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31. 发明申请

US20050158879A1 Polymer brushes for immobilizing molecules to a surface and having water-soluble or water-dispersible segments therein and probes bonded thereto 审中-公开
标题翻译：用于将分子固定在表面上并具有水溶性或水分散性区段的聚合物刷和与其结合的探针
公开(公告)号：US20050158879A1
公开(公告)日：2005-07-21
申请号：US11012416
申请日：2004-12-15
申请人： Gerrit Klaerner , Ralph Nielsen , Paul Mansky , Didier Benoit , Dominique Charmot , Bernd Jandeleit , Laura Mazzola
发明人： Gerrit Klaerner , Ralph Nielsen , Paul Mansky , Didier Benoit , Dominique Charmot , Bernd Jandeleit , Laura Mazzola
IPC分类号： C08F4/00 , C08F220/54 , C08F220/58 , G01N27/447 , G01N33/543 , C12Q1/68
CPC分类号： G01N33/54353 , C08F4/00 , C08F220/54 , C08F220/58 , G01N27/44747 , Y10T428/8305 , Y10T436/10
摘要： Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.
摘要翻译：用于确定生物样品中生物分子的存在和浓度的传感器以聚合物刷的形式提供，所述聚合物刷包含具有表面的基底，所述基底具有用水分散性或水溶性聚合物链段修饰，所述水分散性或水溶性聚合物链段具有结合探针。合成这种传感器的方法优选包括使用受控的自由基聚合技术，特别是使用引发剂，其允许可控结构聚合物改性基材的表面。以这种方式，从表面去除聚合物链中的官能团，这允许溶液化学更具体地再现，具有固体结合探针的优点。

32. 发明授权

US06878344B2 Apparatus for testing compositions in contact with a porous medium 有权
标题翻译：用于测试与多孔介质接触的组合物的装置
公开(公告)号：US06878344B2
公开(公告)日：2005-04-12
申请号：US10116805
申请日：2002-04-05
申请人： Paul Mansky , Richard Tiede , Steve Havadtoy
发明人： Paul Mansky , Richard Tiede , Steve Havadtoy
IPC分类号： B01J19/00 , B01L3/00 , G01N33/36 , G01N35/02 , G01N1/28
CPC分类号： B01L3/5023 , B01J19/0046 , B01J2219/00274 , B01J2219/00315 , B01J2219/00484 , B01J2219/00585 , B01J2219/00659 , B01J2219/00704 , B01L3/5025 , B01L3/50255 , B01L2400/0481 , B01L2400/049 , G01N33/36 , G01N33/367 , G01N35/028 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： An apparatus for use in testing a plurality of compositions in parallel. The apparatus includes an upper plate having a plurality of openings extending therethrough to form upper fluid chambers and a lower plate having a plurality of openings extending at least partially therethrough to form cavities. A central plate having a plurality of openings extending therethrough to form central fluid chambers is positioned between the upper and lower plates with the central chambers in alignment with the upper chambers and the cavities. A porous sheet is interposed between the upper and central plates such that an upper surface of the sheet is in contact with fluid within the upper chamber and a lower surface of the sheet is in contact with fluid within the central chamber. The apparatus further includes a flexible membrane positioned between the lower and central plates such that changes in pressure within the cavities or fluid chambers cause deflection of the membrane to force fluid to pass through the porous sheet.
摘要翻译：用于并行测试多种组合物的装置。该装置包括具有延伸穿过其中以形成上流体室的多个开口的上板，以及具有至少部分地穿过其延伸以形成空腔的多个开口的下板。具有贯穿其中以形成中心流体室的多个开口的中心板位于上板和下板之间，中心室与上室和空腔对准。多孔片介于上板和中板之间，使得片的上表面与上室内的流体接触，并且片的下表面与中心室内的流体接触。该装置还包括位于下板和中心板之间的柔性膜，使得空腔或流体室内的压力变化导致膜的偏转以迫使流体通过多孔板。

33. 发明授权

US06732574B2 Method of using a high throughput viscometer 失效
标题翻译：使用高通量粘度计的方法
公开(公告)号：US06732574B2
公开(公告)日：2004-05-11
申请号：US10104203
申请日：2002-03-22
申请人： Damian Hajduk , Paul Mansky
发明人： Damian Hajduk , Paul Mansky
IPC分类号： G01N1106
CPC分类号： G01N11/06
摘要： An apparatus and method for measuring viscosity or related properties of fluid samples in parallel is disclosed. The apparatus includes a plurality of tubes and reservoirs in fluid communication with the tubes. The tubes provide flow paths for the fluid samples, which are initially contained within the reservoirs. The apparatus also includes a mechanism for filling the reservoirs with the fluid samples, and a device for determining volumetric flow rates of fluid samples flowing from the reservoirs through the plurality of tubes simultaneously. The disclosed apparatus is capable of measuring viscosity or related properties of at least five fluid samples simultaneously. Useful reservoirs and tubes include syringes.
摘要翻译：公开了一种并行测量流体样品的粘度或相关性质的装置和方法。该装置包括与管流体连通的多个管和储存器。管提供流体样品的流动路径，其最初包含在储存器内。该装置还包括用于用流体样本填充储存器的机构，以及用于确定从贮存器同时流过多个管的流体样品的体积流量的装置。所公开的装置能够同时测量至少五个流体样品的粘度或相关性质。有用的储存器和管子包括注射器。

34. 发明授权

US06553318B2 Method for conducting sensor array-based rapid materials characterization 失效
标题翻译：基于传感器阵列的快速材料表征的方法
公开(公告)号：US06553318B2
公开(公告)日：2003-04-22
申请号：US09858048
申请日：2001-05-15
申请人： Paul Mansky
发明人： Paul Mansky
IPC分类号： G01N2726
CPC分类号： G01N25/18 , B01J19/0046 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00707 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/18 , G01N25/005
摘要： There is disclosed a material characterization method. The method may include any combination of several potential steps. According to one of the steps multiple material samples are applied to multiple sensors in an array of sensors. In another step, one or more of the sensors of the array are electrically contacted. In another step, electrical connections are formed between selected sensors and electronic test and measurement apparatus. In another step, electric signals are sent to and received from the sensors in the array wherein the signals correspond to thermal, electrical, mechanical or other properties of the material samples. Preferably, some of the equipment (e.g., the electrical connections) used in the method are standardized to allow equipment such as sensor arrays to be interchangeable with equipment such as the electronic test and measurement apparatus.
摘要翻译：公开了一种材料表征方法。该方法可以包括几个潜在步骤的任何组合。根据步骤之一，将多个材料样品应用于传感器阵列中的多个传感器。在另一步骤中，阵列的一个或多个传感器被电接触。在另一步骤中，在所选择的传感器和电子测试和测量装置之间形成电连接。在另一步骤中，将电信号发送到阵列中的传感器并从其接收，其中信号对应于材料样品的热，电，机械或其他性质。优选地，在该方法中使用的一些设备（例如，电连接）被标准化以允许诸如传感器阵列之类的设备可与诸如电子测试和测量设备的设备互换。

35. 发明授权

US06535822B2 Sensor array for rapid materials characterization 失效
标题翻译：用于快速材料表征的传感器阵列
公开(公告)号：US06535822B2
公开(公告)日：2003-03-18
申请号：US09863532
申请日：2001-05-23
申请人： Paul Mansky , James Bennett
发明人： Paul Mansky , James Bennett
IPC分类号： G01N2726
CPC分类号： G01N25/18 , B01J19/0046 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00707 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/18 , G01N25/005 , G01N27/72
摘要： A sensor-array based materials characterization apparatus includes a sensor array disposed on a substrate; electronic test circuitry for sending and receiving electrical signals; electronic circuitry for routing signals between selected sensors and the electronic test circuitry; and a computer or processor. Preferably, all or part of the electronic test and signal routing circuitry is contained on the same substrate as the sensor array. Additional circuitry and a processor or computer may be physically separate from the substrate carrying the sensor array, and may be connected to the sensor array substrate. During use, multiple samples are applied to the multiple sensors in the array, and signals are sent to and received from selected sensors. Integration of the electronic test and signal routing circuitry onto the same substrate as the sensor array allows for a high density of sensors on a single substrate, permitting rapid analysis of combinatorial libraries.
摘要翻译：基于传感器阵列的材料表征装置包括设置在基板上的传感器阵列; 用于发送和接收电信号的电子测试电路; 用于在所选传感器和电子测试电路之间路由信号的电子电路; 以及计算机或处理器。优选地，电子测试和信号路由电路的全部或部分包含在与传感器阵列相同的衬底上。附加电路和处理器或计算机可以与承载传感器阵列的基板物理分离，并且可以连接到传感器阵列基板。在使用期间，将多个样本应用于阵列中的多个传感器，并将信号发送到所选传感器并从其接收。将电子测试和信号路由电路集成到与传感器阵列相同的衬底上，允许在单个衬底上的高密度传感器，允许快速分析组合库。

36. 发明授权

US06439036B1 Method for evaluating a test fluid 失效
标题翻译：评价试验液的方法
公开(公告)号：US06439036B1
公开(公告)日：2002-08-27
申请号：US09594178
申请日：2000-06-13
申请人： Paul Mansky
发明人： Paul Mansky
IPC分类号： G01N3336
CPC分类号： B01L3/5023 , B01J19/0046 , B01J2219/00274 , B01J2219/00315 , B01J2219/00484 , B01J2219/00585 , B01J2219/00659 , B01J2219/00704 , B01L3/5025 , B01L3/50255 , B01L2400/0481 , B01L2400/049 , G01N33/36 , G01N33/367 , G01N35/028
摘要： A method for evaluating a test fluid as a fabric care composition or as a component thereof The method includes providing a test sheet of fabric comprising a plurality of test regions and simultaneously contacting each of the plurality of test regions with a different test fluid. The method further includes screening the plurality of test regions or the contacted test fluids for a fabric property of interest to evaluate the relative efficacy of the different test fluids.
摘要翻译：一种用于评估作为织物护理组合物或组分的测试流体的方法。该方法包括提供包含多个测试区域并同时使多个测试区域中的每一个与不同测试流体接触的织物测试片。该方法还包括筛选多个测试区域或接触的测试流体以获得感兴趣的织物性质，以评估不同测试流体的相对功效。

37. 发明授权

US09655920B2 Amine polymers for use as bile acid sequestrants 有权
公开(公告)号：US09655920B2
公开(公告)日：2017-05-23
申请号：US13581148
申请日：2011-02-24
申请人： Eric Connor , Kalpesh Biyani , Scott Hecker , Inez Lees , Paul Mansky , YongQi Mu , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Grace Huynh , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
发明人： Eric Connor , Kalpesh Biyani , Scott Hecker , Inez Lees , Paul Mansky , YongQi Mu , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Grace Huynh , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
IPC分类号： A61K31/785 , C08G73/02 , A61K45/06
CPC分类号： A61K31/785 , A61K45/06 , C08G73/02 , C08G73/0206 , A61K2300/00
摘要： The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

38. 发明申请

US20090155370A1 METHODS AND COMPOSITIONS FOR SELECTIVELY REMOVING POTASSIUM ION FROM THE GASTROINTESTINAL TRACT OF A MAMMAL 有权
标题翻译：从牛奶的胃肠道动物中选择性去除钾离子的方法和组合物
公开(公告)号：US20090155370A1
公开(公告)日：2009-06-18
申请号：US12088625
申请日：2006-10-02
申请人： Michael J. Cope , Paul Mansky , Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Kalpesh Biyani , Mingjun Liu , Tony Kwok-Kong Mong , Yan Chen
发明人： Michael J. Cope , Paul Mansky , Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Kalpesh Biyani , Mingjun Liu , Tony Kwok-Kong Mong , Yan Chen
IPC分类号： A61K31/785 , A61K9/14 , A61P1/00
CPC分类号： A61K31/795 , A61K9/0053 , A61K9/14 , A61K9/1694 , A61K9/5026 , A61K31/74 , A61K31/75 , A61K31/785 , A61K33/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
摘要翻译：本发明提供了使用核 - 壳复合材料和包含这种核 - 壳复合材料的组合物来处理离子不平衡的方法和组合物。特别地，本发明提供了核 - 壳颗粒和包含钾结合聚合物的组合物，以及包含钠结合聚合物的核 - 壳颗粒和组合物，并且在每种情况下都是其药物组合物。还公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。本发明的组合物和方法提供治疗高钾血症和与钾离子稳态相关的其它适应症的改进方法，以及用于治疗与钠离子稳态有关的高血压和其它指征。

39. 发明授权

US07179777B2 Laundry treatment compositions comprising a polymer with a cationic and polydialkylsiloxane moiety 有权
标题翻译：洗衣处理组合物，其包含具有阳离子和聚二烷基硅氧烷部分的聚合物
公开(公告)号：US07179777B2
公开(公告)日：2007-02-20
申请号：US10328059
申请日：2002-12-23
申请人： Wilfried Blokzijl , Robert John Carswell , Dominique Charmot , Robert Alan Hunter , Mingjun Liu , Paul Mansky , Victor Nava-Salgado , Giovanni Francesco Unali
发明人： Wilfried Blokzijl , Robert John Carswell , Dominique Charmot , Robert Alan Hunter , Mingjun Liu , Paul Mansky , Victor Nava-Salgado , Giovanni Francesco Unali
IPC分类号： C11D3/37 , C11D9/36
CPC分类号： C11D3/3742 , C11D3/3769 , C11D3/3788 , C11D17/043
摘要： A laundry treatment composition comprising at least one polymeric material comprising a cationic polymer moiety and a polydialkylsiloxane moiety, and at least one other component.
摘要翻译：一种衣物处理组合物，其包含至少一种包含阳离子聚合物部分和聚二烷基硅氧烷部分的聚合材料，以及至少一种其它组分。

40. 发明授权

US06857309B2 High throughput mechanical rapid serial property testing of materials libraries 失效
标题翻译：材料库的高通量机械快速连续性能测试
公开(公告)号：US06857309B2
公开(公告)日：2005-02-22
申请号：US10225942
申请日：2002-08-22
申请人： Paul Mansky
发明人： Paul Mansky
IPC分类号： B01J19/00 , G01N3/00 , G01N13/02 , G01N35/00 , G01N13/00
CPC分类号： G01N13/02 , B01J19/0046 , B01J2219/00315 , B01J2219/00319 , B01J2219/00367 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/00648 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00704 , B01J2219/00731 , B01J2219/00736 , B01J2219/00756 , C40B30/10 , C40B40/14 , G01N3/00 , G01N35/0099
摘要： A library of materials is screened for mechanical properties such as surface tension or interfacial tension. A library of materials is provided. A stimulus such as a stress or force is provided to each member of the library. A response (e.g., a resistance) of each of the materials due to the stimulus is measured and the response, the stimulus or both are recorded and related to provide data. Thereafter, the data is analyzed to reach conclusions regarding the material samples.
摘要翻译：筛选材料库，以获得机械性能，如表面张力或界面张力。提供材料库。向图书馆的每个成员提供诸如压力或力量的刺激。测量由于刺激引起的每种材料的响应（例如，电阻），并且响应，刺激或两者被记录并相关以提供数据。此后，分析数据以得出关于材料样品的结论。

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