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1. 发明申请

US20080033033A1 8-AZAPROSTAGLANDIN DERIVATIVES AND MEDICAL USE THEREOF 审中-公开
标题翻译： 8-AZAPROSTAGLANDIN衍生物及其医疗用途
公开(公告)号：US20080033033A1
公开(公告)日：2008-02-07
申请号：US11749531
申请日：2007-05-16
申请人： Tohru Kambe , Toru Maruyama , Kaoru Kobayashi , Kousuke Tani , Yoshihiko Nakai , Toshihiko Nagase , Takayuki Maruyama , Kiyoto Sakata , Hideyuki Yoshida , Shinsei Fujimura , Akio Nishiura , Nobutaka Abe
发明人： Tohru Kambe , Toru Maruyama , Kaoru Kobayashi , Kousuke Tani , Yoshihiko Nakai , Toshihiko Nagase , Takayuki Maruyama , Kiyoto Sakata , Hideyuki Yoshida , Shinsei Fujimura , Akio Nishiura , Nobutaka Abe
IPC分类号： A61K31/41 , A61K31/4015 , C07D207/18 , C07D257/04
CPC分类号： C07D417/12 , C07D417/14
摘要： The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I) (wherein, all the symbols have the same meanings as that of the specification.) a salt thereof, a solvate thereof or a cyclodextrin clathrate thereof, or a prodrug thereof and them as active ingredient have EP4 agonistic action and thus are considered useful for the prevention and/or treatment of immunological diseases, asthma, neuronal cell death, arthritis, lung failure, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, liver damage, acute hepatitis, nephritis, renal insufficiency, hypertension, myocardial ischemia, systemic inflammatory response syndrome, sepsis, hemophagous syndrome, macrophage activation syndrome, Still's disease, Kawasaki disease, burn, systemic granulomatosis, ulcerative colitis, Crohn's disease, hypercytokinemia at dialysis, multiple organ failure, shock and glaucoma, etc. Furthermore, the compounds also have an action of accelerating bone formation, so it is expected to be useful for the prevention and/or treatment of diseases associated with loss in bone mass, for example, primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss, osteonecrosis, bone formation after bone operation, alternative treatment for bone grafting.
摘要翻译：包含本发明化合物的盐，其盐，其溶剂合物或环糊精包合物，其具有由式（I）表示的8-氮杂前列腺素骨架（其中所有符号具有与说明书相同的含义）或其前药，并且它们作为活性成分具有EP 4激动作用，因此被认为可用于预防和/或治疗免疫疾病，哮喘，神经元细胞死亡，关节炎，肺衰竭，肺纤维化，肺气肿，支气管炎，慢性阻塞性肺疾病，肝损伤，急性肝炎，肾炎，肾功能不全，高血压，心肌缺血，全身炎症反应综合征，败血症，血液综合征，巨噬细胞活化综合征，静脉炎，川崎病，烧伤，系统性肉芽肿病，溃疡性结肠炎，克罗恩病，透析中的高细胞因子血症，多器官功能衰竭，休克和青光眼等。此外，化合物还具有促进骨形成的作用，因此预期可用于预防和/或治疗与骨量丧失相关的疾病，例如原发性骨质疏松症，继发性骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失，骨坏死，骨手术后的骨形成，骨移植的替代治疗。

2. 发明授权

US07256211B1 8-azaprostaglandin derivatives and medical use thereof 失效
标题翻译： 8-氮杂普罗兰前列腺素衍生物及其医疗用途
公开(公告)号：US07256211B1
公开(公告)日：2007-08-14
申请号：US10542724
申请日：2004-01-20
申请人： Tohru Kambe , Toru Maruyama , Kaoru Kobayashi , Kousuke Tani , Yoshihiko Nakai , Toshihiko Nagase , Takayuki Maruyama , Kiyoto Sakata , Hideyuki Yoshida , Shinsei Fujimura , Akio Nishiura , Nobutaka Abe
发明人： Tohru Kambe , Toru Maruyama , Kaoru Kobayashi , Kousuke Tani , Yoshihiko Nakai , Toshihiko Nagase , Takayuki Maruyama , Kiyoto Sakata , Hideyuki Yoshida , Shinsei Fujimura , Akio Nishiura , Nobutaka Abe
IPC分类号： A61K31/40 , A61K31/426 , C07D207/12 , C07D207/36
CPC分类号： C07D417/12 , C07D417/14
摘要： The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I) (wherein, all the symbols have the same meanings as that of the specification) a salt thereof, a solvate thereof or a cyclodextrin clathrate thereof, or a prodrug thereof and them as active ingredient have EP4 agonistic action and thus are considered useful for the prevention and/or treatment of immunological diseases, asthma, neuronal cell death, arthritis, lung failure, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, liver damage, acute hepatitis, nephritis, renal insufficiency, hypertension, myocardial ischemia, systemic inflammatory response syndrome, sepsis, hemophagous syndrome, macrophage activation syndrome, Still's disease, Kawasaki disease, burn, systemic granulomatosis, ulcerative colitis, Crohn's disease, hypercytokinemia at dialysis, multiple organ failure, shock and glaucoma, etc. Furthermore, the compounds also have an action of accelerating bone formation, so it is expected to be useful for the prevention and/or treatment of diseases associated with loss in bone mass, for example, primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss, osteonecrosis, bone formation after bone operation, alternative treatment for bone grafting.
摘要翻译：该药物组合物包含本发明化合物，其具有式（I）表示的8-氮杂前列腺素骨架（其中所有符号具有与说明书相同的含义）其盐，其溶剂合物或环糊精包合物，或其前药和它们作为活性成分具有EP 4激动作用，因此被认为可用于预防和/或治疗免疫疾病，哮喘，神经元细胞死亡，关节炎，肺衰竭，肺纤维化，肺气肿，支气管炎，慢性阻塞性肺疾病，肝损伤，急性肝炎，肾炎，肾功能不全，高血压，心肌缺血，全身炎症反应综合征，败血症，血液综合征，巨噬细胞活化综合征，Still氏病，川崎病，烧伤，全身性肉芽肿病，溃疡性结肠炎，克罗恩病，透析中的高细胞因子血症，多器官功能衰竭，休克和青光眼等。该化合物还具有加速骨形成的作用，因此预期可用于预防和/或治疗与骨质量损失相关的疾病，例如原发性骨质疏松症，继发性骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失，骨坏死，骨手术后的骨形成，骨移植的替代治疗。

3. 发明申请

US20050020686A1 Remedies for diseases with bone mass loss having ep4 agonist as the active ingredient 失效
标题翻译：用ep4激动剂作为活性成分治疗骨质量下降的疾病
公开(公告)号：US20050020686A1
公开(公告)日：2005-01-27
申请号：US10484500
申请日：2002-07-22
申请人： Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
发明人： Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
IPC分类号： A61K45/00 , A61K31/559 , A61P19/08 , A61P19/10 , C07C405/00 , A61K31/557
CPC分类号： C07C405/0033 , A61K9/0019 , A61K9/1647 , A61K9/19 , A61K9/2054 , A61K31/4015 , A61K31/41 , A61K31/5575 , A61K31/559
摘要： A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).
摘要翻译：用于预防和/或治疗与包含EP4激动剂作为活性成分的骨量减少相关的疾病的局部施用的药物组合物。包含具有前列腺素骨架的化合物作为代表的EP4激动剂具有促进骨形成的作用，因此可用于预防和/或治疗与骨质量减少有关的疾病（骨疾病如原发性骨质疏松症，继发性骨质疏松症骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失和骨坏死，术后成骨，骨移植的替代疗法）。

4. 发明授权

US08207223B2 Pharmaceutical composition for treatment of diseases associated with decrease in bone mass comprising EP4 agonist as active ingredient 有权
标题翻译：用于治疗与包含EP4激动剂作为活性成分的骨质量减少相关的疾病的药物组合物
公开(公告)号：US08207223B2
公开(公告)日：2012-06-26
申请号：US12549136
申请日：2009-08-27
申请人： Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
发明人： Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
IPC分类号： A01N37/08 , A01N53/00 , A61K31/215 , A61K31/19 , A61K31/557
CPC分类号： C07C405/0033 , A61K9/0019 , A61K9/1647 , A61K9/19 , A61K9/2054 , A61K31/4015 , A61K31/41 , A61K31/5575 , A61K31/559
摘要： A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).
摘要翻译：用于预防和/或治疗与包含EP4激动剂作为活性成分的骨量减少相关的疾病的局部施用的药物组合物。包含具有前列腺素骨架的化合物作为代表的EP4激动剂具有促进骨形成的作用，因此可用于预防和/或治疗与骨质量减少有关的疾病（骨疾病如原发性骨质疏松症，继发性骨质疏松症骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失和骨坏死，术后成骨，骨移植的替代疗法）。

5. 发明申请

US20100010222A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF DISEASES ASSOCIATED WITH DECREASE IN BONE MASS COMPRISING EP4 AGONIST AS ACTIVE INGREDIENT 有权
标题翻译：用于治疗与包含EP4激动剂作为主动成分的骨质疏松相关的疾病的药物组合物
公开(公告)号：US20100010222A1
公开(公告)日：2010-01-14
申请号：US12549136
申请日：2009-08-27
申请人： Toru MARUYAMA , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
发明人： Toru MARUYAMA , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
IPC分类号： C07D241/04 , C07C405/00 , C07D207/12 , C07D401/12
CPC分类号： C07C405/0033 , A61K9/0019 , A61K9/1647 , A61K9/19 , A61K9/2054 , A61K31/4015 , A61K31/41 , A61K31/5575 , A61K31/559
摘要： A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).
摘要翻译：用于预防和/或治疗与包含EP4激动剂作为活性成分的骨量减少相关的疾病的局部施用的药物组合物。包含具有前列腺素骨架的化合物作为代表的EP4激动剂具有促进骨形成的作用，因此可用于预防和/或治疗与骨质量减少有关的疾病（骨疾病如原发性骨质疏松症，继发性骨质疏松症骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失和骨坏死，术后成骨，骨移植的替代疗法）。

6. 发明申请

US20120202773A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF DISEASES ASSOCIATED WITH DECREASE IN BONE MASS COMPRISING EP4 AGONIST AS ACTIVE INGREDIENT 审中-公开
标题翻译：用于治疗与包含EP4激动剂作为主动成分的骨质疏松相关的疾病的药物组合物
公开(公告)号：US20120202773A1
公开(公告)日：2012-08-09
申请号：US13453434
申请日：2012-04-23
申请人： Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
发明人： Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
IPC分类号： A61K31/4015 , C08B37/16 , A61K31/724 , C07D409/06 , C07D405/10 , C07D405/06 , C07D417/12 , C07D413/12 , C07D417/14 , C07D263/24 , C07D403/12 , C07D409/12 , C07D409/14 , C07D401/12 , A61P19/08 , C07D413/14 , C07D207/26 , B82Y99/00 , B82Y5/00
CPC分类号： C07C405/0033 , A61K9/0019 , A61K9/1647 , A61K9/19 , A61K9/2054 , A61K31/4015 , A61K31/41 , A61K31/5575 , A61K31/559
摘要： A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).
摘要翻译：用于预防和/或治疗与包含EP4激动剂作为活性成分的骨量减少相关的疾病的局部施用的药物组合物。包含具有前列腺素骨架的化合物作为代表的EP4激动剂具有促进骨形成的作用，因此可用于预防和/或治疗与骨质量减少有关的疾病（骨疾病如原发性骨质疏松症，继发性骨质疏松症骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失和骨坏死，术后成骨，骨移植的替代疗法）。

7. 发明授权

US07840565B2 Dictionary creation device and dictionary creation method 有权
标题翻译：字典创作装置和字典创作方法
公开(公告)号：US07840565B2
公开(公告)日：2010-11-23
申请号：US11471538
申请日：2006-06-21
申请人： Hiroshi Kutsumi , Eiichi Naito , Jun Ozawa , Hideyuki Yoshida
发明人： Hiroshi Kutsumi , Eiichi Naito , Jun Ozawa , Hideyuki Yoshida
IPC分类号： G06F17/30
CPC分类号： G06F17/2735 , H04N21/482
摘要： A dictionary creation device and dictionary creation method are provided which optimally create and update a dictionary for classifying, searching, or extracting text information in accordance with a changes in content of text information groups. The dictionary creation device includes a keyword extraction unit that extracts a keyword from inputted text information and a keyword statistics unit that finds statistics regarding an appearance of the keyword. The dictionary creation device further includes a keyword assessment value calculation unit that calculates an assessment value of the extracted keyword based on the statistics regarding the appearance of the keyword, a determination unit that determines whether or not to register or delete the keyword based on the calculated assessment value, a dictionary registration and deletion unit which registers or deletes the keyword in or from a dictionary database based on a result of the determination performed by the determination unit, and the dictionary database.
摘要翻译：提供了一种字典创作装置和字典创作方法，其最佳地创建和更新字典，以便根据文本信息组内容的变化对文本信息进行分类，搜索或提取。字典创建装置包括从输入的文本信息中提取关键字的关键字提取单元和查找关于关键字的外观的统计的关键字统计单元。字典创建装置还包括关键词评估值计算单元，其基于关于关键字的出现的统计来计算提取的关键字的评估值;确定单元，其基于所计算的关键字来确定是否注册或删除关键字评估值，字典登记和删除单元，其基于由确定单元执行的确定的结果和字典数据库，在字典数据库中注册或从字典数据库中注册或删除关键字。

8. 发明授权

US07545063B2 Wire-connection structure of motor 有权
标题翻译：电机线连接结构
公开(公告)号：US07545063B2
公开(公告)日：2009-06-09
申请号：US11468093
申请日：2006-08-29
申请人： Hideyuki Yoshida , Akihiro Watanabe , Kenji Fukuda
发明人： Hideyuki Yoshida , Akihiro Watanabe , Kenji Fukuda
IPC分类号： H02K11/00
CPC分类号： H02K3/522 , H02K5/225
摘要： In a wire-connection structure of a motor, bus rings each formed by a bent wire material into a substantially annular shape and arranged along a stator includes: a plurality of large diameter portions and a plurality of small diameter portions extending alternately in a circumferential direction; and a plurality of link portions extending in a radial direction and connecting the adjacent large diameter portion and small diameter portion to each other. Windings of the coils are wire-connected to the link portions. Therefore, it is unnecessary to form the link portions of the bus rings into a U-shape or double-wire overlapping shape, thereby facilitating processing. Moreover, the width of the wire-connection portion in the circumferential direction does not exceed the thickness of a single wire material, thereby facilitating connection work by a crimping tool in a narrow space. Thus, the structure of a crimping portion for fixing by crimping the winding of the coil to the bus ring is simplified, and a space for inserting the crimping tool is secured to improve workability.
摘要翻译：在电动机的线连接结构中，由弯曲线材形成为大致环状并且沿定子配置的总线环包括：沿圆周方向交替延伸的多个大直径部分和多个小直径部分 ; 以及沿径向延伸并将相邻的大直径部分和小直径部分彼此连接的多个连接部分。线圈的绕线线连接到连接部分。因此，不需要将母线环的连接部分形成为U形或双线重叠形状，从而便于加工。此外，线连接部在圆周方向上的宽度不超过单线材的厚度，从而有助于通过压接工具在狭窄的空间中的连接工作。因此，用于通过将线圈的线圈压接到母线环来固定的压接部的结构被简化，并且确保了用于插入压接工具的空间以提高可操作性。

9. 发明申请

US20060122911A1 E-commerce system and method 审中-公开
公开(公告)号：US20060122911A1
公开(公告)日：2006-06-08
申请号：US11339730
申请日：2006-01-26
申请人： Toshiki Kindo , Hideyuki Yoshida , Takehiko Shida , Hiroshi Takase
发明人： Toshiki Kindo , Hideyuki Yoshida , Takehiko Shida , Hiroshi Takase
IPC分类号： G06Q30/00
CPC分类号： G06Q30/02 , G06Q30/0256 , G06Q30/0277 , G06Q30/0633 , Y10S707/99939
摘要： In an e-commerce system which rearranges merchandise information pieces distributed to a consumer to match preferences of the consumer based on a personal profile with which various keywords contained in the merchandise information pieces and evaluation values corresponding to the keywords are registered where the evaluation values are learned in advance based on preferences of the consumer, while withdrawing a charge of merchandise from an account designated by the consumer to pay to the seller when receiving an order from the rearranged merchandise information pieces, an order for merchandise from the merchandise information pieces distributed to one consumer is placed using the personal profile of another consumer.

10. 发明申请

US20060108270A1 Sewage treatment apparatus and method thereof 审中-公开
标题翻译：污水处理装置及其方法
公开(公告)号：US20060108270A1
公开(公告)日：2006-05-25
申请号：US11210858
申请日：2005-08-25
申请人： Sakae Kosanda , Yuichi Fuchu , Norio Makita , Yoshiharu Yasuhara , Hideyuki Yoshida , Shojiro Watanabe
发明人： Sakae Kosanda , Yuichi Fuchu , Norio Makita , Yoshiharu Yasuhara , Hideyuki Yoshida , Shojiro Watanabe
IPC分类号： C02F1/50
CPC分类号： C02F1/32 , C02F1/74 , C02F1/76 , C02F1/766 , C02F2001/007 , C02F2103/001 , C02F2209/005 , C02F2301/043
摘要： The present invention provides a sewer system having a means to quickly disinfect rainwater-incorporated sewage and pollutant-incorporated rainwater, that is, combined sewer overflow (CSO), separated sewer rainwater overflow and separated sanitary sewer overflow before being discharged to public water body without passing through a sewage treatment plant, and a method and an apparatus for disinfecting rainwater-incorporated sewage and pollutant-incorporated rainwater. One embodiment of the present invention is a sewer system wherein when sewage flows into a sewage treatment plant in an amount of not more than the treatment capacity of the sewage treatment plant, the sewage is subjected to predetermined treatments in the sewage treatment plant, and then disinfection with a chlorine-based disinfectant, and thereafter discharged to public water body, and when sewage containing rainwater in an amount of more than the treatment capacity of the sewage treatment plant flows or may flow into the sewage treatment plant by a big rainfall, the amount of the rainwater-incorporated sewage of more than the treatment capacity is branched in sewer stormwater overflow removing facilities of a sewer, then disinfected with a bromine-based disinfectant, and thereafter discharged to public water body while the rainwater-incorporated sewage in an amount within the treatment capacity of the sewage treatment plant is subjected to predetermined treatments in the sewage treatment plant, then disinfected with a chlorine-based disinfectant, and thereafter discharged to public water body.
摘要翻译：本发明提供了一种下水道系统，其具有快速消毒含雨水污水和污染物引入的雨水的消毒装置，即合并的下水道溢流（CSO），分离的下水道雨水溢流和分离的卫生下水道溢流，在排放到公共水体之前没有通过污水处理厂，以及一种消除含雨水污水和污染物的雨水消毒的方法和装置。本发明的一个实施例是一种下水道系统，其中当污水以不超过污水处理厂的处理能力的量流入污水处理厂时，污水在污水处理厂中进行预定的处理，然后用氯类消毒剂消毒，然后排放到公共水体，如果污水含有超过污水处理厂处理能力的雨水流入或流入污水处理厂，由于大雨，雨水排污量超过处理能力的下水道污水下水道溢流除水设施分流，然后用溴化消毒剂消毒，然后排入公共水体，同时排放含雨水的污水量在污水处理厂的处理能力内，在污水处理厂进行预定处理然后用氯系消毒剂消毒，然后排放到公共水体。

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