液滴可以从微流体装置转移到另一装置用于分析。一个或多个液滴也可以从另一个装置或分析仪器提供给数字微流体装置。

33. 发明申请

US20160313289A1 ROTARY VALVE 审中-公开
标题翻译：旋转阀
公开(公告)号：US20160313289A1
公开(公告)日：2016-10-27
申请号：US15104069
申请日：2014-12-15
申请人： GE Healthcare Bio-Science AB
发明人： Bjorn Olovsson , Thomas Arctaedius
IPC分类号： G01N30/20 , G01N30/46 , F16K11/078 , F16K11/076
CPC分类号： G01N30/20 , B01D15/1821 , F16K11/0743 , F16K11/076 , F16K11/078 , G01N30/466 , G01N30/467 , G01N30/468 , G01N2030/201 , G01N2030/202
摘要： A rotary valve comprising a stator and a rotor, wherein the stator comprises at least three primary connection ports and at least three secondary connection ports, and wherein rotor interconnection paths are arranged to in the different rotor positions interconnect the primary connection ports with the secondary connection ports such that all of at least three secondary connection ports can be connected one at the time to each of at least three primary connection port by rotating the rotor into the different rotor positions. A chromatography system comprising at least three chromatography columns and a column inlet rotary valve, a column outlet rotary valve and a feed recirculation flow path.
摘要翻译：一种包括定子和转子的旋转阀，其中所述定子包括至少三个主连接端口和至少三个次连接端口，并且其中转子互连路径被布置成在不同的转子位置中将所述主连接端口与所述次级连接端口，使得通过将转子旋转到不同的转子位置，所有至少三个二次连接端口可以一次连接到至少三个主要连接端口中的每一个。包括至少三个色谱柱和柱入口旋转阀，柱出口旋转阀和进料再循环流动路径的色谱系统。

34. 发明申请

US20160237111A1 DOWNSTREAM BIOPROCESSING DEVICE 审中-公开
公开(公告)号：US20160237111A1
公开(公告)日：2016-08-18
申请号：US15135263
申请日：2016-04-21
申请人： Therapeutic Proteins International, LLC
发明人： Sarfaraz K. Niazi
IPC分类号： C07K1/16 , B01D15/38 , B01D15/22 , C12M1/00 , B01D15/18
CPC分类号： C07K1/165 , B01D15/02 , B01D15/1892 , B01D15/22 , B01D15/3809 , B01F7/245 , C07K1/22 , C07K1/34 , C12M1/02 , C12M47/10 , C12M47/12 , C12Q1/06 , C12Q1/68 , G01N30/20
摘要： Large-scale downstream processing of secreted recombinant proteins is provided in a single device, wherein the contents of a plurality of bioreactors are combined simultaneous to their harvesting and purification resulting in significant savings of time and the cost of manufacturing.

35. 发明授权

US09388930B2 Fluidic interface valve assembly with elastomeric ferrule device 有权
标题翻译：具有弹性套管装置的流体界面阀组件
公开(公告)号：US09388930B2
公开(公告)日：2016-07-12
申请号：US14025415
申请日：2013-09-12
申请人： IDEX Health & Science LLC
发明人： Carl M. Servin
IPC分类号： F16L47/00 , F16K3/08 , F16K99/00 , F16K5/02 , B01L3/00 , G01N30/20
CPC分类号： F16L47/00 , B01L3/563 , B01L2200/0689 , F16K3/085 , F16K5/0278 , F16K99/0013 , F16K2099/0084 , F16K2099/0086 , G01N30/20 , G01N2030/202 , Y10T137/9247
摘要： A tubing interface having an elongated tube, an elastomeric ferrule and a support ring device disposed around the ferrule. The ferrule includes a bore which is sized for receipt of the tube. The tubing interface further includes a cap member having an exterior surface, an opposed interior surface, and a tube receiving passage extending therethrough. The receiving passage is formed and dimensioned for axial sliding receipt of the tube member therethrough. The cap member further includes a cup-shaped receiving recess extending proximally from the interior surface, and is formed and dimensioned for axial receipt of the proximal end of the ferrule body member and the support ring. When the cap member is mounted to a valve apparatus, the support ring and the elastomeric ferrule device compressively cooperate with the cup-shaped recess to form a fluid-tight seal between the tube port and a communication port of the valve apparatus.
摘要翻译：具有细长管，弹性套圈和围绕套圈设置的支撑环装置的管接口。套圈包括一个孔，其尺寸用于容纳管。管接口还包括具有外表面，相对的内表面和延伸穿过其的管接收通道的帽构件。接收通道的形状和尺寸用于管件穿过其的轴向滑动接收。盖构件还包括从内表面向近侧延伸的杯状容纳凹部，并且形成并且尺寸设计成用于轴向容纳套圈本体构件和支撑环的近端。当盖构件安装到阀装置时，支撑环和弹性套圈装置与杯形凹部压缩配合以在管端口和阀装置的连通口之间形成流体密封。

36. 发明授权

US09377444B2 Diaphragm-sealed valve with improved actuator design 有权
标题翻译：隔膜密封阀具有改进的执行器设计
公开(公告)号：US09377444B2
公开(公告)日：2016-06-28
申请号：US14377670
申请日：2013-02-18
申请人： Mécanique Analytique Inc.
发明人： Yves Gamache
IPC分类号： F16K11/078 , G01N30/20 , F16K11/20 , F16K11/02 , F16K31/122 , G01N30/32
CPC分类号： G01N30/20 , F16K11/02 , F16K11/20 , F16K31/1225 , G01N2030/205 , G01N2030/328 , Y10T137/87716
摘要： A valve includes a valve cap, a valve body and a diaphragm positioned between the valve cap and the valve body. The valve further includes a plurality of plungers movable, by an actuation system, between a closed position where the plunger engages the diaphragm, and an open position where the plunger is disengaged from the diaphragm. Each plunger includes a base section connected to the actuation system and a head projecting away therefrom, a top section extending between the base section and the diaphragm, wherein the top section includes a foot in contact with the head of the base section, and a biasing mechanism biasing the top section away from the diaphragm when the plunger is in the open position. Tangential contact points may also be provided between components of the actuation and the biasing mechanism for preventing a misalignment of the actuation system within the valve body.
摘要翻译：阀包括阀盖，阀体和位于阀盖和阀体之间的隔膜。阀还包括多个柱塞，其可由致动系统在柱塞与隔膜接合的关闭位置和柱塞与隔膜分离的打开位置之间移动。每个柱塞包括连接到致动系统的基座部分和从其突出的头部，在基部部分和隔膜之间延伸的顶部部分，其中顶部部分包括与基部部分的头部接触的脚和偏置机构当柱塞处于打开位置时将顶部偏离隔膜。也可以在致动部件和偏置机构之间提供切向接触点，以防止致动系统在阀体内的不对准。

37. 发明申请

US20160139093A1 HPLC SAMPLE INTRODUCTION WITH COUPLING SAMPLE RESERVOIRS IN PARALLEL BETWEEN MOBILE PHASE DRIVE AND SEPARATION UNIT 审中-公开
标题翻译：高效液相色谱样品介绍与移动相驱动和分离单元并联的联合样品储存
公开(公告)号：US20160139093A1
公开(公告)日：2016-05-19
申请号：US14898392
申请日：2013-06-14
申请人： Agilent Technologies, Inc.
发明人： Klaus Witt , Konstantin Choikhet , Manfred Berndt
IPC分类号： G01N30/20
CPC分类号： G01N30/20 , G01N30/465 , G01N2030/027 , G01N2030/202 , G01N2030/208
摘要： Disclosed is a sample dispatcher configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a separation system configured for separating compounds of the sample fluids. The separation system comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises a plurality of sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof. The sample dispatcher is configured for selectively coupling one of the plurality of sample reservoirs between the mobile phase drive and the separation unit, and further for coupling at least two of the plurality of sample reservoirs in parallel between the mobile phase drive and the separation unit.
摘要翻译：公开了一种样品分配器，其被配置用于将一个或多个样品流体的多个部分单独引入配置用于分离样品流体的化合物的分离系统的流动相的流动。分离系统包括流动相驱动器，其构造成通过分离单元来驱动流动相，该分离单元被配置用于分离流动相中的样品流体的化合物。样品分配器包括多个样品储存器，每个样品储存器被构造用于接收和临时存储相应的样品流体部分或其至少一部分。样品分配器被配置为选择性地将移动相位驱动器和分离单元之间的多个样品储存器中的一个耦合，并且还用于将多个样品储存器中的至少两个并联在流动相驱动器和分离单元之间。

38. 发明申请

US20160082439A1 SPRING-LESS MULTI-POSITION MICRO-FLUIDIC VALVE ASSEMBLY 有权
标题翻译：弹簧式多位置微流量阀组件
公开(公告)号：US20160082439A1
公开(公告)日：2016-03-24
申请号：US14861711
申请日：2015-09-22
申请人： IDEX Health & Science LLC
发明人： Carl M. SERVIN
IPC分类号： B01L3/00 , F16K99/00
CPC分类号： B01L3/567 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2300/12 , B01L2400/06 , F16K11/0743 , F16K99/0003 , F16K99/0013 , F16K99/0028 , F16K99/0034 , F16K99/0042 , F16K2099/0084 , G01N30/20 , G01N2030/202
摘要： A springless rotary shear that produces compression forces by utilizing the stiffness properties of polymer seals. The valve is designed to produce an effective spring load, with inherent sealing force, by deflecting polymer elements whose response depends on stiffness that is governed by each component's elastic modulus and geometry. A stator seal protrudes thousandths of an inch beyond a stator seal housing. When a stator is fastened down to the stator seal housing the clamping forces are transmitted to the stator seal, rotor seal, shaft adapter, bearings and housings, and the assembly is deflected to a flush position, resulting in a sealing force between the rotor and stator seal. The transmitted sealing force is as a function of the stiffness of each component and the protrusion distance of the stator seal above the mating surface prior to fastening the stator.
摘要翻译：一种无弹簧的旋转剪切机，通过利用聚合物密封件的刚度特性产生压缩力。该阀被设计成产生有效的弹簧载荷，具有固有的密封力，通过偏转聚合物元素，其响应取决于由每个组分的弹性模量和几何形状决定的刚度。定子密封件超过定子密封外壳千分之一千分之一英寸。当定子被紧固到定子密封件壳体上时，夹紧力传递到定子密封件，转子密封件，轴适配器，轴承和壳体，并且组件偏转到冲洗位置，导致转子和定子密封。在紧固定子之前，传递的密封力是每个部件的刚度和定子密封件在配合表面上方的突出距离的函数。

39. 发明申请

US20160077062A1 SAMPLE DISPENSER FOR AN ANALYTICAL DEVICE 审中-公开
标题翻译：分析装置的样品分配器
公开(公告)号：US20160077062A1
公开(公告)日：2016-03-17
申请号：US14888366
申请日：2014-03-31
申请人： HAMILTON BONADUZ AG
发明人： Klaus LECKEBUSCH , Tino OTTE
IPC分类号： G01N30/20 , G01N30/06
CPC分类号： G01N30/20 , G01N30/06 , G01N35/1097 , G01N2030/204
摘要： A sample dispenser for an analysis device, in particular for an analysis device working according to the principle of liquid chromatography, in particular high pressure liquid chromatography, or gas chromatography, comprising a sample intake for receiving a sample to be analyzed, an inlet through which an eluent can be supplied, an outlet, and an injection valve arrangement, which can be switched at least from an intake position to an injection position, wherein, at least in the intake position and in the injection position, the inlet is in fluid connection with the outlet to deliver the eluent—if applicable, having the sample added thereto—at least partly to the outlet, wherein, in the intake position, the sample intake is separated from the eluent in a fluid-tight manner, and wherein, in the injection position, the sample in the sample intake can combine with the eluent, wherein the sample dispenser is configured as a disposable component.
摘要翻译：用于分析装置的样品分配器，特别是用于根据液相色谱原理工作的分析装置，特别是高压液相色谱法或气相色谱法，其包括用于接收待分析样品的样品进样口，可以提供洗脱液，出口和喷射阀装置，其可以至少从进气位置切换到喷射位置，其中至少在进气位置和喷射位置中，入口处于流体连接其中出口将至少部分地添加到其上的洗脱液（如果适用的话）输送到出口，其中在进气位置中，样品进口以流体密封的方式与洗脱液分离，并且其中，在注射位置，样品进样中的样品可以与洗脱液结合，其中样品分配器被配置为一次性部件。

40. 发明授权

US09285347B2 Bubble reduction device, chromatography device, bubble reduction method, and bubble reduction program 有权
标题翻译：减泡装置，色谱装置，气泡还原法和气泡减少程序
公开(公告)号：US09285347B2
公开(公告)日：2016-03-15
申请号：US13903191
申请日：2013-05-28
申请人： Seiji Satake , Tokuo Kasai , Akira Sezaki , Takeshi Matsubara
发明人： Seiji Satake , Tokuo Kasai , Akira Sezaki , Takeshi Matsubara
IPC分类号： G01N30/06 , B01D15/16 , G01N30/26 , B01D19/00 , G01N30/04 , G01N30/20 , G01N30/24 , G01N30/88 , B01L3/00 , G01N30/32
CPC分类号： G01N30/06 , B01D15/16 , B01D19/0036 , B01D19/0063 , B01L3/502723 , G01N30/04 , G01N30/20 , G01N30/24 , G01N30/26 , G01N2030/322 , G01N2030/8822
摘要： A bubble reduction device, chromatography device, bubble reduction method and bubble reduction program capable of reducing bubbles in an eluent. Included are a liquid accommodation portion, a liquid supply apparatus, an air layer formation apparatus, a first channel and an evacuation portion. The liquid accommodation portion accommodates a liquid that is to elute an analysis component from a specimen adsorbed to an adsorption portion. The liquid supply apparatus, by operation of a rod pushing up and polling down, sucks and discharges the liquid through an aperture portion of a tube portion, the aperture portion being oriented upward. The air layer formation apparatus forms an air layer in the tube portion. The first channel connects the liquid supply apparatus with the liquid accommodation portion. The evacuation portion is connected to the first channel via a first switching valve and evacuates the air layer through the first channel.
摘要翻译：气泡减少装置，色谱装置，气泡还原方法和气泡减少程序，能够减少洗脱液中的气泡。包括液体容纳部分，液体供应装置，空气层形成装置，第一通道和排气部分。液体容纳部容纳从吸附到吸附部的试样洗脱分析成分的液体。液体供给装置通过操作杆推动并向下排列，通过管部的开口部吸引并排出液体，该开口部朝向上方。空气层形成装置在管部中形成空气层。第一通道将液体供应装置与液体容纳部分连接。排气部经由第一切换阀与第一流路连接，将空气层排出第一流路。

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