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1. 发明申请

US20070004716A1 Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient 有权
标题翻译：羧酸化合物和含有与活性成分相同的药物组合物
公开(公告)号：US20070004716A1
公开(公告)日：2007-01-04
申请号：US10572578
申请日：2004-09-16
申请人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , SeijiKoji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
发明人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , SeijiKoji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
IPC分类号： A61K31/538 , C07D265/36
CPC分类号： C07D307/80 , A61K31/343 , A61K31/538 , C07D265/36 , C07D317/48
摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.
摘要翻译：由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克，支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如，搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有小副作用。

2. 发明授权

US08138335B2 Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient 有权
标题翻译：羧酸化合物和含有与活性成分相同的药物组合物
公开(公告)号：US08138335B2
公开(公告)日：2012-03-20
申请号：US12551860
申请日：2009-09-01
申请人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , Seiji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
发明人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , Seiji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
IPC分类号： C07D265/36 , A61K31/535
CPC分类号： C07D307/80 , A61K31/343 , A61K31/538 , C07D265/36 , C07D317/48
摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.
摘要翻译：由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克，支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如，搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有小副作用。

3. 发明申请

US20100029631A1 CARBOXYLIC ACID COMPOUNDS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME AS THE ACTIVE INGREDIENT 有权
标题翻译：羧酸化合物和含有相同活性成分的药物组合物
公开(公告)号：US20100029631A1
公开(公告)日：2010-02-04
申请号：US12551860
申请日：2009-09-01
申请人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , Seiji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
发明人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , Seiji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
IPC分类号： A61K31/538 , C07D265/36 , A61P37/08 , A61P11/06
CPC分类号： C07D307/80 , A61K31/343 , A61K31/538 , C07D265/36 , C07D317/48
摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.
摘要翻译：由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克，支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如，搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有小副作用。

4. 发明授权

US07601712B2 Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient 有权
标题翻译：羧酸化合物和含有与活性成分相同的药物组合物
公开(公告)号：US07601712B2
公开(公告)日：2009-10-13
申请号：US10572578
申请日：2004-09-16
申请人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , Seiji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
发明人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , Seiji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
IPC分类号： A61K31/535 , A61K31/36 , A61K31/34 , A61K31/335 , C07D265/36 , C07D317/44 , C07D307/00 , C07D319/14
CPC分类号： C07D307/80 , A61K31/343 , A61K31/538 , C07D265/36 , C07D317/48
摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.
摘要翻译：由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克，支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如，搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有小副作用。

5. 发明申请

US20060089353A1 Indole derivative compounds and drugs containing the compounds as the active ingredient 审中-公开
标题翻译：吲哚衍生物化合物和含有这些化合物作为活性成分的药物
公开(公告)号：US20060089353A1
公开(公告)日：2006-04-27
申请号：US10548089
申请日：2004-03-05
申请人： Maki Iwahashi , Atsushi Naganawa , Toshihiko Nishiyama , Toshihiko Nagase , Fumio Nambu
发明人： Maki Iwahashi , Atsushi Naganawa , Toshihiko Nishiyama , Toshihiko Nagase , Fumio Nambu
IPC分类号： A61K31/538 , C07D413/02
CPC分类号： C07D413/12
摘要： An indole derivative compound represented by formula (I) (wherein the symbols in the formula are as mentioned in the specification) and a salt thereof Since the compounds represented by formula (I) binds to PGD2 receptors and shows antagonistic activity, they are believed to be useful for prevention and/or treatment of diseases such as allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, systemic mast cell activating disorder, anaphylaxis shock, airway contraction, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis, urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleep disorder) which are generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, autoimmune disease, chronic articular rheumatism, pleuritis, ulcerative colitis and irritable bowel syndrome.
摘要翻译：由式（I）表示的吲哚衍生物化合物（其中式中的符号如说明书中所述）及其盐由于式（I）表示的化合物与PGD 2 N 2受体结合，它们被认为可用于预防和/或治疗过敏性疾病（如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，全身性肥大细胞活化障碍等疾病，过敏性休克，气道收缩，荨麻疹，湿疹，伴有瘙痒的疾病（如特应性皮炎，荨麻疹），由于行为伴随而产生的疾病（如白内障，视网膜脱离，炎症，感染和睡眠障碍）瘙痒（如搔痒），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，自身免疫性疾病关节炎风湿病，胸膜炎，溃疡性结肠炎和肠易激综合征。

6. 发明授权

US07291644B2 Indole derivatives 失效
标题翻译：吲哚衍生物
公开(公告)号：US07291644B2
公开(公告)日：2007-11-06
申请号：US11412879
申请日：2006-04-28
申请人： Kazuhiko Torisu , Maki Iwahashi , Kaoru Kobayashi , Fumio Nambu
发明人： Kazuhiko Torisu , Maki Iwahashi , Kaoru Kobayashi , Fumio Nambu
IPC分类号： A61K31/335 , C07D265/36 , C07D405/00 , C07D209/02 , C07D209/04
CPC分类号： C07D405/12 , A61K31/405 , A61K31/422 , A61K31/4439 , A61K31/4709 , A61K31/538 , C07D209/22 , C07D401/12 , C07D413/12
摘要： Compounds represented by formula (I) wherein all symbols represent the same meanings as described in specification and salts thereof. Since the compound represented by the formula (I) binds and antagonizes to DP receptor, it is useful for the prevention or treatment against the disease such as allergic disorder, diseases accompanied with itching, secondary diseases generated by behaviors caused by itching, inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, pleuritis complicated by rheumatoid arthritis, cerebrovascular disease, and ulcerative colitis.
摘要翻译：由式（I）表示的化合物，其中所有符号表示与说明书及其盐中所述相同的含义。由于式（I）表示的化合物与DP受体结合并拮抗，因此可用于预防或治疗诸如过敏性疾病，伴有瘙痒的疾病，由瘙痒引起的行为引起的继发性疾病，炎症，慢性阻塞性肺病，局部缺血再灌注障碍，类风湿关节炎并发的胸膜炎，脑血管疾病和溃疡性结肠炎。

7. 发明申请

US20060194864A1 Indole derivatives 失效
公开(公告)号：US20060194864A1
公开(公告)日：2006-08-31
申请号：US11412879
申请日：2006-04-28
申请人： Kazuhiko Torisu , Maki Iwahashi , Kaoru Kobayashi , Fumio Nambu
发明人： Kazuhiko Torisu , Maki Iwahashi , Kaoru Kobayashi , Fumio Nambu
IPC分类号： A61K31/405 , C07D209/42
CPC分类号： C07D405/12 , A61K31/405 , A61K31/422 , A61K31/4439 , A61K31/4709 , A61K31/538 , C07D209/22 , C07D401/12 , C07D413/12
摘要： Compounds represented by formula (I) wherein all symbols represent the same meanings as described in specification. and salts thereof. Since the compound represented by the formula (I) binds and antagonizes to DP receptor, it is useful for the prevention or treatment against the disease such as allergic disorder, diseases accompanied with itching, secondary diseases generated by behaviors caused by itching, inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, pleuritis complicated by rheumatoid arthritis, cerebrovascular disease, and ulcerative colitis.

8. 发明申请

US20050222216A1 Carboxyoic acid compounds and drugs containing the compounds as the active ingredient 有权
标题翻译：羧甲酸化合物和含有化合物的药物作为活性成分
公开(公告)号：US20050222216A1
公开(公告)日：2005-10-06
申请号：US10507885
申请日：2003-03-06
申请人： Maki Iwahashi , Kaoru Kobayashi , Fumio Nambu
发明人： Maki Iwahashi , Kaoru Kobayashi , Fumio Nambu
IPC分类号： A61P1/04 , A61P7/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P25/06 , A61P25/20 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/12 , C07D265/36 , C07D307/80 , C07D319/20 , C07D327/06 , A61K31/44 , A61K31/195 , A61K31/277
CPC分类号： C07D319/20 , C07D209/12 , C07D265/36 , C07D307/80 , C07D327/06
摘要： A carboxylic acid compound represented by formula (I): (meanings of the symbols in the formula are as mentioned in the specification) and a pharmaceutical agent comprising the compound. Since the compound represented by formula (I) binds to a DP receptor and shows antagonistic activity for the DP receptor, it is useful for prevention and/or treatment of diseases such as allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like.
摘要翻译：由式（I）表示的羧酸化合物：（式中符号的含义如说明书中所述）和包含该化合物的药剂。由于式（I）表示的化合物与DP受体结合，对DP受体具有拮抗作用，因此可用于预防和/或治疗过敏性疾病（如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有系统性肥大细胞活化的疾病，过敏性休克，支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（如特应性皮炎和荨麻疹），疾病（如白内障，视网膜脱离，炎症，感染和睡眠障碍），其由伴随瘙痒的行为（例如搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿性关节炎，胸膜炎，溃疡性结肠炎和喜欢。

9. 发明授权

US07351705B2 Carboxylic acid compounds and a pharmaceutical agent comprising the compound as the active ingredient 有权
标题翻译：羧酸化合物和包含该化合物作为活性成分的药剂
公开(公告)号：US07351705B2
公开(公告)日：2008-04-01
申请号：US10507885
申请日：2003-03-06
申请人： Maki Iwahashi , Kaoru Kobayashi , Fumio Nambu
发明人： Maki Iwahashi , Kaoru Kobayashi , Fumio Nambu
IPC分类号： C07D413/12 , C07D265/36 , A61K31/538
CPC分类号： C07D319/20 , C07D209/12 , C07D265/36 , C07D307/80 , C07D327/06
摘要： A carboxylic acid compound represented by formula (I): (meanings of the symbols in the formula are as mentioned in the specification) and a pharmaceutical agent comprising the compound. Since the compound represented by formula (I) binds to a DP receptor and shows antagonistic activity for the DP receptor, it is useful for prevention and/or treatment of diseases such as allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like.
摘要翻译：由式（I）表示的羧酸化合物：（式中符号的含义如说明书中所述）和包含该化合物的药剂。由于式（I）表示的化合物与DP受体结合，对DP受体具有拮抗作用，因此可用于预防和/或治疗过敏性疾病（如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有系统性肥大细胞活化的疾病，过敏性休克，支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（如特应性皮炎和荨麻疹），疾病（如白内障，视网膜脱离，炎症，感染和睡眠障碍），其由伴随瘙痒的行为（例如搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿性关节炎，胸膜炎，溃疡性结肠炎和喜欢。

10. 发明授权

US07135495B2 Indole derivatives 失效
标题翻译：吲哚衍生物
公开(公告)号：US07135495B2
公开(公告)日：2006-11-14
申请号：US10488835
申请日：2002-09-06
申请人： Kazuhiko Torisu , Maki Iwahashi , Kaoru Kobayashi , Fumio Nambu
发明人： Kazuhiko Torisu , Maki Iwahashi , Kaoru Kobayashi , Fumio Nambu
IPC分类号： A61K31/335 , C07D265/36 , C07D405/00 , C07D209/02 , C07D209/04
CPC分类号： A61K31/405 , A61K31/404 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/423 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/498 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5415 , C07D209/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D417/12
摘要： Compounds represented by formula (I) wherein all symbols represent the same meanings as described in specification. and salts thereof. Since the compound represented by the formula (I) binds and antagonizes to DP receptor, it is useful for the prevention or treatment against the disease such as allergic disorder, diseases accompanied with itching, secondary diseases generated by behaviors caused by itching, inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, pleuritis complicated by rheumatoid arthritis, cerebrovascular disease, and ulcerative colitis.
摘要翻译：由式（I）表示的化合物，其中所有符号表示与说明书中所述相同的含义。及其盐。由于式（I）表示的化合物与DP受体结合并拮抗，因此可用于预防或治疗诸如过敏性疾病，伴有瘙痒的疾病，由瘙痒引起的行为引起的继发性疾病，炎症，慢性阻塞性肺病，局部缺血再灌注障碍，类风湿关节炎并发的胸膜炎，脑血管疾病和溃疡性结肠炎。

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