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31. 发明授权

US07255833B2 Apparatus and reaction vessel for controlling the temperature of a sample 有权
标题翻译：用于控制样品温度的装置和反应容器
公开(公告)号：US07255833B2
公开(公告)日：2007-08-14
申请号：US10379291
申请日：2003-03-03
申请人： Ronald Chang , Lee A. Christel , Gregory T. A. Kovacs , William A. McMillan , M. Allen Northrup , Kurt E. Petersen , Farzad Pourahmadi , Steven J. Young , Robert Yuan , Douglas B. Dority
发明人： Ronald Chang , Lee A. Christel , Gregory T. A. Kovacs , William A. McMillan , M. Allen Northrup , Kurt E. Petersen , Farzad Pourahmadi , Steven J. Young , Robert Yuan , Douglas B. Dority
IPC分类号： G01N21/00
CPC分类号： B01L3/508 , B01J19/0093 , B01J2219/00804 , B01J2219/0081 , B01J2219/00873 , B01J2219/0097 , B01L7/52 , B01L2300/042 , B01L2300/0809 , B01L2300/0858 , B01L2300/168 , B01L2300/1805 , F28D2021/0077 , F28F3/12 , F28F21/04 , F28F2280/10 , G01N21/0303 , G01N21/0332 , G01N2035/00326
摘要： This invention provides an apparatus for rapidly heating and/or cooling a sample in a reaction vessel. In some embodiments, the apparatus includes optics for the efficient detection of a reaction product in the vessel. The invention also provides a reaction vessel having a reaction chamber designed for optimal thermal conductance and for efficient optical viewing of reaction products in the chamber.
摘要翻译：本发明提供一种用于在反应容器中快速加热和/或冷却样品的装置。在一些实施例中，该装置包括用于有效检测容器中的反应产物的光学元件。本发明还提供一种反应容器，该反应容器具有设计用于最佳热传导和有效地光学观察室内反应产物的反应室。

32. 发明授权

US06818185B1 Cartridge for conducting a chemical reaction 有权
标题翻译：用于进行化学反应的墨盒
公开(公告)号：US06818185B1
公开(公告)日：2004-11-16
申请号：US09584328
申请日：2000-05-30
申请人： Kurt E. Petersen , William A. McMillan , Farzad Pourahmadi , Ronald Chang , Douglas B. Dority
发明人： Kurt E. Petersen , William A. McMillan , Farzad Pourahmadi , Ronald Chang , Douglas B. Dority
IPC分类号： B01L302
CPC分类号： B01L7/52 , B01L3/502 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0858 , B01L2300/087 , B01L2300/123 , B01L2300/14 , B01L2300/168 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12Q1/6844 , G01N33/5302 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： A device for conducting a chemical reaction comprises a body having at least first and second channels formed therein. A reaction vessel extends from the body. The reaction vessel has a reaction chamber, an inlet port connected to the reaction chamber via an inlet channel, and an outlet port connected to the reaction chamber via an outlet channel. The inlet port of the vessel is connected to the first channel in the body, and the outlet port of the vessel is connected to the second channel in the body.
摘要翻译：用于进行化学反应的装置包括具有形成在其中的至少第一和第二通道的主体。反应容器从身体延伸出来。反应容器具有反应室，通过入口通道连接到反应室的入口端口和经由出口通道连接到反应室的出口。容器的入口连接到体内的第一通道，容器的出口连接到体内的第二通道。

33. 发明授权

US06391541B1 Apparatus for analyzing a fluid sample 有权
标题翻译：用于分析流体样品的装置
公开(公告)号：US06391541B1
公开(公告)日：2002-05-21
申请号：US09583807
申请日：2000-05-30
申请人： Kurt E. Petersen , Michael T. Taylor , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching , Douglas B. Dority , Phillip Belgrader , M. Allen Northrup
发明人： Kurt E. Petersen , Michael T. Taylor , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching , Douglas B. Dority , Phillip Belgrader , M. Allen Northrup
IPC分类号： G01N3353
CPC分类号： B01L3/502 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0809 , B01L2300/087 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12N1/066 , C12N13/00 , Y10S435/81 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/809 , Y10S436/829 , Y10T137/87716 , Y10T137/88046 , Y10T436/255
摘要： A cartridge for separating a desired analyte from a fluid sample has a sample flow path and a lysing chamber in the sample flow path. The lysing chamber contains at least one filter for capturing cells or viruses from the sample as the sample flows through the lysing chamber. Beads are also disposed in the lysing chamber for rupturing the cells or viruses to release the analyte therefrom. An analyte flow path extends from the lysing chamber and diverges from the sample flow path. The analyte flow path preferably leads to a reaction chamber for chemically reacting and optically detecting the analyte. The cartridge also includes at least one flow controller (e.g., valves) for directing the sample into the waste chamber after the sample flows through the lysing chamber and for directing the analyte separated from the sample into the analyte flow path.
摘要翻译：用于从流体样品分离所需分析物的滤筒具有样品流动路径中的样品流动路径和裂解室。裂解室包含至少一个用于在样品流过裂解室时从样品捕获细胞或病毒的过滤器。珠也设置在裂解室中，用于破裂细胞或病毒以从其中释放分析物。分析物流动路径从裂解室延伸并从样品流动路径发散。分析物流动路径优选地导致用于化学反应和光学检测分析物的反应室。该盒还包括至少一个流量控制器（例如阀），用于在样品流过裂解室之后将样品引入废物室，并将从样品分离的分析物引导到分析物流动路径中。

34. 发明申请

US20120329140A1 SAMPLE PROCESSING SYSTEM AND METHOD 有权
公开(公告)号：US20120329140A1
公开(公告)日：2012-12-27
申请号：US13330472
申请日：2011-12-19
申请人： Shazi Iqbal , Steven M. Montgomery , Ronald Chang , Gregory Mote , Douglas B. Dority , Jeffrey S. Ross
发明人： Shazi Iqbal , Steven M. Montgomery , Ronald Chang , Gregory Mote , Douglas B. Dority , Jeffrey S. Ross
IPC分类号： G01N1/31 , C12M1/36
CPC分类号： G01N1/312 , G01N1/30 , G01N1/38 , G01N35/00029 , G01N35/0092 , G01N2001/386 , G01N2035/00534 , G01N2035/00792 , G01N2035/00811 , Y10T436/112499 , Y10T436/25 , Y10T436/2525
摘要： Provided is a system and method for staining of one or more samples, including providing one or more self-contained sample processing receptacles, each of the one or more self-contained sample processing receptacles configured to be inserted into an auto-staining instrument; and enabling one of one or more staining procedures appropriate for the one or more samples as a function of a choice of self-contained sample processing receptacle, each of the one or more self-contained sample processing receptacles configured to process each inserted sample of the one or more samples within the self-contained sample processing receptacle.

35. 发明申请

US20120034705A1 FLUID PROCESSING AND CONTROL 有权
标题翻译：流体加工与控制
公开(公告)号：US20120034705A1
公开(公告)日：2012-02-09
申请号：US13245572
申请日：2011-09-26
申请人： Douglas B. Dority , Ronald Chang
发明人： Douglas B. Dority , Ronald Chang
IPC分类号： G01N1/28
CPC分类号： B01L3/502715 , B01L3/502 , B01L3/50273 , B01L3/502738 , B01L2200/06 , B01L2200/10 , B01L2200/16 , B01L2300/06 , B01L2300/0645 , B01L2300/0681 , B01L2300/0848 , B01L2300/0861 , B01L2300/0877 , B01L2300/123 , B01L2300/14 , B01L2400/0421 , B01L2400/0478 , B01L2400/0487 , B01L2400/0644 , G01N1/18 , G01N1/28 , G01N1/405 , Y10T436/255 , Y10T436/2575
摘要： A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers.
摘要翻译：用于控制多个室之间的流体流动的流体控制和处理系统包括主体，其包括与流体位移区域流体连续耦合的流体处理区域。流体位移区域是可减压的，以将流体吸入流体移动区域并且可加压以从流体位移区域排出流体。身体至少包括一个外部端口。流体处理区域与至少一个外部端口流体耦合。流体位移区域与主体的至少一个外部端口流体耦合。主体相对于多个室可调节以将至少一个外部端口选择性地与多个室流体连通。

36. 发明授权

US08048386B2 Fluid processing and control 有权
标题翻译：流体加工和控制
公开(公告)号：US08048386B2
公开(公告)日：2011-11-01
申请号：US10084409
申请日：2002-02-25
申请人： Douglas B. Dority , Ronald Chang
发明人： Douglas B. Dority , Ronald Chang
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/502 , B01L3/50273 , B01L3/502738 , B01L2200/06 , B01L2200/10 , B01L2200/16 , B01L2300/06 , B01L2300/0645 , B01L2300/0681 , B01L2300/0848 , B01L2300/0861 , B01L2300/0877 , B01L2300/123 , B01L2300/14 , B01L2400/0421 , B01L2400/0478 , B01L2400/0487 , B01L2400/0644 , G01N1/18 , G01N1/28 , G01N1/405 , Y10T436/255 , Y10T436/2575
摘要： A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers. One or more of the chambers may be a processing chamber which includes two ports configured to selectively engage the at least one external port of the body, and a fluid processing material such as an enrichment material or a depletion material. In some embodiments, one or more chambers may include a separation channel, and an electric field may be applied across the separation channel.
摘要翻译：用于控制多个室之间的流体流动的流体控制和处理系统包括主体，其包括与流体位移区域流体连续耦合的流体处理区域。流体位移区域是可减压的，以将流体吸入流体移动区域并且可加压以从流体位移区域排出流体。身体至少包括一个外部端口。流体处理区域与至少一个外部端口流体耦合。流体位移区域与主体的至少一个外部端口流体耦合。主体相对于多个室可调节以将至少一个外部端口选择性地与多个室流体连通。一个或多个室可以是处理室，其包括构造成选择性地接合主体的至少一个外部端口的两个端口，以及诸如富集材料或耗尽材料的流体处理材料。在一些实施例中，一个或多个腔室可以包括分离通道，并且可以跨越分离通道施加电场。

37. 发明授权

US07575721B2 Method and apparatus for storing and dispensing reagent beads 有权
标题翻译：用于存储和分配试剂珠的方法和装置
公开(公告)号：US07575721B2
公开(公告)日：2009-08-18
申请号：US11146304
申请日：2005-06-06
申请人： Ronald Chang , Douglas B. Dority , Steven Michael Montgomery
发明人： Ronald Chang , Douglas B. Dority , Steven Michael Montgomery
IPC分类号： B01L3/00 , G01N31/00 , B01L3/02 , G01N21/03 , G01N1/00 , G01N33/543 , B23Q7/04 , G07F11/16 , B65H5/00 , B65H1/08 , B65H3/00
CPC分类号： B01L3/527 , B01J19/0046 , B01J2219/00468 , B01J2219/005 , B01J2219/00657 , B01L3/0289 , B01L2200/0647 , B01L2200/16 , G01N2035/00574 , Y10T436/25
摘要： Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In one embodiment, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge. The cover tape is insertable through the stripping gap to be pulled against the stripping edge to peel the cover tape from the bead carrier to move the wells of the bead carrier inside the channel toward the dispense opening and expose the wells individually to dispense the reagent beads.
摘要翻译：本发明的实施方案提供了用于存储和分配试剂珠的有效和有效的技术。在一个实施例中，提供了一种用于分配包含在珠子存储装置中的试剂珠粒的装置，其包括具有多个孔的珠粒载体; 设置在所述孔中的多个试剂珠; 以及可剥离地附接到胎圈载体以覆盖孔并将试剂珠保持在孔中的覆盖带。该装置包括一个通道，在该通道中，珠子存放装置使胎圈承载件面向通道的支撑壁，盖带面向通道的剥离壁。剥离壁包括设置在剥离边缘和相对边缘之间的剥离间隙，以及在剥离壁的与剥离边缘相对的一侧上邻近相对边缘设置的分配开口。覆盖带可以通过剥离间隙被插入以被拉靠在剥离边缘上，以从胎圈载体上剥离覆盖带，以将通道内的胎圈载体的孔移动到分配开口，并单独暴露孔以分配试剂珠。

38. 发明申请

US20080286151A1 APPARATUS FOR PERFORMING HEAT-EXCHANGING CHEMICAL REACTIONS 有权
标题翻译：用于执行热交换化学反应的装置
公开(公告)号：US20080286151A1
公开(公告)日：2008-11-20
申请号：US10719073
申请日：2003-11-21
申请人： Ronald Chang , Douglas B. Dority , Lee A. Christel , Robert Yuan , Kurt E. Petersen
发明人： Ronald Chang , Douglas B. Dority , Lee A. Christel , Robert Yuan , Kurt E. Petersen
IPC分类号： G01N33/48
CPC分类号： B01L7/52 , B01J19/0093 , B01J2219/00788 , B01J2219/00873 , B01J2219/00963 , B01J2219/0097 , B01L3/508 , B01L9/00 , B01L2300/042 , B01L2300/0858 , B01L2300/1827 , F28D2021/0077 , F28F13/00 , G01N21/0332 , G01N35/0099 , G01N2035/00376 , G01N2035/0405 , Y10T436/2575
摘要： An apparatus for controlling the temperature of a reaction mixture contained in a chamber of a reaction vessel comprises a thermal surface for contacting a flexible wall of the chamber and an automated machine for increasing the pressure in the chamber. The pressure increase in the chamber is sufficient to force the flexible wall to conform to the thermal surface for good thermal conductance. The apparatus also includes at least one thermal element for heating or cooling the surface to induce a temperature change within the chamber.
摘要翻译：用于控制包含在反应容器的室中的反应混合物的温度的装置包括用于接触室的柔性壁的热表面和用于增加室中的压力的自动化机器。室中的压力增加足以迫使柔性壁与热表面一致，以获得良好的导热性。该装置还包括至少一个热元件，用于加热或冷却表面以引起腔室内的温度变化。

39. 发明授权

US06660228B1 Apparatus for performing heat-exchanging, chemical reactions 有权
标题翻译：反应容器
公开(公告)号：US06660228B1
公开(公告)日：2003-12-09
申请号：US09468690
申请日：1999-12-21
申请人： Ronald Chang , Douglas B. Dority , Lee A. Christel , Robert Yuan , Kurt E. Petersen
发明人： Ronald Chang , Douglas B. Dority , Lee A. Christel , Robert Yuan , Kurt E. Petersen
IPC分类号： B01L300
CPC分类号： B01L7/52 , B01J19/0093 , B01J2219/00788 , B01J2219/00873 , B01J2219/00963 , B01J2219/0097 , B01L3/508 , B01L9/00 , B01L2300/042 , B01L2300/0858 , B01L2300/1827 , F28D2021/0077 , F28F13/00 , G01N21/0332 , G01N35/0099 , G01N2035/00376 , G01N2035/0405 , Y10T436/2575
摘要： The present invention provides an apparatus for performing heat-exchanging chemical reactions, such as nucleic acid amplification. The apparatus includes a reaction vessel having a chamber for holding a sample for chemical reaction and optical detection. The vessel has a rigid frame defining the side walls of the chamber, and flexible sheets attached to opposite sides of the frame to form opposing major walls of the chamber. The frame further includes a port and a channel connecting the port to the chamber. The temperature of the sample is controlled by opposing plates positioned to receive the chamber of the vessel between them. The apparatus also includes a plunger which is inserted into the channel of the vessel to seal the port and increase pressure in the chamber. The increased pressure forces the flexible major walls of the chamber to contact and conform to the surfaces of the plates, thus ensuring optimal thermal conductance between the plates and the chamber. The apparatus also includes thermal elements for heating or cooling the plates, as well as optics for detecting analytes in the sample.
摘要翻译：本发明提供了一种用于进行诸如核酸扩增的热交换化学反应的装置。该装置包括具有用于保持用于化学反应和光学检测的样品的室的反应容器。容器具有限定室的侧壁的刚性框架，以及附接到框架的相对侧的柔性片以形成腔室的相对的主壁。框架还包括端口和将端口连接到室的通道。样品的温度通过相对的板来控制，所述相对的板定位成在它们之间容纳容器的腔室。该装置还包括插入容器的通道以密封端口并增加腔室中的压力的柱塞。增加的压力迫使室的柔性主壁与板的表面接触并且符合板的表面，从而确保板和室之间的最佳热传导。该装置还包括用于加热或冷却板的热元件以及用于检测样品中分析物的光学元件。

40. 发明授权

US06565815B1 Heat exchanging, optically interrogated chemical reaction assembly 有权
标题翻译：热交换，光学询问化学反应组装
公开(公告)号：US06565815B1
公开(公告)日：2003-05-20
申请号：US09194374
申请日：2000-07-25
申请人： Ronald Chang , Lee A. Christel , Gregory T. A. Kovacs , William A. McMillan , M. Allen Northrup , Kurt E. Petersen , Farzad Pourahmadi , Steven J. Young , Robert Yuan , Douglas B. Dority
发明人： Ronald Chang , Lee A. Christel , Gregory T. A. Kovacs , William A. McMillan , M. Allen Northrup , Kurt E. Petersen , Farzad Pourahmadi , Steven J. Young , Robert Yuan , Douglas B. Dority
IPC分类号： F28D700
CPC分类号： G01N21/75 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01J2219/00822 , B01J2219/00828 , B01J2219/00833 , B01J2219/00871 , B01J2219/00873 , B01J2219/00961 , B01J2219/0097 , B01J2219/00986 , B01L3/505 , B01L3/508 , B01L7/52 , B01L2300/042 , B01L2300/0809 , B01L2300/0858 , B01L2300/168 , B01L2300/1805 , F28D2021/0077 , F28F3/12 , F28F21/04 , F28F2280/10 , G01N21/0303 , G01N21/0332 , G01N2035/00326
摘要： The present invention provides a reaction vessel and apparatus for performing heat-exchanging reactions. The vessel has a chamber for holding a sample, the chamber being defined by a plurality of walls, at least two of the walls being light transmissive to provide optical windows to the chamber. The apparatus comprises at least one heating surface for contacting at least one of the plurality of walls, a heat source for heating the surface, and optics positioned to optically interrogate the chamber while the heating surface is in contact with at least one of the plurality of walls. The optics include at least one light source for transmitting light to the chamber through a first one of the light transmissive walls and at least one detector for detecting light exiting the chamber through a second one of the light transmissive walls.
摘要翻译：本发明提供一种用于进行热交换反应的反应容器和装置。容器具有用于保持样品的室，所述室由多个壁限定，至少两个壁是透光的，以向室提供光学窗口。该装置包括用于接触多个壁中的至少一个的至少一个加热表面，用于加热该表面的热源，以及定位成光学询问该室的光学器件，同时该加热表面与多个壁板中的至少一个接触墙壁所述光学器件包括至少一个光源，用于通过第一透光壁将光传输到室，以及至少一个检测器，用于检测通过第二透光壁离开室的光。

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