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31. 发明授权

US07963283B2 Myoelectrically activated respiratory leak sealing 有权
标题翻译：肌电活化呼吸道密封
公开(公告)号：US07963283B2
公开(公告)日：2011-06-21
申请号：US10466699
申请日：2002-01-16
申请人： Christer Sinderby
发明人： Christer Sinderby
IPC分类号： A61M16/00
CPC分类号： A61B5/0488 , A61M16/024 , A61M16/04 , A61M16/0409 , A61M16/0415 , A61M16/044 , A61M16/0461 , A61M2230/08 , A61M2230/60
摘要： The method and system are for sealing/unsealing (regulating) airway leaks occurring between the ventilator circuit and respiratory airways during lung ventilatory support in response to myoelectrical activity of diaphragm. Myolectrical activity of a patient's respiratory-related muscle is sensed to detect respiratory effort, and to produce a myoelectrical signal representative of the sensed muscle myoelectrical activity. Respiratory flow and pressure can also be measured to produce respective respiratory pressure and respiratory flow signals. A logic trigger sealing/unsealing of airway leaks in relation to the myoelectrical signal, respiratory flow signal and/or respiratory pressure signal to assist respiration of the patient. The amplitude of the myoelectrical signal is compared to a given threshold, and airway leaks are sealed when the amplitude of the myoelectrical signal is higher than this threshold. Increment of myoelectrical signal amplitude can be also detected to trigger the airway leak regulating device to seal the airway leaks, while decrement of the myoelectrical signal amplitude can be detected to unseal the airway leaks and thus permit air evacuation from the patient's lungs.
摘要翻译：该方法和系统用于在肺通气支持期间响应于隔膜的肌电活动来密封/开封（调节）呼吸机回路和呼吸道之间发生的气道泄漏。检测患者呼吸相关肌肉的肌电活动以检测呼吸力，并产生代表感测肌肉肌电活动的肌电信号。也可以测量呼吸流量和压力，以产生相应的呼吸压力和呼吸流量信号。相对于肌电信号，呼吸流量信号和/或呼吸压力信号，气道的逻辑触发器密封/开封泄漏以辅助患者的呼吸。将肌电信号的幅度与给定阈值进行比较，并且当肌电信号的幅度高于该阈值时，气道泄漏被密封。还可以检测到肌电信号幅度的增加，以触发气道泄漏调节装置来密封气道泄漏，同时可以检测到肌电信号振幅的减小，以开启气道泄漏，从而允许从患者肺部排出空气。

32. 发明授权

US06962155B1 Target drive ventilation gain controller and method 失效
标题翻译：目标驱动通风增益控制器和方法
公开(公告)号：US06962155B1
公开(公告)日：2005-11-08
申请号：US09364592
申请日：1999-07-30
申请人： Christer Sinderby
发明人： Christer Sinderby
IPC分类号： A61M16/00 , A61N1/05
CPC分类号： A61N1/05 , A61M16/026 , A61M2210/1014 , A61M2230/08 , A61M2230/60
摘要： A gain controller and method for controlling the value of a gain is used in conjunction with an electrode array for detecting a signal representative of respiratory drive output of a patient during inspiration, and a lung ventilator for assisting inspiration of the patient. The gain controller comprises an input for receiving the signal representative of respiratory drive output; a comparator for determining whether the signal representative of respiratory drive output is higher or lower than a target drive signal; and a gain adjustment unit for increasing the value of a gain when the amplitude of the signal representative of respiratory drive output is higher than the amplitude of the target drive signal and for decreasing the value of this gain when the amplitude of the signal representative of respiratory drive output is lower than the amplitude of the target drive signal. The gain is applied to the signal representative of respiratory drive output to produce an amplified respiratory drive output representative signal used for controlling the lung ventilator. The advantage of target drive ventilation is that this mode of ventilation does not depend on pressure, flow or volume measurements. A leaky ventilatory line will introduce a change in respiratory drive which will change the ventilatory assist in order to return the respiratory drive to its target level. Also, changes in the patient's metabolic or patho-physiological status which result in altered respiratory drive will be compensated.
摘要翻译：用于控制增益值的增益控制器和方法与用于在吸气期间检测代表患者的呼吸驱动输出的信号的电极阵列结合使用，以及用于辅助患者的吸气的肺呼吸机。增益控制器包括用于接收代表呼吸驱动输出的信号的输入端; 用于确定代表呼吸驱动输出的信号是否高于或低于目标驱动信号的比较器; 以及增益调整单元，用于当表示呼吸驱动输出的信号的幅度高于目标驱动信号的幅度时增加增益的值，并且当表示呼吸的信号的幅度时减小该增益的值驱动输出低于目标驱动信号的幅度。增益被应用于代表呼吸驱动输出的信号，以产生用于控制肺呼吸机的放大的呼吸驱动输出代表信号。目标驱动器通风的优点在于这种通风方式不依赖于压力，流量或体积测量。泄漏的通气线将引入呼吸驱动器的变化，这将改变通气辅助以使呼吸驱动器返回到其目标水平。此外，患者代谢或病理生理状态的变化导致呼吸道传播改变将得到补偿。

33. 发明授权

US06588423B1 Method and device responsive to myoelectrical activity for triggering ventilatory support 有权
标题翻译：响应肌电活动以触发通气支持的方法和装置
公开(公告)号：US06588423B1
公开(公告)日：2003-07-08
申请号：US09623061
申请日：2001-06-22
申请人： Christer Sinderby
发明人： Christer Sinderby
IPC分类号： F16K3102
CPC分类号： A61B5/04884 , A61M16/026 , A61M2210/1014 , A61M2230/40 , A61M2230/60 , A61M2230/005
摘要： A method and device for triggering ventilatory support to assist the patient's respiration. Myoelectrical activity of a patient's respiratory-related muscle is sensed to detect respiratory effort, and to produce a myoelectrical signal representative of the sensed muscle myoelectrical activity. Respiratory flow and pressure can also be measured to produce respective respiratory pressure and respiratory flow signals. A logic trigger circuit triggers ventilatory support in relation to the myoelectrical signal, respiratory flow signal and/or respiratory pressure signal to assist respiration of the patient. The amplitude of the myolectrical signal is compared to a given threshold, and ventilatory support is triggered when the amplitude of the myoelectrical signal is higher than this threshold. Increment of myoelectrical signal amplitude can also be detected to trigger ventilatory support, while decrement of the myoelectrical signal amplitude can be detected to request non-triggering of the ventilatory support.
摘要翻译：一种用于触发通气支持以辅助患者呼吸的方法和装置。感测患者呼吸相关肌肉的肌电活动以检测呼吸力，并产生代表感测肌肉肌电活动的肌电信号。也可以测量呼吸流量和压力，以产生相应的呼吸压力和呼吸流量信号。逻辑触发电路相对于肌电信号，呼吸流量信号和/或呼吸压力信号触发通气支持以辅助患者的呼吸。将肌电信号的幅度与给定阈值进行比较，当肌电信号的幅度高于该阈值时，通气支持被触发。也可以检测到肌电信号幅度的增加以触发通气支持，同时可以检测出肌电信号幅度的减小，以请求非触发通气支持。

34. 发明授权

US5671752A Diaphragm electromyography analysis method and system 失效
标题翻译：隔膜肌电图分析方法及系统
公开(公告)号：US5671752A
公开(公告)日：1997-09-30
申请号：US414494
申请日：1995-03-31
申请人： Christer Sinderby , Alejandro Grassino , Sven Friberg , Lars Lindstrom
发明人： Christer Sinderby , Alejandro Grassino , Sven Friberg , Lars Lindstrom
IPC分类号： A61B5/0488 , A61M16/00 , A61M16/20 , A61B5/04
CPC分类号： A61B5/04884 , A61B5/7214 , A61B5/0492 , A61M2210/1014 , A61M2230/08 , A61M2230/60
摘要： In the method and system for electromyographic analysis of a striated muscle, electromyographic signals produced by the muscle are detected by means of an array of electrodes passing through the center of the muscle depolarizing region. Each electromyographic signal comprises an electromyographic component and a noise component. The position of the center of the muscle depolarizing region is then determined by detecting a reversal of polarity of the electromyographic components of the signals. Finally, two signals of opposite polarities amongst the electromyographic signals are subtracted. The subtraction subtracts the noise components of the two signals from each other but adds the electromyographic components of the two signals together to produce an electromyographic signal of improved signal-to-noise ratio. Advantageously, the array of electrodes is a linear array of successive electrodes, the center of the muscle depolarizing region is located between the electrodes of a given pair of successive electrodes, and the two signals of opposite polarities detected through the two pairs of successive electrodes adjacent to the given pair on opposite sides thereof are subtracted.
摘要翻译：在横纹肌肌电图分析的方法和系统中，通过穿过肌肉去极化区域的中心的电极阵列来检测由肌肉产生的肌电信号。每个肌电信号包括肌电图分量和噪声分量。然后通过检测信号的肌电图分量的极性反转来确定肌肉去极化区域的中心的位置。最后，减去肌电信号中相反极性的两个信号。减法相互减去两个信号的噪声分量，但将两个信号的肌电分量相加在一起以产生具有改善的信噪比的肌电信号。有利地，电极阵列是连续电极的线性阵列，肌肉去极化区域的中心位于给定的一对连续电极的电极之间，并且通过两对连续电极相邻的两个相邻极性的两个信号相邻减去相对侧的给定对。

35. 发明授权

US08720441B2 Determining patient-ventilator breath contribution index in spontaneously breathing, mechanically ventilated patients 有权
标题翻译：在自发呼吸机械通气患者中确定患者呼吸机呼吸作用指数
公开(公告)号：US08720441B2
公开(公告)日：2014-05-13
申请号：US13059545
申请日：2009-08-26
申请人： Christer Sinderby
发明人： Christer Sinderby
IPC分类号： A61B5/08 , A61M16/00
CPC分类号： A61B5/08 , A61B5/0488 , A61B5/087 , A61B5/687 , A61M16/021 , A61M2016/0039 , A61M2230/60 , A61M2230/005
摘要： The present invention relates to a system and method for determining a patient-ventilator breath contribution index in a spontaneously breathing, mechanically ventilated patient. A patient's efficiency to generate an inspiratory volume without mechanical ventilatory assist and a patient's efficiency to generate an inspiratory volume with mechanical ventilatory assist are calculated and used to determine the patient-ventilator breath contribution index.
摘要翻译：本发明涉及一种用于在自发呼吸机械通气的患者中确定患者 - 呼吸机呼吸作用指数的系统和方法。计算患者产生吸气量而没有机械通气辅助的效率，并且计算患者通过机械通气辅助产生吸气体积的效率，并用于确定患者呼吸机呼吸作用指数。

36. 发明授权

US08554299B2 Electrode for physiological signal measurements and method for making same 有权
标题翻译：用于生理信号测量的电极及其制造方法
公开(公告)号：US08554299B2
公开(公告)日：2013-10-08
申请号：US13474283
申请日：2012-05-17
申请人： Christer Sinderby , Norm Comtois , Göran Rydgren , Tord Lindner
发明人： Christer Sinderby , Norm Comtois , Göran Rydgren , Tord Lindner
IPC分类号： A61B5/042
CPC分类号： A61N1/05 , A61B5/0492 , A61J15/0007 , A61J15/0073 , H01R11/18 , H01R2201/12 , Y10T29/49117 , Y10T29/53204
摘要： The present invention is concerned with an electrode and electrode catheter using thin metallic threads or wires, for example, microwires having diameters as low as 10−6 to 10−4 meters or less. The embodiments allow for the efficient mounting of at least one electrode on a catheter, resulting in the creation of a flexible ring-microelectrode that is suitable for, amongst other things, the detection of myoelectrical activity in a patient's muscle, such as the diaphragm or other inspiratory-related muscle.
摘要翻译：本发明涉及使用细金属线或电线的电极和电极导管，例如具有低至10-6至10-4米或更小直径的微丝。这些实施例允许在导管上有效地安装至少一个电极，导致创建柔性环 - 微电极，其特别适用于检测患者肌肉中的肌电活动，例如隔膜或其他吸气相关的肌肉。

37. 发明申请

US20120226125A1 Electrode for Physiological Signal Measurements and Method for making Same 有权
标题翻译：生理信号测量用电极及其制作方法
公开(公告)号：US20120226125A1
公开(公告)日：2012-09-06
申请号：US13474283
申请日：2012-05-17
申请人： Christer Sinderby , Norm Comtois , Göran Rydgren , Tord Lindner
发明人： Christer Sinderby , Norm Comtois , Göran Rydgren , Tord Lindner
IPC分类号： A61B5/0492
CPC分类号： A61N1/05 , A61B5/0492 , A61J15/0007 , A61J15/0073 , H01R11/18 , H01R2201/12 , Y10T29/49117 , Y10T29/53204
摘要： The present invention is concerned with an electrode and electrode catheter using thin metallic threads or wires, for example, microwires having diameters as low as 10−6 to 10−4 meters or less. The embodiments allow for the efficient mounting of at least one electrode on a catheter, resulting in the creation of a flexible ring-microelectrode that is suitable for, amongst other things, the detection of myoelectrical activity in a patient's muscle, such as the diaphragm or other inspiratory-related muscle.
摘要翻译：本发明涉及使用细金属线或电线的电极和电极导管，例如具有低至10-6至10-4米或更小直径的微丝。这些实施例允许在导管上有效地安装至少一个电极，导致创建柔性环 - 微电极，其特别适用于检测患者肌肉中的肌电活动，例如隔膜或其他吸气相关的肌肉。

38. 发明申请

US20090084382A1 CATHETER POSITIONING METHOD AND COMPUTERIZED CONTROL UNIT FOR IMPLEMENTING THE METHOD 有权
标题翻译：导线定位方法和实现方法的计算机控制单元
公开(公告)号：US20090084382A1
公开(公告)日：2009-04-02
申请号：US12238938
申请日：2008-09-26
申请人： Fredrik Jalde , Joachim Saellvin , Christer Sinderby
发明人： Fredrik Jalde , Joachim Saellvin , Christer Sinderby
IPC分类号： A61M16/00
CPC分类号： A61B5/08 , A61B5/0421 , A61B5/0488 , A61M16/00 , A61M16/024 , A61M2016/0021 , A61M2202/0208 , A61M2210/1014 , A61M2210/105 , A61M2230/04 , A61M2230/08 , A61M2230/60 , A61M2230/005
摘要： A control unit for a ventilator is arranged to receive, from each of a number of electrode pairs on an esophageal catheter a bioelectric signal having an ECG component. The control unit has a calculating unit that determines the ECG component of each of the bioelectric signals and a position unit that determines the position of the catheter in relation to the patient's diaphragm based on a comparison the amplitudes of ECG components of the bioelectric signals.
摘要翻译：用于呼吸机的控制单元布置成从食管导管上的多个电极对中的每一个接收具有ECG分量的生物电信号。控制单元具有计算单元，其基于比较生物电信号的ECG分量的幅度，确定每个生物电信号的ECG分量和确定导管相对于患者隔膜的位置的位置单元。

39. 发明申请

US20050011519A1 Myoelectrically activated respiratory leak sealing 有权
标题翻译：肌电活化呼吸道密封
公开(公告)号：US20050011519A1
公开(公告)日：2005-01-20
申请号：US10466699
申请日：2002-01-16
申请人： Christer Sinderby
发明人： Christer Sinderby
IPC分类号： A61B5/0488 , A61M16/00 , A61M16/04 , A61M16/06 , A62B7/00
CPC分类号： A61B5/0488 , A61M16/024 , A61M16/04 , A61M16/0409 , A61M16/0415 , A61M16/044 , A61M16/0461 , A61M2230/08 , A61M2230/60
摘要： The method and system are for sealing/unsealing (regulating) airway leaks occuring between the ventilator circuit and respiratory airways during lung ventilatory support in response to myoelectrical activity of diaphgram. Myolectrical activity of a patient's respiratory-related muscle is sensed to detect respiratory effort, and to produce a myoelectrical signal representative of the sensed muscle myoelectrical activity. Respiratory flow and pressure can also be measured to produce respective respiratory pressure and respiratory flow signals. A logic trigger sealing/unsealing of airway leaks in relation to the myoelectrical signal, respiratory flow signal and/or respiratory pressure signal to assist respiration of the patient. The amplitude of the myoelectrical signal Is compare to a given threshold, and airway leaks are sealed when the amplitude of the myoelectrical signal is higher than this threshold. Increment of myoelectrical signal amplitude can be also detected to trigger the airway leak regulating device to seal the airway leaks, while decrement of the myoelectrical signal amplitude can be detected to unseal the airway leaks and thus permit air evacuation from the patient's lungs.
摘要翻译：该方法和系统用于在肺通气支持期间对呼吸机回路和呼吸道呼吸之间的气道泄漏进行密封/开封（调节），以响应腹膜的肌电活动。检测患者呼吸相关肌肉的肌电活动以检测呼吸力，并产生代表感测肌肉肌电活动的肌电信号。也可以测量呼吸流量和压力，以产生相应的呼吸压力和呼吸流量信号。相对于肌电信号，呼吸流量信号和/或呼吸压力信号，气道的逻辑触发器密封/开封泄漏以辅助患者的呼吸。肌电信号的幅度与给定阈值相比，当肌电信号的幅度高于该阈值时，气道泄漏被密封。还可以检测到肌电信号幅度的增加，以触发气道泄漏调节装置来密封气道泄漏，同时可以检测到肌电信号振幅的减小，以开启气道泄漏，从而允许从患者肺部排出空气。

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