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31. 发明授权

US06707036B2 Ionization apparatus and method for mass spectrometer system 失效
标题翻译：电离装置及质谱仪系统
公开(公告)号：US06707036B2
公开(公告)日：2004-03-16
申请号：US10105172
申请日：2002-03-21
申请人： Alexander A. Makarov , Pavel V. Bondarenko
发明人： Alexander A. Makarov , Pavel V. Bondarenko
IPC分类号： H01J4900
CPC分类号： H01J49/067 , H01J49/0418 , H01J49/164
摘要： An ionization apparatus for connection to a mass analyzer is provided. The ionization apparatus comprises a sample slide having at least two sample spots containing analytes to be analyzed by a mass analyzer, means for delivering energy to one of the sample spots to release and ionize the analytes to form ions, and an interface connecting the one of the sample spot to the analyzer. The interface comprises a chamber having an orifice in close proximity to the one of the sample spots and defining a first region encompassing the one of the sample spots, and an ion guide disposed in the chamber and leading to the mass analyzer in a second region. Means for sustaining a pressure substantially lower than atmospheric within the first region is provided for capturing the ions while other sample spots are maintained at atmospheric pressure. Means for sustaining a pressure within the second region substantially lower than the pressure within the first region is provided.
摘要翻译：提供了一种用于连接到质量分析器的电离装置。电离装置包括具有至少两个样品点的样品载片，所述样品点含有要由质量分析仪分析的分析物，用于将能量传递到样品点之一以释放和离子化分析物以形成离子的装置，以及将样品点到分析仪。所述界面包括具有紧邻所述一个所述样品斑点的孔口并且限定包围所述样品斑点中的一个的第一区域的腔室和设置在所述腔室中并在第二区域中通向所述质量分析器的离子导管。提供用于在第一区域内维持基本上低于大气压力的装置用于捕获离子，而其它样品斑点保持在大气压。提供了在第二区域内保持基本上低于第一区域内的压力的装置。

32. 发明授权

US10074528B2 Data acquisition system and method for mass spectrometry 有权
公开(公告)号：US10074528B2
公开(公告)日：2018-09-11
申请号：US13994312
申请日：2011-12-15
申请人： Alexander A. Makarov , Anastassios Giannakopulos , Matthias Biel
发明人： Alexander A. Makarov , Anastassios Giannakopulos , Matthias Biel
IPC分类号： H01J49/02 , H01J49/00
CPC分类号： H01J49/025 , H01J49/0036
摘要： The invention provides a data acquisition system and method for detecting ions in a mass spectrometer, comprising: a detection system for detecting ions comprising two or more detectors for outputting two or more detection signals in separate channels in response to ions arriving at the detection system; and a data processing system for receiving and processing the detection signals in separate channels of the data processing system and for merging the processed detection signals to construct a mass spectrum; wherein the processing in separate channels comprises removing noise from the detection signals by applying a threshold to the detection signals. The detection signals are preferably produced in response to the same ions, the signals being shifted in time relative to each other. The invention is suitable for a TOF mass spectrometer.

33. 发明授权

US09520280B2 Ion detection 有权
标题翻译：离子检测
公开(公告)号：US09520280B2
公开(公告)日：2016-12-13
申请号：US13993316
申请日：2011-12-14
申请人： Alexander A. Makarov
发明人： Alexander A. Makarov
IPC分类号： H01J49/00 , H01J49/28 , H01J49/02 , H01J49/38 , H01J49/42
CPC分类号： H01J49/282 , H01J49/027 , H01J49/08 , H01J49/38 , H01J49/4245
摘要： Mass analyzers and methods of ion detection for a mass analyzer are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.
摘要翻译：提供了用于质量分析仪的质量分析仪和离子检测方法。静电场发生器提供静电场，使离子包沿着一个方向振荡。在比离子振荡的周期短的持续时间内检测脉冲瞬态信号，或使用具有明显小于离子谐波运动的跨度的宽度的脉冲检测电极。还检测到谐波瞬态信号。然后基于脉冲瞬态信号和谐波瞬态信号来识别关于质荷比的离子强度。

34. 发明授权

US08841605B2 Method of ion abundance augmentation in a mass spectrometer 有权
标题翻译：质谱仪中离子丰度增加的方法
公开(公告)号：US08841605B2
公开(公告)日：2014-09-23
申请号：US12296746
申请日：2007-04-13
申请人： Alexander A. Makarov
发明人： Alexander A. Makarov
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/42 , H01J49/0031 , H01J49/0045
摘要： A method of improving the detection limits of a mass spectrometer by: generating sample ions from an ion source; storing the sample ions in a first ion storage device; ejecting the stored ions into an ion selection device; selecting and ejecting ions of a chosen mass to charge ratio out of the ion selection device; storing the ions ejected from the ion selection device in a second ion storage device without passing them back through the ion selection device; repeating the preceding steps so as to augment the ions of the said chosen mass to charge ratio stored in the second ion storage device; and transferring the augmented ions of the said chosen mass to charge ratio back to the first ion storage device for subsequent analysis.
摘要翻译：一种通过以下步骤改进质谱仪的检测限的方法：从离子源产生样品离子; 将样品离子存储在第一离子存储装置中; 将所储存的离子喷射到离子选择装置中; 从所述离子选择装置中选择和排出所选择的质荷比的离子; 将从所述离子选择装置喷出的离子存储在第二离子存储装置中，而不将其返回通过所述离子选择装置; 重复前述步骤，以便增加存储在第二离子存储装置中的所选择的质荷比的离子; 以及将所述选择的质量与充电比例的增强离子转移回到第一离子存储装置，用于随后的分析。

35. 发明授权

US08674293B2 Multireflection time-of-flight mass spectrometer 有权
标题翻译：多重反射飞行时间质谱仪
公开(公告)号：US08674293B2
公开(公告)日：2014-03-18
申请号：US13790760
申请日：2013-03-08
申请人： Alexander A. Makarov , Dmitry E. Grinfeld , Mikhail A. Monastyrskiy
发明人： Alexander A. Makarov , Dmitry E. Grinfeld , Mikhail A. Monastyrskiy
IPC分类号： H01J49/40 , H01J49/26 , B01D59/44
CPC分类号： H01J49/406 , H01J49/061 , H01J49/405
摘要： A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.
摘要翻译：公开了一种在多反射飞行时间质谱仪中反射离子的方法。该方法包括将离子导向具有多个电极的离子反射镜，并向离子镜电极施加电压以产生电场，使得离子的平均轨迹与离子反射镜的对称平面相交并离开离子反射镜，其中离子由反射镜在空间上聚焦到第一位置并且在时间上聚焦到与第一位置不同的第二位置。还公开了用于执行该方法的装置。

36. 发明授权

US08581185B2 Ion storage device with direction-selective radial ejection 有权
标题翻译：具有方向选择性径向喷射的离子存储装置
公开(公告)号：US08581185B2
公开(公告)日：2013-11-12
申请号：US13226390
申请日：2011-09-06
申请人： Alexander A. Makarov , Eduard V. Denisov , Alexander Kholomeev
发明人： Alexander A. Makarov , Eduard V. Denisov , Alexander Kholomeev
IPC分类号： H01J49/42 , H01J49/26 , B01D59/44
CPC分类号： H01J49/0031 , H01J49/022 , H01J49/36 , H01J49/423 , H01J49/427
摘要： The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.
摘要翻译：本发明提供质谱仪中的射频（RF）电源。电源向存储设备的电极提供RF信号以产生捕获场。射频场通常在离子喷射之前倒塌。在说明性实施例中，RF电源包括RF信号电源; 布置成接收由RF信号电源提供的信号并提供用于向离子存储装置的电极供应的输出RF信号的线圈; 以及分流器，其包括可操作以在第一打开位置和第二关闭位置之间切换的开关，其中分流器使线圈输出短路。

37. 发明申请

US20130264474A1 Ion Detection System and Method 有权
标题翻译：离子检测系统及方法
公开(公告)号：US20130264474A1
公开(公告)日：2013-10-10
申请号：US13993590
申请日：2011-12-13
申请人： Alexander Kholomeev , Alexander A. Makarov
发明人： Alexander Kholomeev , Alexander A. Makarov
IPC分类号： H01J49/02 , H01J49/40
CPC分类号： H01J49/0031 , H01J43/00 , H01J49/025 , H01J49/40
摘要： A detection system and a method for detecting ions which have been separated in a time-of-flight (TOF) mass analyser, comprising an amplifying arrangement for converting ions into packets of secondary particles and amplifying the packets of secondary particles, wherein the amplifying arrangement is arranged so that each packet of secondary particles produces at least a first output and a second output separated in time and so that during the delay between producing the first and second output the first output produced by a packet of secondary particles is used for modulating the second output produced by the same packet. An increased dynamic range of detection and protection of the detection system against intense ion pulses is thereby provided.
摘要翻译：一种用于检测在飞行时间质谱仪（TOF）质量分析仪中已分离的离子的检测系统和方法，包括用于将离子转换成二次粒子的分组并放大次级粒子的分组的放大装置，其中放大装置布置成使得每个二次粒子的分组产生至少第一输出和在时间上分离的第二输出，并且使得在产生第一和第二输出之间的延迟期间，由二次粒子的分组产生的第一输出用于调制第二个输出由同一个数据包产生。从而提供了检测系统对强离子脉冲的动态检测范围的增加。

38. 发明授权

US08288714B2 Ion trapping 有权
标题翻译：离子捕获
公开(公告)号：US08288714B2
公开(公告)日：2012-10-16
申请号：US12944357
申请日：2010-11-11
申请人： Alexander A. Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
发明人： Alexander A. Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
IPC分类号： H01J49/00
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.
摘要翻译：本发明涉及一种捕获离子和离子捕获组件的方法。特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。本发明提供了一种捕获离子捕获组件的靶离子阱中的离子的方法，该方法包括一系列体积排列使得离子可以从一个体积向下一个体积横越，该体积包括目标离子阱，从而使离子被允许反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。电位可用于从离子捕获组件的相应末端反射离子。任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

39. 发明授权

US07985950B2 Parallel mass analysis 有权
标题翻译：平行质量分析
公开(公告)号：US07985950B2
公开(公告)日：2011-07-26
申请号：US12521688
申请日：2007-12-27
申请人： Alexander A. Makarov , Stevan Horning
发明人： Alexander A. Makarov , Stevan Horning
IPC分类号： H01J49/26 , H01J27/02
CPC分类号： H01J49/009 , H01J49/425
摘要： A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap.
摘要翻译：提供了一种质谱系统和方法。来自离子源的离子存储在第一离子存储装置和第二离子存储装置中。在第一喷射时间段期间，离子从第一离子存储装置喷射到第一质量分析装置，以在第一分析时间段期间进行分析。在第二喷射时间段期间，离子从第二离子存储装置喷射到第二质量分析装置。离子存储装置串联连接，使得第一离子存储装置的离子传送孔与第二离子存储装置的离子传送孔连通。第一分析时间段和第二喷射时间段至少部分重叠。

40. 发明申请

US20110101218A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20110101218A1
公开(公告)日：2011-05-05
申请号：US12992557
申请日：2009-06-01
申请人： Alexander A. Makarov , Alexander Kholomeev
发明人： Alexander A. Makarov , Alexander Kholomeev
IPC分类号： H01J49/26 , B01D59/44 , H02J4/00
CPC分类号： H01J49/022 , H01J49/0031 , Y10T307/696
摘要： A method of switching between two modes of power supply to a mass analyser is provided. In a first mode of operation, operated for a first predefined time duration, a first power supply, coupled to the mass analyser, generates a first non zero potential, whilst a second power supply, disconnected from the mass analyser, generates a second non-zero potential. In a second mode of operation, operated for a second predefined time duration, the second potential is coupled to the mass analyser, whilst the first power supply, disconnected from the mass analyser, generates the first potential. These predefined time durations are selected such that only one of: the first potential; and the second potential is coupled to the mass analyser at any time, and such that the first and second modes of operation are carried out at least once within a predetermined length of time.
摘要翻译：提供了一种在质量分析器的两种供电模式之间切换的方法。在第一操作模式下，在第一预定义的持续时间内操作，耦合到质量分析器的第一电源产生第一非零电位，而与质量分析器断开的第二电源产生第二非零电位，零电位。在第二操作模式中，在第二预定持续时间内操作，第二电位耦合到质量分析器，而与质量分析器断开的第一电源产生第一电位。选择这些预定义的持续时间，使得仅一个：第一个电位; 并且第二电位在任何时间耦合到质量分析器，并且使得第一和第二操作模式在预定时间长度内进行至少一次。

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