专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

US20080033033A1 8-AZAPROSTAGLANDIN DERIVATIVES AND MEDICAL USE THEREOF 审中-公开
标题翻译： 8-AZAPROSTAGLANDIN衍生物及其医疗用途
公开(公告)号：US20080033033A1
公开(公告)日：2008-02-07
申请号：US11749531
申请日：2007-05-16
申请人： Tohru Kambe , Toru Maruyama , Kaoru Kobayashi , Kousuke Tani , Yoshihiko Nakai , Toshihiko Nagase , Takayuki Maruyama , Kiyoto Sakata , Hideyuki Yoshida , Shinsei Fujimura , Akio Nishiura , Nobutaka Abe
发明人： Tohru Kambe , Toru Maruyama , Kaoru Kobayashi , Kousuke Tani , Yoshihiko Nakai , Toshihiko Nagase , Takayuki Maruyama , Kiyoto Sakata , Hideyuki Yoshida , Shinsei Fujimura , Akio Nishiura , Nobutaka Abe
IPC分类号： A61K31/41 , A61K31/4015 , C07D207/18 , C07D257/04
CPC分类号： C07D417/12 , C07D417/14
摘要： The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I) (wherein, all the symbols have the same meanings as that of the specification.) a salt thereof, a solvate thereof or a cyclodextrin clathrate thereof, or a prodrug thereof and them as active ingredient have EP4 agonistic action and thus are considered useful for the prevention and/or treatment of immunological diseases, asthma, neuronal cell death, arthritis, lung failure, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, liver damage, acute hepatitis, nephritis, renal insufficiency, hypertension, myocardial ischemia, systemic inflammatory response syndrome, sepsis, hemophagous syndrome, macrophage activation syndrome, Still's disease, Kawasaki disease, burn, systemic granulomatosis, ulcerative colitis, Crohn's disease, hypercytokinemia at dialysis, multiple organ failure, shock and glaucoma, etc. Furthermore, the compounds also have an action of accelerating bone formation, so it is expected to be useful for the prevention and/or treatment of diseases associated with loss in bone mass, for example, primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss, osteonecrosis, bone formation after bone operation, alternative treatment for bone grafting.
摘要翻译：包含本发明化合物的盐，其盐，其溶剂合物或环糊精包合物，其具有由式（I）表示的8-氮杂前列腺素骨架（其中所有符号具有与说明书相同的含义）或其前药，并且它们作为活性成分具有EP 4激动作用，因此被认为可用于预防和/或治疗免疫疾病，哮喘，神经元细胞死亡，关节炎，肺衰竭，肺纤维化，肺气肿，支气管炎，慢性阻塞性肺疾病，肝损伤，急性肝炎，肾炎，肾功能不全，高血压，心肌缺血，全身炎症反应综合征，败血症，血液综合征，巨噬细胞活化综合征，静脉炎，川崎病，烧伤，系统性肉芽肿病，溃疡性结肠炎，克罗恩病，透析中的高细胞因子血症，多器官功能衰竭，休克和青光眼等。此外，化合物还具有促进骨形成的作用，因此预期可用于预防和/或治疗与骨量丧失相关的疾病，例如原发性骨质疏松症，继发性骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失，骨坏死，骨手术后的骨形成，骨移植的替代治疗。

32. 发明授权

US07196198B2 Benzoic acid derivatives, processes for the preparation thereof and pharmaceutical agents comprising the same as active ingredient 失效
标题翻译：苯甲酸衍生物，其制备方法和包含其作为活性成分的药剂
公开(公告)号：US07196198B2
公开(公告)日：2007-03-27
申请号：US10737901
申请日：2003-12-18
申请人： Kousuke Tani , Kaoru Kobayashi , Takayuki Maruyama
发明人： Kousuke Tani , Kaoru Kobayashi , Takayuki Maruyama
IPC分类号： C07D211/72 , C07D211/84
CPC分类号： C07D213/30 , C07B2200/07 , C07C233/55 , C07C235/38 , C07C235/84 , C07C255/60 , C07C323/62 , C07C2601/02 , C07C2603/18 , C07D213/75 , C07D213/80 , C07D215/06 , C07D215/12 , C07D215/14 , C07D263/34 , C07D307/68 , C07D333/38
摘要： An agent comprising the benzoic acid of formula (I) wherein A, B, R6, R7 are carbocyclic ring, heterocyclic ring, etc.; R1 is hydroxy etc.; R2, R3, R4 are alkyl etc.; R5, D, E are alkylene, etc.; G is oxygen etc., as active ingredient. The compound of formula (I) is considered to be useful for the treatment and/or prophylaxis of bone diseases, cancer, systemic granuloma, immunological diseases, allergy, atopy, asthma, gumboil, gingivitis, periodontitis, neurocyte death, Alzheimer's diseases, lungs injury, pulmopathy, acute hepatitis, nephritis, myocardial ischemia, Kawasaki disease, ambustion, ulcerative colitis, Crohn's disease, multiple organ failure, sleeping disorder, platelet aggregation, etc.
摘要翻译：包含式（I）的苯甲酸的试剂

33. 发明申请

US20070004716A1 Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient 有权
标题翻译：羧酸化合物和含有与活性成分相同的药物组合物
公开(公告)号：US20070004716A1
公开(公告)日：2007-01-04
申请号：US10572578
申请日：2004-09-16
申请人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , SeijiKoji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
发明人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , SeijiKoji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
IPC分类号： A61K31/538 , C07D265/36
CPC分类号： C07D307/80 , A61K31/343 , A61K31/538 , C07D265/36 , C07D317/48
摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.
摘要翻译：由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克，支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如，搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有小副作用。

34. 发明申请

US20060258728A1 Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient 失效
标题翻译：羧酸衍生物化合物和包含这些化合物作为活性成分的药物
公开(公告)号：US20060258728A1
公开(公告)日：2006-11-16
申请号：US10486220
申请日：2002-08-08
申请人： Kousuke Tani , Masaki Asada , Kaoru Kobayashi , Masami Narita , Mikio Ogawa
发明人： Kousuke Tani , Masaki Asada , Kaoru Kobayashi , Masami Narita , Mikio Ogawa
IPC分类号： A61K31/4178 , A61K31/4172 , A61K31/4152 , A61K31/192 , A61K31/4035 , A61K31/325
CPC分类号： C07D231/12 , C07C59/68 , C07C69/734 , C07C69/736 , C07C69/738 , C07C229/34 , C07C309/66 , C07C309/67 , C07C309/73 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/29 , C07C311/51 , C07C317/18 , C07C317/22 , C07C317/40 , C07C317/50 , C07C323/19 , C07C323/42 , C07C323/59 , C07C323/60 , C07D233/56 , C07D249/08
摘要： A carboxylic acid derivative of formula (I): wherein R1 is —COOH, —COOR6, etc.; A is a single bond, alkylene, etc.; R2 is alkyl, alkoxy, etc.; B is a carbocyclic ring or a heterocyclic ring; Q is alkylnene-Cyc2, etc.; D is a linking chain; and R3 is alkyl, a carbocyclic ring or a heterocyclic ring, or a non-toxic salt thereof. The compound of formula (I) binds to PGE2 receptor, especially subtypes EP3 and/or EP4 and show the antagonizing activity, are useful for the prevention and/or treatment of diseases induced pain, itch, urticaria, allergy, urinary frequency, urinary disturbance, Alzheimer's disease, cancer, dysmenorrhea, endometriosis, etc.
摘要翻译：式（I）的羧酸衍生物：其中R 1是-COOH，-COOR 6等; A是单键，亚烷基等; R 2是烷基，烷氧基等; B是碳环或杂环; Q是亚烷基-Si 2等; D是连接链; 和R 3是烷基，碳环或杂环，或其无毒盐。式（I）化合物与PGE2受体结合，特别是亚型EP 3和/或EP 4，并显示出拮抗活性，用于预防和/或治疗疾病引起的疼痛，瘙痒，荨麻疹，过敏，尿频，尿失调，阿尔茨海默病，癌症，痛经，子宫内膜异位症等。

35. 发明授权

US07135495B2 Indole derivatives 失效
标题翻译：吲哚衍生物
公开(公告)号：US07135495B2
公开(公告)日：2006-11-14
申请号：US10488835
申请日：2002-09-06
申请人： Kazuhiko Torisu , Maki Iwahashi , Kaoru Kobayashi , Fumio Nambu
发明人： Kazuhiko Torisu , Maki Iwahashi , Kaoru Kobayashi , Fumio Nambu
IPC分类号： A61K31/335 , C07D265/36 , C07D405/00 , C07D209/02 , C07D209/04
CPC分类号： A61K31/405 , A61K31/404 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/423 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/498 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5415 , C07D209/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D417/12
摘要： Compounds represented by formula (I) wherein all symbols represent the same meanings as described in specification. and salts thereof. Since the compound represented by the formula (I) binds and antagonizes to DP receptor, it is useful for the prevention or treatment against the disease such as allergic disorder, diseases accompanied with itching, secondary diseases generated by behaviors caused by itching, inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, pleuritis complicated by rheumatoid arthritis, cerebrovascular disease, and ulcerative colitis.
摘要翻译：由式（I）表示的化合物，其中所有符号表示与说明书中所述相同的含义。及其盐。由于式（I）表示的化合物与DP受体结合并拮抗，因此可用于预防或治疗诸如过敏性疾病，伴有瘙痒的疾病，由瘙痒引起的行为引起的继发性疾病，炎症，慢性阻塞性肺病，局部缺血再灌注障碍，类风湿关节炎并发的胸膜炎，脑血管疾病和溃疡性结肠炎。

36. 发明授权

US07119419B2 Detailed description of the presently preferred embodiments 有权
标题翻译：现有优选实施例的详细描述
公开(公告)号：US07119419B2
公开(公告)日：2006-10-10
申请号：US10506752
申请日：2003-12-19
申请人： Yoshihiro Kato , Katsumi Okayama , Kaoru Kobayashi , Tetsuya Yamamoto , Minoru Ikarashi
发明人： Yoshihiro Kato , Katsumi Okayama , Kaoru Kobayashi , Tetsuya Yamamoto , Minoru Ikarashi
IPC分类号： H01L23/552
CPC分类号： H01L27/222 , B82Y10/00 , H01L23/552 , H01L2224/16 , H01L2924/01004 , H01L2924/01019 , H01L2924/01025 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/1305 , H01L2924/3025 , H01L2924/00
摘要： A memory device is proposed which enables to guarantee the operation of MRAM elements being magnetically shielded against a large external magnetic fields without being affected by an internal leakage magnetic field. The MRAM elements 30 which are shielded by magnetic shield layers 33, 34 are placed at an intermediate region 41 avoiding an edge region 43 and a center region 42 of the magnetic shield layers 33, 34 so that the MRAM element is secured to operate normally without being affected by the internal leakage magnetic field avoiding the edge region 43 where the magnetic shield effect is reduced by the exterior magnetic field, and avoiding the central region 42 where the internal leakage magnetic field is large.
摘要翻译：提出了一种存储器件，其能够保证MRAM元件的操作不被大的外部磁场屏蔽，而不受内部泄漏磁场的影响。由磁屏蔽层33,34屏蔽的MRAM元件30被放置在中间区域41处，避免了磁屏蔽层33,34的边缘区域43和中心区域42，使得MRAM元件被固定以正常地操作而没有受到内部泄漏磁场的影响，避免了由外部磁场减小磁屏蔽效应的边缘区域43，并且避免了内部泄漏磁场较大的中心区域42。

37. 发明授权

US07098234B2 Indole derivatives, process for preparation of the same and use thereof 失效
公开(公告)号：US07098234B2
公开(公告)日：2006-08-29
申请号：US10793725
申请日：2004-03-08
申请人： Kazuhiko Torisu , Kaoru Kobayashi , Fumio Nambu
发明人： Kazuhiko Torisu , Kaoru Kobayashi , Fumio Nambu
IPC分类号： A61K31/405 , C07D209/12
CPC分类号： C07D401/12 , A61K31/404 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/423 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/498 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5415 , C07D209/08 , C07D403/12 , C07D405/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D417/12
摘要： Indole derivatives represented by formula (I): (wherein all symbols are described in the description), a process for the preparation of the same and a DP receptor antagonist comprising it as an active ingredient. Since the compounds of formula (I) binds to and are antagonistic to a DP receptor, they are useful in for the prevention and/or treatment of diseases, for example, allergic diseases (allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma, food allergy, etc., systemic mastocytosis; disorders due to systemic mastocyte activation, anaphylactic shock, bronchoconstriction, urticaria, eczema, etc.), diseases accompanied with itching (atopic dermatitis, urticaria, etc.), secondary diseases caused by behaviors (scratching behaviors, beating, etc.) (cataract, retinal detachment, inflammation, infection, sleep disorder, etc.), inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, cerebrovascular disorder, pleuritis complicated by rheumatoid arthritis, ulcerative colitis, and the like.

38. 发明申请

US20060060027A1 Method for producing magnetic particle, magnetic particle and magnetic material 有权
公开(公告)号：US20060060027A1
公开(公告)日：2006-03-23
申请号：US11258569
申请日：2005-10-25
申请人： Katsumi Okayama , Kaoru Kobayashi , Koichiro Inomata , Satoshi Sugimoto , Yoshihiro Kato
发明人： Katsumi Okayama , Kaoru Kobayashi , Koichiro Inomata , Satoshi Sugimoto , Yoshihiro Kato
IPC分类号： B22F9/24
CPC分类号： B82Y30/00 , B22F1/0018 , B22F1/0059 , B22F9/24 , B22F9/305 , B22F2998/00 , B82Y25/00 , B82Y40/00 , C22C32/0094 , H01F1/0054 , H01F41/30 , H01F41/301 , Y10S977/777 , Y10S977/783 , Y10T428/12146 , Y10T428/254 , Y10T428/256 , Y10T428/257 , Y10T428/29 , Y10T428/2991 , Y10T428/2998 , B22F3/02
摘要： A method for producing a magnetic particle forming a magnetic material for absorbing electromagnetic waves comprises the steps of mixing an organometallic complex or a metal salt with a chain polymer and dissolving the mixture in a solvent (step S1); raising the temperature of the mixture to reaction temperature (step S2), carrying out a reaction at the reaction temperature (step S3); and forming the magnetic particle having a structure that the periphery of each fine particle formed from the organometallic complex or the metal salt is surrounded by the chain polymer and recovering the formed magnetic particle after the reaction (step S4). The magnetic particle has a nanogranular structure to become a magnetic material for absorbing electromagnetic waves. Such a magnetic particle is produced by a wet reaction. Thus, a larger amount of magnetic particle can be produced by one reaction.

39. 发明申请

US20050230788A1 Magnetic shield member, magnetic shield structure, and magnetic memory device 失效
标题翻译：磁屏蔽构件，磁屏蔽结构和磁存储装置
公开(公告)号：US20050230788A1
公开(公告)日：2005-10-20
申请号：US11053650
申请日：2005-02-08
申请人： Yoshihiro Kato , Yoshinori Ito , Tatsushiro Hirata , Katsumi Okayama , Kaoru Kobayashi
发明人： Yoshihiro Kato , Yoshinori Ito , Tatsushiro Hirata , Katsumi Okayama , Kaoru Kobayashi
IPC分类号： H01L23/00 , G11C11/16 , H01L21/8246 , H01L23/552 , H01L27/105
CPC分类号： H01L23/552 , G11C11/16 , H01L2924/0002 , H01L2924/00
摘要： It is an object of the invention to relax magnetic saturation and realize a high-performance magnetic shield effect that is suitable for magnetic devices such as an MRAM. A magnetic shield member of the invention is suitable for a magnetic memory device in which a magnetic random access memory (MRAM) consisting of a TMR element formed by stacking a magnetization fixed layer with a direction of magnetization fixed and a magnetic layer, in which a direction of magnetization can be changed, via a tunnel barrier layer is sealed by a sealing material such as resin. A planar shape or a sectional shape of magnetic shield plates provided on the sealing material in order to magnetically shield the MRAM is a shape in which a side substantially perpendicular to a direction of an outer magnetic field and a side substantially parallel to the direction of an outer magnetic field are not orthogonal to each other, in particular, circular, polygonal, or the like, whereby it is possible to relax magnetic saturation of the magnetic shield plate and keep the magnetic shield effect.
摘要翻译：本发明的目的是松弛磁饱和，实现适用于MRAM等磁性装置的高性能磁屏蔽效果。本发明的磁屏蔽部件适用于磁性随机存取存储器（MRAM），其中磁性随机存取存储器（MRAM）由通过堆积固定磁化方向的磁化固定层形成的TMR元件和磁性层组成，其中，磁化方向可以改变，通过隧道阻挡层被树脂等密封材料密封。设置在密封材料上以磁屏蔽MRAM的磁屏蔽板的平面形状或截面形状是这样的形状，其中，基本上垂直于外部磁场的方向的侧和基本上平行于外部磁场彼此不正交，特别是圆形，多边形等，从而可以缓和磁屏蔽板的磁饱和并保持磁屏蔽效果。

40. 发明申请

US20050226030A1 Magnetic memory device 审中-公开
标题翻译：磁存储器件
公开(公告)号：US20050226030A1
公开(公告)日：2005-10-13
申请号：US10504626
申请日：2003-12-12
申请人： Yoshihiro Kato , Katsumi Okayama , Kaoru Kobayashi , Tetsuya Yamamoto , Minoru Ikarashi
发明人： Yoshihiro Kato , Katsumi Okayama , Kaoru Kobayashi , Tetsuya Yamamoto , Minoru Ikarashi
IPC分类号： G11C11/15 , H01L21/8246 , H01L23/00 , H01L23/495 , H01L23/552 , H01L27/105 , H01L43/02 , H01L43/08 , G11C11/00
CPC分类号： H01L23/49575 , H01L23/552 , H01L2924/0002 , H01L2924/00
摘要： A magnetic memory device in which an MRAM element is magnetically shielded from a large external magnetic field in an satisfactory manner, making it possible to surely achieve an operation free of problems in a magnetic field generated by the environment in which the MRAM element is used. A magnetic random access memory (MRAM) (30) is constituted by a TMR element (10) having a magnetized pinned layer (4), (6) with fixed direction of magnetization and a magnetic layer (memory layer) (2) with changeable direction of magnetization stacked on one another, mounted on a substrate together with another element (38), such as a DRAM, wherein a magnetic shielding layer (33), (34) is formed in a region corresponding to an area occupied by the MRAM element (30) or/and a magnetic shielding layer (33), (34) is with a distance of 15 mm or less between the opposite sides (especially, a length or a width).
摘要翻译：一种磁记录装置，其中MRAM元件以令人满意的方式从大的外部磁场磁屏蔽，使得可以可靠地实现在由使用MRAM元件的环境产生的磁场中没有问题的操作。磁性随机存取存储器（MRAM）（30）由具有固定磁化方向的磁化钉扎层（4），（6）的TMR元件（10）和具有可变形的磁性层（存储层）（2）构成彼此堆叠的磁化方向，与诸如DRAM的另一元件（38）一起安装在基板上，其中在与MRAM占据的区域对应的区域中形成磁屏蔽层（33）（34）元件（30）或/和磁屏蔽层（33），（34）在相对侧（特别是长度或宽度）之间的距离为15mm以下。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式