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31. 发明授权

US5508999A Method and system for designing least cost local access networks 失效
标题翻译：用于设计最低成本的本地接入网络的方法和系统
公开(公告)号：US5508999A
公开(公告)日：1996-04-16
申请号：US131045
申请日：1993-10-01
申请人： Louis A. Cox, Jr. , Yuping Qiu , George E. Tegan , Xiaorong Sun
发明人： Louis A. Cox, Jr. , Yuping Qiu , George E. Tegan , Xiaorong Sun
IPC分类号： H04L12/24 , H04Q3/00 , H04Q11/04 , H04L12/28
CPC分类号： H04L41/22 , H04L41/0826 , H04L41/145 , H04Q3/002 , H04Q3/0083 , H04J2203/0057 , H04L41/0823
摘要： A method and system is provided for use in cooperation with a computer having a memory for generating an optimized transition plan for the placement and interconnection of carrier hubs in a local access network having a plurality of Central Offices (COs), Serving Wire Centers (SWCs) and Point-of-Presence (POP) exchange carriers such that calls may be routed at least cost. In operation, the total number and location of existing SWCs within the network must be determined along with the total switched and special access demand. Thereafter, known tariff rates for selected channel terminals, transport channels and multiplexers must be determined along with the total number of DS3 lines from each SWC to its corresponding POP. By expressing determined network demand as selected mixed-integer program decision variables and determining a corresponding set of logical constraints consistent with these decision variables, the optimized placement of hubs within the local access network may be determined. In addition, the corresponding location and type of channel terminals, transport channels and multiplexers may be implemented all accordance with the mixed-integer program and an electrical signal corresponding thereto may be generated for receipt by the computer memory. This information may thereafter be retrieved from computer memory and graphically displayed on a user-friendly interface.
摘要翻译：提供了一种与具有存储器的计算机配合使用的方法和系统，所述存储器用于生成用于在具有多个中心局（CO），服务线中心（SWC）的本地接入网络中的载波集线器的放置和互连的优化转换计划）和点对点（POP）交换运营商，使得呼叫可以以至少成本路由。在运营中，网络中现有的SWC的总数和位置必须与总的交换和特殊访问需求一起确定。此后，必须确定所选频道终端，运输频道和多路复用器的已知电费率，以及每个SWC到其相应POP的DS3线路总数。通过将确定的网络需求表示为选定的混合整数程序决策变量并确定与这些决策变量一致的对应的一组逻辑约束，可以确定集线器在本地接入网络内的优化布局。此外，可以根据混合整数程序来实现信道终端，传输信道和多路复用器的相应位置和类型，并且可以生成与之对应的电信号以供计算机存储器接收。此后可以从计算机存储器检索该信息，并以图形方式显示在用户友好界面上。

32. 发明授权

US5450317A Method and system for optimized logistics planning 失效
标题翻译：优化物流规划方法与系统
公开(公告)号：US5450317A
公开(公告)日：1995-09-12
申请号：US158128
申请日：1993-11-24
申请人： Lu Lu , Yuping Qiu , Louis A. Cox, Jr.
发明人： Lu Lu , Yuping Qiu , Louis A. Cox, Jr.
IPC分类号： G06Q10/06 , G06Q10/08 , G06Q30/02 , G06F15/20 , G06G7/418
CPC分类号： G06Q10/06 , G06Q10/06314 , G06Q10/06315 , G06Q10/06316 , G06Q10/087 , G06Q30/0202
摘要： An improved logistics planning method and system for recommending optimal order quantities and timing, choice of vendor locations and storage locations, and transportation modes, for individual items and for product families. The system is designed for use in cooperation with the computer having memory and incorporates item, customer, supplier, and routing information databases. In operation, the item, customer and supplier databases are accessed in order to provide customer and warehouse demand forecasts. The routing and customer databases are similarly accessed to provide transportation cost forecasts necessary to determine optimized routing modes for selected items, customers and suppliers. The demand and transportation costs are processed in accordance with a dynamic programming model to determine stock and non-stock order/shipment solutions for the selected items and customers, including optimized supplier and routing selection, order timing and quantity.
摘要翻译：改进的物流计划方法和系统，用于为个别物品和产品系列推荐最佳订单数量和时间，供应商位置和仓储位置的选择以及运输方式。该系统设计用于与具有存储器的计算机配合使用，并结合了项目，客户，供应商和路由信息数据库。在操作中，访问项目，客户和供应商数据库，以提供客户和仓库需求预测。类似地访问路由和客户数据库，以提供确定所选项目，客户和供应商的优化路由模式所必需的运输成本预测。根据动态规划模型处理需求和运输成本，以确定所选项目和客户的库存和非库存订单/运输解决方案，包括优化的供应商和路由选择，订单时间和数量。

33. 发明授权

US07723536B2 Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof 有权
标题翻译：多羟基二烯基内酯的合成技术和中间体及其模拟物
公开(公告)号：US07723536B2
公开(公告)日：2010-05-25
申请号：US12072730
申请日：2008-02-28
申请人： Amos B. Smith, III , Thomas J. Beauchamp , Matthew J. LaMarche , Yuping Qiu , Michael D. Kaufman , Hirokazu Arimoto , David R. Jones , Kaoru Kobayashi
发明人： Amos B. Smith, III , Thomas J. Beauchamp , Matthew J. LaMarche , Yuping Qiu , Michael D. Kaufman , Hirokazu Arimoto , David R. Jones , Kaoru Kobayashi
IPC分类号： C07F9/02 , C07F9/28
CPC分类号： C07C271/12 , C07B2200/07 , C07D213/30 , C07D263/22 , C07D303/16 , C07D309/10 , C07D309/30 , C07D309/32 , C07D319/06 , C07D339/08 , C07D407/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07F7/1804 , C07F7/1892 , C07F9/5428 , C07F9/5442
摘要： Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.
摘要翻译：提供了可用于制备含内酯化合物如discodermolide的合成方法和中间体以及模拟discodermolide的化学或生物活性的化合物。

34. 发明申请

US20100076191A1 PROCESS FOR PREPARING TRIAZOLE SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES AND NOVEL SALT FORMS PRODUCED THEREIN 有权
标题翻译：制备三唑取代的氮杂双环氧哌嗪衍生物及其生产的新型盐形式的方法
公开(公告)号：US20100076191A1
公开(公告)日：2010-03-25
申请号：US12548809
申请日：2009-08-27
申请人： NACHIMUTHU SOUNDARARAJAN , Yuping Qiu , Wenhao Hu , David R. Kronenthal , Pierre Sirard , Jean Lajeunesse , Robert Droghini , Ramakrishnan Chidambaram , Xinhua Qian , Kenneth J. Natalie , Shawn K. Pack , Nathan Reising , Erqing Tang , Michael G. Fakes , Qi Gao , Feng Qian , Blisse J. Vakkalagadda , Chiajen Lai , Shan-Ming Kuang
发明人： NACHIMUTHU SOUNDARARAJAN , Yuping Qiu , Wenhao Hu , David R. Kronenthal , Pierre Sirard , Jean Lajeunesse , Robert Droghini , Ramakrishnan Chidambaram , Xinhua Qian , Kenneth J. Natalie , Shawn K. Pack , Nathan Reising , Erqing Tang , Michael G. Fakes , Qi Gao , Feng Qian , Blisse J. Vakkalagadda , Chiajen Lai , Shan-Ming Kuang
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07C311/49 , C07D213/26
摘要： A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
摘要翻译：提供制备三唑取代的氮杂糊精乙酸哌嗪衍生物的方法。还提供了在上述方法中制备的新型中间体和新的N-1和无定形形式的1,2,3-三唑取代的氮杂寡脱氧乙酸哌嗪衍生物及其制备方法。

35. 发明申请

US20060293304A1 Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein 有权
公开(公告)号：US20060293304A1
公开(公告)日：2006-12-28
申请号：US11455338
申请日：2006-06-19
申请人： Nachimuthu Soundararajan , Yuping Qiu , Wenhao Hu , David Kronenthal , Pierre Sirard , Jean Lajeunesse , Robert Droghini , Ramakrishnan Chidambaram , Xinhua Qian , Kenneth Natalie , Shawn Pack , Nathan Reising , Erqing Tang , Michael Fakes , Qi Gao , Feng Qian , Blisse Vakkalagadda , Chiajen Lai , Shan-Ming Kuang
发明人： Nachimuthu Soundararajan , Yuping Qiu , Wenhao Hu , David Kronenthal , Pierre Sirard , Jean Lajeunesse , Robert Droghini , Ramakrishnan Chidambaram , Xinhua Qian , Kenneth Natalie , Shawn Pack , Nathan Reising , Erqing Tang , Michael Fakes , Qi Gao , Feng Qian , Blisse Vakkalagadda , Chiajen Lai , Shan-Ming Kuang
IPC分类号： C07D471/02 , A61K31/55 , A61K31/5377 , A61K31/496 , A61K31/4745
CPC分类号： C07D471/04 , C07C311/49 , C07D213/26
摘要： A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.

36. 发明申请

US20060178393A1 1H-imidazo[4,5-d]thieno[3,2-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same 有权
标题翻译： 1H-咪唑并[4,5-d]噻吩并[3,2-b]吡啶基三环化合物和包含它们的药物组合物
公开(公告)号：US20060178393A1
公开(公告)日：2006-08-10
申请号：US11346986
申请日：2006-02-03
申请人： William Pitts , Jagabandhu Das , Yuping Qiu , Steven Spergel
发明人： William Pitts , Jagabandhu Das , Yuping Qiu , Steven Spergel
IPC分类号： A61K31/4745 , C07D498/14
CPC分类号： C07D495/14
摘要： The present invention provides for thiazolopyridine-based tricyclic compounds having the formula (I), wherein R1, R2, R5, R6 and R7 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译：本发明提供具有式（I）的噻唑并吡啶类三环化合物，其中R 1，R 2，R 5，R 5， SUP＆gt; 6＆gt;和R＆lt; 7＆gt;如本文所述。本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。

37. 发明授权

US5789605A Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof 失效
公开(公告)号：US5789605A
公开(公告)日：1998-08-04
申请号：US759817
申请日：1996-12-03
申请人： Amos B. Smith, III , Yuping Qiu , Michael Kaufman , Hirokaza Arimoto , David R. Jones , Kaoru Kobayashi
发明人： Amos B. Smith, III , Yuping Qiu , Michael Kaufman , Hirokaza Arimoto , David R. Jones , Kaoru Kobayashi
IPC分类号： C07D303/16 , A61K31/047 , A61K31/12 , A61K31/27 , A61K31/336 , A61K31/351 , A61K31/366 , A61K31/422 , A61K31/427 , A61K31/5355 , A61K31/7028 , A61P35/00 , A61P37/06 , C07C239/06 , C07D263/22 , C07D309/10 , C07D309/30 , C07D309/32 , C07D319/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07F7/18 , C07H23/00 , C07D407/06
CPC分类号： C07D413/12 , C07C239/06 , C07D263/22 , C07D309/30 , C07D319/06 , C07F7/1892
摘要： Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.

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